TW201347762A - 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 - Google Patents

高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 Download PDF

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Publication number
TW201347762A
TW201347762A TW102115308A TW102115308A TW201347762A TW 201347762 A TW201347762 A TW 201347762A TW 102115308 A TW102115308 A TW 102115308A TW 102115308 A TW102115308 A TW 102115308A TW 201347762 A TW201347762 A TW 201347762A
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TW
Taiwan
Prior art keywords
laquinimod
patient
effective
human patient
drug
Prior art date
Application number
TW102115308A
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English (en)
Chinese (zh)
Inventor
Dan Bar-Zohar
Original Assignee
Teva Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49514859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW201347762(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of TW201347762A publication Critical patent/TW201347762A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW102115308A 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 TW201347762A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261641389P 2012-05-02 2012-05-02

Publications (1)

Publication Number Publication Date
TW201347762A true TW201347762A (zh) 2013-12-01

Family

ID=49514859

Family Applications (2)

Application Number Title Priority Date Filing Date
TW102115308A TW201347762A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途
TW106117959A TW201804997A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW106117959A TW201804997A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Country Status (21)

Country Link
US (3) US20130303569A1 (enExample)
EP (1) EP2844255A4 (enExample)
JP (2) JP2015515985A (enExample)
KR (1) KR20150013658A (enExample)
CN (2) CN105832733A (enExample)
AR (1) AR090885A1 (enExample)
AU (1) AU2013256352A1 (enExample)
BR (1) BR112014027010A2 (enExample)
CA (1) CA2870684A1 (enExample)
CL (1) CL2014002935A1 (enExample)
EA (1) EA201492010A1 (enExample)
HK (1) HK1206246A1 (enExample)
IL (1) IL235337A0 (enExample)
MX (1) MX2014013039A (enExample)
PE (1) PE20150161A1 (enExample)
PH (1) PH12014502447A1 (enExample)
SG (1) SG11201406594UA (enExample)
TW (2) TW201347762A (enExample)
UY (1) UY34775A (enExample)
WO (1) WO2013166166A1 (enExample)
ZA (1) ZA201408820B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2851525A1 (en) 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN104093310A (zh) 2012-02-03 2014-10-08 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
JP6215238B2 (ja) 2012-02-16 2017-10-18 テバ ファーマシューティカル インダストリーズ リミティド N−エチル−n−フェニル−1,2−ジヒドロ−4,5−ジ−ヒドロキシ−1−メチル−2−オキソ−3−キノリンカルボキサミド、その製剤、および使用
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
BR112015007782A2 (pt) * 2012-10-12 2017-07-04 Teva Pharma laquinimod para reduzir danos talâmicos na esclerose múltipla
EP2916915A4 (en) 2012-11-07 2016-06-22 Teva Pharma LAQUINIMOD AMINE SALTS
BR112015019564A2 (pt) * 2013-02-15 2017-07-18 Teva Pharma tratamento de esclerose múltipla com laquinimod
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
AR098924A1 (es) * 2013-12-23 2016-06-22 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida
WO2015168103A1 (en) * 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
WO2017027512A1 (en) * 2015-08-13 2017-02-16 Teva Pharmaceutical Industries Ltd. Use of laquinimod to treat traumatic brain injury
US20190108912A1 (en) * 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
ES3009670T3 (en) * 2018-07-20 2025-03-31 Merck Patent Gmbh A substituted amino-pyrimidine compound for use in a method for treatment and prevention of multiple sclerosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
HRP20160455T1 (hr) * 2004-09-09 2016-07-15 Yeda Research And Development Co., Ltd. Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
US20080118553A1 (en) * 2006-06-12 2008-05-22 Anton Frenkel Tannate salt form of polypeptide mixtures, their preparation and use
JP2012530701A (ja) * 2009-06-19 2012-12-06 テバ ファーマシューティカル インダストリーズ リミティド 多発性硬化症のラキニモドでの治療
EP2523668A1 (en) * 2010-01-13 2012-11-21 Ramot at Tel-Aviv University Ltd Treatment of multiple sclerosis
CA2851525A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
BR112015019564A2 (pt) * 2013-02-15 2017-07-18 Teva Pharma tratamento de esclerose múltipla com laquinimod

Also Published As

Publication number Publication date
AR090885A1 (es) 2014-12-10
KR20150013658A (ko) 2015-02-05
CN105832733A (zh) 2016-08-10
US20150265592A1 (en) 2015-09-24
US20130303569A1 (en) 2013-11-14
CL2014002935A1 (es) 2015-03-06
AU2013256352A1 (en) 2014-11-27
ZA201408820B (en) 2016-06-29
EP2844255A4 (en) 2015-10-14
PE20150161A1 (es) 2015-02-22
JP2015515985A (ja) 2015-06-04
EA201492010A1 (ru) 2015-06-30
HK1206246A1 (en) 2016-01-08
PH12014502447A1 (en) 2015-01-12
JP2017222691A (ja) 2017-12-21
MX2014013039A (es) 2015-02-04
EP2844255A1 (en) 2015-03-11
BR112014027010A2 (pt) 2017-06-27
IL235337A0 (en) 2014-12-31
CN104284663A (zh) 2015-01-14
TW201804997A (zh) 2018-02-16
WO2013166166A1 (en) 2013-11-07
UY34775A (es) 2013-11-29
SG11201406594UA (en) 2014-11-27
US20160000775A1 (en) 2016-01-07
CA2870684A1 (en) 2013-11-07

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