TW201626974A - Dripping container - Google Patents

Abstract

Provided is a configuration that can effectively reduce the pressing force required for dripping in a dripping container in which the internal pressure required for dripping to be started is set. An eye drop container 1 is provided with a container 10 which has an opening part 15 and contains a liquid and a dripping part 20 that is disposed at the opening part 15 and starts dripping when the internal pressure of the container 10 reaches a predetermined dripping pressure. The dripping pressure at which the dripping part 20 starts dripping is at least 1.07 atm, and the container 10 is formed in a flat shape with a material which is resilient. Also, the dripping pressure is set to a range of 1.08 to 1.24 atm, while the dripping pressure at which dripping is started by pressing the flat portions of the container 10 is 20 N or less.

Description

Drop the container

The present invention relates to a dripping container for dripping a liquid contained in a container from a lower portion of a drip.

[Background technique]

In the eye drop container which is a dripping container, it is known that when the internal pressure of the container formed into a cylindrical shape reaches a predetermined pressure, the valve of the lower part is opened and the medicine drops. As a person who discloses such a dropping container, for example, Patent Document 1 is known. Patent Document 1 discloses a configuration of an eye drop container in which a hydraulic pressure is applied to a chemical solution accommodated in a container body by pressing a container, and the chemical liquid passes between a pressure valve and a plug member and is discharged to the outside. In the eye drop container of Patent Document 1, the pressure member is prevented from leaking from the opening of the pressure valve by a pressing member that presses the pressure valve in a direction opposite to the direction in which the chemical liquid is discharged. Further, Patent Document 2 discloses a squeeze bottle (eye drop container) including a bottle body including a snake belly. In the pressure feed bottle of Patent Document 2, the bell belly has a plurality of wrinkles in the discharge direction, so that the discharge of the liquid droplets can be freely adjusted with a small force.

[Previous Technical Literature]

[Patent Literature]

[Patent Document 1] Patent No. 5531013

[Patent Document 2] International Publication No. 2006/011473

In the eye drop container, when the preservative is not added to the drug solution, a backflow prevention valve may be provided at the tip end of the nozzle in order to prevent contamination due to the outside air flowing into the container. In such an eye drop container, in order to start dripping, the internal pressure of the container must be increased until the backflow prevention valve is opened. When the internal pressure required to start the dripping is high, the container must be pressed with a relatively strong force accordingly. In this respect, the configuration disclosed in Patent Document 1 adjusts the internal pressure by the elasticity of the pressing member. However, if a high internal pressure is set, the pressing force required to lower the medicine droplet is also increased. On the other hand, in the configuration disclosed in Patent Document 2, the bellows having a plurality of wrinkles in the discharge direction can reduce the pressure feeding force of the pressing container, but since the shape of the container is a bellows shape, the thickness thereof will be Unevenness occurs, and sometimes the moisture permeability of the container increases. Also, there is room for improvement from the point of view of usability.

An object of the present invention is to provide a configuration capable of effectively reducing a pressing force required for dripping in a dripping container in which an internal pressure required for starting dripping is set.

The present invention relates to a drip container comprising: a container having an opening and accommodating a liquid; and a drip portion disposed at the opening, and starting to drip when an internal pressure of the container reaches a predetermined drip pressure; The dropping pressure at which the dropping portion starts to drip is 1.07 atm or more, and the container is formed into a flat shape by a material having resilience.

Preferably, in the drip portion, the dropping pressure is set to a range of 1.08 atm to 1.24 atm or less, and the container is pressed against the flat portion to start dropping. Below 20N.

Preferably, the drip portion is formed in a cylindrical shape, and the container is formed to have a width narrower than a diameter of the drip portion.

The flatness ratio of the above container is preferably in the range of 1.4 or more and 2.2 or less.

According to the present invention, it is possible to effectively reduce the pressing force required for dropping in the dripping container in which the internal pressure required for starting the dripping is set.

1‧‧‧ eye drop container (drop container)

10‧‧‧ Container

15‧‧‧ openings

201‧‧‧ eye drop container (drop container)

210‧‧‧ Container

301‧‧‧ eye drop container (drop container)

310‧‧‧ Container

Fig. 1 is a perspective view showing the appearance of an eye drop container as a dripping container according to the first embodiment.

Fig. 2 is a front view of the container of the first embodiment.

Fig. 3 is a side view of the container of the first embodiment.

Fig. 4 is a bottom view of the container of the first embodiment.

Fig. 5 is a front view of the container of the second embodiment.

Fig. 6 is a side view of the container of the second embodiment.

Fig. 7 is a bottom view of the container of the second embodiment.

Fig. 8 is a front view of the container of the third embodiment.

Fig. 9 is a side view of the container of the third embodiment.

Fig. 10 is a bottom view of the container of the third embodiment.

Fig. 11 is a view showing the state of the eye drop container provided in the pressing device.

Fig. 12 is a view showing a state of an eye drop container pressed by a pressing device.

Fig. 13 is a view showing a state of the eye drop container after the pressing of the pressing device is released.

Hereinafter, preferred embodiments of the drip container of the present invention will be described with reference to the drawings.

In the present invention, the "flatness ratio" means the ratio of the length of the long diameter of the container to the length of the short diameter (the length of the long diameter/the length of the short diameter), and as the container tends to be flat, the flatness ratio is expressed as Greater than 1 value. Here, the term "long diameter" means the length of the container body in the longitudinal direction, and the "short diameter" means the length of the container body in the shorter direction.

Hereinafter, the dropping container 1 will be described as an example of the dropping container. Fig. 1 is a perspective view showing an appearance of an eye drop container 1 as a dripping container according to the first embodiment.

The eye drop container 1 of the present embodiment has a function of preventing contamination of the chemical solution due to the inflow of external air from the outside, and is used for a chemical liquid or the like to which no preservative is added. As shown in Fig. 1, the eye drop container 1 is provided with a container 10 for storing a chemical liquid, and a dropping portion 20 for dropping the contained chemical liquid.

First, the container 10 will be described. Fig. 2 is a front view of the container 10 of the first embodiment. Fig. 3 is a side view of the container 10 of the first embodiment. Fig. 4 is a bottom view of the container 10 of the first embodiment.

The container 10 is constructed of a material that is flexible and resilient. For example, polyethylene, polypropylene, polyethylene terephthalate or the like can be used as the material of the container 10. As shown in FIGS. 1 to 3, the container 10 of the present embodiment is constituted by a container body 11 that forms a space in which a chemical liquid is stored, and a mounting portion 12 on which the dropping portion 20 is attached.

The container body 11 is configured to have a flat shape of the flat portion 11a. When the eye drop is performed, the flat portion 11a becomes an operation portion that is pressed by the user.

The mounting portion 12 is formed in a cylindrical shape and is connected to the upper portion of the container body 11. A circular opening 15 is formed on the upper surface of the mounting portion 12. Moreover, the fitting portion 13 in which the dropping portion 20 is fitted and the flange portion 14 are formed in the mounting portion 12.

As shown in Fig. 4, the container body 11 of the first embodiment has a substantially elliptical cross-sectional shape. The short diameter a (width) of the container body 11 is narrower than the diameter L of the mounting portion 12 formed in a cylindrical shape.

Further, the thickness of the container body 11 in the direction orthogonal to the short diameter a in the bottom view is taken as the long diameter d1. Here, if the flatness ratio of the container (previous container) of the true round in the bottom view is calculated (the length of the long diameter/the length of the short diameter), the flattening ratio is 1.0. The container main body 11 of the first embodiment has a flattening ratio of more than 1.0. In the first embodiment, the shape of the container is formed such that the flattening ratio (d1/a) is 1.4. Here, the term "long diameter" refers to the length of the container body 11 in the longitudinal direction when viewed from the side of the lower portion 20 or the bottom surface of the container body 11, and the short diameter means the side of the lower portion 20 of the drop or the bottom surface of the container body 11. The length of the container body 11 in the shorter direction when viewed from the side.

The drop lower portion 20 will be described. The dropping portion 20 is fixed to the mounting portion 12 of the container body 11 by press fitting, and functions as an aseptic device that blocks the inside and the outside of the container 10. In the present embodiment, an OSD (Ophthalmic Squeeze Dispenser) manufactured by Aptar Corporation is used as the dropping portion 20.

As shown in FIG. 1, the dropping portion 20 includes a main body portion 21 formed in a cylindrical shape, and a nozzle portion 22 disposed at the center of the upper surface of the main body portion 21. The main body portion 21 is configured to include a load mechanism including a load valve and a pressing member (for example, a coil spring), and opens the liquid passage when the internal pressure of the container 10 exceeds a predetermined drip pressure. In addition, the dropping pressure in this embodiment means the internal pressure of the container 10 when the chemical liquid is dripped from the dripping lower part 20. In the present embodiment, a dropping pressure of 1.07 atm or more is used.

Further, in the main body portion 21, an air introduction path in which a filter for introducing clean air into the container 10 is disposed as another passage other than the liquid passage. When the internal pressure of the container 10 reaches the dropping pressure, the liquid medicine is dripped from the front end of the nozzle portion 22. If it is not dripped, air does not flow from the outside of the container 10 through the drip port, so that the inside of the container 10 is kept in a sterile state. As such, the drip lower portion 20 functions as an aseptic device.

The eye drop container 1 of the first embodiment is configured as described above. When the eye drop container 1 is used, the internal volume of the container 10 is compressed by pressing the flat portion 11a of the container body 11 to raise the internal pressure to the dropping pressure, and the liquid medicine is dripped from the dropping portion 20.

Next, the eye drop container 201 of the second embodiment will be described. The eye drop container 201 of the second embodiment includes a container 210 having a shape different from that of the container 10 of the eye drop container 1 of the first embodiment. Fig. 5 is a front view of the container 210 of the second embodiment. Fig. 6 is a side view of the container 210 of the second embodiment. Fig. 7 is a bottom view of the container 210 of the second embodiment. The same components as those described in the first embodiment are denoted by the same reference numerals, and detailed description thereof may be omitted.

As shown in FIGS. 5 and 6, the container 210 is composed of a container body 211 that forms a space in which the chemical liquid is stored, and a mounting portion 12 on which the dropping portion 20 is attached.

The container body 211 is configured to have a flat shape of the flat portion 211a. As shown in FIG. 7, the container body 211 is formed in a substantially elliptical cross-sectional shape, and the flat portion 211a has a flat surface. The short diameter b (width) of the container body 211 is narrower than the diameter L of the mounting portion 12 formed in a cylindrical shape. Further, compared with the ratio of the short diameter of the container main body 11 of the container main body 11 of the first embodiment to the diameter of the mounting portion 12, the ratio of the short diameter of the container main body 211 of the second embodiment is small (formed to be wide). Amplitude).

As shown in FIG. 7, when the thickness of the container main body 211 in the direction orthogonal to the short diameter b is the long diameter d2 in the bottom view, the long diameter d2 is longer than the diameter L of the mounting portion 12. Further, the flattening ratio can be calculated from (d2/b). In the second embodiment, the shape of the container is formed so that the flattening ratio is 1.7.

The dropping portion 20 is attached to the mounting portion 12 of the container body 211. The dripping of the chemical liquid is performed by pressing the flat portion 211a of the container body 211 in the same manner as the eye drop container 1 of the first embodiment. The eye drop container 201 of the second embodiment is configured as described above.

Next, the eye drop container 301 of the third embodiment will be described. The eye drop container 301 of the third embodiment includes the container 310 having a shape different from that of the container 10 of the eye drop container 1 of the first embodiment and the container 210 of the second embodiment. Fig. 8 is a front view of the container 310 of the third embodiment. Fig. 9 is a side view of the container 310 of the third embodiment. Fig. 10 is a bottom view of the container 310 of the third embodiment. The same components as those described in the first embodiment and the second embodiment are denoted by the same reference numerals, and detailed description thereof may be omitted.

As shown in FIGS. 8 and 9, the container 310 is composed of a container body 311 that forms a space in which the chemical liquid is stored, and a mounting portion 12 on which the dropping portion 20 is attached.

The container body 311 is configured to have a flat shape of the flat portion 311a. As shown in FIG. 10, the container body 311 has a substantially elliptical cross-sectional shape, and the flat portion 311a has a gentle curved surface. The short diameter c (width) of the container body 211 is narrower than the diameter L of the mounting portion 12 formed in a cylindrical shape. Further, when the thickness of the container main body 311 in the direction orthogonal to the short diameter c is taken as the long diameter d3 in the bottom view, the long diameter d3 is also longer than the diameter L of the mounting portion 12. Further, the flattening ratio can be calculated from (d3/c). In the third embodiment, the shape of the container is formed such that the flattening ratio is 2.2. That is, the container 310 of the third embodiment has a larger flattening ratio than the container 10 of the first embodiment and the container 210 of the second embodiment.

The dropping portion 20 is attached to the mounting portion 12 of the container body 311. The dripping of the chemical liquid is performed by pressing the flat portion 311a of the container body 311 in the same manner as the eye drop container 1 of the first embodiment. The eye drop container 301 of the third embodiment is configured as described above.

In the case of the eye drop container 1 (the eye drop container 201 and the eye drop container 301) of the present embodiment, when the lower portion 20 having the load valve is used to maintain the sterilized state, it is necessary to prevent the contamination of the chemical liquid. Drop the pressure (for example, 1.07 atm or more). Therefore, the previous eye drop container having a sterile function requires a large force in order to drip the drug solution. Therefore, in the present embodiment, by making the shape of the container 10 (the container 210 and the container 310) flat, the pressing force required to start the dripping is reduced, and the load valve can be efficiently transferred to the drip nozzle 20 The composition of the pressure.

In other words, according to the eye drop container 1, the eye drop container 201, and the eye drop container 301 of the present embodiment, the following effects are exhibited. The eye drop container 1 (the eye drop container 201 and the eye drop container 301) includes a container 10 (a container 210 and a container 310) having an opening 15 and containing a liquid, and a dropping portion 20 disposed in the opening 15 when the container When the internal pressure of 10 (container 210, container 310) reaches a predetermined drip pressure, it starts to drip. The dropping pressure of the lower portion 20 which starts to drip is 1.07 atm or more, and the container 10 (the container 210 and the container 310) is formed into a flat shape by a material having resilience.

Thereby, the dropping pressure of the drip portion 20 can be maintained high, the chemical liquid contamination due to the inflow of air from the outside can be prevented, and the pressing force required for dripping the liquid can be effectively reduced, thereby preventing both pollution prevention. And operational improvement. Further, since the portion to which the force is applied is flat, the pressing force can be efficiently transmitted to achieve smooth dripping.

Further, the drip portion 20 of the present embodiment is formed in a cylindrical shape, and the container 10 (the container 210 and the container 310) is formed such that its width (short diameter a, b, c) is shorter than the diameter L of the drip portion 20.

Thereby, the internal pressure can be raised with a lower pressing force, and the operational performance is improved.

Further, in the eye drop container 1, the eye drop container 201, and the eye drop container 301 of the above embodiment, from the viewpoint of reducing the pressing force, the ratio of the long diameter to the short diameter of the container, that is, the flattening ratio is preferable. 1.4 or more and 2.2 or less. Moreover, the container volume of the eye drop container 1 and the eye drop container 201 is preferably 5 mL or more and 20 mL or less. Further, the thickness of the container forming the liquid accommodating space is preferably 0.1 mm or more and 1.0 mm or less.

Next, a method of measuring the dropping pressure set in the dropping portion 20 will be described. Hereinafter, the eye drop container 201 of the second embodiment will be described as an example of a method of measuring the dropping pressure. Fig. 11 is a view showing the state of the eye drop container 201 provided in the pressing force measuring device 40. Fig. 12 is a view showing the state of the eye drop container 201 pressed by the pressing force measuring device 40. Fig. 13 is a view showing the state of the eye drop container 201 after the pressing of the pressure measuring device 40 is released.

First, a liquid (matrix) is filled into the container 210, and the dropping portion 20 is fixed to the mounting portion 12. In the present embodiment, a 10 mL container 210 is filled with a substrate of 1.5 mL of eye drops. Then, after dropping a drop of liquid, the nozzle portion 22 was wiped to measure the weight A.

In the present embodiment, the pressing force measuring device 40 is used for the measurement of the dropping pressure. As shown in FIG. 11, the pressing force measuring device 40 is provided with the fixing rod 41 and the pressing rod 42 which are arranged in the opposing direction. The fixing rod 41 is fixed such that the front end portion is in contact with one side of the flat portion 211a. The pressing rod 42 is configured to be movable in the axial direction thereof, and the pressing rod 42 can be brought into contact with the flat portion 211a of the other side by moving to one side. The eye drop container 201 is provided on the pressing force measuring device 40 in a state in which the fixing rod 41 and the pressing rod 42 are sandwiched from both sides. In the present embodiment, a fixing rod 41 and a pressing rod 42 made of iron having a diameter of 10 mm are used.

As shown in FIG. 12, the flat portion 211a on both sides of the eye drop container 201 is pressed in by moving the pressing rod 42 to one side. The pressing by the pressing bar 42 continues until one drop of liquid is dropped from the lower portion 20 of the drop. Stop pressing at the point of dropping the liquid. Then, the injection needle 50 is pierced into the bottom of the container 210, and the dropping is terminated. In this state, the injection needle 50 is pulled out and inserted into another position, and water is injected into the inside of the container 210. After the container 210 is filled with water, the injection needle 50 is pulled out.

As shown in FIG. 13, the pressing rod 42 is retracted and the container 210 is stopped, so that the container 210 is returned to the original state. In this state, the water adhering to the drip lower portion 20 and the container 10 was wiped off, and the weight B was measured.

Then, the injection needle 50 is inserted into a space which is generated by returning the container 210 to its original shape, and water is injected to fill the container 210 with the liquid. After the injection needle 50 was pulled out, the water adhering to the drip portion 20 and the container 10 was wiped off, and the weight C was measured.

The volume compression ratio in the container 210 was calculated based on the measured weight A, weight B, and weight C. According to the wave-to-ear law, the volume compression ratio = internal pressure (atm) is established, and the dropping pressure can be calculated by setting the atmospheric pressure to 1 atm. Further, the volume compression ratio in the container 210 can be calculated by the following formula 1.

(weight C-weight A) / ((weight C - weight A) - (weight C - weight B))

Weight C-weight A: volume inside the container before compression (mL)

Weight C-weight B: container compression volume (mL) when dropped

[Examples]

Next, the difference between the eye drop container (Comparative Example) using the cylindrical container and the eye drop container (Example) which is formed into a flat container in the present embodiment will be described. In the following description, the comparative example and the examples all used a capacity of 10 mL and were composed of polyethylene. Into the container. Further, in the lower portion 20, an OSD manufactured by Aptar Co., Ltd. was used in the same manner as in the above embodiment. Also, any of the materials were measured at room temperature at that time.

First, the results of the dropping pressures obtained by the above-described measurement methods for the comparative examples and the examples are shown in Table 1. In the measurement of Table 1, the substrate as the eye drop was carried out using a substrate of TAPROS (registered trademark) MINI eye drops. In Table 1, the weight A is the weight before compression. The weight B is the weight after dropping one drop and returning. The weight C is the weight after the recovery and the container is filled with water. Further, the shapes of the examples in Table 1 were the same as those of the second embodiment and the third embodiment.

As shown in Table 1, it was found that there was no difference in the dropping pressure between the comparative example and the examples, and the dropping pressure of the dropping portion 20 (OSD manufactured by Aptar Co., Ltd.) was in the range of 1.17 atm to 1.24 atm.

Then, the measurement results of the pressing force were measured for the comparative examples and the examples, and the results of the verification of the effects of the present invention are shown in Tables 2 and 3.

First, the shape of each of the comparative examples and the examples of Table 2 and Table 3 of the OSD manufactured by Aptar Corporation will be described for the dropping portion 20. In Table 2, the flatness ratio, the length of the long diameter, the length of the short diameter, and the wall thickness (mm) of Comparative Example 1 and Examples 1 to 4 are shown. Further, the wall thickness refers to the thickness of the wall portion of the container body which is separated from the outside by the inside of the container. The comparative example in Table 2 is the same as the user in Table 1, which is an eye drop container using a cylindrical container. In the first embodiment, an eye drop container using a container corresponding to the shape of the eye drop container 1 of the first embodiment is used. In the second embodiment, an eye drop container of a container corresponding to the shape of the eye drop container 201 of the second embodiment (which is formed to have a large width with respect to the eye drop container 1) is used. In the same manner as in the first embodiment, the eye drop container having the container corresponding to the shape of the eye drop container 1 of the first embodiment has a wall thickness of 0.8 mm and is formed to have a wall thickness of 0.6 mm as compared with the first embodiment. thick. In the fourth embodiment, an eye drop container of a container corresponding to the shape of the eye drop container 301 of the third embodiment (formed to have a flattening ratio) is used.

Comparative Example 1 and Examples 1 to 4 shown in Table 3 correspond to Comparative Example 1 and Examples 1 to 4 shown in Table 2. Further, in Table 3, as in Table 1, each container was a container made of polyethylene and having a capacity of 10 mL. Further, as described above, the drip portion 20 is the same as Table 1, and an OSD manufactured by Aptar Corporation is used.

According to the results of Tables 1 to 3, although the dropping pressure of the container between the comparative example and the example did not largely differ, the pressing force (N) required to drop one drop was greatly reduced. For example, in Comparative Example 1 in which a cylindrical container was used in the prior art, when the filling amount was 3.5 mL, the pressing force required for dropping was 21.6 N, and when the filling amount was 1.5 mL, it was 27.1 N. In Example 1, regardless of the amount of filling, it was able to drip at a pressing force of 15.0 N. It is also known that in Example 2, when the filling amount is 3.5 mL, it can be dropped at a pressing force of 16.0 N, and when it is 1.5 mL, it can also be dropped at a pressing force of 16.5 N. Further, in Example 3, when the filling amount was 3.5 mL, it was able to drip at a pressing force of 18.5 N, and when it was 1.5 mL, it was allowed to drip at a pressing force of 19.9 N. Similarly, in Example 4, when the filling amount was 3.5 mL, it was able to drip at a pressing force of 18.4 N, and when it was 1.5 mL, it was also allowed to drip at a pressing force of 19.5 N. Thus, it can be confirmed that all of the first to fourth embodiments to which the present invention is applied can be dropped at a pressing force of 20 N or less.

Further, in the first and second embodiments, the rate of increase in the pressing force due to the difference in the filling amount was smaller than in the comparative example, and even when the eye drop container was continuously used, the same pressing was possible. The pressure drops. Moreover, the time required for dropping is also short, and both of Example 1 and Example 2 are less than half the time. In the third and fourth embodiments, the rate of increase in the pressing force due to the difference in the filling amount was also smaller than in the comparative example.

According to the above measurement results, in the eye drop container of the embodiment of the OSD manufactured by Aptar, the dropping pressure of the dropping portion 20 is set to be in the range of 1.17 atm or more and 1.24 atm or less, and the container 10 of the examples 1 to 4 (the container 210) The drip pressure at which the container 310) is pressed to the flat portion and starts to drip is 20 N or less. By configuring the container in this manner, the pressing force required to start the dripping can be greatly reduced as compared with the conventional configuration using the container having the cylindrical shape, and the dropping operation can be smoothly performed.

Next, the embodiment will be described using a dropping portion 20 different from the OSD manufactured by Aptar. In the present embodiment, the lower portion 20 is made of Novelia (registered trademark) manufactured by Nemera. Novelia (registered trademark) is a load mechanism including a load valve or the like, and opens the liquid passage when the internal pressure of the container exceeds a predetermined drip pressure, and functions as the same as the OSD manufactured by Aptar. By.

First, the measurement results of the range of the dropping pressure set in Novelia (registered trademark) are shown in Table 4. In Table 4, the dropping pressure of the lower portion 20 as Novelia (registered trademark) measured by the same method as in Table 1 is shown. Further, other conditions were the same as those of the experimental results shown in Table 1 except that Novelia (registered trademark) was used for the dropping portion 20.

As shown in Table 4, there was no difference in the dropping pressure between the comparative example and the example, and the dropping pressure of the dropping portion 20 (Novelia (registered trademark) manufactured by Nemera Co., Ltd.) was in the range of 1.08 atm to 1.12 atm. That is, it can be confirmed that when Novele (registered trademark) is used in the lower portion 20 of the present embodiment, the dropping pressure at which the dropping starts is also 1.08 or more.

Next, a comparative example and an example of Table 5 and Table 6 of Novelia (registered trademark) manufactured by Nemera Co., Ltd. are used for the dropping portion 20. Comparative Example 2 in Table 5 is an eye drop container using a cylindrical container, similarly to the user in Table 4. In the fifth embodiment, an eye drop container of a container corresponding to the shape of the eye drop container 1 of the first embodiment is used. In the sixth embodiment, an eye drop container of a container corresponding to the shape of the eye drop container 201 of the second embodiment (which is formed to have a large width with respect to the eye drop container 1) is used.

Comparative Example 2 and Examples 5 and 6 shown in Table 6 correspond to Comparative Example 2 and Examples 5 and 6 shown in Table 5. In Table 6, in order to compare the difference in pressing force required between the comparative example and the example, the pressing force (N) at the time of dropping one drop was measured by the same method as in Table 3.

As shown in the results of Tables 4 to 6, when the lower portion 20 was made of Novelia (registered trademark) manufactured by Nemera Co., the pressure dropped by the dropping portion 20 between Comparative Example 2 and Example 5 and Example 6 was There is no big difference. On the other hand, it is understood that there is a large difference in pressing force (N) between Comparative Example 2 and Example 5 and Example 6 in order to drop one drop. For example, in Comparative Example 2, when the filling amount is 3.5 mL, the required pressing force is 17.8 N, and when the filling amount is 1.5 mL, it is 22.2 N. On the other hand, in Example 5, when the filling amount was 3.5 mL, the pressing force was 7.7 N, and when the filling amount was 1.5 mL, it was still 8.9 N, and in Example 6, when the filling amount was 3.5 mL, pressing force When it is 8.7 N, when the filling amount is 1.5 mL, the pressing force is also 8.7 N. In other words, it can be confirmed that both of Example 5 and Example 6 can drop one drop at a force of less than half as compared with Comparative Example 2, and when using Novelia (registered trademark) manufactured by Nemera, it can also be pressed at a pressure of 20 N or less. dropping. Further, as is clear from Table 6, in Example 5 and Example 6, as compared with the comparative example, the rate of increase in the pressing force due to the difference in the filling amount was small, and even when the eye drop container was continuously used, the same pressing was possible. The pressure drops.

In the example shown in Table 3, a comparative experiment was carried out using the dropping eye container of the OSD manufactured by Aptar Corporation as an example, and in the example shown in Table 6, Nemera was used. A drop container of Novelia (registered trademark) manufactured by the company was compared as an example. That is, in the experiments of Tables 3 and 6, it can be confirmed from the experimental results of Tables 1 and 4 that the drip pressure is expressed as a drip portion 20 of 1.07 atm or more including 1.0814 atm which is the lower limit of Table 4, and it can be confirmed. The effect when the container body of the present invention is applied.

Furthermore, according to the experimental results, it can be confirmed that if the dropping pressure of the container is lowered, the dropping pressure is also lowered. Therefore, at least the dropping pressure is 1.0814 atm including the lower limit of Table 4 and 1.24 atm above the upper limit of Table 1. In the range of 1.08 atm or more and 1.24 atm, the dropping pressure can be made 20 N or less. In other words, when using the OSD manufactured by Aptar (Tables 1 to 3) and Novelia (registered trademark) manufactured by Nemera (Tables 4 to 6), it is able to greatly compare with the eye drop container of the comparative example. A significant effect of the pressure required to drop one drop is reduced.

Further, it has also been confirmed that by setting the flattening ratio in the range of 1.4 to 2.2, it is possible to effectively reduce the remarkable effect of the drip pressing force required for dripping. From the viewpoint of further reducing the pressure, it is more preferably in the range of 1.4 to 1.7. Further, from the viewpoint of reducing the pressure required, it is better from the comparison between Example 1 and Example 3 that the thickness is thinner.

Although the preferred embodiments of the drip container of the present invention have been described above, the present invention is not limited to the above embodiment, and can be appropriately modified. For example, in the above-described embodiment, a load mechanism including a load valve and a pressing member (for example, a coil spring) is provided, and if the internal pressure of the container exceeds a predetermined drip pressure, the liquid passage is opened by Aptar Co., Ltd. The Novale (registered trademark) manufactured by OSD or Nemera Co., Ltd. is used as an example of the dropping portion 20, but the configuration of the dropping portion may be appropriately changed as long as it requires a certain internal pressure for dripping. For example, it may be a configuration in which a filter is used to form a load portion, and if the internal pressure reaches the dropping pressure, it passes through the filter and starts to drip.

The shape of the containers 10, 210, and 310 of the above embodiment is not limited, and the shape of the container may be a recessed portion or a double structure, and the shape thereof may be appropriately changed.

The flattening ratio or the wall thickness of the above embodiment is not limited, and the numerical value thereof may be appropriately changed depending on the circumstances.

1‧‧‧ eye drop container (drop container)

10‧‧‧ Container

11‧‧‧ container body

11a‧‧‧flat section

14‧‧‧Flange

20‧‧‧Drip

21‧‧‧ Body Department

22‧‧‧Nozzle Department

Claims (5)

A dripping container comprising: a container having an opening and accommodating a liquid; and a drip portion disposed at the opening, and starting to drip when an internal pressure of the container reaches a predetermined drip pressure; wherein the drip The dropping pressure at which the dropping is started is 1.07 atm or more, and the container is formed into a flat shape by using a material having resilience. The dropping container according to the first aspect of the invention, wherein the dropping pressure of the lower portion of the drip is set to be in a range of from 1.08 atm to 1.24 atm, and the pressing force of the container which is pressed to the flat portion and started to drip is 20 N or less. The dropping container according to claim 1 or 2, wherein the dropping portion is formed in a cylindrical shape, and the container is formed to have a width narrower than a diameter of the dropping portion. The dropping container according to claim 1 or 2, wherein the flatness of the container is in a range of 1.4 or more and 2.2 or less. The dropping container according to item 3 of the patent application, wherein the flatness ratio of the container is in a range of 1.4 or more and 2.2 or less.