TW201347762A - 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 - Google Patents

高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 Download PDF

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Publication number
TW201347762A
TW201347762A TW102115308A TW102115308A TW201347762A TW 201347762 A TW201347762 A TW 201347762A TW 102115308 A TW102115308 A TW 102115308A TW 102115308 A TW102115308 A TW 102115308A TW 201347762 A TW201347762 A TW 201347762A
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TW
Taiwan
Prior art keywords
laquinimod
patient
effective
human patient
drug
Prior art date
Application number
TW102115308A
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English (en)
Chinese (zh)
Inventor
Dan Bar-Zohar
Original Assignee
Teva Pharma
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Application filed by Teva Pharma filed Critical Teva Pharma
Publication of TW201347762A publication Critical patent/TW201347762A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
TW102115308A 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 TW201347762A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261641389P 2012-05-02 2012-05-02

Publications (1)

Publication Number Publication Date
TW201347762A true TW201347762A (zh) 2013-12-01

Family

ID=49514859

Family Applications (2)

Application Number Title Priority Date Filing Date
TW106117959A TW201804997A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途
TW102115308A TW201347762A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW106117959A TW201804997A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Country Status (21)

Country Link
US (3) US20130303569A1 (enExample)
EP (1) EP2844255A4 (enExample)
JP (2) JP2015515985A (enExample)
KR (1) KR20150013658A (enExample)
CN (2) CN105832733A (enExample)
AR (1) AR090885A1 (enExample)
AU (1) AU2013256352A1 (enExample)
BR (1) BR112014027010A2 (enExample)
CA (1) CA2870684A1 (enExample)
CL (1) CL2014002935A1 (enExample)
EA (1) EA201492010A1 (enExample)
HK (1) HK1206246A1 (enExample)
IL (1) IL235337A0 (enExample)
MX (1) MX2014013039A (enExample)
PE (1) PE20150161A1 (enExample)
PH (1) PH12014502447A1 (enExample)
SG (1) SG11201406594UA (enExample)
TW (2) TW201804997A (enExample)
UY (1) UY34775A (enExample)
WO (1) WO2013166166A1 (enExample)
ZA (1) ZA201408820B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201401330YA (en) 2011-10-12 2014-05-29 Teva Pharma Treatment of multiple sclerosis with combination of laquinimod and fingolimod
US9161935B2 (en) 2012-02-03 2015-10-20 Teva Pharmaceutical Industries, Ltd. Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNF therapy
AR090073A1 (es) 2012-02-16 2014-10-15 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinolinacarboxamida, su preparacion y usos
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
US20140107154A1 (en) * 2012-10-12 2014-04-17 Teva Pharmaceutical Industries, Ltd. Laquinimod for reducing thalamic damage in multiple sclerosis
CA2890194A1 (en) 2012-11-07 2014-05-15 Teva Pharmaceutical Industries Ltd. Amine salts of laquinimod
EP2956137A4 (en) * 2013-02-15 2016-08-03 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS WITH LAQUINIMOD
WO2014153145A2 (en) 2013-03-14 2014-09-25 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
AR098924A1 (es) * 2013-12-23 2016-06-22 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida
UY36099A (es) * 2014-04-29 2016-02-29 Teva Pharma Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad
WO2017027512A1 (en) * 2015-08-13 2017-02-16 Teva Pharmaceutical Industries Ltd. Use of laquinimod to treat traumatic brain injury
US20190108912A1 (en) * 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
JP7724151B2 (ja) * 2018-07-20 2025-08-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 多発性硬化症の治療及び予防方法における使用のための置換されたアミノ-ピリミジン化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
PL1797109T3 (pl) * 2004-09-09 2016-11-30 Mieszaniny polipeptydów, kompozycje zawierające je i procesy ich wytwarzania oraz ich zastosowania
WO2007146331A1 (en) * 2006-06-12 2007-12-21 Teva Pharmaceutical Industries, Ltd. Tannate salt form of polypeptide mixtures, their preparation and use
HUE026406T2 (en) * 2009-06-19 2016-06-28 Teva Pharma Treatment of multiple sclerosis with laquinimod
EP2523668A1 (en) * 2010-01-13 2012-11-21 Ramot at Tel-Aviv University Ltd Treatment of multiple sclerosis
SG11201401330YA (en) * 2011-10-12 2014-05-29 Teva Pharma Treatment of multiple sclerosis with combination of laquinimod and fingolimod
EP2956137A4 (en) * 2013-02-15 2016-08-03 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS WITH LAQUINIMOD

Also Published As

Publication number Publication date
CA2870684A1 (en) 2013-11-07
ZA201408820B (en) 2016-06-29
EP2844255A1 (en) 2015-03-11
TW201804997A (zh) 2018-02-16
HK1206246A1 (en) 2016-01-08
US20160000775A1 (en) 2016-01-07
PE20150161A1 (es) 2015-02-22
JP2015515985A (ja) 2015-06-04
CN104284663A (zh) 2015-01-14
PH12014502447A1 (en) 2015-01-12
EP2844255A4 (en) 2015-10-14
CL2014002935A1 (es) 2015-03-06
AR090885A1 (es) 2014-12-10
UY34775A (es) 2013-11-29
KR20150013658A (ko) 2015-02-05
BR112014027010A2 (pt) 2017-06-27
SG11201406594UA (en) 2014-11-27
CN105832733A (zh) 2016-08-10
AU2013256352A1 (en) 2014-11-27
WO2013166166A1 (en) 2013-11-07
JP2017222691A (ja) 2017-12-21
US20150265592A1 (en) 2015-09-24
IL235337A0 (en) 2014-12-31
US20130303569A1 (en) 2013-11-14
EA201492010A1 (ru) 2015-06-30
MX2014013039A (es) 2015-02-04

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