TW201628621A - 泛素活化酶抑制劑及輻射之施用 - Google Patents

泛素活化酶抑制劑及輻射之施用 Download PDF

Info

Publication number
TW201628621A
TW201628621A TW104135034A TW104135034A TW201628621A TW 201628621 A TW201628621 A TW 201628621A TW 104135034 A TW104135034 A TW 104135034A TW 104135034 A TW104135034 A TW 104135034A TW 201628621 A TW201628621 A TW 201628621A
Authority
TW
Taiwan
Prior art keywords
cancer
day
weeks
administered
compound
Prior art date
Application number
TW104135034A
Other languages
English (en)
Chinese (zh)
Inventor
尼爾 班斯
馬克 海爾
麥可 米爾荷蘭
維克 珊諾特拉
蘇吉歐 路易斯 珊特拉那 索妥
達珊 薩婆
Original Assignee
千禧製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 千禧製藥公司 filed Critical 千禧製藥公司
Publication of TW201628621A publication Critical patent/TW201628621A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077Beam delivery systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details
    • A61N2005/1098Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW104135034A 2014-10-29 2015-10-23 泛素活化酶抑制劑及輻射之施用 TW201628621A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462072299P 2014-10-29 2014-10-29
US201562199011P 2015-07-30 2015-07-30

Publications (1)

Publication Number Publication Date
TW201628621A true TW201628621A (zh) 2016-08-16

Family

ID=55858198

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104135034A TW201628621A (zh) 2014-10-29 2015-10-23 泛素活化酶抑制劑及輻射之施用

Country Status (5)

Country Link
US (1) US10335411B2 (enExample)
EP (1) EP3212651B1 (enExample)
JP (1) JP6697453B2 (enExample)
TW (1) TW201628621A (enExample)
WO (1) WO2016069393A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6697453B2 (ja) 2014-10-29 2020-05-20 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. ユビキチン活性化酵素阻害物質及び放射線の投与
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2553476C2 (ru) 2007-08-02 2015-06-20 Миллениум Фармасьютикалз, Инк. Способ синтеза ингибиторов е1-активирующего фермента
US9227971B2 (en) 2010-01-19 2016-01-05 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2013123169A1 (en) 2012-02-17 2013-08-22 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
JP6697453B2 (ja) 2014-10-29 2020-05-20 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. ユビキチン活性化酵素阻害物質及び放射線の投与

Also Published As

Publication number Publication date
US10335411B2 (en) 2019-07-02
US20170333434A1 (en) 2017-11-23
JP6697453B2 (ja) 2020-05-20
EP3212651A1 (en) 2017-09-06
EP3212651A4 (en) 2018-07-25
EP3212651B1 (en) 2021-02-24
JP2017533221A (ja) 2017-11-09
WO2016069393A1 (en) 2016-05-06

Similar Documents

Publication Publication Date Title
JP7187308B2 (ja) Dna損傷剤とatr阻害剤との組み合わせを使用する、がんを処置するための方法
JP6141866B2 (ja) 置換ベンジルピラゾール類
RU2632464C1 (ru) Замещенные триазолопиридины и их применение в качестве ингибиторов тирозин треонин киназы (ттк)
JP2022510501A (ja) 化合物、医薬組成物、ならびに化合物の調製方法及びatrキナーゼ阻害剤としてのその使用方法
TW202309022A (zh) 用於治療具egfr突變之癌症之胺基取代雜環
JP2025143330A (ja) タンパク質チロシンホスファターゼ阻害剤及びそれらの使用方法
JP6697453B2 (ja) ユビキチン活性化酵素阻害物質及び放射線の投与
US10479765B2 (en) Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents
WO2016208595A1 (ja) Brk阻害化合物
TW200413377A (en) Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
JP2019509990A (ja) チェックポイントキナーゼ1(chk1)阻害剤として有用な3,5−二置換ピラゾール、並びにその調製及び用途
JP2025503422A (ja) Pd-l1を標的とするための方法及び組成物
US20220401424A1 (en) Azalactam Compounds as HPK1 Inhibitors
JP6698648B2 (ja) ユビキチン活性化酵素阻害物質及び化学療法剤の投与
TW202132285A (zh) 經取代異吲哚啉基2,2’-聯嘧啶基化合物、其類似物及使用其之方法
CN114206896A (zh) 环状脱氧核糖核苷酸化合物
JP5886868B2 (ja) 置換ピリミド[1,2−b]インダゾールおよびPI3K/AKT経路のモジュレーターとしてのそれらの使用
WO2022036312A2 (en) Inhibitors of ack1/tnk1 tyrosine kinase
WO2022036310A2 (en) Inhibitors of ack1/tnk1 tyrosine kinase
US20230390303A1 (en) Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
WO2025259811A1 (en) Methods and compositions for modulating splicing
HK40063264A (en) Cyclic deoxyribonucleotide compounds