CN105816184A - Blood glucose measuring method and apparatus - Google Patents
Blood glucose measuring method and apparatus Download PDFInfo
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- CN105816184A CN105816184A CN201510005041.4A CN201510005041A CN105816184A CN 105816184 A CN105816184 A CN 105816184A CN 201510005041 A CN201510005041 A CN 201510005041A CN 105816184 A CN105816184 A CN 105816184A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 234
- 239000008280 blood Substances 0.000 title claims abstract description 234
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 133
- 239000008103 glucose Substances 0.000 title claims abstract description 133
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000012360 testing method Methods 0.000 claims abstract description 64
- 238000006243 chemical reaction Methods 0.000 claims abstract description 41
- 238000012937 correction Methods 0.000 claims abstract description 36
- 238000012545 processing Methods 0.000 claims abstract description 32
- 238000009792 diffusion process Methods 0.000 claims abstract description 19
- 238000003780 insertion Methods 0.000 claims abstract description 3
- 230000037431 insertion Effects 0.000 claims abstract description 3
- 230000003213 activating effect Effects 0.000 claims description 18
- 238000005259 measurement Methods 0.000 claims description 15
- 230000004069 differentiation Effects 0.000 claims description 5
- 230000005540 biological transmission Effects 0.000 claims description 4
- 238000005534 hematocrit Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000008601 Polycythemia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention provides a blood glucose measuring method and apparatus. The blood sugar measuring apparatus comprises a test sheet and a blood glucose machine, wherein the test sheet has a reaction layer, at least one sensing terminal arranged under the reaction layer and a plurality of work terminals; one end of the reaction layer receives blood of a testee and diffuses the same via a capillary action; the sensing terminal has a certain length and is arranged along the reaction layer to sense a blood diffusion range of the reaction layer; the blood glucose machine comprises a test sheet receiver, a calculation unit electrically connected to the test sheet receiver and a processing unit; the processing unit is coupled to the test sheet receiver and the calculation unit; the test sheet receiver can receive an insertion of the test sheet and electrically contact with the sensing terminal and the plurality of work terminals; the calculation unit can calculate correction blood specific volume vale according to the blood diffusion range and diffusion time sensed by the sensing terminal; the processing unit can generate a primary blood glucose value according to a signal transmitted by the plurality of work terminals; and the primary blood glucose value can be corrected according to the correction blood specific volume value and a final blood glucose value can be calculated.
Description
Technical field
The present invention is about a kind of blood glucose measuring equipment, particularly relates to a kind of method and device utilizing blood specific volume correction blood glucose measuring value.
Background technology
Diabetes are one of modern civilization diseases, when hypoinsulinism in blood, often result in blood glucose and cannot be efficiently converted into as energy, and unnecessary blood glucose is easily hoarded in vivo, may cause the cardiovascular disease such as apoplexy;Even if patient is during medication treatment, it is still necessary to confirm that diet, motion be whether normal, to prevent the danger of disease by detecting blood glucose value thick and fast.
During the diseased subjects of diabetes mostly is, old people, in order to assist the correct operation blood glucose machine of diabetics, the most relatively advanced blood glucose machine utilizes blood glucose test to insert blood glucose machine and automatically detects blood glucose level data.Blood glucose test is the glucose biological sensor of a kind of advanced person, and blood glucose machine need to be coordinated to measure the blood sugar content in blood with the principle of electro chemical analysis;Having some bus in tradition blood glucose test, each bus both-end forms the conversion zone being coated with tool glucoseoxidase in electrode and sensing terminals, and described electrode respectively;When blood penetrates into after conversion zone, it may occur that electrochemical reaction and produce an electronic signal, this electronic signal is transferred to sensing terminals via bus, blood glucose test is inserted in subsequently in the reading groove of blood glucose machine, can blood sugar content in interpretation blood.Additionally, tradition blood glucose test need to mutually be criticized the blood glucose value after use, and every batch of blood glucose test measurement by the adjustment parameter correction preset in blood glucose machine with blood glucose machine, to reach accurate measuring value.But, the adjustment parameter of blood glucose machine is to take general average to set, measurement person for all ages and classes layer there is no different correction parameters, in the case of one size fits all, older and the measurement of baby children child, or health status has the correction of adjustment parameter that different testee sets in being suitable for blood glucose machine the most completely, so accurate blood glucose measuring value cannot not reached all the time because of the adjustment parameter depending on people.
Summary of the invention
The purpose of the present invention is providing a kind of blood glucose method for measurement and device, its blood glucose value measured in order to utilize blood bulking value adjustment, and then reaches to meet testee self-condition state, reduces error amount, to obtain accurate blood glucose value.
In order to achieve the above object, the invention provides a blood glucose measuring equipment, comprising:
One test piece, including a conversion zone, and it is located at least one sensing terminals below this conversion zone and a plurality of activating terminal, one end of this conversion zone is in order to receive the blood from testee, and spread by capillarity, this sensing terminals has a length, and it is arranged along this conversion zone, in order to sense the range of scatter of the blood of this conversion zone;And
One blood glucose machine, including a test piece receptor, one computing unit being electrically connected at this test piece receptor, and a processing unit, it is coupled to this test piece accepter and this computing unit, this test piece receptor is in order to accept the insertion of this test piece this sensing terminals in electrical contact and this activating terminal a plurality of, blood range of scatter that this computing unit senses according to this sensing terminals and diffusion time, and then calculate a correction blood bulking value, the signal that this processing unit transmits according to these activating terminal a plurality of produces a preliminary blood glucose value, and according to this correction blood bulking value this preliminary blood glucose value of adjustment, and then calculate a result blood glucose value.
Further, wherein this blood glucose machine further includes a storage element and an operation interface, this storage element is coupled to this computing unit and this processing unit, and store some groups in advance with reference to blood bulking value, each this reference blood bulking value of group is differentiation according to age and sex, this operation interface is located at a surface of this blood glucose machine, and before inserting this test piece for user, look-ahead operations sets sex and the age of testee.
Further, wherein this diffusion time is with millisecond as unit of account.
Further, wherein when this correction blood bulking value is less than 35 percent, then this preliminary blood glucose value at least needs to add one first numerical value, in order to produce this result blood glucose value.
Further, wherein when this correction blood bulking value is higher than 55 percent, then this preliminary blood glucose value at least needs to reduce by a second value, in order to produce this result blood glucose value.
The present invention also provides for a kind of blood glucose method for measurement, including:
Step 1: provide a test piece, it includes a conversion zone, and is located at least one sensing terminals below this conversion zone and a plurality of activating terminal;
Step 2: a blood glucose machine is provided, it include a test piece receptor, one be electrically connected at the computing unit of this test piece receptor, one operation interface, and a processing unit, this blood glucose machine is coupled to this test piece accepter, this operation interface and this computing unit;
Step 3: this test piece is inserted this test piece receptor, in order to this sensing terminals in electrical contact and this activating terminal a plurality of;
Step 4: the blood of testee instills one end of this conversion zone, is made blood be spread by the capillarity of this conversion zone, and is sensed the range of scatter of the blood of this conversion zone by this sensing terminals;
Step 5: these activating terminal a plurality of transmission signal, to this processing unit, makes this processing unit obtain a preliminary blood glucose value, and the range of scatter of this sensing terminals transmission blood and the electronic signal of diffusion time are to this computing unit;
Step 6: blood range of scatter that this computing unit senses according to this sensing terminals and diffusion time, and then calculate a correction blood bulking value;And
Step 7: this processing unit is this preliminary blood glucose value of adjustment according to this correction blood bulking value, and then calculates a result blood glucose value.
Further, wherein this blood glucose machine further includes a storage element, and it is coupled to this computing unit and this processing unit, and stores some groups in advance with reference to blood bulking value, each this reference blood bulking value of group is differentiation according to age and sex, and this operation interface is located at a surface of this blood glucose machine.
Further, further including step 2a, user, before inserting this test piece, sets sex and the age of testee in advance in this operation interface operation.
Further, wherein when this correction blood bulking value is less than 35 percent, then this preliminary blood glucose value at least needs to add one first numerical value, in order to produce this result blood glucose value.
Further, when this correction blood bulking value is higher than 55 percent, then this preliminary blood glucose value at least needs to reduce by a second value, in order to produce this result blood glucose value.
Blood glucose method for measurement of the present invention and device, by blood in the range of scatter of the conversion zone of test piece and diffusion velocity, and then calculate correction blood bulking value, recycle the preliminary blood glucose value of its adjustment, the result blood glucose value finally drawn is enable to meet the condition of testee self, rather than be the meansigma methods utilizing majority as correction parameter, effectively solve tradition blood sugar test accurate, easily by the age of testee, sex or the shortcoming of health influence amount measured value not.
Accompanying drawing explanation
Fig. 1 is the three-dimensional combination schematic diagram of blood glucose measuring equipment of the present invention.
Fig. 2 is the perspective exploded view of Fig. 1.
Fig. 3 is the perspective exploded view of test piece of the present invention.
Fig. 4 is the use schematic diagram of blood glucose measuring equipment of the present invention.
Fig. 5 is the flow chart of blood glucose method for measurement of the present invention.
In figure, blood glucose measuring equipment 1
Test piece 2
Conversion zone 21
Sensing terminals 22
Activating terminal 23
Blood glucose machine 3
Test piece receptor 31
Computing unit 32
Processing unit 33
Storage element 34
Operation interface 35
Blood glucose method for measurement 4
Step S1 ~ S7
Step S2a.
Detailed description of the invention
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, so that those skilled in the art can be better understood from the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Referring to the preferred embodiment that Fig. 1 and Fig. 4 is blood glucose measuring equipment 1 of the present invention, it discloses a kind of blood glucose machine 3 and is available for the test piece 2 that blood glucose machine 3 reads.Test piece 2 is a kind of electronics test piece, including a conversion zone 21, and is located at least one sensing terminals 22 below conversion zone 21 and plural number activating terminal 23, and sensing terminals 22 has a length, and it prolongs conversion zone 21 and arranges.It is made that conversion zone 21 is that adhesive-bonded fabric etc. has the material of capillary structure, and its one end is in order to receive the blood from testee, and the blood of described testee can be adopted by general blood collecting pen (not shown), then instills conversion zone 21.
Blood glucose machine 3 includes test piece receptor 31, computing unit 32, processing unit 33, storage element 34 and an operation interface 35.The side of blood glucose machine 3 is located at by test piece receptor 31, and has an opening and insert for test piece 2, and can sensing terminals 22 in electrical contact and plural number activating terminal 23.Computing unit 32 and processing unit 33 can be an integrated circuit respectively, and are coupled to test piece receptor 31 and storage element 34.Operation interface 35 is located at a surface of blood glucose machine 3, and it can be a touch display screen, maybe can have some buttons and be used as operating and setting, and operation interface is electrically connected at processing unit 33.Storage element 34 can be a flash memory, is used in order to store data.Aforementioned computing unit 32, processing unit 33, storage element 34 and operation interface 35 are integrated with on a circuit board.
It is a feature of the present invention that and utilize blood diffusion velocity, that is blood flowing speed, and then calculate a blood bulking value, then according to the blood glucose value measured by the correction of this blood bulking value, calculate the accurate blood glucose value best suiting the condition of testee own afterwards.Blood specific volume (Hematocrit, Hct), or claim Hematocrit, haematocrit or packed cell volume, refer to the volume that erythrocyte is shared in blood, it is in the mode of percentage ratio for representing, can be different because of age and sex, and blood specific volume increase may be caused by erythrocytosis or pachyemia.When blood specific volume is on the low side, generally indicate anemia, higher, may there is erythrocyte hypertrophy problem.In other words, when blood specific volume height, representing that blood is denser, blood flow rate is the most slack-off;In like manner, when blood specific volume is low, representing that blood is leaner, blood flow rate accelerates naturally.The present invention is i.e. the diffusion velocity utilizing blood in test piece, calculates a blood bulking value, then the blood glucose value tentatively recorded according to the blood bulking value adjustment calculated, and then can measure accurate blood glucose value according to the health of testee itself.
Referring to Fig. 5 is the flow chart that the present invention utilizes the method 4 of blood specific volume correction blood glucose measuring value, and it includes step S1: provide a test piece 2, and it includes a conversion zone 21, and is located at least one sensing terminals 22 below conversion zone 21 and plural number activating terminal 23;Step S2: a blood glucose machine 3 is provided, it includes that a test piece receptor 31, is electrically connected at the operation interface 35 that the computing unit 32, of test piece receptor 31 is located at a surface of blood glucose machine 3, and a processing unit 33, it is coupled to this test piece accepter 31, this operation interface 35 and this computing unit 32, and further including a storage element 34, it is coupled to computing unit 32 and processing unit 33;Step S3: test piece 2 is inserted test piece receptor 31, in order to sensing terminals 22 in electrical contact and plural number activating terminal 23;Step S4: the blood of testee instills one end of conversion zone 21, makes blood pass through the capillarity diffusion of conversion zone 21, and is sensed the range of scatter of the blood of conversion zone 21 by sensing terminals 22;Step S5: plural number activating terminal 23 transmits signal to processing unit 33, makes processing unit 33 obtain a preliminary blood glucose value and be stored in this storage element 34, and sensing terminals 22 transmits the range of scatter of blood and the electronic signal of diffusion time to computing unit 32;Step S6: blood range of scatter that computing unit 32 senses according to sensing terminals 22 and diffusion time, and then calculate a correction blood bulking value;And step S7: processing unit 33 is the preliminary blood glucose value of adjustment according to correction blood bulking value, and then calculates a result blood glucose value.
Special instruction be, when correcting blood bulking value less than 35 percent, then preliminary blood glucose value at least needs to add one first numerical value, in order to produce this result blood glucose value, and when correcting blood bulking value higher than 55 percent, then preliminary blood glucose value at least needs to reduce by a second value, in order to produce this result blood glucose value.In being embodied as in one, if correction blood bulking value is 25 percent, then this first numerical value i.e. calculates via processing unit 33 with the ratio of gap 10, and adds preliminary blood glucose value after calculating, then result blood glucose value will be greater than preliminary blood glucose value;In like manner, if correction blood bulking value is 70 percent, then this second value i.e. calculates via processing unit 33 with the ratio of gap 1 15, and deducts in preliminary blood glucose value after calculating, then result blood glucose value will be less than preliminary blood glucose value.For example, when a child detects blood glucose, its correction blood bulking value is typically likely lower than 35 percent, now, then according to preceding method, the first numerical value is added preliminary blood glucose value, again in another is implemented, when an older is tested, its correction blood bulking value typically could possibly be higher than 55 percent, then according to preceding method, preliminary blood glucose value is deducted second value, so, the blood glucose value that testee is measured the most more meets himself condition.
In addition to abovementioned steps, storage element 34 separately can store some groups in advance with reference to blood bulking value, those group reference blood bulking values are differentiation according to age and sex, and each of which group is with reference to blood bulking value one age of correspondence, sex and the blood flowing speed within a unit interval and distance thereof.According to the setting of above-mentioned reference blood bulking value, adding step S2a before step S3, user is before inserting test piece 2, and in advance in sex and the age of operation interface 35 operating and setting testee, then row inserts test piece 2.Unit 32 to be calculated receives blood range of scatter and the diffusion time that sensing terminals 22 senses, calculate a correction blood bulking value, and calculated correction blood bulking value and with reference to the gap ratio between blood bulking value by processing unit 33 according to reference blood bulking value and the sex of testee and age, it is added into preliminary blood glucose value again, calculates result blood glucose value afterwards.
In sum, blood glucose method for measurement of the present invention and device, by blood in the range of scatter of the conversion zone 21 of test piece 2 and diffusion velocity, and then calculate correction blood bulking value, recycle the preliminary blood glucose value of its adjustment, make the result blood glucose value finally drawn, it can meet the condition of testee self, rather than be the meansigma methods utilizing majority as correction parameter, therefore effectively solve tradition blood sugar test accurate, easily by the age of testee, sex or the shortcoming of health influence amount measured value not.
Embodiment described above is only the preferred embodiment lifted by absolutely proving the present invention, and protection scope of the present invention is not limited to this.The equivalent that those skilled in the art are made on the basis of the present invention substitutes or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (10)
1. a blood glucose measuring equipment, it is characterised in that comprising:
One test piece, including a conversion zone, and it is located at least one sensing terminals below this conversion zone and a plurality of activating terminal, one end of this conversion zone is in order to receive the blood from testee, and spread by capillarity, this sensing terminals has a length, and it is arranged along this conversion zone, in order to sense the range of scatter of the blood of this conversion zone;And
One blood glucose machine, including a test piece receptor, one computing unit being electrically connected at this test piece receptor, and a processing unit, it is coupled to this test piece accepter and this computing unit, this test piece receptor is in order to accept the insertion of this test piece this sensing terminals in electrical contact and this activating terminal a plurality of, blood range of scatter that this computing unit senses according to this sensing terminals and diffusion time, and then calculate a correction blood bulking value, the signal that this processing unit transmits according to these activating terminal a plurality of produces a preliminary blood glucose value, and according to this correction blood bulking value this preliminary blood glucose value of adjustment, and then calculate a result blood glucose value.
2. blood glucose measuring equipment as claimed in claim 1, it is characterized in that, wherein this blood glucose machine further includes a storage element and an operation interface, this storage element is coupled to this computing unit and this processing unit, and storing some groups of reference blood bulking values in advance, each this reference blood bulking value of group is differentiation according to age and sex, and this operation interface is located at a surface of this blood glucose machine, before inserting this test piece for user, look-ahead operations sets sex and the age of testee.
3. blood glucose measuring equipment as claimed in claim 1, it is characterised in that wherein this diffusion time is with millisecond as unit of account.
4. blood glucose measuring equipment as claimed in claim 1, it is characterised in that wherein when this correction blood bulking value is less than 35 percent, then this preliminary blood glucose value at least needs to add one first numerical value, in order to produce this result blood glucose value.
5. blood glucose measuring equipment as claimed in claim 1, it is characterised in that wherein when this correction blood bulking value is higher than 55 percent, then this preliminary blood glucose value at least needs to reduce by a second value, in order to produce this result blood glucose value.
6. a blood glucose method for measurement, it is characterised in that including:
Step 1: provide a test piece, it includes a conversion zone, and is located at least one sensing terminals below this conversion zone and a plurality of activating terminal;
Step 2: a blood glucose machine is provided, it include a test piece receptor, one be electrically connected at the computing unit of this test piece receptor, one operation interface, and a processing unit, this blood glucose machine is coupled to this test piece accepter, this operation interface and this computing unit;
Step 3: this test piece is inserted this test piece receptor, in order to this sensing terminals in electrical contact and this activating terminal a plurality of;
Step 4: the blood of testee instills one end of this conversion zone, is made blood be spread by the capillarity of this conversion zone, and is sensed the range of scatter of the blood of this conversion zone by this sensing terminals;
Step 5: these activating terminal a plurality of transmission signal, to this processing unit, makes this processing unit obtain a preliminary blood glucose value, and the range of scatter of this sensing terminals transmission blood and the electronic signal of diffusion time are to this computing unit;
Step 6: blood range of scatter that this computing unit senses according to this sensing terminals and diffusion time, and then calculate a correction blood bulking value;And
Step 7: this processing unit is this preliminary blood glucose value of adjustment according to this correction blood bulking value, and then calculates a result blood glucose value.
7. blood glucose method for measurement as claimed in claim 6, it is characterized in that, wherein this blood glucose machine further includes a storage element, it is coupled to this computing unit and this processing unit, and store some groups in advance with reference to blood bulking value, each this reference blood bulking value of group is differentiation according to age and sex, and this operation interface is located at a surface of this blood glucose machine.
8. blood glucose method for measurement as claimed in claim 7, it is characterised in that further include step 2a, user, before inserting this test piece, sets sex and the age of testee in advance in this operation interface operation.
9. blood glucose method for measurement as claimed in claim 6, it is characterised in that wherein when this correction blood bulking value is less than 35 percent, then this preliminary blood glucose value at least needs to add one first numerical value, in order to produce this result blood glucose value.
10. blood glucose method for measurement as claimed in claim 6, it is characterised in that when this correction blood bulking value is higher than 55 percent, then this preliminary blood glucose value at least needs to reduce by a second value, in order to produce this result blood glucose value.
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CN201510005041.4A CN105816184B (en) | 2015-01-06 | 2015-01-06 | Blood glucose method for measurement and its device |
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CN201510005041.4A CN105816184B (en) | 2015-01-06 | 2015-01-06 | Blood glucose method for measurement and its device |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI735137B (en) * | 2019-08-02 | 2021-08-01 | 華廣生技股份有限公司 | Physiological signal sensing device |
CN114137218A (en) * | 2020-09-04 | 2022-03-04 | 百略医学科技股份有限公司 | Blood glucose detection device capable of correcting measured value according to blood volume ratio |
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CN103998619A (en) * | 2011-12-22 | 2014-08-20 | 霍夫曼-拉罗奇有限公司 | Method for determining an analyte concentration |
CN104838258A (en) * | 2012-12-04 | 2015-08-12 | 霍夫曼-拉罗奇有限公司 | Method for hematocrit correction and glucose meter adapted therefor |
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