TW201623956A - Blood glucose measuring method and apparatus thereof - Google Patents

Abstract

A blood glucose measuring method and its apparatus, including a specimen and a blood glucose meter. The specimen comprises a reaction layer, at least one sensing terminal provided at the bottom of the reaction layer, and a plurality of working terminals. One end of the reaction layer is used for receiving the subject's blood, which is diffused through capillary action; the sensing terminal has a length and is disposed along the reaction layer for sensing the blood diffusion range in the reaction layer. The blood glucose meter comprises a specimen receptacle, one computing unit electrically connected to the specimen receptacle, and one processing unit coupled to the specimen receptacle and the computing unit. The specimen receptacle is used for receiving the insertion of the specimen while electrically contacting with the sensing terminal and the plurality of working terminals. On the basis of the blood diffusion range and diffusion time measured by the sensing terminal, the computing unit calculates a corrected hematocrit value. Based on signals transmitted by the plurality of working terminals, the processing unit produces a preliminary blood glucose level, and adjusts the preliminary blood glucose level according to the corrected hematocrit value, so as to calculate a final blood glucose level.

Description

Blood glucose measuring method and device thereof 【0001】

The invention relates to a blood glucose measuring device, in particular to a method and a device for correcting blood sugar measuring value by using hematocrit.

【0002】

Diabetes is one of the modern civilization diseases. When the insulin secretion in the blood is insufficient, it often causes blood sugar to be unable to be effectively converted into energy. Excess blood sugar is easy to accumulate in the body, which may cause cardiovascular diseases such as stroke; even if the patient is taking medication In the meantime, it is still necessary to check the blood sugar level intensively to confirm whether the diet and exercise are normal, so as to prevent the risk of the disease.

[0003]

Most of the patients with diabetes are middle-aged and elderly. In order to assist diabetic patients to operate the blood glucose machine correctly, the more advanced blood glucose meter on the market uses blood glucose test pieces to insert blood glucose meters to automatically detect blood sugar data. The blood glucose test piece is an advanced glucose biosensor, which is required to measure the blood sugar content in the blood by the principle of electrochemical analysis with the blood glucose machine; the traditional blood glucose test piece has a plurality of conductive strips, and the electrodes and the senses are formed at the double ends of the conductive strips respectively. Measuring the terminal, and the electrode is covered with a reaction layer with glucose oxidase; when the blood penetrates into the reaction layer, an electrochemical reaction occurs to generate an electronic signal, and the electronic signal is transmitted to the sensing terminal via the conductive strip, and then The blood glucose test piece is inserted into the reading tank of the blood glucose machine to interpret the blood sugar level in the blood. In addition, the traditional blood glucose test strips need to be used in batch with the blood glucose machine, and the blood glucose values measured by each batch of blood glucose test strips are corrected by the preset calibration parameters in the blood glucose meter to achieve a more accurate measurement value. However, the calibration parameters of the blood glucose machine are set by the general average value, and there are no different calibration parameters for the different age groups. In the case of one-piece application, the measurement of the elderly and infants, or the state of health Different subjects are not completely suitable for the calibration of the calibration parameters set in the blood glucose machine, so the adjustment parameters that cannot be determined by the person can not reach the accurate blood glucose measurement value.

[0004]

The object of the present invention is to provide a blood glucose measuring method and a device thereof, which are used for adjusting a blood glucose value measured by a blood specific volume value, thereby achieving compliance with a subject's own condition state, and reducing an error value to obtain an accurate Blood sugar level.

[0005]

In order to achieve the foregoing objective, the blood glucose measuring device of the present invention comprises a test piece comprising a reaction layer, and at least one sensing terminal and a plurality of working terminals disposed under the reaction layer, and one end of the reaction layer is received from the tested And the diffusion of the blood through the capillary action, the sensing terminal having a length extending from the reaction layer for sensing the diffusion range of the blood of the reaction layer; and a blood glucose meter comprising a test strip receiver, a computing unit electrically coupled to the test strip receiver, and a processing unit coupled to the test strip receiver and the computing unit, the test strip receiver for accepting insertion of the test strip and electrically contacting the test strip a sensing terminal and the plurality of working terminals, wherein the calculating unit calculates a blood specific volume value according to the blood diffusion range and the diffusion time sensed by the sensing terminal, and the processing unit generates the signal according to the signal transmitted by the plurality of working terminals An initial blood glucose level is adjusted, and the preliminary blood glucose value is adjusted according to the corrected blood specific volume value, thereby calculating a result blood glucose value.

[0006]

According to the foregoing device, the blood glucose measuring method of the present invention comprises the following steps: providing a test piece comprising a reaction layer, and at least one sensing terminal and a plurality of working terminals disposed under the reaction layer; Step 2: providing a blood glucose machine The method includes a test strip receiver, a computing unit electrically coupled to the test strip receiver, an operation interface, and a processing unit coupled to the test strip receiver, the operation interface, and the computing unit; Step 3: insert the test piece into the test piece receiver for electrically contacting the sensing terminal and the plurality of working terminals; Step 4: dropping blood of the test subject into one end of the reaction layer, so that blood is passed by The capillary action of the reaction layer is diffused, and the diffusion range of the blood of the reaction layer is sensed by the sensing terminal; Step 5: the plurality of working terminals transmit signals to the processing unit, so that the processing unit obtains a preliminary blood glucose level, The sensing terminal transmits an electronic signal of the diffusion range and the diffusion time of the blood to the calculating unit; Step 6: the calculating unit calculates the blood diffusion range and the diffusion time according to the sensing terminal, thereby calculating A hematocrit correction value; and Step 7: the processing unit based on the corrected hematocrit value of blood glucose adjustment of the initial value, and then a calculated result of the blood glucose level.

【0007】

According to one embodiment of the present invention, when the corrected hematocrit value is less than 35 percent, the preliminary blood glucose level is at least added to a first value for generating the resulting blood glucose level.

[0008]

According to one embodiment of the present invention, when the corrected hematocrit value is higher than 55 percent, the preliminary blood glucose level is reduced by at least a second value for generating the resulting blood glucose level.

【0009】

The blood glucose measuring method and device of the present invention calculate the corrected hematocrit value by using the diffusion range and the diffusion speed of the blood in the reaction layer of the test piece, and then adjusting the preliminary blood sugar level by using the blood glucose level to make the final result blood sugar. The value can meet the testee's own conditions, instead of using the average of the majority as a correction parameter, effectively solving the shortcomings of the traditional blood glucose test is not accurate enough, and it is easy to influence the measured value by the age, gender or physical condition of the subject.

[0019]

1‧‧‧ blood glucose measuring device
2‧‧‧ test strips
21‧‧‧Reaction layer
22‧‧‧Sensor terminal
23‧‧‧Working terminal
3‧‧‧ blood glucose machine
31‧‧‧Slice Receiver
32‧‧‧Computation unit
33‧‧‧Processing unit
34‧‧‧ storage unit
35‧‧‧Operator interface
4‧‧‧ Blood glucose measurement method
S1~S7‧‧‧ steps
S2a‧‧‧ steps

[0010]

The first figure is a three-dimensional combination diagram of the blood glucose measuring device of the present invention.
The second figure is a perspective exploded view of the first figure.
The third figure is a three-dimensional exploded view of the test piece of the present invention.
The fourth figure is a schematic diagram of the use of the blood glucose measuring device of the present invention.
The fifth figure is a flow chart of the blood glucose measuring method of the present invention.

[0011]

Referring to the first and fourth figures, a preferred embodiment of the blood glucose measuring device 1 of the present invention discloses a blood glucose meter 3 and a test strip 2 that can be read by the blood glucose meter 3. The test strip 2 is an electronic test strip comprising a reaction layer 21 and at least one sensing terminal 22 and a plurality of working terminals 23 disposed under the reaction layer 21. The sensing terminal 22 has a length which is extended by the reaction layer 21. The reaction layer 21 is made of a material having a capillary structure such as a non-woven fabric, and one end thereof receives blood from a subject, and the blood of the subject can be collected by a general blood collection pen (not shown) and then dropped into the reaction layer. twenty one.

[0012]

The blood glucose machine 3 includes a test strip receiver 31, a computing unit 32, a processing unit 33, a storage unit 34, and an operation interface 35. The test strip receiver 31 is disposed on one side of the blood glucose meter 3 and has an opening for inserting the test strip 2 and electrically contacting the sensing terminal 22 and the plurality of working terminals 23. The computing unit 32 and the processing unit 33 can each be an integrated circuit and coupled to the test strip receiver 31 and the storage unit 34. The operation interface 35 is disposed on a surface of the blood glucose meter 3, which may be a touch display screen, or may have a plurality of buttons for operation setting, and the operation interface is electrically connected to the processing unit 33. The storage unit 34 can be a flash memory for storing data. The foregoing computing unit 32, processing unit 33, storage unit 34 and operating interface 35 are integrated on a circuit board.

[0013]

The invention is characterized in that the blood diffusion rate, that is, the blood flow velocity, is used to calculate a hematocrit value, and the measured blood glucose value is corrected according to the hematocrit value, and then the condition corresponding to the subject is calculated. One of the precise blood sugar levels. Hematocrit (Hct), or hematocrit, hematocrit or hematocrit, refers to the volume of red blood cells in the blood, expressed as a percentage, depending on age and gender. Increased hematocrit may be caused by increased red blood cells or blood concentration. When the hematocrit is low, it usually indicates anemia. If it is high, there may be a problem of red blood cell proliferation. In other words, when the hematocrit is high, it means that the blood is thicker and the blood flow velocity is naturally slower. Similarly, when the hematocrit is low, it means that the blood is thinner and the blood flow speed is naturally faster. The invention utilizes the diffusion speed of blood on the test piece, calculates a specific blood volume value, and then adjusts the preliminary measured blood sugar value according to the calculated hematocrit value, thereby further according to the physical condition of the subject itself. Measure the exact blood sugar level.

[0014]

Please refer to FIG. 5 is a flow chart of a method 4 for correcting blood glucose measurement using blood specific volume according to the present invention. The method includes the following steps: providing a test strip 2 including a reaction layer 21 and disposed under the reaction layer 21 At least one sensing terminal 22 and a plurality of working terminals 23; Step S2: providing a blood glucose meter 3, comprising a test strip receiver 31, a computing unit 32 electrically connected to the test strip receiver 31, and a blood glucose meter An operating interface 35 of one surface, and a processing unit 33 coupled to the test strip receiver 31, the operating interface 35 and the computing unit 32, and further comprising a storage unit 34 coupled to the computing unit 32 and the processing unit 33; Step S3: inserting the test strip 2 into the test strip receiver 31 for electrically contacting the sensing terminal 22 and the plurality of working terminals 23; Step S4: dropping the blood of the subject into the reaction layer 21 At one end, the blood is diffused by the capillary action of the reaction layer 21, and the diffusion range of the blood of the reaction layer 21 is sensed by the sensing terminal 22; Step S5: the plurality of working terminals 23 transmit signals to the processing unit 33, so that the processing unit 33 obtains a preliminary blood glucose value and stored in the storage unit 34, feeling The measuring terminal 22 transmits the electronic signal of the diffusion range and the diffusion time of the blood to the calculating unit 32; Step S6: The calculating unit 32 calculates a blood specific volume value according to the blood diffusion range and the diffusion time sensed by the sensing terminal 22 And step S7: the processing unit 33 adjusts the preliminary blood glucose level according to the corrected blood specific volume value, and further calculates a result blood glucose value.

[0015]

In particular, when the corrected hematocrit value is less than 35 percent, the preliminary blood glucose level needs to be added at least a first value to generate the result blood glucose value, and when the corrected hematocrit value is higher than the percentage At 55 o'clock, the initial blood glucose level needs to be reduced by at least a second value to generate the resulting blood glucose level. In a specific implementation, if the corrected hematocrit value is 25 percent, the first value is calculated by the processing unit 33 at a ratio of 10% of the difference, and the preliminary blood glucose value is added after the calculation, and the result is blood glucose. The value will be greater than the initial blood glucose level; for the same reason, if the corrected hematocrit value is 70%, the second value is calculated by the processing unit 33 at a ratio of 15% of the difference, and is deducted from the preliminary blood glucose after the calculation. Value, the resulting blood glucose value will be less than the initial blood glucose value. For example, when a young child detects blood glucose, the corrected hematocrit value may generally be less than 35 percent. At this time, the first value is added to the preliminary blood glucose value according to the foregoing method, and in another implementation, When the elder is tested for one year, the corrected hematocrit value may generally be higher than 55 percent. The initial blood glucose value is deducted from the second value according to the above method. Thus, the blood glucose value measured by the subject is naturally more in line with the blood glucose value. Own conditions.

[0016]

In addition to the foregoing steps, the storage unit 34 may further store a plurality of sets of reference blood specific volume values, the reference blood specific volume values being distinguished according to age and gender, wherein each set of reference blood specific volume values corresponds to an age and gender. And its blood flow rate in a unit of time and distance. According to the setting of the reference blood specific volume value, the step S2a is added before the step S3, and before the insertion of the test piece 2, the user first operates the operation interface 35 to set the sex and age of the subject, and then inserts the test piece 2. The calculation unit 32 receives the blood diffusion range and the diffusion time sensed by the sensing terminal 22, calculates a corrected blood specific volume value, and is calculated by the processing unit 33 according to the reference blood specific volume value and the gender and age of the subject. Correct the ratio of the difference between the hematocrit value and the reference hematocrit value, then add it to the initial blood glucose level, and then calculate the resulting blood glucose level.

[0017]

In summary, the blood glucose measuring method and apparatus of the present invention calculate the corrected hematocrit value by using the diffusion range and the diffusion speed of the blood in the reaction layer 21 of the test piece 2, and then using the same to adjust the preliminary blood sugar level. The resulting blood glucose value can meet the testee's own conditions, instead of using the average of the majority as a correction parameter, so effectively solving the traditional blood glucose test is not accurate enough, and is easily determined by the age and gender of the subject. Or the physical condition affects the shortcomings of the measured value.

[0018]

The above detailed description is intended to be illustrative of a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and other equivalents and modifications may be made without departing from the spirit of the invention. Changes are intended to be included in the scope of the patents covered by the present invention.

1‧‧‧ blood glucose measuring device

3‧‧‧ blood glucose machine

31‧‧‧Slice Receiver

32‧‧‧Computation unit

33‧‧‧Processing unit

34‧‧‧ storage unit

35‧‧‧Operator interface

Claims (10)

[Item 1] A blood glucose measuring device comprising:
a test piece comprising a reaction layer, and at least one sensing terminal and a plurality of working terminals disposed under the reaction layer, one end of the reaction layer for receiving blood from the subject and diffusing through capillary action, the feeling The measuring terminal has a length extending from the reaction layer for sensing the diffusion range of the blood of the reaction layer; and a blood glucose meter comprising a test strip receiver and a calculation electrically connected to the test strip receiver And a processing unit coupled to the test strip receiver and the computing unit, the test strip receiver is configured to receive the test strip and electrically contact the sensing terminal and the plurality of working terminals, the computing unit Calculating a corrected blood specific volume value according to the blood diffusion range and the diffusion time sensed by the sensing terminal, the processing unit generates a preliminary blood glucose value according to the signal transmitted by the plurality of working terminals, and according to the corrected blood specific volume The initial blood glucose value is adjusted to calculate a blood sugar level. [Item 2] The blood glucose measuring device of claim 1, wherein the blood glucose meter further comprises a storage unit and an operation interface, the storage unit is coupled to the calculation unit and the processing unit, and stores a plurality of groups of references in advance. The blood specific volume value, the reference blood volume value of the group is distinguished according to the age and the gender, and the operation interface is disposed on one surface of the blood glucose machine, and is used for the user to insert the test piece, and the user is set to operate first. Gender and age. [Item 3] The blood glucose measuring device according to claim 1, wherein the diffusion time is calculated in milliseconds. [Item 4] The blood glucose measuring device according to claim 1, wherein when the corrected hematocrit value is less than 35 percent, the preliminary blood glucose value is at least added to a first value for generating the blood glucose. value. [Item 5] The blood glucose measuring device according to claim 1, wherein when the corrected blood specific volume value is higher than 55 percent, the preliminary blood glucose value is reduced by at least a second value to generate the blood glucose. value. [Item 6] A blood glucose measuring method comprising:
Step 1: providing a test piece comprising a reaction layer, and at least one sensing terminal and a plurality of working terminals disposed under the reaction layer;
Step 2: providing a blood glucose meter, comprising: a test strip receiver, a computing unit electrically connected to the test strip receiver, an operation interface, and a processing unit coupled to the test strip receiver, the Operating interface and the computing unit;
Step 3: insert the test piece into the test piece receiver for electrically contacting the sensing terminal and the plurality of working terminals;
Step 4: dropping blood of the test subject into one end of the reaction layer, allowing blood to diffuse by the capillary action of the reaction layer, and sensing the diffusion range of the blood of the reaction layer by the sensing terminal;
Step 5: The plurality of working terminals transmit signals to the processing unit, so that the processing unit obtains a preliminary blood glucose level, and the sensing terminal transmits an electronic signal of a diffusion range and a diffusion time of the blood to the computing unit;
Step 6: The calculation unit calculates a blood specific volume value according to the blood diffusion range and the diffusion time sensed by the sensing terminal; and step 7: the processing unit adjusts the corrected blood specific volume value according to the corrected blood specific volume value. The initial blood glucose level, and then a calculated blood glucose value. [Item 7] The blood glucose measuring method of claim 6, wherein the blood glucose meter further comprises a storage unit coupled to the computing unit and the processing unit, and pre-stored a plurality of sets of reference blood volume values, The reference blood volume values of these groups are differentiated according to age and gender, and the operation interface is set on one surface of the blood glucose machine. [Item 8] The method for measuring blood sugar according to claim 7 further includes the step 2a, wherein the user operates the interface to set the gender and age of the subject before inserting the test piece. [Item 9] The method for measuring blood sugar according to claim 6, wherein when the corrected hematocrit value is less than 35 percent, the preliminary blood glucose value is at least added to a first value for generating the blood glucose. value. [Item 10] According to the method for measuring blood sugar according to Item 6 of the patent application, when the corrected hematocrit value is higher than 55 percent, the preliminary blood glucose value needs to be reduced by at least a second value for generating the blood glucose level. .