TW201717926A - 用於治療尤文氏家族腫瘤(ewing family tumors)的組成物及方法 - Google Patents

用於治療尤文氏家族腫瘤(ewing family tumors)的組成物及方法 Download PDF

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Publication number
TW201717926A
TW201717926A TW105126878A TW105126878A TW201717926A TW 201717926 A TW201717926 A TW 201717926A TW 105126878 A TW105126878 A TW 105126878A TW 105126878 A TW105126878 A TW 105126878A TW 201717926 A TW201717926 A TW 201717926A
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TW
Taiwan
Prior art keywords
tyrosine kinase
kinase inhibitor
imatinib
biguanide compound
tumor
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Application number
TW105126878A
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English (en)
Chinese (zh)
Inventor
虹 趙
天賜 王
Original Assignee
衛理公會醫院
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Publication date
Application filed by 衛理公會醫院 filed Critical 衛理公會醫院
Publication of TW201717926A publication Critical patent/TW201717926A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105126878A 2015-08-24 2016-08-23 用於治療尤文氏家族腫瘤(ewing family tumors)的組成物及方法 TW201717926A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562209197P 2015-08-24 2015-08-24
US201562209645P 2015-08-25 2015-08-25

Publications (1)

Publication Number Publication Date
TW201717926A true TW201717926A (zh) 2017-06-01

Family

ID=58101236

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105126878A TW201717926A (zh) 2015-08-24 2016-08-23 用於治療尤文氏家族腫瘤(ewing family tumors)的組成物及方法

Country Status (7)

Country Link
US (1) US10765675B2 (enExample)
EP (1) EP3340978A4 (enExample)
JP (1) JP2018525413A (enExample)
CN (1) CN106714795A (enExample)
CA (1) CA2995642A1 (enExample)
TW (1) TW201717926A (enExample)
WO (1) WO2017035057A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108034726B (zh) * 2018-01-18 2021-07-30 四川大学华西医院 检测mlh1表达水平的试剂在制备肿瘤靶向药敏感性检测试剂盒中的用途
WO2022093789A1 (en) * 2020-10-27 2022-05-05 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of apex, alone and in combination with other cancer drugs to inhibit growth of cancer cells
WO2025097033A1 (en) * 2023-11-01 2025-05-08 City Of Hope Metformin combination therapy for use in cancer treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1641940A4 (en) 2003-07-01 2009-09-02 Mor Research Applic Ltd DETERMINING PROGNOSIS IN PATIENTS WITH EWING SARCOMA BY GENETIC PROFILES
WO2008089034A2 (en) * 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
WO2011050210A1 (en) * 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
JP5967827B2 (ja) * 2009-12-09 2016-08-10 アジオス ファーマシューティカルズ, インコーポレイテッド Idh変異体をもつことを特徴とする癌治療用の治療的活性化合物
CA2938626A1 (en) * 2013-07-26 2015-01-29 John Rothman Compositions to improve the therapeutic benefit of bisantrene

Also Published As

Publication number Publication date
US10765675B2 (en) 2020-09-08
CN106714795A (zh) 2017-05-24
EP3340978A4 (en) 2019-04-10
US20180243299A1 (en) 2018-08-30
WO2017035057A1 (en) 2017-03-02
CA2995642A1 (en) 2017-03-02
JP2018525413A (ja) 2018-09-06
EP3340978A1 (en) 2018-07-04

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