TWI684466B - Blood absorbent material and manufacturing method thereof - Google Patents

Abstract

A blood absorbent material includes a first monomer and a solvent dissolving the first monomer to form a platelet absorbent material. Another blood absorbent material includes a first monomer, a second monomer and a solvent. The first monomer reacts with the second monomer in free-radical polymerization to form a complex polymer. The complex polymer is dissolved in the solvent to produce a platelet absorbent material. In blood isolation, the platelet absorbent material attracts platelets and functional groups of proteins thereof to cause unbalance of the blood for accelerating precipitation and isolation of corpuscles from plasma.

Description

Blood adsorption material and its manufacturing method

The present invention relates to a blood adsorbent material and a manufacturing method thereof; in particular, to a blood adsorbent material that promotes the activation of platelets (platelet) and a manufacturing method thereof; more particularly, to a blood adsorbent material and a manufacturing method thereof suitable for manufacturing hemostatic materials, Blood separation (isolation) materials or materials that promote wound healing.

For example, conventional blood separation methods, such as the invention patent of the "Blood Separation Method" patent No. I395612 of the Republic of China, disclose a blood separation method. The blood separation method includes: providing a flow channel, a film having a plurality of holes, and a collection groove, and the flow channel is stacked on the film, and the collection groove is corresponding to the flow channel on the other side of the film; driving a blood Flow, and when contacting the membrane, it moves substantially parallel to the membrane; collects the blood in the collection tank through the plasma of the pores of the membrane. In addition, the blood cells in the blood are blocked by the film, and other parts of the blood pass through the holes of the film, so that the part of the blood passing through the holes of the film is plasma.

As mentioned above, the aforementioned film No. I395612 has a first surface and a second surface, and the first surface has a plurality of arc surfaces. The holes are arranged between the arc surfaces, and the second surface corresponds to the holes and has a plurality of concave regions. The pore size of these holes ranges from 1 micron to 50 microns. The material of the film includes metals and/or alloys.

However, the aforementioned blood separation method No. I395612 only uses the membrane, and the pore size of the pores of the membrane ranges from 1 micron to 50 microns Meter. In fact, the aforementioned No. I395612 uses the membrane to block and filter blood cells in the blood, and uses the pores of the membrane to allow filtration through the plasma. Therefore, the aforementioned blood separation method No. I395612 is only suitable for separating general blood cells, and it is not suitable for separating platelets or blood cells. Therefore, the conventional blood separation device and its method inevitably have the potential to further provide the separation of platelets and blood cells.

Another conventional blood separation method, such as the new patent of "Blood Separation Device" of the Republic of China Patent Announcement No. M483797, which discloses a blood separation device. The blood separation device includes a sleeve, an inner rod assembly, a top cover and a bottom cover. The sleeve has a first end and a second end, and respectively forms a first opening and a second opening. The inner rod assembly is coaxially arranged in the sleeve in a sleeve connection manner, and the inner rod assembly includes a rod body and a groove body connected with each other by threads. The top cover is sleeved to close the first opening, and the bottom cover is sleeved to close the second opening. The bottom cover has a central through hole to allow the rod body to penetrate and connect to the groove body. The blood separation device is used to separate platelet-rich plasma, and the same device can be used for blood extraction, centrifugation and specific blood stratification extraction.

Another conventional blood separation method, such as the new patent for "plasma collection device" No. M475927 of the Republic of China, discloses a plasma collection device. The plasma collection device includes a tube, a cover, a piston, a piston and a push rod. The tube body sequentially forms a first tube body portion, a tube neck portion, and a second tube body portion along an axial direction. The first tube body portion has a first opening and an outer flange, and the second tube body portion has a second opening, and the tube neck is connected to the first tube body portion and the second tube body portion. The cover body is used to cover the first opening, and the cover body has an inner plug portion and an outer ring portion, and the inner plug portion is accommodated in the first tube body portion. In addition, the outer ring portion abuts the outer flange so that the cover body covers the first opening. The piston is disposed in the second tube body portion to close the second opening. The push rod and the piston are correspondingly arranged in the second tube body, and the push rod slides against the piston in the axial direction The piston is driven to adjust the blood stratification position. The plasma collection device is a centrifuge tube device for blood separation, which can be used for centrifugal operation of blood separation.

Another conventional blood separation method, such as the new patent of "Separation Autologous Blood Concentrator" No. M466716 of the Republic of China, discloses a kind of autologous blood concentrator. The autologous blood concentrator includes an upper bottle body and a lower bottle body. The top of the lower bottle body has several convection holes, and the lower part of the upper bottle body has a spin ring and an isolating plate, and the isolating plate is driven by the spin ring to conduct or not conduct to the lower bottle body Convection holes. The lower part of the lower bottle body is provided with a float plug and a screw cap, and the height of the float plug is changed by the adjustment of the screw cap. A cap or a sleeve is selected on the top of the upper bottle body, and a valve plug is sleeved inside the sleeve. A column tube is arranged at the center of the valve plug to connect the column at the center of the sleeve. A check valve is additionally arranged on one side of the valve plug, and a nozzle or a soft plug is further provided on one side of the sleeve. The autologous blood concentrator separates the blood into a plasma layer, a platelet rich plasma [PRP] layer and a blood layer by gradient centrifugation.

However, the aforementioned blood separation device No. M483797, plasma collection device No. M475927 and "autologous blood concentrator No. M466716" all use rotary centrifugation to separate plasma and platelets, and the separation of plasma and platelets by centrifugation The shortcomings of too long operation time, high equipment cost and excessive weight.

Another conventional platelet separation device, such as the invention patent for the "platelet taking device" No. 515720 of the Republic of China, discloses a platelet separation device. The platelet separation device includes a centrifugal separator, a first path, a second path, a plasma collection bag, a platelet collection bag, and a controller. The centrifugal separator has a blood storage space and a rotor, and the blood storage space communicates with the first-class inlet and the first-class outlet. According to the rotation of the rotor, the blood introduced from the inlet is centrifuged in the blood storage space Way to separate plasma and platelets. The first passage sends blood into the centrifugal separator, and the second passage discharges the centrifugal separator, and the first passage and the second passage are connected to a blood collection bag.

As mentioned above, the aforementioned No. 515720 discharges the plasma from the centrifugal separator to the plasma collection bag through the second passage, and flows the plasma from the plasma collection bag back to the centrifugal separator through the first passage, thus being separated by the centrifuge To obtain platelets. The first path has a blood delivery pump, and the second path is connected to a platelet collection bag. The controller is used to control the operation of the rotor of the centrifugal separator and the operation of the blood supply pump. In addition, during blood collection, the controller can change the number of revolutions of the rotor in accordance with the amount of blood flowing into the centrifugal separator through the first passage.

However, the aforementioned platelet separation device No. 515720 uses the rotor to separate plasma and platelets by centrifugation, and the separation of plasma and platelets by centrifugation has the disadvantages of too long separation operation time, high equipment cost and excessive weight.

Therefore, there is inevitably a need for further improvements in conventional platelet separation devices and methods. The aforementioned Patent Announcements No. I395612, No. M483797, No. M475927, No. M466716 and No. 515720 are only a reference to the technical background of the present invention and illustrate the current state of technological development, which is not intended to limit the scope of the present invention.

In view of this, in order to meet the above technical problems and needs, the present invention provides a blood adsorbent material and a manufacturing method thereof, which uses at least one monomer material to make a blood adsorbent material, and when performing blood separation, the blood adsorbent material The monomer material adsorbs the functional groups of platelets and their proteins and disrupts the blood balance, which leads to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma. Therefore, the separation efficiency can be greatly improved compared with conventional plasma and platelet separation methods.

The main object of the present invention is to provide a blood adsorbent material and a manufacturing method thereof, which uses at least one monomer material to make a blood adsorbent material, and when performing blood separation, the monomer material of the blood adsorbent material adsorbs platelets and proteins The functional group does not disrupt the blood balance, thus leading to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma, so as to achieve the purpose of separating platelets, blood cells and plasma.

In order to achieve the above object, the blood adsorption material according to the preferred embodiment of the present invention includes: a first monomer material having a functional group for adsorbing platelets and proteins, and the first monomer material promotes the release of growth factors by the platelets; and At least one organic solvent, which dissolves the first monomer material to form a platelet adsorption material; wherein when separating blood, the first monomer material of the platelet adsorption material adsorbs the functional groups of platelets and their proteins and disrupts blood balance , Which leads to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma.

In order to achieve the above objective, another preferred embodiment of the blood adsorption material of the present invention includes: a first monomer material having a functional group for adsorbing platelets and proteins, and the first monomer material promotes the release of growth factors by the platelets A second monomer material, which has a functional group that adsorbs platelets and their proteins, and the second monomer material promotes the release of growth factors by the platelets, and free radical polymerization of the first monomer material and the second monomer material Reaction to generate a composite polymer material; and at least one organic solvent, which dissolves the composite polymer material to form a platelet adsorption material; wherein the platelet adsorption material composite polymer material adsorbs platelets and The functional groups of its protein disrupt the blood balance, thus leading to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma.

The first monomer material or the second of the preferred embodiment of the present invention The monomer material is selected from a monomer that promotes platelet adsorption.

In the preferred embodiment of the present invention, the platelet adsorption promoting monomer is selected from primary amine, secondary amine, tertiary amine, quaternary amine, positively charged monomer, or any combination thereof.

In the preferred embodiment of the present invention, the first monomer material or the second monomer material is selected from a monomer having a hydrophobic group.

In the preferred embodiment of the present invention, the monomer having a hydrophobic group is selected from a monomer containing a long carbon chain, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, its isomers or any combination thereof .

In the preferred embodiment of the present invention, the first monomer material is 0.1 to 99.9 weight percent of the composite monomer material.

In the preferred embodiment of the present invention, the second monomer material is 0.1 to 99.9 weight percent of the composite monomer material.

In a preferred embodiment of the present invention, the platelet adsorption material is made into a blood separation gel or a blood separation coating.

In a preferred embodiment of the present invention, a porous material or a fine structure material is coated or impregnated on the platelet adsorbing material.

In order to achieve the above object, a method for manufacturing a blood adsorption material according to a preferred embodiment of the present invention includes: preparing a first monomer material; dissolving the first monomer material with at least one organic solvent to form a monomer material solution; and using The monomer material solution is made into a platelet adsorption material, wherein the first monomer material adsorbs the functional groups of platelets and their proteins, and the first monomer material promotes the release of growth factors by the platelets.

In order to achieve the above object, a method for manufacturing a blood adsorption material according to another preferred embodiment of the present invention includes: performing radical polymerization on a first monomer material and a second monomer material to generate a composite polymer material; Precipitating and purifying the composite polymer material to obtain a composite copolymer material; using at least one organic solvent to dissolve the composite copolymer material to form a composite copolymer material solution; and using the composite copolymer material solution to make a Platelet adsorption material, wherein the composite polymer material of the platelet adsorption material adsorbs the functional groups of platelets and their proteins, and the composite polymer material promotes the release of growth factors by the platelets.

In the preferred embodiment of the present invention, the first monomer material is selected from a monomer that promotes platelet adsorption.

In the preferred embodiment of the present invention, the platelet adsorption promoting monomer is selected from primary amine, secondary amine, tertiary amine, quaternary amine, positively charged monomer, or any combination thereof.

In the preferred embodiment of the present invention, the second monomer material is selected from a monomer having a hydrophobic group.

In the preferred embodiment of the present invention, the monomer having a hydrophobic group is selected from a monomer containing a long carbon chain, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, its isomers or any combination thereof .

In a preferred embodiment of the present invention, the platelet adsorption material is made into a blood separation gel or a blood separation coating.

In a preferred embodiment of the present invention, a porous material or a fine structure material is coated or impregnated on the platelet adsorption material to make a blood adsorption substrate.

11‧‧‧ Platelet adsorption material

110‧‧‧fine structure

110a‧‧‧fine structure

110b‧‧‧fine structure

110c‧‧‧fine structure

110d‧‧‧fine structure

S1‧‧‧Step

S2‧‧‧Step

S3‧‧‧Step

S4‧‧‧Step

Figure 1: Schematic flow chart of the method for manufacturing the blood adsorbent material according to the first preferred embodiment of the present invention.

Fig. 2: A schematic flow chart of a method for manufacturing a blood adsorption material according to a second preferred embodiment of the present invention.

Figures 3(a) to 3(g): Schematic diagrams of chemical structures of various amine monomer materials used in the blood adsorption material of the preferred embodiment of the present invention.

Fig. 4: A schematic diagram of the chemical structure of a monomer material with a hydrophobic group used in the blood adsorption material of the preferred embodiment of the present invention.

Fig. 5: The blood adsorption material of the preferred embodiment of the present invention uses a fine structure material and forms a schematic perspective view of the platelet adsorption material.

Figures 6(a) to 6(d): a schematic front view of various fine structures of the blood adsorption material of the preferred embodiment of the present invention.

In order to fully understand the present invention, preferred embodiments will be exemplified below and described in detail in conjunction with the accompanying drawings, and they are not intended to limit the present invention.

The blood adsorbent material of the preferred embodiment of the present invention, its manufacturing method, its blood separation and extraction method and its device are suitable for the separation and extraction of whole blood into various whole products or related products, such as: thick blood cells, fresh frozen plasma, cryoprecipitate Products, platelet thick liquid, white blood cell thick liquid or related products, but it is not intended to limit the scope of application of the present invention. The blood separation and extraction method and device of the preferred embodiment of the present invention are suitable for various medical scientific researches, treating patients [eg: Achilles tendon rupture or arthritis treatment], medical beauty industry [eg: treating baldness, reducing wrinkles Or increase the collagen layer effect], medical rehabilitation [for example: rehabilitation after surgery or dental implant surgery], medical products or related industries, but it is not intended to limit the scope of application of the present invention.

Fig. 1 shows a schematic flow chart of a method for manufacturing a blood adsorbent material according to a first preferred embodiment of the present invention, which includes three main steps S1 to S3, but it is not intended to limit the sequence of the present invention without departing from the scope of the present invention Below, the sequence of steps of the preferred embodiment of the present invention can be appropriately changed, divided, added, merged or reduced.

Please refer to FIG. 1, the method for manufacturing a blood adsorbent material according to the first preferred embodiment of the present invention includes step S1: First, the system is prepared in an appropriate manner Prepare a first monomer material [monomer]. For example, the first monomer material is selected from a monomer that promotes the adsorption of platelets, a monomer with a hydrophobic group, or a monomer material that has functional groups for adsorbing platelets and their proteins and promotes the release of growth factors by the platelets.

Referring again to FIG. 1, the method for manufacturing a blood adsorbent material according to the first preferred embodiment of the present invention includes step S2: Next, the first monomer material is dissolved with at least one organic solvent to form a monomer material solution. For example, the organic solvent may be selected from various organic solvents or solutions containing suitable organic solvents.

Referring again to FIG. 1, the method for manufacturing a blood adsorbent material according to the first preferred embodiment of the present invention includes step S3: Next, a platelet adsorbent material is prepared using the monomer material solution, wherein the first monomer material adsorbs Functional groups of platelets and their proteins, and when the first monomer material is in contact with blood, it can promote the release of growth factors from the platelets. Therefore, the platelet adsorption material is suitable for making hemostatic materials, blood separation materials or Materials that promote wound healing.

Please refer to FIG. 1 again. For example, another preferred embodiment of the present invention selects the platelet adsorption material as a blood separation gel or a blood separation coating. A porous material or a micro-structure material is selectively coated or impregnated into the platelet adsorption material to make a blood adsorption substrate.

FIG. 2 shows a schematic flow chart of a method for manufacturing a blood adsorbent material according to a second preferred embodiment of the present invention, which includes four main steps S1 to S4, but it is not intended to limit the sequence of the present invention without departing from the scope of the present invention Below, the sequence of steps of the preferred embodiment of the present invention can be appropriately changed, divided, added, merged or reduced.

Referring to FIG. 2, the method for manufacturing a blood adsorbent material according to a second preferred embodiment of the present invention includes step S1: First, a first monomer material and a second monomer material are subjected to radical polymerization reaction to generate Repeat Combined polymer materials. For example, the first monomer material is 0.1 to 99.9 weight percent of the composite polymer material, and the second monomer material is 0.1 to 99.9 weight percent of the composite polymer material. The blood adsorption material of another preferred embodiment of the present invention includes a first monomer material, a second monomer material and a third monomer material.

Please refer to FIG. 2 again. For example, the first monomer material and the second monomer material are selected from a platelet-adsorbing monomer, a monomer with a hydrophobic group, or a platelet-adsorbing protein and its protein Functional groups and monomer materials that promote the release of growth factors from the platelets, and the first monomer material and the second monomer material are different monomer materials.

Referring again to FIG. 2, the method for manufacturing a blood adsorbent material according to the second preferred embodiment of the present invention includes step S2: Next, the composite polymer material is chemically precipitated and purified in an appropriate processing device [precipitation and purification] to obtain a composite copolymer material [composite polymer].

Referring again to FIG. 2, the method for manufacturing a blood adsorbent material according to the second preferred embodiment of the present invention includes step S3: Next, the composite copolymer material is dissolved with at least one organic solvent to form a composite copolymer material solution, In order to carry out subsequent processing operations, such as: coating, dipping or other processing operations.

Referring again to FIG. 2, the method for manufacturing a blood adsorbent material according to a second preferred embodiment of the present invention includes step S4: Next, a platelet adsorbent material is prepared by using the composite copolymer material solution, for example: blood separation gel, blood Separation coatings, hemostatic materials, blood separation materials, wound healing materials or other medical related materials.

Figures 3(a) to 3(g) show schematic diagrams of chemical structures of various amine monomer materials used in the blood adsorption material of the preferred embodiment of the present invention. Please refer to Figures 1, 2, and 3(a) to 3(g), the first monomer material and the second monomer material are monomers for promoting platelet adsorption, which are selected from primary amines, secondary amines, Tertiary amine, quaternary amine, positively charged monomer or any combination thereof.

FIG. 4 shows a schematic diagram of the chemical structure of a monomer material with a hydrophobic group used in the blood adsorption material according to the preferred embodiment of the present invention. Please refer to Figures 1, 2 and 4, the first monomer material is selected from a monomer containing a long carbon chain, dipropylene glycol methyl ether acrylate, propylene glycol methyl ether acrylate, its isomers or any of them combination. The monomer with a hydrophobic matrix is a soft ether-based acrylic compound with carbon chains of various lengths, and the carbon number of the carbon chain is 0-12.

FIG. 5 shows a schematic perspective view of the blood adsorption material of the preferred embodiment of the present invention using fine-structured materials and forming platelet adsorption material. The blood adsorption material of the preferred embodiment of the present invention uses a fine structure material. Referring to FIG. 5, a platelet adsorption material 11 includes a fine structure 110, and the fine structure 110 is formed on the surface of a fine structure, so as to increase the platelet adsorption area of the platelet adsorption material 11. The fine structure 110 has a size from several nanometers to hundreds of nanometers or several micrometers.

Figures 6(a) to 6(d) show front views of various fine structures of the blood adsorption material according to the preferred embodiment of the present invention, which corresponds to Figure 5. Please refer to FIG. 6(a) again. For example, the platelet adsorption material 11 of the preferred embodiment of the present invention includes a fine structure 110a having a plurality of inclined grooves, and the plurality of inclined grooves are selected to equal The pitch or unequal pitch extends parallel to each other on the surface of the fine structure.

Please refer to FIG. 6(b). According to another preferred embodiment of the present invention, the platelet adsorption material 11 includes a fine structure 110b including a plurality of circular convex portions or a plurality of circular concave portions, and the number A plurality of circular convex portions or a plurality of circular concave portions are arranged in a regular equidistant or gradually irregularly changing unequal manner to form a circular convex dot array or a circular concave array on the surface of the fine structure.

Please refer to FIG. 6(c). According to another preferred embodiment of the present invention, the platelet adsorbing material 11 includes a fine structure 110c including elliptical convex portions or elliptical concave portions, and the ellipses Bump part or several The elliptical cavity parts are arranged in a regular equidistant or gradually irregularly changing unequal manner to form an elliptical convex dot array or an elliptical concave cavity array on the surface of the fine structure.

Please refer to FIG. 6(d). According to another preferred embodiment of the present invention, the platelet adsorption material 11 includes a fine structure 110d including a plurality of first groove grooves and a plurality of second groove grooves, and the first groove The groove portion and the second groove groove portion cross each other to form a cross array on the surface of the microstructure, and the first groove groove portion and the second groove groove portion form a plurality of vertical columnar bodies.

The foregoing preferred embodiment only exemplifies the present invention and its technical features, and the technology of this embodiment can still be appropriately implemented with various substantial equivalent modifications and/or replacements; therefore, the scope of the present invention is subject to the appended patent application The scope defined by the scope shall prevail. The copyright in this case is restricted to the use of patent applications in the Republic of China.

S1‧‧‧Step

S2‧‧‧Step

S3‧‧‧Step

Claims (10)

A blood adsorption material, comprising: a first monomer material having a functional group for adsorbing platelets and their proteins, and the first monomer material has a function of promoting growth factor release of the platelets, and the first monomer material is selected The monomer with a hydrophobic group is an ether-based acrylic compound with a carbon chain, or the first monomer material is selected from primary amine, secondary amine, tertiary amine, quaternary amine or any combination thereof , Or the first monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate; and at least one organic solvent that dissolves the first monomer material to form a platelet adsorption material; wherein the primary amine, The chemical structure of secondary amine, tertiary amine or quaternary amine includes chemical structure (a), (b), (c), (d), (e), (f) or (g):

When separating blood, the first monomer material of the platelet adsorbing material adsorbs the functional groups of platelets and proteins and achieves a mechanism of disrupting blood balance, thus leading to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma. A blood adsorption material, comprising: a first monomer material having a functional group for adsorbing platelets and their proteins, and the first monomer material has a function of promoting growth factor release of the platelets, and the first monomer material is selected The monomer with a hydrophobic group is an ether-based acrylic compound with a carbon chain, or the first monomer material is selected from primary amine, secondary amine, tertiary amine, quaternary amine or any combination thereof , Or the first monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate; a second monomer material having a functional group that adsorbs platelets and their proteins, and the second monomer material has a promotion The platelet releases the growth factor function, and the second monomer material is selected from a monomer having a hydrophobic group is an ether-based acrylic compound having a carbon chain, or the second monomer material is selected from a primary amine and a second Primary amine, tertiary amine, quaternary amine or any combination thereof, or the second monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate, the first monomer material and the second monomer The material undergoes free radical polymerization to produce a composite polymer material; and at least one organic solvent, which dissolves the composite polymer material to form a platelet adsorption material; wherein the primary amine, secondary amine, tertiary amine or tetra The chemical structure of grade amines includes chemical structures (a), (b), (c), (d), (e), (f) or (g):

When separating blood, the composite polymer material of the platelet adsorbing material adsorbs the functional groups of platelets and proteins and achieves a mechanism of destroying blood balance, thus leading to accelerated blood cell sedimentation to accelerate the separation of blood cells and plasma. The blood adsorption material according to item 1 or 2 of the patent application scope, wherein the first monomer material is selected from dipropylene glycol methyl ether acrylate or its isomer of propylene glycol methyl ether acrylate or any combination thereof. The blood adsorption material according to item 2 of the scope of the patent application, wherein the second monomer material is selected from dipropylene glycol methyl ether acrylate or a propylene glycol methyl ether acrylate isomer or any combination thereof. The blood adsorption material according to item 2 of the patent application scope, wherein the first monomer material is 0.1 to 99.9 weight percent of the composite monomer material, and the second monomer material is 0.1 to 99.9 weight percent of the composite monomer material 99.9 weight percent. A method for manufacturing blood adsorbent material, comprising: preparing a first monomer material, and the first monomer material is selected from a hydrophobic group-containing monomer is an ether-based acrylic compound having a carbon chain, or the The first monomer material is selected from primary amine, secondary amine, tertiary amine, quaternary amine or any combination thereof, or the first monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate; wherein The chemical structure of the primary amine, secondary amine, tertiary amine or quaternary amine includes chemical structure (a), (b), (c), (d), (e), (f) or (g) :

Dissolving the first monomer material with at least one organic solvent to form a monomer material solution; and using the monomer material solution to make a platelet adsorption material, wherein the first monomer material adsorbs the functional groups of platelets and their proteins And, the first monomer material has the function of promoting the growth factor release of the platelet, and achieving a mechanism of disrupting blood balance. A method for manufacturing blood adsorption material, comprising: subjecting a first monomer material and a second monomer material to radical polymerization reaction, and the first monomer material and the second monomer material have a growth factor promoting the release of the platelet Function to generate a composite polymer material, and the first monomer material is selected from a monomer with a hydrophobic group is an ether-based acrylic compound with a carbon chain, or the first monomer material is selected from a first class Amine, secondary amine, tertiary amine, quaternary amine, or any combination thereof, or the first monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate, and the second monomer material is selected from A monomer with a hydrophobic group is an ether-based acrylic compound with a carbon chain, or the second monomer material is selected from a primary amine, a secondary amine, a tertiary amine, a quaternary amine, or any combination thereof, Or the second monomer material is selected from dipropylene glycol methyl ether acrylate or propylene glycol methyl ether acrylate; wherein the chemical structure of the primary amine, secondary amine, tertiary amine or quaternary amine includes chemical structure (a), (b), (c), (d), (e), (f) or (g):

Precipitating and purifying the composite polymer material to obtain a composite copolymer material; using at least one organic solvent to dissolve the composite copolymer material to form a composite copolymer material solution; and using the composite copolymer material solution to make a Platelet adsorption material, and the platelet adsorption material adsorbs the functional groups of platelets and their proteins and achieves a mechanism of disrupting blood balance. The method for manufacturing a blood adsorption material according to item 6 or 7 of the patent application scope, wherein the first monomer material is selected from dipropylene glycol methyl ether acrylate or a propylene glycol methyl ether acrylate isomer or any combination thereof . The method for manufacturing a blood adsorption material according to item 7 of the patent application scope, wherein the second monomer material is selected from dipropylene glycol methyl ether acrylate or a propylene glycol methyl ether acrylate isomer or any combination thereof. The method for manufacturing a blood adsorption material according to item 6 or 7 of the patent application scope, wherein a platelet adsorption material is coated or impregnated with a porous material or a fine structure material to make a blood adsorption substrate.

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