TW201620494A - Composition, cosmetic material - Google Patents

Abstract

A composition including ceramide and labdenoic acid, and a cosmetic material including the above composition is provided.

Description

Composition, cosmetics

The present invention relates to a composition and a cosmetic.

The stratum corneum of the skin surface mainly contains keratinocytes and keratinocyte lipids. The keratinocyte intercellular lipid acts to maintain keratinocytes to each other, to construct a lipid barrier, to prevent foreign matter from invading from the outside, and to maintain moisture inside the skin. The keratinocyte intercellular lipid is a group of compounds (ceramide) in which sphingosine is bonded to a fatty acid by a sphingosine (ceramide) as a main component.

If the neuropterin can be supplied to the skin surface from the outside, the barrier function and the like can be improved. Therefore, neuroterpene is attracting attention as a component of a cosmetic or skin external preparation applied to the skin surface.

However, since neuroamide has high crystallinity, there is a problem that stability in a composition such as a cosmetic is low.

A composition containing at least one of a specific polyglycerin fatty acid ester or a glycerin mono-fatty acid ester in a neuropterin is known as a composition which has been tried to solve the problem (see Patent Document 1 and Patent). Literature 2). According to the composition, the ceramides can be crystallized. The precipitation inhibition is a predetermined level.

[Prior Art Literature] [Patent Literature]

Patent Document 1: Japanese Patent Laid-Open No. 2011-073992

Patent Document 2: Japanese Patent Laid-Open Publication No. 2013-053146

However, the previous composition still inhibits the crystallization of neuralamines. The room for precipitation.

Accordingly, an object of the present invention is to provide a composition which can suppress the crystallization of a neuropterin in a composition and precipitate, thereby improving the stability of the neuropterin in the composition, and suppressing the nerve amide in the cosmetic. A cosmetic which crystallizes and precipitates, thereby improving the stability of the neuropterin in the cosmetic.

The gist of the present invention is as follows.

The composition of the present invention is characterized by comprising a neurosteroid and a labdenoic acid. Here, in the composition of the present invention, the ratio of the labousanic acid to the neurosteroid is preferably from 0.01 to 100, more preferably from 0.1 to 50.

The cosmetic of the present invention is characterized by comprising the composition of the present invention.

Further, the "ratio" of the components of the present invention and the components contained in the cosmetic of the present invention means the mass ratio.

According to the composition of the present invention, it is possible to suppress the crystallization of the neuropterin in the composition and precipitate it, thereby improving the stability of the neuropterin in the composition. According to the cosmetic of the present invention, it is possible to suppress the precipitation of the neuropterin in the cosmetic material, thereby improving the stability of the neuropterin in the cosmetic.

1 is a photograph showing the results of microscopic observation of a composition according to the present invention and a composition which is a comparative example of the present invention under polarized light at a magnification of 20 times and an exposure time of 1/300 second using an upright microscope. . (a) is a photograph of a composition containing the neuropterin and labousic acid according to the present invention (Example A7), and (b) is a composition comprising a neural amine and jojoba oil which is the present invention. Photograph of the composition of Comparative Example (Comparative Example A3).

Hereinafter, embodiments of the composition of the present invention and the cosmetic of the present invention will be described in detail.

(composition)

The composition of one example of the present invention (hereinafter also referred to as "an example of a composition") must contain a neurosteroid and a labothelic acid.

The present inventors have found that a labranate has an effect of alleviating the crystallinity of a neurosteroid in a composition containing a neurosteroid and a labothenic acid. According to the composition of the present invention, it is possible to suppress the crystallization of the neuropterin in the composition and precipitate it, thereby improving the stability of the neuropterin in the composition. Although it is known that Laudans have a moisturizing effect Fruit, whitening effect, etc., but with inhibition of ceramide crystallization. The case of the effect of precipitation is neither documented nor suggested in any of the documents.

Further, according to the composition of the present invention, as described above, the stability of the neuroketamine in the composition is improved, so that the nervous amine can be uniformly applied to the skin. Therefore, the barrier function of the stratum corneum on the skin surface, the effect of preventing foreign matter from entering, and the moisturizing effect can be improved.

-Neuroamines -

The ceramide in the present invention is a compound having a structure in which a sphingoid and a fatty acid are bonded to a fatty acid as a basic structure (hereinafter, also referred to as "basic neuropterin"). a derivative of basic neuropterin (hereinafter also referred to as "neuroguanamine derivative"), a rim similar to the basic neuropterin and its derivative (hereinafter, also referred to as "neuroguanamine" Analogs"), sphingosines.

The neuropteramines in the present invention may be derived from synthetics, natural products (e.g., plant extracts), and the like.

--Basic nervous amine --

The basic structure of the basic neuropterin includes a structure represented by the following formula (S1).

Further, among the basic neuropterin represented by the formula (S1), the neurosteroid 1 to the neurosteroid 10 is particularly a neuropterin (skin ceramide) contained in the stratum corneum of a human.

In addition, in the nervous guanamine derived from humans or other animals, there are various modifications regarding the alkyl sphingoids and the alkyl chain length of the fatty acid shown in the above formula (S1). The basic neuropterin also contains a compound having the same skeleton as the compound represented by the formula (S1) except for the alkyl chain length.

Further, the basic neuropterin can be optical using a natural type (D(-) body) As the active material, an optically active substance of a non-natural type (L(+) body) may be used, and a mixture of a natural type and an unnatural type may also be used. The relative steric arrangement of the plurality of asymmetric carbons in the structure of the basic neural guanamine may be a natural stereo configuration, or a non-natural stereo configuration other than the other, or may be a mixture of the same The resulting stereo configuration.

The sphingoid alcohol moiety contained in the neuropterin includes natural sphingosine and its rim. Specific examples of the natural sphingosine include sphingosine, dihydrosphingosine, phytosphingosine, and 6-hydroxysphingosine (above, S1), sphingadienine, dehydrosphingosine, dehydrogenated sphingosine, and N-alkylated compounds (eg, N-methylated) and B Derivatives such as sputum and the like.

Examples of the fatty acid moiety contained in the neuropterin include a saturated fatty acid, an α-hydroxy fatty acid, an ω-hydroxy fatty acid, and the like.

The sphingosine moiety and the fatty acid moiety contained in the neuropterin may be derived from a composition, a natural product (for example, a plant extract), or the like.

--Neuroamine derivatives --

The neural guanamine derivative may, for example, be a neuroindolamine compound (hereinafter, also referred to as "glycosideamine") modified by a saccharide in a molecule. Examples of the saccharide to be used in the glycosylamine include monosaccharides such as glucose and galactose; disaccharides such as lactose and maltose; and monosaccharides or disaccharides by Portuguese. Or oligosaccharide or oligosaccharide Sugar and so on. Further, other neuropterin derivatives may also be exemplified by a neurosteroid compound in which a saccharide-like substance substituted by a hydroxyl group contained in a saccharide unit of a saccharide is modified in the molecule by a saccharide-like saccharide (hereinafter, Also known as "sugar-ceramides"). Examples of the saccharide-like material to be used in the glycosylamine-based rims include glucosamine, glucuronic acid, and N-acetyl glucosamine.

The number of saccharide units in the glycosylamine and the glycosylamine steroid is preferably from 1 to 5, more preferably 1 or 2, from the viewpoint of dispersion stability in the composition (in the glycoside) In the case of an amine, the saccharide is glucose or lactose, respectively, and particularly preferably 1.

Glycosylamines and glycosylamines can be obtained by chemical synthesis or by the purchase of commercially available products.

For the commercial product of the glycosaminoglycan, for example, the product name "plant sphingosine alcohol liquid FR1" manufactured by Gunan Store Co., Ltd. is mentioned.

--Neuroamine analogues --

The neural guanamine compound is exemplified by the following formula (S2).

--Sphingosine --

Further, the sphingosines of the present invention also include sphingosine. Examples of the sphingosine include those of the sphingosine moiety contained in the above-mentioned neuropterin.

Specific examples of the phytosphingosine which can be preferably used in the present invention include, for example, "Phytosphingosine" (trade name) manufactured by Evonik Goldschmidt GmbH.

As the exemplified by the ceramides, one type may be used alone or two or more types may be used in combination.

From the viewpoint of sufficiently obtaining the effects of the present invention, the neuropterin in the present invention is preferably a basic neuropterin, and more preferably a skin ceramide, and more preferably a neuropterin 2.

- Laudans -

The labudaic acid in the present invention means a compound represented by the following formula (S3).

Wherein R ¹ represents -CH ₂ OH or COOR ⁶ , wherein R ⁶ represents hydrogen, a lower alkyl group having 1 to 3 carbon atoms or a cation capable of forming a salt with COO-, R ² to R ⁵ independently represents a hydrogen atom or a methyl group, and ... A... represents =C(CH ₃ )-, -C(CH ₃ )=, -C(=CH ₂ )-, -CH(CH ₃ )- or -C (OH)(CH ₃ )-].

The labothelic acid in the present invention may be derived from a composition, a natural product (for example, a plant extract), or the like.

The compound represented by the formula (S3) contains a compound represented by the following formula (S4).

[In the formula, the three dash-based bonds represent two single bonds and one double bond], and the compound contains the labdan-8-ene-15-acid represented by the following formula (S5) to (S7) ( (S5)), labdan-7-ene-15-acid ((S6)), labdan-8(17)-ene-15-acid ((S7)).

Further, the compounds of the formula (S5) to (S7) may be respectively heated or The isomerization is carried out by heating in the presence of an acid catalyst, and the ratio of (S5) to (S6) to (S7) can be changed to, for example, about 1:1:1, 8:2:0 or 7:3:0 or the like.

As the exemplified as the labyrin acid, one type may be used alone or two or more types may be used in combination.

The carboxyl group of the labothelic acid used in the present invention may be a free carboxylic acid, or may be a carboxylate, an alkali metal salt such as a sodium salt or a potassium salt; an alkaline earth metal salt such as a calcium salt or a magnesium salt. An ammonium salt; a primary amine salt such as a monomethylammonium salt; a secondary amine salt such as a dimethylammonium salt or a dicyclohexylammonium salt; or an amine salt such as a tertiary amine salt such as a trimethylammonium salt.

When the carboxyl group is a free carboxylic acid, the oil solubility of the lauric acid can be improved, and when the carboxyl group is a carboxylate, the water solubility of the lauric acid can be improved. Therefore, in the present invention, water-soluble labrinic acid and oil-soluble labousic acid can be used separately as needed.

The conversion of the free carboxylic acid to the carboxylate can be easily carried out, for example, by reaction with an alkali metal hydroxide, an alkaline earth metal hydroxide, an amine or the like, and vice versa, from a carboxylate to a free carboxylic acid. For example, it can be easily carried out by reaction with hydrochloric acid, sulfuric acid or the like.

In the case where the labothelic acid is obtained by chemical synthesis, the synthesis method can be, for example, a method of producing a labranic acid by a dehydration reaction of Laudanic acid (J. Chem. Soc., 1956, 4262-4271). In addition, another synthesis method may also use the following method: First, using manool or sclareol by using an alcohol as a solvent, using vanadium or molybdic acid as a catalyst, in the presence of boric acid Allyl rearrangement reaction to form allyl alcohol, after which the allyl alcohol is used The hydrazine-phosphine complex is used as an oxidation reaction of a catalyst to form an aldehyde, and further, the aldehyde is formed into a carboxylic acid by an oxidation reaction in the presence of an oxidizing agent such as sodium chlorite or guanamine sulfuric acid, and finally, The carboxylic acid is made into a labdanic acid by a dehydration reaction using an acid catalyst.

In the case of obtaining a labothelic acid by extraction from a plant, the plant to be used is not particularly limited as long as it is a plant containing a labophyllin or a salt thereof, and is preferably a plant of the family Cistaceae, especially More preferably, Cistus ladaniferus L., Cistus creticus L., Cistus monoperiensis L., Cistus salvifolius . These plants may be used alone or in combination of two or more.

The part of the plant used for the extraction is not particularly limited, and examples thereof include leaves, branches, stems, and bark. Alternatively, the extraction may be carried out immediately after the collection of the plants, or after drying of the collected plants, or after treatment (for example, cutting or powdering) of the dried plants. The solvent used in the extraction is desirably water, a lower alcohol, a petroleum ether, a hydrocarbon, or a combination thereof. Here, the lower alcohol refers to an alcohol having 1 to 4 carbon atoms, and among them, methanol or ethanol is preferred.

Here, the ratio of the labdanic acid to the neurosteroid is preferably 0.01 or more. When the ratio is made 0.01 or more, the effect of improving the stability of the neuropterin in the composition can be sufficiently ensured. Further, the ratio is preferably 100 or less. When the ratio is 100 or less, the effect of ensuring the retention of moisture in the stratum corneum and the effect of improving the stability of the neuropterin in the composition can be obtained.

The ratio of the labdanic acid to the neurosteroid is preferably 0.1 or more, and more preferably 0.25 or more, in the same meaning as the lower limit. Further, it is preferably 50 or less, and more preferably 20 or less, in the same meaning as the meaning of the upper limit.

An example of the composition may be a composition containing only a nervous amine and a labothenic acid. In this case, the neural amines and the labousuric acid can be mixed without a solvent.

An example of the composition may contain components other than the nervous amines and the labousin. In addition to the components of the nervous amines and the labousuric acid, oils, alcohols, water, surfactants, humectants, gelling agents (aqueous gelling agents and oily gelling agents) and viscosity-increasing agents may be mentioned. Agent, powder, UV absorber, preservative and antibacterial agent, antioxidant, beauty ingredients (whitening agent, cell activator, anti-inflammatory agent, blood circulation promoter, skin astringent, anti-lipid leakage agent, etc.), vitamins , amino acids, nucleic acids, hormones, and the like. These may be used alone or in combination of two or more.

(cosmetic)

The cosmetic of one example of the present invention (hereinafter also referred to as "an example of a cosmetic") must contain a composition of an example of the present invention.

According to the cosmetic of the present invention, the effect of the composition of the present invention can be obtained, the effect of improving the stability of the neuropterin in the cosmetic, the barrier function of the stratum corneum on the skin surface, and the prevention can be prevented. The effect of foreign matter intrusion and the effect of moisturizing effect.

The ratio of the neuropterin to the cosmetic of one example can be 0.0001% by mass or more, preferably 0.001% by mass or more, and more preferably 0.005% by mass or more. Further, the ratio may be 10% by mass or less, preferably 5% by mass or less, and more preferably 1% by mass or less.

In addition, the ratio of the labdanic acid to the cosmetic of one example may be 0.0005% by mass or more, preferably 0.001% by mass or more, and more preferably 0.01% by mass or more. Further, the ratio may be 20% by mass or less, preferably 10% by mass or less, and more preferably 1% by mass or less.

In the case of the cosmetic of the present invention, it is preferable to use a suitably selected surfactant as a component other than the ceramide and the labothenic acid, and it is preferable to use it. Anionic and/or nonionic surfactants are particularly preferred for use with water-soluble, nonionic surfactants.

As described above, the neurosteroids in the cosmetic of the present invention are preferably a natural optically active substance, and more preferably a neuropterin or a neuropterin 2, from the viewpoint of improving the barrier function and the like. , neuropterin 3, neuropterin 4, neuropterin 5, neuropterin 6, sphingosine, phytosphingosine, glycosylamine, if also considered versatility, it is especially good for neural crest Amine 2, neural guanamine 3, neural guanamine 6.

Inhibition of the crystallization of neuralamines. From the viewpoint of precipitation or the function of improving the barrier function, the labousanic acid in the cosmetic of the present invention is preferably the labdan-8-ene-15-acid (formula (S5)) or labdan-7. -ene-15-acid (formula (S6)), labdan-8(17)-ene-15-acid (formula (S7)).

An example of a cosmetic can be prepared in various forms such as a liquid, an emulsion, a cream, a solid, a gel, or a paste. Further, an example of the cosmetic preparation can be prepared in various forms such as an oily system, an oil-in-water emulsion system, or an oil-in-water emulsion system. An example of a cosmetic may be a lotion, an emulsion, a cream, a beauty lotion, a makeup oil, a lip cream, a hand cream, or the like. Skincare cosmetics such as facial cleansers, cleansing materials; foundation, makeup base, blush, eye shadow, mascara, eyeliner, eyebrows (eyebrow), over coat agent, lipstick, lip gloss, etc. Makeup makeup; hair tonic, hair cream, shampoo, moisturizing A cosmetic material for scalp or hair styling such as rinse, conditioner, and hair styling; and various cosmetic materials such as massage cosmetics.

Further, the cosmetic of the present invention also contains medicated cosmetics. Further, the composition of the present invention may be contained in addition to the cosmetic, for example, an external preparation for skin.

The composition of the present invention can be produced, for example, by mixing a neural amine with a labousuric acid, and heating the mixture at a temperature higher than the melting point of the neuropterin (for example, 70 to 140 ° C). Thereafter, it is slowly cooled (for example, at 2 ° C / min to 30 ° C / min).

As shown in the description of the specification of the present application, the present invention can provide a crystallization of a nervous steroid containing labyronic acid as an active ingredient. Crystallization of precipitation inhibitors and neuralamines using labranate. Precipitation inhibition method.

[Examples]

Hereinafter, the present invention will be described in more detail by way of examples, but the invention should not be construed as limited.

<Test P>Manufacture of Laudanic Acid

Hereinafter, Production Example 1 of Laudanic Acid will be described.

By using the compound represented by the following formula (S8) as a starting material, the compound represented by the following formula (S4) and the formula (S10) is used to produce the following formula (S4) used in the following test. Salicylic acid. Further, the wave line in the following formula (S8) is represented by a double bond as an E body, a Z body, or a mixture thereof.

690.68 g of a 1,2,4-trimethylbenzene solution of the primary allyl alcohol of the formula (S8) was added to a 2 L reaction vessel equipped with a drain pipe and a thermometer. Dichloro(p-Cymene)ruthenium(II)) 21.733g and tris(4-methoxyphenyl)phosphine 23.93 of dichloro(p-Cymene)ruthenium(II) under nitrogen atmosphere at 31 °C g is added to the reaction vessel. The reaction solution was heated at 170 ° C to 180 ° C for 2 hours to carry out an oxidation reaction of the aldehyde. Thereafter, it was cooled to 46 ° C, thereby stopping the reaction. A part of the reaction solution after the reaction was stopped was analyzed by High Performance Liquid Chromatography (HPLC) to determine the conversion and yield of the reaction (conversion: 100%, yield: 61.95%) . 710 g of a 1,2,4-trimethylbenzene solution containing the aldehyde of the formula (S9) was used in the next reaction without purification.

710 g of a 1,2,4-trimethylbenzene solution of the aldehyde of the formula (S9), 300 g of 1,2,4-trimethylbenzene, and 0.2 g of acetic acid were added to a 2 L reaction vessel equipped with a thermometer. Aminesulfonic acid (H ₂ NSO ₂ OH) 54.57 g and water 27.28 g. The mixture was cooled to -5 °C in a dry ice-acetone bath. Then, an aqueous solution prepared by dissolving 80% of sodium chlorite (NaClO ₂ ) 63.54 g in water of 190.6 g was added dropwise over -8 ° C to -4 ° C over 100 minutes. After reacting at this temperature for 2 hours, 425 g of a 20% aqueous solution of Na ₂ SO _{3 was} added dropwise thereto at -5 ° C to -3 ° C for 30 minutes, and then stirred at 40 ° C to 50 ° C for 30 minutes to cause peroxide. Completely decomposed. After liquid separation, the mixture was washed twice with 250 g of 5% brine to obtain 1000 g of a 1,2,4-trimethylbenzene solution of the hydroxycarboxylic acid of the formula (S10). This was used in the next reaction without purification.

1000 g of a 1,2,4-trimethylbenzene solution of the hydroxycarboxylic acid of the formula (S10) and 2.68 g of a 20% sulfuric acid aqueous solution were added to a 2 L reaction vessel equipped with a drain pipe and a thermometer, and heated under reflux. The dehydration reaction was carried out for 3 hours while draining from 170 ° C to 176 ° C. After completion of the reaction, the reaction solution was cooled, and 74.9 g of a 28% sodium methoxide methanol solution was added to form a sodium salt as a carboxylic acid as a product. 154 g of water was added thereto, and as a result, it was separated into a neutral component of the upper layer and a sodium salt component of the lower layer of the carboxylic acid. After the upper layer was removed, the lower layer was washed twice with heptane 200 mL. To the lower layer, 200 mL of heptane and 95.2 g of a 20% aqueous sulfuric acid solution were added, and the carboxylic acid was extracted with heptane while converting the sodium salt of the carboxylic acid into a carboxylic acid. After recovering the product by heating the solvent under reduced pressure, the product was subjected to vacuum distillation to obtain 100 g of a double bond position isomer mixture of the carboxylic acid represented by the above formula (S4). The yield was 35.8%.

Hereinafter, Production Example 2 of Laudanic Acid will be described.

Molecular steaming of commercially available labdanum absolute 10g Distillation was carried out, and 4.3 g of a fraction having a boiling point of 180 ° C to 220 ° C / 13.3 Pa (hereinafter referred to as Ext-1) was collected. When this Ext-1 was analyzed, it was found that Ext-1 contains labdan-8-ene-15-acid (formula (S5)), labdan-7-ene-15-acid (formula (S6)), labor Dan-8(17)-ene-15-acid (formula (S7)).

<Test A> Laudanic acid inhibits the crystallization of neuralamines. Confirmation of the effect of precipitation (Example A7)

In a 50 mL beaker, 1.0 g of neuropterin 2 and 9.0 g of the labyrin acid of Production Example 1 were mixed without a solvent. The following preparations (1) and (2) were subjected to the compositions thus prepared. The details of the composition are shown in Table 1 (in addition, the composition is represented by weight ratio in Table 1).

(1) Determination of crystallization temperature of neural guanamine

The prepared composition was heated to 120 ° C to prepare a transparent solution (homogeneous solution), and then cooled to 40 ° C while stirring. The crystallization of the neuropterin in the process was visually observed. When the white crystal was observed, the temperature at this time was measured as the temperature of the ceramide precipitation, and no white crystal was observed until 40 °C. In the case of the substance, it is assumed that there is no crystal precipitation of a neurolamine (indicated by "○" in Table 1 to be described later). The results are shown in Table 1. Further, after cooling, almost no crystallization of the labyrin acid was observed.

(2) Microscopic observation

The composition which was 40 ° C was observed under a polarizing condition using an Upright Microscope (manufactured by Olympus Co., Ltd.) under the conditions of a magnification of 20 times and an exposure time of 1/300 second. In addition, under the polarized light, the neural crest When the amine is present in the form of crystals in the composition, it is observed as a white bright material. A part of the results is shown in Fig. 1 (a) and Fig. 1 (b).

(Examples A1 to A6, Examples A8 to A14, Comparative Example A1 to Comparative Example A4)

The composition was prepared in the same manner as in Example A7 except that the composition shown in Table 1 was used, and the experiments of (1) and (2) were carried out. The results are shown in Table 1.

According to the results of <Test A>, it is clear that the labdanic acid has a high ability to dissolve the neural amines and shows inhibition of the crystallization of the neural amines. The effect of precipitation.

<Test B> Lauranic acid inhibits the crystallization of neural amides in cosmetics. Confirmation of the effect of precipitation

(Example B1)

The neuropterin II, the labranic acid of Production Example 1, and the PEG 60 hydrogenated castor oil were mixed, and the mixture was heated to 100 ° C to prepare a homogeneous solution (solution A). To the solution, 1,3-butanediol and ethanol were added, and while being kept at 50 ° C, they were mixed so as to be uniform (solution B). Solution B was added to the purified water, and the solution was slowly cooled to 40 °C. In this manner, a cosmetic (make lotion) containing a cosmetic component in addition to the nervous steroids and the labousuric acid is prepared. The details of the cosmetic (makeup) are shown in Table 2 (in addition, the composition is expressed by weight % in Table 2).

(Light transmittance measurement)

An experiment for measuring the transmittance of the prepared composition was carried out. The prepared composition was heated to 40 ° C to prepare a transparent solution (homogeneous solution), and then allowed to stand at room temperature. The light transmittance at 550 nm immediately after standing and after 3 days from the start of standing was measured using a spectrophotometer (UV-2500PC UV-VIS REDCORDING SPECTROPHOTOMETER, manufactured by Shimadzu Corporation). A glass cell having an optical path length of 10 mm (optical path width: 10 mm) was used for the measurement, and purified water was used as a reference sample. The light transmittance was determined by the following criteria. The results are shown in Table 2.

[Judgement criteria] (judgment result: judgment content)

×: less than 10%

△: 30% or more ~ less than 50%

○: 50% or more ~ less than 70%

◎: 70% or more

(Example B2 to Example B9)

A cosmetic was prepared in the same manner as in Example B1 except that the composition shown in Table 2 was used, and an experiment for measuring the light transmittance was carried out. The results are shown in Table 2.

According to the results of <Test B>, it is clear that in the cosmetics containing the cosmetic component in addition to the neuropterin and the labrinic acid, the ability of the labyrin acid to dissolve the neural amines is also high, and it is also shown. Inhibits the crystallization of neural steroids. The effect of precipitation.

<Test C> Confirmation of the improvement effect of the barrier function of the skin of the cosmetic

(Example C1)

In the same manner as in <Test B>, the components shown in Table 3 were used to prepare a cosmetic containing a cosmetic component in addition to the nervous amines and the labrinic acid. The details of the cosmetic are shown in Table 3 (in addition, the composition is expressed by weight ratio in Table 3).

An experiment for confirming the effect of improving the barrier function was performed on the prepared cosmetic. The upper arm of 10 healthy males of 20 to 30 generations was treated with acetone ether to form rough skin. The prepared cosmetic material was continuously applied to the rough skin twice a day for two times per arm. The amount of moisture evapotranspiration (TEWL) of the skin was measured using a moisture evapotranspiration meter (Vapometer, manufactured by Delfin). In addition, the amount of moisture evapotranspiration is calculated as a relative value when the amount of water evaporation in the case where any treatment is not performed on rough skin is set to 100. Based on the average of the relative values, the moisturizing effect of the cosmetic is determined by the following criteria. The results are shown in Table 3.

[Judgement criteria] (judgment result: judgment content)

◎: The average value of relative values is less than 80

○: The average value of the relative values is 80 or more and less than 90

△: The average value of the relative values is 90 or more and less than 100

×: The average value of relative values is 100 or more

(Comparative Example C1, Comparative Example C2)

In addition to the composition shown in Table 3, a cosmetic was prepared in the same manner as in Example C1, and an experiment for confirming the effect of improving the barrier function was performed. The results are shown in Table 3.

According to the results of <Test C>, it is clear that the cosmetic containing the cosmetic component in addition to the neuropterin and the labrinic acid also maintains the barrier function improving effect of the skin originally provided by the neurosteroid.

<Test D>

Hereinafter, the composition according to the present invention and the composition according to the present invention are shown A formulation example of a cosmetic and an external preparation for skin. Further, % in the following Examples D1 to D4 is a value in which the total amount is 100% by mass.

(Embodiment D1)

A cosmetic liquid was prepared using the ingredients shown below.

The components 1 to 10 were mixed, and the mixture was heated to 90 ° C to prepare a homogeneous solution (solution A). Then, the components 11 to 16 were mixed, and the mixture was heated to 70 ° C to prepare a homogeneous solution (solution B). Solution B was added to solution A and emulsified at 70 ° C (solution C). The solution C was cooled to 40 ° C, and the 17 was added thereto, and thoroughly mixed to obtain a cosmetic liquid.

The prepared beauty liquid was subjected to the same experiment as the experiment of measuring the light transmittance in <Test B>, and the same experiment as the experiment for confirming the effect of improving the barrier function in <Test C>. It can be seen that the cosmetic liquid of Example D1 inhibits the crystallization of neuralamines. The effect of precipitation and the effect of improving barrier function are excellent.

(Example D2)

The emulsion was prepared using the ingredients shown below.

The components 1 to 10 were mixed, and the mixture was heated to 90 ° C to prepare a homogeneous solution (solution A). Then, the components 11 to 14 were mixed, and the mixture was heated to 70 ° C to prepare a homogeneous solution (solution B). Solution A was added to Solution B, cooled to room temperature, and the 15 and 16 were added thereto, and sufficiently mixed to obtain an emulsion.

4. For the prepared emulsion, observe the crystallization of neural amines. The experiment of the case of precipitation and the experiment similar to the experiment which confirmed the effect of the barrier function improvement in <Test C>. It can be seen that the emulsion of Example D2 inhibits the crystallization of neural amines. The effect of precipitation and the effect of improving barrier function are excellent.

(Example D3)

A solid lip balm was prepared using the ingredients shown below.

The components 1 to 7 were mixed, and the mixture was heated to 100 ° C to prepare a homogeneous solution (solution A). Then, the component 8 to the component 10 were added to the solution A, and the mixture was sufficiently mixed (solution B). The solution B was poured into a gold dish, and solidified by cooling to obtain a solid lip balm.

4. For the prepared solid lip balm, observe the crystallization of neural amines. Experiments in the case of precipitation and experiments to confirm the improvement of the barrier function of the skin. It can be seen that the solid lip balm of Example D3 inhibits the crystallization of neural amines. The effect of precipitation and the effect of improving barrier function are excellent.

(Example D4)

A sunscreen was prepared using the ingredients shown below.

The components 1 to 7 were mixed, and the mixture was heated to 70 ° C to heat and swell (solution A). Then, the components 8 to 12 were mixed, and the mixture was heated to 70 ° C to prepare a homogeneous solution (solution B). The solution B was added to the solution A to be emulsified, and then cooled to room temperature (solution C). The component 13 and the component 14 were added to the solution C, and sufficiently mixed (solution D). The component 15 was added to the solution D and thoroughly mixed to obtain a sunscreen.

4. For the prepared sunscreen, observe the crystallization of neural amines. Experiments in the case of precipitation and experiments to confirm the improvement of the barrier function of the skin. It can be seen that the sunscreen of Example D4 inhibits the crystallization of neuralamines. The effect of precipitation and the effect of improving barrier function are excellent.

[Industrial availability]

According to the composition of the present invention, inhibition of ceramide crystallization in the composition It is precipitated, thereby improving the stability of the neuropterin in the composition. According to the cosmetic of the present invention, it is possible to suppress the precipitation of the neuropterin in the cosmetic material, thereby improving the stability of the neuropterin in the cosmetic.

Claims (4)

A composition comprising a neuropterin and a labousuric acid. The composition according to claim 1, wherein the ratio of the labousanic acid to the neurosteroid is 0.01 to 100. The composition according to claim 2, wherein the ratio of the labousanic acid to the neurosteroid is from 0.1 to 50. A cosmetic composition comprising the composition according to any one of claims 1 to 3.