TW201416738A - Fabrication of fiber optical tweezers - Google Patents
Fabrication of fiber optical tweezers Download PDFInfo
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本發明係有關於一種光纖光學鑷夾之製程,尤其是指一種於整體製作上更為簡便,且能降低其製作成本,並於使用上具有高捕捉效率及低捕捉功率,使得其能更便於在生物醫學領域上的應用,而在其整體施行使用上更增實用功效特性之光纖光學鑷夾之製程創新設計者。The invention relates to a process for optical fiber optical clamping, in particular to a simpler overall manufacturing, and can reduce the manufacturing cost thereof, and has high capturing efficiency and low capturing power in use, which makes it more convenient. An innovative manufacturer of fiber optic optical clips for applications in the biomedical field and for the practical use of their applications.
按,光學鑷夾〔亦稱光鉗〕是指利用光或光能捕捉微小物體,其係為一種非接觸式捕捉的夾具,使得被捕捉物不但可以避免以往受到接觸式鑷夾造成的形變、刮傷或破壞情況發生,且還可以於低干擾的情況下操控,並觀察活體的微生物、細胞或血球等行為。Press, optical clamp (also known as optical clamp) refers to the use of light or light energy to capture tiny objects, which is a non-contact capture fixture, so that the captured object can not only avoid the deformation caused by the contact clamp, Scratches or damage can occur, and can also be manipulated with low interference, and observe the behavior of microorganisms, cells or blood cells in the living body.
而該光學鑷夾目前一般主要可分為透鏡式及光纖式兩種類型;其中,透鏡式光學鑷夾系統是由許多光學元件建構而成,使得其整體系統的建構較為複雜、操控性較差、成本較為昂貴,且此系統需時常反覆調整各個光學元件,使光路依照實驗設計之路徑前進,而若再加裝其他光學元件,系統就變得更加複雜,光軸的調整也相對困難,加上佔用較大的實體空間,及其雷射輸出功率高,易破壞活體細胞之被捕捉物,致令其在整體結構設計上仍存在有改進之空間。The optical clamps are generally mainly classified into two types: a lenticular type and an optical fiber type; wherein the lenticular optical clamping system is constructed by a plurality of optical components, so that the overall system construction is complicated and the handling is poor. The cost is relatively expensive, and the system needs to adjust each optical component repeatedly, so that the optical path advances according to the path of the experimental design, and if other optical components are added, the system becomes more complicated, and the adjustment of the optical axis is relatively difficult, plus Occupying a large physical space, and its high laser output power, easy to damage the captured objects of living cells, so that there is still room for improvement in the overall structural design.
至於光纖式光學鑷夾則相較於透鏡式光學鑷夾所佔實體空間較小、操作零活性較高、成本較低;也因此,於2005年10月11日公告有第I241421號「製造雙曲線形式光纖透鏡之方法」及於2006年葉斯銘先生之國立中山大學的光電工程研究所博士論文「橢圓光纖微透鏡之研究」中,皆提出應用於通訊領域之雷射光與光纖耦合匹配的光纖微透鏡製程方法,但其使用的蝕刻液是氫氟酸與機油〔HF/oil〕之混合液,在製作過程中需進行蝕刻液調合的步驟,並再清洗殘留於光纖上的油汙,增加製程時間及困難度;此外,其主要應用於通訊領域之雷射光與光纖耦合匹配,無法直接應用於光纖光學鑷夾系統。As for the optical fiber optical clamp, the physical space is smaller than that of the lenticular optical clamp, the operation zero activity is higher, and the cost is lower; therefore, on October 11, 2005, there is a publication No. I241421 "Manufacturing Double "Method of Curved Fiber Lens" and in the "Study on Elliptical Fiber Microlens" of the Institute of Optoelectronic Engineering, National University of Sun Yat-sen University in 2006, Mr. Ye Siming, the fiber-optic coupling of laser light and fiber coupling is applied in the field of communication. The lens processing method, but the etching liquid used is a mixture of hydrofluoric acid and engine oil [HF/oil], and the etching liquid is required to be blended in the manufacturing process, and the oil remaining on the optical fiber is further cleaned to increase the processing time. And difficulty; in addition, its main application in the field of communication laser light and fiber coupling matching, can not be directly applied to fiber optic optical clamping system.
另,於2009年陳國良先生之國立高雄應用科技大學的光電與通訊工程研究所碩士論文「光纖光學鑷夾之研製」中,則受上述製程技術啟發,改變製程中使用之蝕刻液與蝕刻參數,並使加工的光纖端面符合光學鑷夾之應用;但因製程時間過長,以及所使用的光纖皆為多模態光纖〔MMF〕之光學鑷夾,所以輸出雷射光會產生多模態,且所需雷射光功率高,不適用於生醫領域之活體捕捉。In addition, in 2009, Mr. Chen Guoliang's master's thesis of the Institute of Optoelectronics and Communication Engineering of the National Kaohsiung University of Applied Sciences, "Development of Fiber Optic Optical Clamps", was inspired by the above process technology to change the etching solution and etching parameters used in the process. And the processed fiber end face conforms to the application of the optical clamp; however, since the process time is too long and the optical fibers used are optical clamps of the multi-mode optical fiber (MMF), the output laser light generates multi-mode, and The required laser light power is high, and it is not suitable for living body capture in the field of biomedicine.
又,於2011年陳文堡先生之國立高雄應用科技大學的光電與通訊工程研究所碩士論文「光纖光學鑷夾應用於捕捉微粒與酵母菌之研究」中,雖已提出單模態光纖〔SMF〕之光學鑷夾,解決模態上的問題,但製程方法依然耗時,且加工後光纖頭波導效果不佳,造成輸出雷射光損耗大,使輸出功率仍高,於其製作良率上亦偏低。In addition, in 2011, Mr. Chen Wenbao’s master's thesis of the Institute of Optoelectronics and Communication Engineering of the National Kaohsiung University of Applied Sciences, “Study on the application of fiber optic optical clamps to capture microparticles and yeasts”, has proposed single-mode fiber [SMF]. The optical clamp solves the modal problem, but the process method is still time consuming, and the effect of the fiber-optic waveguide after processing is not good, resulting in a large loss of output laser light, so that the output power is still high, and the production yield is also high. Low.
緣是,發明人秉持多年該相關行業之豐富設計開發及實際製作經驗,針對現有之結構再予以研究改良,提供一種光纖光學鑷夾之製程,以期達到更佳實用價值性之目的者。The reason is that the inventor has been carrying out research and development and practical production experience of the relevant industry for many years, and has researched and improved the existing structure to provide a process for optical fiber optical clamping, in order to achieve better practical value.
本發明之主要目的在於提供一種光纖光學鑷夾之製程,其係於整體製作上更為簡便,且能降低其製作成本,並於使用上具有高捕捉效率及低捕捉功率,使得其能更便於在生物醫學領域上的應用,而在其整體施行使用上更增實用功效特性者。The main object of the present invention is to provide a process for optical fiber optical clamping, which is simpler in overall manufacturing, can reduce the manufacturing cost thereof, and has high capturing efficiency and low capturing power in use, which makes it more convenient. It is applied in the field of biomedicine, and it is more practical and useful in its overall application.
本發明光纖光學鑷夾之製程之主要目的與功效,係由以下具體技術手段所達成:The main purpose and effect of the process of the optical fiber optical clamp of the present invention are achieved by the following specific technical means:
其主要係包括下列步驟:Its main steps include the following steps:
剝除:剪裁適當長度之光纖,並剝除光纖之纖衣層〔Cladding〕而漏出纖芯層〔Core〕;Stripping: cutting the fiber of the appropriate length, and stripping the fiber layer of the fiber and leaking the core layer [Core];
清潔:將光纖清洗潔淨;Cleaning: clean the fiber;
切割:將光纖之纖芯層〔Core〕端面切割平整化;Cutting: flattening the end face of the core layer of the optical fiber;
蝕刻:將光纖予以固定,於一容器內加入氧化物緩衝蝕刻液〔Buffer Oxide Etch﹐BOE〕再將固定之光纖對應容器設置,令待加工之光纖纖芯層〔Core〕末端浸入氧化物緩衝蝕刻液進行蝕刻,光纖之纖芯層〔Core〕末端即會形成錐形狀;Etching: the optical fiber is fixed, an oxide buffering etchant (Buffer Oxide Etch, BOE) is added to a container, and the fixed fiber is disposed corresponding to the container, so that the end of the core of the fiber to be processed is immersed in the oxide buffer etching. The liquid is etched, and the end of the core layer of the optical fiber forms a tapered shape;
微透鏡加工:對錐形狀之光纖纖芯層〔Core〕末端利用兩端電弧裝置進行融燒,使其形成半球形之透鏡化光纖,即完成製作。Microlens processing: The end of the cone-shaped fiber core layer (Core) is melted by a two-end arc device to form a hemispherical lensized fiber, which is completed.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該剝除步驟係利用光纖剝線鉗對光纖進行剪裁及剝除纖衣層〔Cladding〕。A preferred embodiment of the process for fabricating a fiber optic optical clip of the present invention, wherein the stripping step utilizes an optical fiber stripper to cut and strip the fiber.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該切割步驟係利用光纖切割刀對光纖之纖芯層〔Core〕端面進行切割平整化。In a preferred embodiment of the process of the optical fiber optical chuck of the present invention, the cutting step is to cut and planarize the end face of the core layer of the optical fiber by using a fiber cutter.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該蝕刻步驟所使用之容器係為聚丙乙烯材質。A preferred embodiment of the process for fabricating the optical fiber optical chuck of the present invention, wherein the container used in the etching step is made of polypropylene.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該蝕刻步驟所使用之氧化物緩衝蝕刻液,其係由經水稀釋40%之氟化氨〔NH4F〕及經水稀釋49%之氫氟酸兩種液體以6:1的方式調製而成。A preferred embodiment of the process for the optical fiber optical chuck of the present invention, wherein the oxide buffering etching solution used in the etching step is diluted with 40% ammonia fluoride [NH 4 F] and diluted with water by water. The two hydrofluoric acid liquids are prepared in a 6:1 manner.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該蝕刻步驟係將固定之光纖置於容器上方,令待加工之光纖之纖芯層〔Core〕末端浸入氧化物緩衝蝕刻液進行垂直式蝕刻。A preferred embodiment of the process of the optical fiber optical chuck of the present invention, wherein the etching step is to place the fixed optical fiber on the upper side of the container, so that the end of the core layer of the optical fiber to be processed is immersed in the oxide buffer etchant for vertical Etching.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該蝕刻步驟係將固定之光纖置於容器側邊,令待加工之光纖之纖芯層〔Core〕末端浸入氧化物緩衝蝕刻液進行水平式蝕刻。A preferred embodiment of the process of the optical fiber optical chuck of the present invention, wherein the etching step is to place the fixed fiber on the side of the container, so that the end of the core layer of the fiber to be processed is immersed in the oxide buffer etchant. Horizontal etching.
本發明光纖光學鑷夾之製程的較佳實施例,其中,於進行蝕刻步驟後再進行觀察步驟,利用金相顯微鏡觀察光纖之纖芯層〔Core〕末端是否為錐形狀,若成功即可進行下一步驟,若失敗則直接視為廢品。A preferred embodiment of the process of the optical fiber optical chuck of the present invention, wherein the observation step is performed after the etching step, and the metal core microscope is used to observe whether the end of the core layer of the optical fiber is tapered, and if successful, it can be performed. The next step, if it fails, is directly considered as scrap.
本發明光纖光學鑷夾之製程的較佳實施例,其中,該觀察步驟於利用金相顯微鏡觀察到光纖之纖芯層〔Core〕末端為錐形狀後,能直接進行光學捕捉實驗測試。In a preferred embodiment of the process for fabricating the optical fiber optical chuck of the present invention, the observation step can directly perform an optical capture experimental test after observing the end of the core layer of the optical fiber by a metallographic microscope.
本發明光纖光學鑷夾之製程的較佳實施例,其中,於進行微透鏡加工步驟後再進行觀察步驟,利用金相顯微鏡觀察光纖之纖芯層〔Core〕末端,並進行光學捕捉實驗測試。In a preferred embodiment of the process for the optical fiber optical chuck of the present invention, the observation step is performed after the microlens processing step, and the core end of the core layer of the optical fiber is observed by a metallographic microscope, and an optical capture experiment is performed.
為令本發明所運用之技術內容、發明目的及其達成之功效有更完整且清楚的揭露,茲於下詳細說明之,並請一併參閱所揭之圖式及圖號:For a more complete and clear disclosure of the technical content, the purpose of the invention and the effects thereof achieved by the present invention, it is explained in detail below, and please refer to the drawings and drawings:
首先,請參閱第一圖本發明之製作流程示意圖所示,本發明主要係包括下列步驟:First, please refer to the first figure, which shows the schematic diagram of the production process of the present invention. The present invention mainly includes the following steps:
剝除:利用光纖剝線鉗剪裁適當長度之光纖(1),並剝除光纖(1)之纖衣層〔Cladding〕(11)而漏出纖芯層〔Core〕(12);Stripping: using a fiber stripper to cut the appropriate length of the fiber (1), and stripping the fiber layer (11) of the fiber (1) and leaking the core layer (Core) (12);
清潔:將光纖(1)清洗潔淨;Cleaning: clean the fiber (1);
切割:利用光纖切割刀將光纖(1)之纖芯層〔Core〕(12)端面切割平整化;Cutting: the end face of the core layer (Core) (12) of the optical fiber (1) is flattened by a fiber cutter;
蝕刻:將光纖(1)予以固定,於一聚丙乙烯之容器(2)內加入氧化物緩衝蝕刻液〔Buffer Oxide Etch﹐BOE〕(3),該氧化物緩衝蝕刻液(3)是由經水稀釋40%之氟化氨〔NH4F〕及經水稀釋49%之氫氟酸兩種液體以6:1的方式調製而成,再將固定之光纖(1)置於容器(2)上方或側邊,令待加工之光纖(1)之纖芯層〔Core〕(12)末端浸入氧化物緩衝蝕刻液(3)進行垂直式蝕刻,將光纖(1)之纖芯層〔Core〕(12)垂直浸入氧化物緩衝蝕刻液(3)中〔請一併參閱第二圖本發明之光纖垂直式蝕刻狀態動作示意圖(一)所示〕,光纖(1)之纖芯層〔Core〕(12)末端即會形成錐形狀〔請一併參閱第三圖本發明之光纖垂直式蝕刻狀態動作示意圖(二)及第四圖本發明之光纖垂直式蝕刻狀態動作示意圖(三)所示〕;本發明亦可令光纖(1)之纖芯層〔Core〕(12)水平浸入氧化物緩衝蝕刻液(3)中進行水平式蝕刻〔請一併參閱第五圖本發明之光纖水平式蝕刻狀態動作示意圖(一)所示〕,光纖(1)之纖芯層〔Core〕(12)末端同樣即會形成錐形狀〔請一併參閱第六圖本發明之光纖水平式蝕刻狀態動作示意圖(二)及第七圖本發明之光纖水平式蝕刻狀態動作示意圖(三)所示〕;Etching: the optical fiber (1) is fixed, and an oxide buffer etchant (Buffer Oxide Etch, BOE) (3) is added to a container (2) of a polypropylene material. The oxide buffer etchant (3) is made of water. Diluting 40% of ammonium fluoride [NH 4 F] and 49% of hydrofluoric acid diluted with water to prepare a 6:1 solution, and placing the fixed fiber (1) above the container (2) Or the side, so that the end of the core layer (12) of the fiber (1) to be processed is immersed in the oxide buffer etchant (3) for vertical etching, and the core layer of the fiber (1) is (Core) ( 12) Vertically immersed in the oxide buffer etchant (3) (please refer to the second diagram of the optical fiber vertical etch state operation diagram (1) of the present invention), the core layer of the optical fiber (1) (Core) ( 12) The end will form a tapered shape (please refer to the third figure for the operation of the optical fiber vertical etching state of the present invention (2) and the fourth figure of the present invention. The etched state operation diagram (3) is shown; the present invention can also make the core layer [Core] (12) of the optical fiber (1) horizontally immersed in the oxide buffer etchant (3) for horizontal etching [please refer to Fig. 5 is a schematic view showing the operation of the horizontal etching state of the optical fiber of the present invention (1), and the end of the core layer (Core) of the optical fiber (1) is also formed into a tapered shape (please refer to the sixth figure together) The schematic diagram of the optical horizontal etching state of the invention (2) and the seventh diagram of the optical horizontal etching state of the present invention (3) is shown;
觀察:利用金相顯微鏡觀察光纖(1)之纖芯層〔Core〕(12)末端是否為錐形狀,若成功即可進行下一步驟,或直接進行光學捕捉實驗測試,若失敗則直接視為廢品;Observation: Observe the end of the core layer (Core) (12) of the fiber (1) by a metallographic microscope. If it is successful, proceed to the next step, or directly perform the optical capture test. If it fails, it is directly regarded as Waste product
微透鏡加工:對錐形狀之光纖(1)纖芯層〔Core〕(12)末端利用兩端電弧裝置進行融燒〔請一併參閱第八圖本發明之光纖融燒狀態動作示意圖(一)所示〕,使其形成半球形之透鏡化光纖(1)〔請一併參閱第九圖本發明之光纖融燒狀態動作示意圖(二)所示〕;Microlens processing: the end of the fiber (1) core layer (Core) (12) is melted by the arc device at both ends (please refer to the eighth figure for the operation of the fiber melt state of the present invention (1) </ RTI> shown to form a hemispherical lensed fiber (1) [please refer to the ninth figure of the present invention for the operation of the fiber melt state diagram (2)];
觀察:利用金相顯微鏡觀察光纖(1)之纖芯層〔Core〕(12)末端,並進行光學捕捉實驗測試。Observation: The end of the core layer [Core] (12) of the optical fiber (1) was observed by a metallographic microscope, and an optical capture experiment was conducted.
如此一來,即可令光線通過該光纖(1),且經由光纖(1)之纖芯層〔Core〕(12)末端的半球形狀讓光線產生折射,使得於該光纖(1)靠近微粒後,即能利用光纖(1)之纖芯層〔Core〕(12)末端折射的光線對微粒進行捕捉,以能將微粒移動到所需位置處。In this way, the light can pass through the optical fiber (1), and the light is refracted through the hemispherical shape at the end of the core layer (Core) of the optical fiber (1), so that the optical fiber (1) is close to the particle. The particles can be captured by the light refracted at the end of the core (Core) (12) of the optical fiber (1) to move the particles to a desired position.
藉由以上所述,本發明結構之組成與使用實施說明可知,本發明與現有結構相較之下,本發明主要係於整體製作上更為簡便,且能降低其製作成本,並於使用上具有高捕捉效率及低捕捉功率,使得其能更便於在生物醫學領域上的應用,而在其整體施行使用上更增實用功效特性者。As described above, the composition and use of the structure of the present invention show that the present invention is mainly simpler in overall fabrication than the prior art, and can reduce the manufacturing cost and use thereof. It has high capture efficiency and low capture power, making it more convenient for applications in the biomedical field, and more practical and functional features in its overall implementation.
然而前述之實施例或圖式並非限定本發明之產品結構或使用方式,任何所屬技術領域中具有通常知識者之適當變化或修飾,皆應視為不脫離本發明之專利範疇。However, the above-described embodiments or drawings are not intended to limit the structure or the use of the present invention, and any suitable variations or modifications of the invention will be apparent to those skilled in the art.
綜上所述,本發明實施例確能達到所預期之使用功效,又其所揭露之具體構造,不僅未曾見諸於同類產品中,亦未曾公開於申請前,誠已完全符合專利法之規定與要求,爰依法提出發明專利之申請,懇請惠予審查,並賜准專利,則實感德便。In summary, the embodiments of the present invention can achieve the expected use efficiency, and the specific structure disclosed therein has not been seen in similar products, nor has it been disclosed before the application, and has completely complied with the provisions of the Patent Law. And the request, the application for the invention of a patent in accordance with the law, please forgive the review, and grant the patent, it is really sensible.
(1)...光纖(1). . . optical fiber
(11)...纖衣層(11). . . Fiber coating
(12)...纖芯層(12). . . Core layer
(2)...容器(2). . . container
(3)...氧化物緩衝蝕刻液(3). . . Oxide buffer etchant
第一圖:本發明之製作流程示意圖First: Schematic diagram of the production process of the present invention
第二圖:本發明之光纖垂直蝕刻狀態動作示意圖(一)Second: Schematic diagram of the operation of the optical etched state of the optical fiber of the present invention (1)
第三圖:本發明之光纖垂直蝕刻狀態動作示意圖(二)Third: Schematic diagram of the operation of the optical etched state of the optical fiber of the present invention (2)
第四圖:本發明之光纖垂直蝕刻狀態動作示意圖(三)Figure 4: Schematic diagram of the vertical etched state of the optical fiber of the present invention (3)
第五圖:本發明之光纖水平式蝕刻狀態動作示意圖(一)Fig. 5 is a schematic view showing the action of the horizontal etching state of the optical fiber of the present invention (1)
第六圖:本發明之光纖水平式蝕刻狀態動作示意圖(二)Figure 6: Schematic diagram of the horizontal etching state of the optical fiber of the present invention (2)
第七圖:本發明之光纖水平式蝕刻狀態動作示意圖(三)Figure 7: Schematic diagram of the horizontal etching state of the optical fiber of the present invention (3)
第八圖:本發明之光纖融燒狀態動作示意圖(一)Figure 8: Schematic diagram of the action of the fiber-melting state of the present invention (1)
第九圖:本發明之光纖融燒狀態動作示意圖(二)Ninth diagram: Schematic diagram of the operation of the fiber-melting state of the present invention (2)
無no
Claims (10)
剝除:剪裁適當長度之光纖,並剝除光纖之纖衣層〔Cladding〕而漏出纖芯層〔Core〕;
清潔:將光纖清洗潔淨;
切割:將光纖之纖芯層〔Core〕端面切割平整化;
蝕刻:將光纖予以固定,於一容器內加入氧化物緩衝蝕刻液〔Buffer Oxide Etch﹐BOE〕再將固定之光纖對應容器設置,令待加工之光纖纖芯層〔Core〕末端浸入氧化物緩衝蝕刻液進行蝕刻,光纖之纖芯層〔Core〕末端即會形成錐形狀;
微透鏡加工:對錐形狀之光纖纖芯層〔Core〕末端利用兩端電弧裝置進行融燒,使其形成半球形之透鏡化光纖,即完成製作。A process for optical fiber optical clamping, which mainly comprises the following steps:
Stripping: cutting the fiber of the appropriate length, and stripping the fiber layer of the fiber and leaking the core layer [Core];
Cleaning: clean the fiber;
Cutting: flattening the end face of the core layer of the optical fiber;
Etching: the optical fiber is fixed, an oxide buffering etchant (Buffer Oxide Etch, BOE) is added to a container, and the fixed fiber is disposed corresponding to the container, so that the end of the core of the fiber to be processed is immersed in the oxide buffer etching. The liquid is etched, and the end of the core layer of the optical fiber forms a tapered shape;
Microlens processing: The end of the cone-shaped fiber core layer (Core) is melted by a two-end arc device to form a hemispherical lensized fiber, which is completed.
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Cited By (3)
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CN107357044A (en) * | 2017-08-28 | 2017-11-17 | 重庆三峡医药高等专科学校 | A kind of step multimode fibre optical tweezer based on skew ray annular light field |
TWI611228B (en) * | 2016-08-11 | 2018-01-11 | 國立高雄應用科技大學 | Optical fiber microlens structure of optical tweezers and manufacturing method thereof |
CN111117860A (en) * | 2019-11-04 | 2020-05-08 | 桂林电子科技大学 | Cell micro-scalpel based on optical fiber glimmer hand and preparation method thereof |
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TWI569016B (en) | 2015-10-19 | 2017-02-01 | 國立高雄應用科技大學 | Light-trapping cancer cell stage testing method |
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US4469554A (en) * | 1983-04-05 | 1984-09-04 | At&T Bell Laboratories | Etch procedure for optical fibers |
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TWI611228B (en) * | 2016-08-11 | 2018-01-11 | 國立高雄應用科技大學 | Optical fiber microlens structure of optical tweezers and manufacturing method thereof |
CN107357044A (en) * | 2017-08-28 | 2017-11-17 | 重庆三峡医药高等专科学校 | A kind of step multimode fibre optical tweezer based on skew ray annular light field |
CN111117860A (en) * | 2019-11-04 | 2020-05-08 | 桂林电子科技大学 | Cell micro-scalpel based on optical fiber glimmer hand and preparation method thereof |
CN111117860B (en) * | 2019-11-04 | 2022-04-19 | 桂林电子科技大学 | Cell micro-scalpel based on optical fiber glimmer hand and preparation method thereof |
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