TW201627014A - Blood absorbent material and manufacturing method thereof - Google Patents

Abstract

A blood absorbent material includes a first monomer and a solvent dissolving the first monomer to form a platelet absorbent material. Another blood absorbent material includes a first monomer, a second monomer and a solvent. The first monomer reacts with the second monomer in free-radical polymerization to form a complex polymer. The complex polymer is dissolved in the solvent to produce a platelet absorbent material. In blood isolation, the platelet absorbent material attracts platelets and functional groups of proteins thereof to cause unbalance of the blood for accelerating precipitation and isolation of corpuscles from plasma.

Description

Blood adsorbing material and manufacturing method thereof

The present invention relates to a blood adsorbent material and a method of manufacturing the same; and more particularly to a blood adsorbent material for promoting platelet activation and a method for producing the same; and more particularly to a blood adsorbent material and a method for producing the same, which are suitable for use in the manufacture of a hemostatic material, Blood isolation material or material that promotes wound healing.

For example, a conventional blood separation method, such as the blood separation method and the invention patent of the Republic of China Patent Publication No. I395612, discloses a blood separation method. The blood separation method comprises: providing a first-class channel, a film having a plurality of holes, and a collecting groove, wherein the flow channel is stacked on the film, the collecting groove is disposed on the other side of the film; and driving a blood Flowing, and in contact with the film, moves substantially parallel to the film; the collection of the blood passes through one of the pores of the film. In addition, the blood cells in the blood are blocked by the film, and the other portion of the blood passes through the holes of the film, such that the portion of the blood that passes through the holes of the film is plasma.

The film of the above-mentioned No. I395612 has a first surface and a second surface, and the first surface has a plurality of curved surfaces. The holes are disposed between the curved faces, and the second surface corresponds to the holes, and has a plurality of recessed regions. The pores have a pore size ranging from 1 micron to 50 microns. The material of the film includes metals and/or alloys.

However, the blood separation method of the above-mentioned No. I395612 uses only the film, and the pore diameter of the film ranges from 1 micrometer to 50 micrometers. Meter. In fact, the aforementioned No. I395612 utilizes the film to block the filtration of blood cells in the blood and utilize the pores of the film to allow filtration through the plasma. Thus, the blood separation method of the aforementioned No. I395612 is only suitable for isolating general blood cells, and is not suitable for isolating platelets or blood cells. Thus, conventional blood separation devices and methods thereof necessarily have the potential to further provide for the isolation of platelets and blood cells.

Another conventional blood separation method, such as the blood separation device of the Republic of China Patent Publication No. M483797, discloses a blood separation device. The blood separation device comprises a sleeve, an inner rod assembly, a top cover and a bottom cover. The sleeve has a first end and a second end, and respectively defines a first opening and a second opening. The inner rod assembly is coaxially disposed in the sleeve in a sleeve manner, and the inner rod assembly includes a rod body and a groove body which are screwed to each other. The top cover sleeve closes the first opening, and the bottom cover sleeve closes the second opening. The bottom cover has a central through hole to allow the rod body to be connected to the groove. The blood separation device is used for separating platelet-rich plasma, and the same device can be used to perform blood extraction, centrifugation and extraction of specific blood stratification.

Another conventional blood separation method, such as the plasma collection device of the Republic of China Patent Publication No. M475927, discloses a plasma collection device. The plasma collection device comprises a tube body, a cover body, a piston, a piston and a push rod. The tube body sequentially forms a first tube body portion, a tube neck portion and a second tube body portion along an axial direction. The first tubular body portion has a first opening and an outer flange, and the second tubular body portion has a second opening, and the tubular neck portion connects the first tubular body portion and the second tubular body portion. The cover body covers the first opening, and the cover body has an inner plug portion and an outer ring portion, and the inner plug portion is received in the first tube body portion. Additionally, the outer ring portion abuts the outer flange such that the cover covers the first opening. The piston is disposed in the second tubular body portion to close the second opening. The push rod is disposed in the second tube corresponding to the piston, and the push rod slides in the axial direction against the piston The piston is driven to achieve an adjustment of the blood stratification position. The plasma collection device is a centrifuge tube device for blood separation that allows blood separation to be performed in a centrifugal manner.

Another conventional blood separation method, such as the Separation of Autologous Blood Concentrator from the Republic of China Patent Publication No. M466716, discloses a separate autologous blood concentrator. The isolated autologous blood concentrator comprises an upper bottle and a lower bottle. The top of the lower bottle body has a plurality of convection holes, and the lower portion of the upper bottle body has a rotating control ring and a separating plate, and the rotating control ring is used to drive the separating plate to conduct or not to the lower bottle body. Convection hole. A vortex plug and a screw cap are disposed at a lower portion of the lower bottle body, and the height of the slewing plug is changed by the regulation of the screw cap. A cover or a sleeve is selected on the top of the upper bottle body, and a valve plug is sleeved inside the sleeve. The center of the valve plug is provided with a column tube to connect the column of the center of the sleeve. One side of the valve plug is further provided with a one-way valve, and a nozzle or a soft plug is disposed on one side of the sleeve. The isolated autologous blood concentrator centrifuges the blood into a plasma layer, a platelet thick plasma (PRP) layer, and a blood layer by gradient centrifugation.

However, the blood separation device of the above-mentioned No. M483797, the plasma collection device of No. M475927, and the isolated autologous blood concentrator of No. M466716 both use plasma separation to separate plasma and platelets, and separate the plasma and platelets by centrifugation. The shortcomings of long working hours, high equipment costs and excessive weight.

Another conventional platelet separation device, such as the 〝 〝 platelet-taking device 〞 515 720, discloses a platelet separation device. The platelet separation device comprises a centrifugal separator, a first passage, a second passage, a plasma take-up bag, a platelet take-up bag, and a controller. The centrifugal separator has a blood storage space and a rotor, and the blood storage space is connected to the first-class inlet and the first-class outlet. According to the rotation of the rotor, the blood introduced from the inlet is centrifuged in the blood storage space. Ways to separate plasma from platelets. The first passage delivers blood to the centrifugal separator, and the second passage discharges the centrifugal separator, and the first passage and the second passage are connected to a blood take-up bag.

According to the above, No. 515720, the centrifugal separator discharges plasma to the plasma taking bag via the second passage, and flows the plasma of the plasma taking bag back to the centrifugal separator via the first passage, so that the centrifugal separation is performed. Get platelets. The first passage has a blood donation pump and the second passage is connected to a platelet take-up pouch. The controller is for controlling the action of the rotor of the centrifugal separator and the action of the blood pump. Further, at the time of blood collection, the controller can change the number of revolutions of the rotor in accordance with the amount of blood inflow flowing into the centrifugal separator through the first passage.

However, the platelet separation device of the aforementioned No. 515720 uses the rotor to centrifugally separate plasma and platelets, and the separation of plasma and platelets by centrifugation has the disadvantages of excessive separation operation time, high equipment cost, and excessive weight.

Therefore, there is a need for a further improvement in the conventional platelet separation device and method thereof. The foregoing patent publications No. I395612, No. M483797, No. M475927, No. M466716, and No. 515720 are merely references to the technical background of the present invention and the state of the art is not intended to limit the scope of the present invention.

In view of the above, in order to meet the above technical problems and needs, the present invention provides a blood adsorbing material and a method of manufacturing the same, which utilizes at least one monomer material to form a blood adsorbing material, and when performing blood separation, the blood adsorbing material The monomer material adsorbs the functional groups of platelets and their proteins and destroys the blood balance, thus leading to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma. Therefore, the separation efficiency can be greatly improved compared with the conventional plasma and platelet separation method.

The main object of the present invention is to provide a blood absorbing material And a method of manufacturing the same, which utilizes at least one monomer material to form a blood adsorbent material, and when separating blood, the monomer material of the blood adsorbing material adsorbs functional groups of platelets and proteins thereof and destroys blood balance, thereby causing acceleration Blood cells settle to accelerate the separation of blood cells and plasma for the purpose of separating platelets, blood cells and plasma.

In order to achieve the above object, a blood adsorbent material according to a preferred embodiment of the present invention comprises: a first monomer material that adsorbs a functional group of platelets and proteins thereof, and the first monomer material promotes release of growth factors from the platelets; and at least An organic solvent that dissolves the first monomer material to form a platelet adsorbent material; wherein, when separating blood, the first monomer material of the platelet adsorbing material adsorbs functional groups of platelets and proteins thereof and destroys blood balance, This results in accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma.

In order to achieve the above object, a blood adsorbent material according to another preferred embodiment of the present invention comprises: a first monomer material that adsorbs a functional group of platelets and proteins thereof, and the first monomer material promotes release of growth factors by the platelets; a second monomer material that adsorbs a functional group of the platelet and the protein thereof, and the second monomer material promotes release of the growth factor by the platelet, and the first monomer material and the second monomer material are subjected to radical polymerization, a composite polymer material; and at least one organic solvent, which dissolves the composite polymer material to form a platelet adsorption material; wherein when the blood is separated, the composite polymer material of the platelet adsorption material adsorbs platelets and proteins thereof The functional group destroys blood balance, which leads to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma.

The first monomer material or the second embodiment of the preferred embodiment of the present invention The monomer material is selected from a cell that promotes platelet adsorption.

The platelet-adsorbing monomer of the preferred embodiment of the invention is selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, a quaternary amine, a positively charged monomer, or any combination thereof.

In the preferred embodiment of the invention, the first monomer material or the second monomer material is selected from a monomer having a hydrophobic group.

The hydrophobic group-containing monomer of the preferred embodiment of the invention is selected from the group consisting of a long carbon chain-containing monomer, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, an isomer thereof, or any combination thereof. .

The first monomer material of the preferred embodiment of the invention is from 0.1 to 99.9 weight percent of the composite monomer material.

The second monomer material of the preferred embodiment of the invention is from 0.1 to 99.9 weight percent of the composite monomer material.

In a preferred embodiment of the invention, the platelet adsorbent material is formed as a blood separation gel or a blood separation coating.

In a preferred embodiment of the invention, a porous material or a microstructured material is coated or impregnated into the platelet adsorbent material.

In order to achieve the above object, a method for producing a blood adsorbent according to a preferred embodiment of the present invention comprises: preparing a first monomer material; dissolving the first monomer material with at least one organic solvent to form a monomer material solution; The monomer material solution is formed into a platelet adsorbent material, wherein the first monomer material adsorbs a functional group of the platelet and its protein, and the first monomer material promotes release of the growth factor by the platelet.

In order to achieve the above object, a method for manufacturing a blood adsorbing material according to another preferred embodiment of the present invention comprises: performing a radical polymerization reaction on a first monomer material and a second monomer material to form a composite polymer material; Precipitation and purification of the composite polymer material to obtain a composite copolymer material; dissolving the composite copolymer material by using at least one organic solvent to form a composite copolymer material solution; and forming a composite copolymer material solution The platelet adsorbing material, wherein the composite polymer material of the platelet adsorbing material adsorbs a functional group of the platelet and the protein thereof, and the composite polymer material promotes release of the growth factor by the platelet.

The first monomer material of the preferred embodiment of the invention is selected from the group consisting of a platelet-adsorbing monomer.

The platelet-adsorbing monomer of the preferred embodiment of the invention is selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, a quaternary amine, a positively charged monomer, or any combination thereof.

The second monomer material of the preferred embodiment of the invention is selected from the group consisting of a monomer having a hydrophobic group.

The hydrophobic group-containing monomer of the preferred embodiment of the invention is selected from the group consisting of a long carbon chain-containing monomer, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, an isomer thereof, or any combination thereof. .

In a preferred embodiment of the invention, the platelet adsorbent material is formed as a blood separation gel or a blood separation coating.

In a preferred embodiment of the present invention, a porous material or a fine structural material is coated or immersed in the platelet adsorbing material to form a blood adsorbing substrate.

11‧‧‧ platelet adsorption material

110‧‧‧Microstructure

110a‧‧‧Microstructure

110b‧‧‧Microstructure

110c‧‧‧Microstructure

110d‧‧‧Microstructure

S1‧‧‧ steps

S2‧‧‧ steps

S3‧‧‧ steps

S4‧‧‧ steps

Fig. 1 is a flow chart showing a method of producing a blood adsorbent material according to a first preferred embodiment of the present invention.

Fig. 2 is a flow chart showing a method of manufacturing a blood adsorbent material according to a second preferred embodiment of the present invention.

3(a) to 3(g) are diagrams showing the chemical structure of various amine monomer materials for the blood adsorbent material of the preferred embodiment of the present invention.

Fig. 4 is a view showing the chemical structure of a blood adsorbent material according to a preferred embodiment of the present invention using a monomer material having a hydrophobic group.

Fig. 5 is a perspective view showing the blood adsorbing material of the preferred embodiment of the present invention using a fine structural material and forming a platelet adsorbing material.

6(a) to 6(d) are schematic front views showing various fine structures of the blood absorbing material of the preferred embodiment of the present invention.

In order to fully understand the present invention, the preferred embodiments of the present invention are described in detail below, and are not intended to limit the invention.

The blood adsorbent material of the preferred embodiment of the present invention, the method for producing the same, the blood separation and extraction method thereof and the device thereof are suitable for separating and extracting whole blood into various whole products or related products, for example, blood cell thick liquid, fresh frozen plasma, frozen sedimentation. A product, a platelet thick liquid, a white blood cell thick liquid or a related product thereof, but it is not intended to limit the scope of application of the present invention. The blood separation and extraction method and device thereof according to the preferred embodiment of the present invention are suitable for use in various medical scientific research, treating patients (for example, Achilles tendon rupture or treating arthritis), medical and aesthetic industries (for example, treating baldness and reducing wrinkles) Or increase the role of collagen layer], medical rehabilitation (for example: rehabilitation after surgery or implant surgery), pharmaceutical products or related industries, but it is not intended to limit the scope of application of the present invention.

1 is a schematic flow chart showing a method for manufacturing a blood adsorbent according to a first preferred embodiment of the present invention, which comprises three main steps S1 to S3, but is not intended to limit the order of steps of the present invention without departing from the scope of the present invention. In the following, the order of steps of the preferred embodiment of the invention may be varied, divided, added, combined or reduced.

Referring to FIG. 1, a method for manufacturing a blood adsorbent according to a first preferred embodiment of the present invention includes the step S1: first, in an appropriate manner. Prepare a first monomer material [monomer]. For example, the first monomer material is selected from a monomer that promotes platelet adsorption monomer, a hydrophobic group, or a monomeric material that adsorbs platelets, a protein thereof, and a growth factor that promotes the platelet release.

Referring to FIG. 1 again, the method for manufacturing a blood adsorbent according to the first preferred embodiment of the present invention comprises the step S2: Next, the first monomer material is dissolved by using at least one organic solvent to form a monomer material solution. For example, the organic solvent may be selected from various organic solvents or solutions containing a suitable organic solvent.

Referring to FIG. 1 again, the method for manufacturing a blood adsorbent according to the first preferred embodiment of the present invention comprises the step S3: subsequently, using the monomer material solution to form a platelet adsorbent, wherein the first monomer material is adsorbed. a functional group of platelets and proteins thereof, and when the first monomer material is in contact with blood, the platelets are released to release growth factors, and thus the platelet adsorbing material is suitable for use as a hemostatic material, a blood separation material, or Promotes wound healing materials.

Referring again to FIG. 1, for example, another preferred embodiment of the present invention selects the platelet adsorbent material as a blood separation gel or a blood separation paint. A porous material or a micro-structure material is selectively coated or immersed in the platelet adsorbing material to form a blood adsorbing substrate.

2 is a schematic flow chart showing a method for manufacturing a blood adsorbent according to a second preferred embodiment of the present invention, which comprises four main steps S1 to S4, but is not intended to limit the order of steps of the present invention without departing from the scope of the present invention. In the following, the order of steps of the preferred embodiment of the invention may be varied, divided, added, combined or reduced.

Referring to FIG. 2, a method for manufacturing a blood adsorbent according to a second preferred embodiment of the present invention comprises the step S1: first, a first monomer material and a second monomer material are subjected to radical polymerization to generate One complex Polymer materials. For example, the first monomer material is 0.1 to 99.9 weight percent of the composite polymer material, and the second monomer material is 0.1 to 99.9 weight percent of the composite polymer material. The blood adsorbent material of another preferred embodiment of the present invention is selected to include a first monomer material, a second monomer material, and a third monomer material.

Referring to FIG. 2 again, for example, the first monomer material and the second monomer material are selected from a monomer that promotes platelet adsorption monomer, a hydrophobic group, or an adsorbed platelet, and a protein thereof. a functional group and a monomer material that promotes release of the growth factor from the platelet, and the first monomer material and the second monomer material are different monomer materials.

Referring to FIG. 2 again, the method for manufacturing a blood adsorbent according to the second preferred embodiment of the present invention comprises the step S2: subsequently, selecting and chemically precipitating and purifying the composite polymer material in a suitable processing device [precipitation and Purification to obtain a composite polymer.

Referring to FIG. 2 again, the method for manufacturing a blood adsorbent according to the second preferred embodiment of the present invention comprises the step S3: subsequently, dissolving the composite copolymer material with at least one organic solvent to form a composite copolymer material solution, For subsequent processing operations such as coating, dipping or other processing operations.

Referring to FIG. 2 again, the method for manufacturing a blood adsorbent according to the second preferred embodiment of the present invention comprises the step S4: subsequently, using the composite copolymer material solution to form a platelet adsorbing material, such as blood separation gel and blood. Separation of coatings, hemostatic materials, blood separation materials, wound healing materials or other medical related materials.

Figures 3(a) through 3(g) show schematic diagrams showing the chemical structures of various amine monomer materials for blood adsorbent materials in accordance with a preferred embodiment of the present invention. Referring to Figures 1, 2 and 3(a) to 3(g), the first monomer material and the second monomer material are for promoting platelet adsorption monomer, which is selected from the group consisting of a primary amine and a secondary amine. A tertiary amine, a quaternary amine, a positively charged monomer, or any combination thereof.

Fig. 4 is a view showing the chemical structure of a blood absorbing material of a preferred embodiment of the present invention using a monomer material having a hydrophobic group. Referring to Figures 1, 2 and 4, the first monomer material is selected from the group consisting of a long carbon chain-containing monomer, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, an isomer thereof or any combination. The monomer having a hydrophobic matrix is a soft ether-based acrylic compound having carbon chains of various lengths, and the carbon chain has a carbon number of 0 to 12.

Fig. 5 is a perspective view showing the use of a fine structure material for a blood absorbing material according to a preferred embodiment of the present invention and forming a platelet absorbing material. The blood adsorbing material of the preferred embodiment of the present invention uses a fine structural material. Referring to Fig. 5, a platelet adsorbing material 11 comprises a fine structure 110, and the fine structure 110 is formed on a surface of a fine structure to increase the platelet-adsorbing area of the platelet adsorbing material 11. The microstructure 110 has a size ranging from a few nanometers to a few hundred nanometers or a few micrometers.

6(a) to 6(d) are schematic front views showing the use of various fine structures of the blood absorbing material of the preferred embodiment of the present invention, which corresponds to Fig. 5. Referring to FIG. 6(a) again, for example, the platelet adsorbing material 11 of the preferred embodiment of the present invention comprises a microstructure 110a having a plurality of inclined grooves, and the plurality of inclined grooves are selected to wait. Spacing or unequal spacing extends parallel to each other on the surface of the microstructure.

Referring to FIG. 6(b), in another preferred embodiment of the present invention, the platelet adsorbing material 11 comprises a microstructure 110b comprising a plurality of circular bump portions or a plurality of circular recess portions, and the number The circular bump portions or the plurality of circular recess portions are arranged in a unequal manner in a regular equidistant or gradually regular manner to form an array of circular bumps or an array of circular recesses on the surface of the microstructure.

Referring to FIG. 6(c), in another preferred embodiment of the present invention, the platelet adsorbing material 11 comprises a microstructure 110c comprising a plurality of elliptical bumps or a plurality of elliptical pockets, and the plurality of ellipse Bump or several The elliptical pockets are arranged in an unequal manner in regular equidistant or gradually regular variations to form an array of elliptical bumps or an array of elliptical pockets on the surface of the microstructure.

Referring to FIG. 6(d), in another preferred embodiment of the present invention, the platelet adsorbing material 11 comprises a microstructure 110d comprising a plurality of first groove portions and a plurality of second groove portions, and the first groove The groove portion and the second groove portion intersect each other to form a cross array on the surface of the fine structure, and the first groove portion and the second groove portion form a plurality of vertical columnar bodies.

The foregoing preferred embodiments are merely illustrative of the invention and the technical features thereof, and the techniques of the embodiments can be carried out with various substantial equivalent modifications and/or alternatives; therefore, the scope of the invention is subject to the appended claims. The scope defined by the scope shall prevail. The copyright limitation of this case is used for the purpose of patent application in the Republic of China.

S1‧‧‧ steps

S2‧‧‧ steps

S3‧‧‧ steps

Claims (10)

A blood absorbing material comprising: a first monomer material that adsorbs a functional group of platelets and proteins thereof, and the first monomer material promotes the platelet releasing growth factor; and at least one organic solvent that dissolves the first a monomer material to form a platelet adsorbent material; wherein, when separating blood, the first monomer material of the platelet adsorbing material adsorbs functional groups of platelets and proteins thereof and destroys blood balance, thereby causing accelerated blood cell sedimentation to accelerate separation Blood cells and plasma. A blood absorbing material comprising: a first monomer material that adsorbs functional groups of platelets and proteins thereof, and the first monomer material promotes release of growth factors from the platelets; a second monomer material that adsorbs platelets and a functional group of the protein, and the second monomer material promotes release of the growth factor by the platelet, and the first monomer material and the second monomer material are subjected to radical polymerization to form a composite polymer material; and at least one An organic solvent which dissolves the composite polymer material to form a platelet adsorption material; wherein, when separating blood, the composite polymer material of the platelet adsorption material adsorbs functional groups of platelets and proteins and destroys blood balance, thereby causing acceleration The blood cells settle to accelerate the separation of blood cells and plasma. The blood adsorbing material according to claim 1 or 2, wherein the first monomer material is selected from a monomer which promotes a platelet adsorbing monomer or a hydrophobic group, or the first monomer material is selected. From a primary amine, a secondary amine, a tertiary amine, a quaternary amine, a positively charged monomer, or any combination thereof, or the first monomer material is selected from the group consisting of a long carbon chain-containing monomer, dipropylene glycol methyl ether acrylate , propylene glycol methyl ether acrylate, its isomer or any combination thereof. The blood sorbent material according to claim 2, wherein the second monomer material is selected from a monomer that promotes a platelet-adsorbing monomer or a hydrophobic group, or the first monomer material is selected from the group consisting of Amine, secondary amine, tertiary An amine, a quaternary amine, a positively charged monomer or any combination thereof, or the first monomer material is selected from the group consisting of a long carbon chain-containing monomer, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, and the same Isomer or any combination thereof. The blood sorbent material according to claim 2, wherein the first monomer material is 0.1 to 99.9 weight percent of the composite monomer material, and the second monomer material is 0.1 to 9 99.9 weight percent. A blood adsorbing material and a method of manufacturing the same, comprising: preparing a first monomer material; dissolving the first monomer material with at least one organic solvent to form a monomer material solution; and using the monomer material solution A platelet adsorbent material, wherein the first monomer material adsorbs a functional group of platelets and proteins thereof, and the first monomer material promotes release of growth factors by the platelets. A blood adsorbing material and a manufacturing method thereof, comprising: performing a radical polymerization reaction on a first monomer material and a second monomer material to form a composite polymer material; and precipitating and purifying the composite polymer material, Obtaining a composite copolymer material; dissolving the composite copolymer material by using at least one organic solvent to form a composite copolymer material solution; and using the composite copolymer material solution to form a platelet adsorption material. The method for producing a blood adsorbent according to claim 6 or 7, wherein the first monomer material is selected from a monomer which promotes a platelet adsorption monomer or a hydrophobic group, or the first monomer. The material is selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, a quaternary amine, a positively charged monomer, or any combination thereof, or the first monomer material is selected from a monomer containing a long carbon chain, dipropylene glycol methyl ether. Acrylate, propylene glycol methyl ether acrylate, its isomers or any combination thereof. The manufacturer of blood absorbing materials according to item 7 of the patent application scope The method wherein the second monomer material is selected from a monomer that promotes a platelet-adsorbing monomer or a hydrophobic group, or the first monomer material is selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and a fourth-order An amine, a positively charged monomer, or any combination thereof, or the first monomer material is selected from the group consisting of a long carbon chain containing monomer, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, its isomers or Any of its compositions. The method for producing a blood adsorbent according to claim 6 or 7, wherein a porous material or a fine structure material is coated or immersed in the platelet adsorbing material to form a blood adsorbing substrate.