TW201542227A - 利用il-13拮抗劑選擇性治療氣喘之方法 - Google Patents

利用il-13拮抗劑選擇性治療氣喘之方法 Download PDF

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TW201542227A
TW201542227A TW104111463A TW104111463A TW201542227A TW 201542227 A TW201542227 A TW 201542227A TW 104111463 A TW104111463 A TW 104111463A TW 104111463 A TW104111463 A TW 104111463A TW 201542227 A TW201542227 A TW 201542227A
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seq
antagonist
patient
air marker
antibody
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TW104111463A
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Chinese (zh)
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麥克 羅特
史蒂芬 勒維茲奇
愛咪 達馬斯克
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諾華公司
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L5/00Structural features of suction cleaners
    • A47L5/12Structural features of suction cleaners with power-driven air-pumps or air-compressors, e.g. driven by motor vehicle engine vacuum
    • A47L5/22Structural features of suction cleaners with power-driven air-pumps or air-compressors, e.g. driven by motor vehicle engine vacuum with rotary fans
    • A47L5/28Suction cleaners with handles and nozzles fixed on the casings, e.g. wheeled suction cleaners with steering handle
    • A47L5/30Suction cleaners with handles and nozzles fixed on the casings, e.g. wheeled suction cleaners with steering handle with driven dust-loosening tools, e.g. rotating brushes
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/02Nozzles
    • A47L9/04Nozzles with driven brushes or agitators
    • A47L9/0427Gearing or transmission means therefor
    • A47L9/0444Gearing or transmission means therefor for conveying motion by endless flexible members, e.g. belts
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/02Nozzles
    • A47L9/04Nozzles with driven brushes or agitators
    • A47L9/0455Bearing means therefor
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/02Nozzles
    • A47L9/04Nozzles with driven brushes or agitators
    • A47L9/0461Dust-loosening tools, e.g. agitators, brushes
    • A47L9/0466Rotating tools
    • A47L9/0477Rolls
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/10Filters; Dust separators; Dust removal; Automatic exchange of filters
    • A47L9/16Arrangement or disposition of cyclones or other devices with centrifugal action
    • A47L9/1683Dust collecting chambers; Dust collecting receptacles
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/32Handles
    • A47L9/325Handles for wheeled suction cleaners with steering handle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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TW104111463A 2014-04-11 2015-04-09 利用il-13拮抗劑選擇性治療氣喘之方法 TW201542227A (zh)

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US201461978604P 2014-04-11 2014-04-11

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US (2) US10066267B2 (enExample)
EP (1) EP3129497B1 (enExample)
JP (2) JP2017513937A (enExample)
KR (1) KR20160138095A (enExample)
CN (1) CN106536754B (enExample)
AU (2) AU2015246037B2 (enExample)
BR (1) BR112016023238A2 (enExample)
CA (1) CA2943326A1 (enExample)
MX (1) MX2016013372A (enExample)
RU (1) RU2694980C2 (enExample)
TW (1) TW201542227A (enExample)
WO (1) WO2015155710A1 (enExample)

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WO2018008749A1 (ja) 2016-07-08 2018-01-11 TAK-Circulator株式会社 Mex3b遺伝子の発現を抑制する核酸、mex3b遺伝子発現抑制剤、mex3b遺伝子発現を抑制する方法及びmex3b遺伝子発現に起因する疾病の予防又は治療剤
US10650928B1 (en) * 2017-12-18 2020-05-12 Clarify Health Solutions, Inc. Computer network architecture for a pipeline of models for healthcare outcomes with machine learning and artificial intelligence
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US10643749B1 (en) 2019-09-30 2020-05-05 Clarify Health Solutions, Inc. Computer network architecture with machine learning and artificial intelligence and automated insight generation
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CN113215245A (zh) * 2021-05-21 2021-08-06 广州合一生物科技有限公司 一种用于儿童哮喘个体化用药的基因检测试剂盒及其应用
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RU2694980C2 (ru) 2019-07-18
AU2018202260A1 (en) 2018-04-26
JP2020079241A (ja) 2020-05-28
RU2016144177A (ru) 2018-05-11
MX2016013372A (es) 2017-01-26
AU2018202260B2 (en) 2019-12-12
JP2017513937A (ja) 2017-06-01
US10066267B2 (en) 2018-09-04
BR112016023238A2 (pt) 2017-10-17
US20170029894A1 (en) 2017-02-02
CN106536754B (zh) 2021-04-16
EP3129497B1 (en) 2021-09-08
CN106536754A (zh) 2017-03-22
RU2016144177A3 (enExample) 2018-12-13
WO2015155710A9 (en) 2016-05-19
AU2015246037B2 (en) 2018-04-12
KR20160138095A (ko) 2016-12-02
WO2015155710A1 (en) 2015-10-15
EP3129497A1 (en) 2017-02-15
AU2015246037A1 (en) 2016-10-06
CA2943326A1 (en) 2015-10-15
US20200178741A1 (en) 2020-06-11

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