TW201412728A - 新穎吡啶衍生物 - Google Patents
新穎吡啶衍生物 Download PDFInfo
- Publication number
- TW201412728A TW201412728A TW102129708A TW102129708A TW201412728A TW 201412728 A TW201412728 A TW 201412728A TW 102129708 A TW102129708 A TW 102129708A TW 102129708 A TW102129708 A TW 102129708A TW 201412728 A TW201412728 A TW 201412728A
- Authority
- TW
- Taiwan
- Prior art keywords
- chloro
- pyridin
- cyclopropanecarbonyl
- pyrrolidine
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12181247 | 2012-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201412728A true TW201412728A (zh) | 2014-04-01 |
Family
ID=46851300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102129708A TW201412728A (zh) | 2012-08-21 | 2013-08-19 | 新穎吡啶衍生物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9409882B2 (enExample) |
| EP (1) | EP2888244A1 (enExample) |
| JP (1) | JP2015530997A (enExample) |
| KR (1) | KR20150044947A (enExample) |
| CN (1) | CN104583198A (enExample) |
| AR (1) | AR092172A1 (enExample) |
| AU (1) | AU2013305102A1 (enExample) |
| BR (1) | BR112015003217A2 (enExample) |
| CA (1) | CA2879796A1 (enExample) |
| CL (1) | CL2015000354A1 (enExample) |
| CO (1) | CO7200259A2 (enExample) |
| CR (1) | CR20150073A (enExample) |
| EA (1) | EA025166B1 (enExample) |
| HK (1) | HK1206716A1 (enExample) |
| IL (1) | IL237128A0 (enExample) |
| IN (1) | IN2015DN00962A (enExample) |
| MA (1) | MA37893A1 (enExample) |
| MX (1) | MX2015002026A (enExample) |
| PE (1) | PE20150995A1 (enExample) |
| PH (1) | PH12015500262A1 (enExample) |
| SG (1) | SG11201500900YA (enExample) |
| TW (1) | TW201412728A (enExample) |
| WO (1) | WO2014029722A1 (enExample) |
| ZA (1) | ZA201500625B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3419970T1 (sl) * | 2016-02-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Novi pirolidinski derivati |
| TWI764976B (zh) | 2017-01-24 | 2022-05-21 | 日商安斯泰來製藥股份有限公司 | 取代苯基二氟甲基之脯胺酸醯胺化合物 |
| WO2026032128A1 (en) * | 2024-08-05 | 2026-02-12 | Biofront Therapeutics (Beijing) Co., Ltd. | Cathepsin l inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903610D0 (sv) | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds II |
| WO2006073361A1 (en) | 2005-01-06 | 2006-07-13 | Astrazeneca Ab | Novel pyridine compounds |
| CN101370805B (zh) | 2006-01-24 | 2011-04-27 | 埃科特莱茵药品有限公司 | 吡啶衍生物 |
| EP2164840A2 (en) * | 2007-05-09 | 2010-03-24 | Vertex Pharmaceuticals Incorporated | Modulators of cftr |
| BRPI0820203A2 (pt) | 2007-11-30 | 2015-06-16 | Hoffmann La Roche | Compostos de pirrdina, processo para a sua preparação, composição farmacêutica que os compreende, uso de composto e método para o tratamento e/ou profilaxia de diabetes mellitus do tipo ii e outras enfermidades |
| CN101965345B (zh) | 2008-03-06 | 2014-05-28 | 埃科特莱茵药品有限公司 | 吡啶化合物 |
| MX2011011094A (es) | 2009-04-20 | 2011-11-04 | Hoffmann La Roche | Derivados de prolina como inhibidores de catepsina. |
| US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| JP6130383B2 (ja) | 2011-09-30 | 2017-05-17 | エンドゥ ファーマシューティカルズ，インコーポレイティド | ピリジン誘導体 |
-
2013
- 2013-08-19 SG SG11201500900YA patent/SG11201500900YA/en unknown
- 2013-08-19 IN IN962DEN2015 patent/IN2015DN00962A/en unknown
- 2013-08-19 TW TW102129708A patent/TW201412728A/zh unknown
- 2013-08-19 EP EP13750339.7A patent/EP2888244A1/en not_active Withdrawn
- 2013-08-19 HK HK15107145.2A patent/HK1206716A1/xx unknown
- 2013-08-19 BR BR112015003217A patent/BR112015003217A2/pt not_active Application Discontinuation
- 2013-08-19 MA MA37893A patent/MA37893A1/fr unknown
- 2013-08-19 PE PE2015000231A patent/PE20150995A1/es not_active Application Discontinuation
- 2013-08-19 CN CN201380043572.1A patent/CN104583198A/zh active Pending
- 2013-08-19 CA CA2879796A patent/CA2879796A1/en not_active Abandoned
- 2013-08-19 EA EA201590363A patent/EA025166B1/ru not_active IP Right Cessation
- 2013-08-19 MX MX2015002026A patent/MX2015002026A/es unknown
- 2013-08-19 KR KR20157006927A patent/KR20150044947A/ko not_active Withdrawn
- 2013-08-19 AU AU2013305102A patent/AU2013305102A1/en not_active Abandoned
- 2013-08-19 JP JP2015527877A patent/JP2015530997A/ja active Pending
- 2013-08-19 WO PCT/EP2013/067218 patent/WO2014029722A1/en not_active Ceased
- 2013-08-20 AR ARP130102939A patent/AR092172A1/es unknown
-
2015
- 2015-01-27 ZA ZA2015/00625A patent/ZA201500625B/en unknown
- 2015-02-05 IL IL237128A patent/IL237128A0/en unknown
- 2015-02-06 PH PH12015500262A patent/PH12015500262A1/en unknown
- 2015-02-09 CO CO15025964A patent/CO7200259A2/es unknown
- 2015-02-11 CR CR20150073A patent/CR20150073A/es not_active Application Discontinuation
- 2015-02-16 CL CL2015000354A patent/CL2015000354A1/es unknown
- 2015-02-20 US US14/627,175 patent/US9409882B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150044947A (ko) | 2015-04-27 |
| PE20150995A1 (es) | 2015-06-29 |
| US20150307472A1 (en) | 2015-10-29 |
| CO7200259A2 (es) | 2015-02-27 |
| MA37893A1 (fr) | 2017-08-31 |
| IN2015DN00962A (enExample) | 2015-06-12 |
| EA201590363A1 (ru) | 2015-06-30 |
| IL237128A0 (en) | 2015-03-31 |
| CA2879796A1 (en) | 2014-02-27 |
| SG11201500900YA (en) | 2015-03-30 |
| CN104583198A (zh) | 2015-04-29 |
| EA025166B1 (ru) | 2016-11-30 |
| AU2013305102A1 (en) | 2015-02-12 |
| EP2888244A1 (en) | 2015-07-01 |
| CL2015000354A1 (es) | 2015-10-23 |
| US9409882B2 (en) | 2016-08-09 |
| AR092172A1 (es) | 2015-03-25 |
| HK1206716A1 (en) | 2016-01-15 |
| ZA201500625B (en) | 2016-08-31 |
| JP2015530997A (ja) | 2015-10-29 |
| BR112015003217A2 (pt) | 2017-07-04 |
| CR20150073A (es) | 2015-03-13 |
| MX2015002026A (es) | 2015-06-05 |
| PH12015500262A1 (en) | 2015-03-30 |
| WO2014029722A1 (en) | 2014-02-27 |
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