TW201513882A - 抗－催乳激素受體抗體調配物 - Google Patents
抗－催乳激素受體抗體調配物 Download PDFInfo
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- TW201513882A TW201513882A TW103109457A TW103109457A TW201513882A TW 201513882 A TW201513882 A TW 201513882A TW 103109457 A TW103109457 A TW 103109457A TW 103109457 A TW103109457 A TW 103109457A TW 201513882 A TW201513882 A TW 201513882A
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- Prior art keywords
- prlr antibody
- prlr
- antibody formulation
- antibody
- formulation
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Neurology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (1)
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| US201361799629P | 2013-03-15 | 2013-03-15 |
Publications (1)
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| WO (1) | WO2014143909A1 (cg-RX-API-DMAC7.html) |
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| CN104302664B (zh) | 2012-03-14 | 2021-11-26 | 瑞泽恩制药公司 | 多特异性抗原结合分子及其用途 |
| US20160002342A1 (en) * | 2013-03-15 | 2016-01-07 | Xinghang Ma | Anti-prolactin receptor antibody formulations |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| US9545451B2 (en) | 2013-08-21 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Anti-PRLR antibodies and methods for killing PRLR-expressing cells |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| NZ737726A (en) | 2015-07-06 | 2023-03-31 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| EP4506016A3 (en) | 2015-12-18 | 2025-06-04 | Upstream Bio, Inc. | Pharmaceutical composition containing anti-human tslp receptor antibody |
| IL249795B (en) | 2016-02-05 | 2020-01-30 | Grifols Worldwide Operations Ltd | Intradermal administration of an immunoglobulin preparation g |
| EP3448891A1 (en) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| EP3518971A4 (en) | 2016-09-28 | 2020-05-13 | Board Of Regents, The University Of Texas System | ANTIBODIES AND THERAPEUTIC PROTEIN FORMULATIONS AND USES THEREOF |
| IL266917B2 (en) | 2016-11-29 | 2023-10-01 | Regeneron Pharma | Anti-human prolactin receptor (prlr) antibody-drug conjugates and use thereof in combination therapy of prlr positive breast cancer |
| MY197202A (en) * | 2017-03-16 | 2023-05-31 | Lg Chemical Ltd | A liquid formulation of anti-tnf alpha antibody |
| TW201836647A (zh) | 2017-04-06 | 2018-10-16 | 美商艾伯維有限公司 | 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途 |
| JP7297672B2 (ja) | 2017-04-13 | 2023-06-26 | アジェナス インコーポレイテッド | 抗ｃｄ１３７抗体およびその使用方法 |
| ES2932861T3 (es) * | 2018-01-26 | 2023-01-27 | Hoffmann La Roche | Composiciones de IL-22 Fc y procedimientos de uso |
| SG11202007363TA (en) | 2018-02-07 | 2020-08-28 | Regeneron Pharma | Methods and compositions for therapeutic protein delivery |
| JOP20210229A1 (ar) | 2019-02-18 | 2023-01-30 | Lilly Co Eli | صيغة جسم مضاد علاجي |
| CN120548195A (zh) | 2022-11-07 | 2025-08-26 | 上游生物公司 | 包含抗人类tslp受体抗体的药物组合物和其使用方法 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AU2003293543A1 (en) * | 2002-12-13 | 2004-07-09 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CA2932012A1 (en) * | 2006-08-18 | 2008-02-21 | Novartis Ag | Prlr-specific antibody and uses thereof |
| ATE551071T1 (de) * | 2006-09-08 | 2012-04-15 | Medimmune Llc | Humanisierte anti-cd19-antikörper und ihre verwendung für die behandlung von krebs, transplantationen und autoimmunerkrankungen |
| MX2009006199A (es) * | 2006-12-11 | 2009-06-22 | Hoffmann La Roche | Formulacion parenteral de anticuerpos abeta. |
| US20100189723A1 (en) * | 2007-01-11 | 2010-07-29 | Peter Andreas Nicolai Reumert Wagtmann | Anti-kir antibodies, formulations, and uses thereof |
| RU2010120674A (ru) * | 2007-10-22 | 2011-11-27 | Шеринг Корпорейшн (US) | Полностью человеческие анти-vegf-антитела и способы их применения |
| KR20140019035A (ko) * | 2008-09-19 | 2014-02-13 | 에프. 호프만-라 로슈 아게 | 신규한 항체 제형 |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| CN104490767A (zh) * | 2009-05-04 | 2015-04-08 | 艾伯维生物技术有限公司 | 人抗TNF-α抗体的稳定高蛋白质浓度制剂 |
| EP2332995A1 (en) | 2009-12-10 | 2011-06-15 | Bayer Schering Pharma Aktiengesellschaft | Neutralizing prolactin receptor antibodies and their therapeutic use |
| BR112012013148A2 (pt) * | 2009-12-29 | 2017-03-21 | F Hoffmann - La Roche Ag | formulação farmacêutica e uso |
| US20110223208A1 (en) * | 2010-03-09 | 2011-09-15 | Beth Hill | Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| US20160002342A1 (en) * | 2013-03-15 | 2016-01-07 | Xinghang Ma | Anti-prolactin receptor antibody formulations |
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2014
- 2014-03-14 US US14/772,369 patent/US20160002342A1/en not_active Abandoned
- 2014-03-14 TW TW103109457A patent/TW201513882A/zh unknown
- 2014-03-14 CA CA2906101A patent/CA2906101A1/en not_active Abandoned
- 2014-03-14 CN CN201480016050.7A patent/CN105025925A/zh active Pending
- 2014-03-14 AR ARP140101101A patent/AR095496A1/es unknown
- 2014-03-14 EP EP14722033.9A patent/EP2968538A1/en not_active Withdrawn
- 2014-03-14 HK HK16103172.6A patent/HK1215175A1/zh unknown
- 2014-03-14 WO PCT/US2014/028078 patent/WO2014143909A1/en not_active Ceased
- 2014-03-14 UY UY0001035460A patent/UY35460A/es not_active Application Discontinuation
- 2014-03-14 JP JP2016502699A patent/JP2016515515A/ja active Pending
- 2014-03-14 US US14/213,497 patent/US9023357B2/en active Active
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| US20140271659A1 (en) | 2014-09-18 |
| CN105025925A (zh) | 2015-11-04 |
| WO2014143909A1 (en) | 2014-09-18 |
| US9023357B2 (en) | 2015-05-05 |
| UY35460A (es) | 2014-10-31 |
| US20160002342A1 (en) | 2016-01-07 |
| HK1215175A1 (zh) | 2016-08-19 |
| AR095496A1 (es) | 2015-10-21 |
| CA2906101A1 (en) | 2014-09-18 |
| EP2968538A1 (en) | 2016-01-20 |
| JP2016515515A (ja) | 2016-05-30 |
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