TW201315536A - Facility for manufacturing collagen - Google Patents

Abstract

A facility for manufacturing collagen includes an actuation device, a cover connected to the actuation device, a bracket device following the cover to have a large-range up and down movement, a swing device linked to the bracket device to have at a small-range movement, and a tank device disposed under the cover. The tank device is utilized to receive a solution. The bracket device is utilized to load materials. In the period of the bracket device dipped in the solution, the solution and the raw material are chemically reacted to obtain a finished product of collagen.

Description

Equipment for making collagen

The present invention relates to an apparatus for producing collagen, and more particularly to an apparatus for producing collagen using animal tissues.

Conventionally, collagen is produced by breaking or dissolving animal tissues such as pig skin, and then treating it with an acid solution and/or an alkali solution to obtain collagen.

However, the above-mentioned manufacturing method can destroy fibers in animal tissues, and thus, for example, the Republic of China TW I284665 and TW 201103947A1 patents have developed novel manufacturing methods. In the methods of the two patents, the connective tissue (e.g., the skin of an animal) is first sliced, and then the thin slices are soaked in a chemical solution, and finally the finished porous collagen matrix is obtained. The two patents are hereby incorporated by reference.

However, the two patented methods have been successfully developed and there is no suitable equipment for the quantitative production of collagen. The innovative design of this case is sufficient to meet this demand.

Accordingly, it is an object of the present invention to provide an apparatus suitable for mass production of collagen.

Still another object of the present invention is to provide an apparatus for producing collagen in which the quality of the finished product is uniform and good.

Another object of the present invention is to provide an apparatus for producing collagen which is efficient in production.

It is still another object of the present invention to provide an apparatus for producing collagen which is easy to handle.

Accordingly, the present invention provides an apparatus for producing collagen, comprising: a tank device including a reaction tank for supporting a solution; a tray device for supporting a raw material, and the raw material reacting with the solution to form the collagen a protein; and an actuating device that interlocks the cradle device; the cradle device is above the solution when the actuating device is in the first position; and the cradle device is when the actuating device is in the second position In the solution.

Preferably, the apparatus includes a rocking device that interlocks the carriage device such that the carriage device repeatedly moves along the trajectory in the solution to promote reaction of the material with the solution.

Preferably, the trough device includes a lid for closing the reaction trough; the actuating device is coupled to the lid, the lid being linked to the carriage means.

Preferably, the rocking device includes a slide bar slidably passing through the cover, and one end of the slide bar is coupled to the bracket device.

Preferably, the rocking device includes a driver, a first gear eccentrically fixed to the driver, and a second gear coupled to the slider; when the actuation device is in the first position, the second gear is not engaged The first gear; the second gear engages the first gear when the actuating device is in the second position.

Preferably, the rocking device includes a blocking member fixed to the sliding bar; the cover contacts the blocking member during a portion of the movement of the actuating device between the first position and the second position Causing the slider together with the cover; when the actuating device is in the second position, the cover does not contact the blocking member, the slider is movable relative to the cover, and the first gear transmits the first The two gears and the slider cause the carriage to reciprocate between a higher third position and a lower four position in the solution.

Preferably, the rocking device comprises a connecting member, a slider and a guide rail; the second gear is pivotally connected to the connecting member, the connecting member is fixed to the slider and the sliding rod, and the sliding rod is slidably connected to the guiding rail.

Preferably, the bracket device comprises a plurality of frames; each of the frames includes a first side and a second side opposite to each other, and a top portion disposed on the first side and the second side a plurality of ears at the bottom, the direction of the notch of the ears at the top is opposite to the direction of the notch of the ears at the bottom; by the engagement of the ears, the frames are prevented from being on the first side and The direction of the second side is separated.

Preferably, each of the frames further includes a third side and a fourth side opposite to each other, and a ring disposed on the fourth side; the bracket device includes a lock bar, the lock bar is detachable The ground is placed in the ring, thereby preventing the frames from separating in the direction of the third side and the fourth side.

Preferably, each of the frames further includes a rib disposed on the third side and a groove extending from the fourth side to the third side; the bracket device includes a tray of raw materials, the tray being received in the groove; the rib and the lock bar respectively restrict movement of the tray toward the third side and the fourth side.

Preferably, the tank means comprises a heat exchanger adjacent to the reaction tank for heat exchange with the solution.

Preferably, the apparatus includes an air suction device coupled to the cover for extracting gas between the solution and the cover; the carrier device including a lock lever and a plurality of materials for receiving the material a frame; each of the frames including ears that detachably engage the frames; the lock bars detachably extend through the frames to prevent the ears from disengaging.

Preferably, the trough device includes a vibrating machine for vibrating the solution.

Preferably, the reaction tank includes a convection opening for promoting the flow of the solution.

Preferably, the reaction tank includes a bottom surface, a slope extending obliquely upward from the bottom surface, a side surface extending upward from the other end of the slope, and a discharge port provided on the bottom surface.

Preferably, the cover comprises a transparent inspection window.

Preferably, the apparatus includes a solution supply device coupled to the lid.

Preferably, the apparatus includes an isolation chamber, the reaction chamber, the bracket assembly, and the cover being located within the isolation chamber.

Preferably, the actuating device and the rocking device are located partially outside the isolation chamber and another portion thereof is located within the isolation chamber.

Preferably, the apparatus includes a cleaning device detachably suspended from a side wall of the isolation chamber.

Those skilled in the art will be able to appreciate the additional benefits and other objects of the invention as defined in the claims.

The foregoing and other objects, features, and advantages of the invention are apparent from the

As shown in Figures 1 and 2, a preferred embodiment of the apparatus 1 for producing collagen of the present invention comprises an isolation chamber 2, a trough device 3 fixed to the lower half of the isolation chamber 2, and a carriage device 4 disposed above the trough device 3. The actuating device 5 and the rocking device 6 disposed at the top of the isolation chamber 2, the cleaning device 7 disposed on the side wall of the isolation chamber 2, and the solution supply device 8, the air suction device 9, and the thermometer 10 disposed on the tank device 3.

The isolation chamber 2 in this embodiment is, for example, a rectangular body clean room including a top wall 21 and four side walls 22.

The tank device 3 includes a reaction tank 31, a heat exchanger (in this embodiment, a heat exchange tank) 32 disposed outside the three side surfaces of the reaction tank 31, and is disposed outside the isolation chamber 2 for supplying a heat exchange medium (for example, water) a first pump (not shown) to the heat exchanger 32, a vibrator 33 disposed outside one side surface of the heat exchanger 32 and outside the isolation chamber 2, and a vibration machine 33 disposed above the reaction tank 31 and located at the top wall of the isolation chamber 2 Cover 34 below 21 .

The reaction tank 31 includes four side surfaces 311, a smaller bottom surface 312, and two larger slopes 313 extending obliquely downward from the opposite side surfaces 311 to the bottom surface 312, respectively, on the opposite side of the bottom surface 312. The notch 314, the discharge port 315 formed at the bottom surface 312, and the plurality of convection ports 316 provided on the two opposite side surfaces thereof. One or more (two in this embodiment are exemplified) transparent inspection windows 341 (Fig. 3) are provided on the cover 34. The vibrating machine 33 may be an ultrasonic vibrating machine, an electromagnetic wave vibrating machine, or another type of vibrating machine. The heat exchanger 32 is located in the four side surfaces 311 of the reaction tank 31, and is provided with one side surface 311 of the vibrating machine 33 and two side surfaces 311 adjacent to the side surface 311. The heat exchanger 32 located outside the three side surfaces 311 of the reaction tank 31 can be partitioned into three separate heat exchange tanks that communicate with a cold water and hot water supply device (not shown) disposed outside the isolation chamber 2.

As shown in Figures 4 and 5, the cradle device 4 includes a plurality of hollow frames 41, a tray 42 placed within the frame 41, and a lock bar 43 extending along the sides of the frames 41. Each frame 41 includes a plurality of first protrusions 411 and second protrusions 412 staggered up and down along the first and second sides of the frame 41, and each pair of adjacent first protrusions 411 and second a plurality of grooves 413 defined by the convex portion 412, a rib 414 fixed to the center of the third side of the frame 41 and extending upward and downward, a ring 415 fixed to the outer side of the fourth side of the frame 41 opposite to the third side, and A plurality of lying U-shaped ears 416 are secured to the top and bottom of the first and second sides of the frame 41, respectively. The notch at the top ear portion 416 is, for example, toward the inner side of the frame 41, and the notch at the bottom portion 416 is, for example, toward the outer side of the frame 41. The longitudinal direction of the ears 416 and the grooves 413 extend between the third and fourth sides. As shown in FIG. 6, the tray 42 includes a flat rectangular and open receiving member 421, a restricting member 422 that is opposite to the receiving member 421 and has an opening larger than the opening of the receiving member 421, and is formed on the receiving member 421 and the restricting member 422. A plurality of holes 423.

As shown in FIGS. 1 and 2, the actuating device 5 is exemplified by a hydraulic cylinder or a pneumatic cylinder in the present embodiment, which includes a fixing member 51 and a movable member 52 movable relative to the fixing member 51. The fixing member 51 is fixed on the outer side of the top wall 21 of the isolation chamber 2; one end of the movable member 52 is slidable in the fixing member 51, the body of the movable member 52 slidably penetrates the top wall 21 of the isolation chamber 2, and the movable member 52 is further One end is fixed to the cover 34.

The number of the rocking devices 6 can be matched with the number of the bracket devices 4. In this embodiment, two sets of rocking devices 6 are taken as an example. Each set of rocking device 6 includes a driver (e.g., motor) 61 fixed to the outside of the top wall 21 of the isolation chamber 2, a first gear 62 eccentrically fixed to the output shaft of the actuator 61, and a fixed outer side of the top wall 21 of the isolation chamber 2 a guide rail 63, a slider 64 partially covering the guide rail 63 and sliding along the guide rail 63, an engaging member 65 fixed to the slider 64, a second gear 66 pivotally connected to the engaging member 65, and one end fixed to the engaging member 65 and A slide bar 67 slidingly passing through the top wall 21 of the isolation chamber 2 and the cover 34, a hook 68 fixed to the other end of the slide bar 67, and a stopper 69 fixed to the middle of the slide bar 67.

One end of the air suction device 9 is fixed to the cover 34, and the other end (not shown) of the air suction device is disposed outside the isolation chamber 2. One end of the solution supply device 8 is fixed to the cover 34, and the other end (not shown) of the solution supply device 8 is disposed outside the isolation chamber 2. The thermometer 10 is fixed to the bottom of the cover 34. One end of the cleaning device 7 is similar to the shower head, which is detachably suspended from the side wall 22 of the isolation chamber 2, and the other end (not shown) of the cleaning device is disposed outside the isolation chamber, which provides pressurized cleaning liquid.

operating

As shown in Fig. 6, the raw material 11 (e.g., animal tissue, pigskin, etc.) is first cut into, for example, a sheet of about 11 cm x 16 cm and placed in the receiving member 421 of the tray 42, and secondly, the restricting member 422 is used to cover the receiving member. 421. Then, as shown in Figs. 4 and 5, the tray 42 containing the material 11 is inserted into the groove 413 between the first convex portion 411 and the second convex portion 412 of the frame 41 until the tray 42 is pressed against the rib 414. When the respective grooves 413 of the frame 41 are filled with the tray 42, the ring 415 of the frame 41 is inserted with the lock lever 43. Since the upper end of the lock lever 43 has a larger outer diameter and the outer diameter is larger than the inner diameter of the ring 415, the lock lever 43 can be held in each of the rings 415 without falling, whereby the lock lever 43 and the opposite side The ribs 414 can confine the trays 42 within the frame 41.

The bracket device 4 can be hung from the hook 68 of the rocking device 6 before or after the insertion of the tray 42. Next, as shown in Figures 1 and 2, the actuating device 5 is actuated, and the movable member 52 of the actuating device 5 drives the cover 34 to move downward from the highest first position until the cover 34 seals the notch 314 of the reaction tank 31. The second position (Fig. 7). When the cover 34 is moved downward, the slide bar 67 of the rocking device 6 and the bracket device 4 suspended from the lower end of the slide bar 67 cause the blocking member 69 to always contact the upper surface of the cover 34 and accompany it due to its own weight. The lid 34 is moved downward so that the tray device 4 enters the reaction tank 31.

As shown in FIGS. 7, 2, and 1, when the cover 34 is lowered to the notch 314 closer to the reaction tank 31, the slide lever 67 of the rocking device 6, the second gear 66, the engaging member 65, and the slider 64 are also on the guide rail. The guide 63 is lowered to a state where the second gear 66 meshes with the first gear 62. At this time, the bracket device 4, the slide bar 67, the second gear 66, the engaging member 65, and the slider 64 can no longer continue to descend, but the cover 34 can still continue to descend by a small distance under the action of the actuating device 5, so that The cover 34 completely seals the notch 314 of the reaction tank 31, and the blocking member 69 is at a distance from the upper surface of the cover 34.

At this time, the end of the solution supply device 8 and the thermometer 10 are also located in the reaction tank 31, so that the solution supply device 8 can inject different chemical solutions (for example, acid or alkali solution) 12 required for different manufacturing steps into the reaction tank 31, so that The cradle device 4 is immersed in the chemical solution 12. The chemical solution 12 can flow into the tray 42 through the holes 423 of the receiving member 421 and the restricting member 422 to contact the raw material 11 and react. Further, the first pump supplies a high temperature heat exchange medium to the heat exchanger 32 to indirectly heat the solution 12 in the reaction tank 31. The operator can confirm by the thermometer 10 whether the solution 12 has been heated to a suitable reaction temperature (e.g., about 37 ° C). In addition, a vibrating machine 33 is also activated which emits an ultrasonic or electromagnetic wave vibration solution 12 to increase the reaction rate between the raw material 11 and the solution 12. Since the vibration provided by the vibrating machine 33 causes the friction between the molecules of the solution 12 to raise the temperature of the solution 12, the first pump can supply a low temperature heat exchange medium to the heat exchanger 32 to indirectly cool the solution 12 to an appropriate one. temperature reflex. Further, a second pump (not shown) pressurizes the solution 12 to be sprayed from the convection opening 316 provided on one side surface 311 of the reaction tank 31 to the raw material 11 to promote convection of the solution 12 and to enhance the between the raw material 11 and the solution 12. The reaction is carried out, and the solution 12 can be returned to the second pump from the convection opening 316 provided on the other side surface 311 of the reaction tank 31, and the solution 12 is recycled as such.

As shown in FIGS. 8 and 9, during the reaction, it is preferred to activate the actuator 61 to rotate the driver 61 to the eccentric first gear 62, and the first gear 62 to drive the second gear 66. Since the output shaft of the driver 61 is not fixed to the center of the first gear 62, that is, to another point other than the center of the first gear 62, the third position of the first gear 62 is opposite to the tip of the third gear 62 as shown in FIG. The distance between the top wall 21 of the isolation chamber 2 is large, resulting in a higher height of the second gear 66, the slider 67, and the bracket device 4 relative to the bottom surface 312 of the reaction tank 31; conversely, the fourth as shown in FIG. In position, the distance of the top end of the first gear 62 relative to the top wall 21 of the isolation chamber 2 is small, resulting in a lower height of the second gear 66, the slider 67, and the carriage means 4 relative to the bottom surface 312 of the reaction vessel 31. By means of the rocking device 6, during the reaction in which the cradle device 4 is immersed in the solution 12, the cradle device 4 can reciprocate up and down (e.g., about 5 cm) in the solution 12 to promote convection of the solution 12 and The reaction between the raw material 11 and the solution 12 was uniform.

On the other hand, as shown in Figs. 7, 2, and 1, when the solution 12 is poured into the reaction tank 31, part of the air in the reaction tank 31 is confined in the solution 12 and adheres to the surface of the raw material 11 to form bubbles. These bubbles make the local raw material 11 at this point incapable of contacting the solution 12, that is, there is no chemical reaction there, which affects the quality of the finished product. Therefore, after the solution 12 is poured into the reaction tank 31, the air suction device 9 is also activated to draw a gap between the liquid level between the lid 34 and the solution 12 to cause the bubbles confined in the solution 12 to move upward and The solution 12 is broken at the liquid level, thereby discharging bubbles in the solution 12 to ensure product quality.

During the reaction, the reaction inside the reaction tank 31 can be observed from the inspection window 341 of the cover 34. When the first reaction step is completed, the solution can be drained from the discharge port 315 of the reaction tank 31, and the slope 313 of the reaction tank 31 can help the solution 12 to completely flow out of the reaction tank 31 without remaining in the reaction tank 31. The actuating device 5 is then actuated and the movable member 52 of the actuating device 5 is moved relative to the fixed member 51 to raise the cover 34 to open the notch 314. At this time, the operator can hold the cleaning device 7 to eject the pressurized cleaning liquid to rinse the tray device 4 and the reaction tank 31. At the beginning of the rise of the cover 34, the bracket device 4, the slide bar 67, the second gear 66, the engaging member 65, and the slider 64 do not rise with the cover 34. When the cover 34 continues to rise, the upper surface of the cover 34 will hit the blocking member 69 fixed to the middle of the slider 67, such contact such that the blocking member 69, the bracket device 4, the slider 67, the second gear 66, and the engaging member 65 And the slider 64 begins to rise to the highest point with the cover 34. When the second gear 66 is raised to a range of rotation away from the first gear, the components such as the carriage device 4, the slide lever 67, and the second gear 66 are no longer reciprocated up and down.

When the second reaction step is to be started, the discharge port 315 of the reaction tank 31 is closed, and the actuator 5 is again activated to lower the lid 34. At the initial stage of the falling of the cover 34, the bracket device 4, the slide bar 67, the second gear 66, the engaging member 65, and the slider 64 are lowered with the cover 34 due to gravity, so the blocking member 69 is always maintained in contact with the cover 34. . When the slide bar 67 and the second gear 66 are lowered with the cover 34 until the second gear 66 meshes with the first gear 62, the carriage device 4, the slide bar 67, the second gear 66, the engagement member 65, and the slider 64 are no longer Ascending, only the lid 34 continues to descend to the notch 314 of the closed reaction tank 31. Next, the operation of the first reaction step is repeated, but the solution supply device 8 can infuse the chemical solution 12 different from the first reaction step to perform different chemical reactions.

After all the reaction steps have been completed, the solution 12 is drained from the discharge port 315 of the reaction tank 31, and then the actuator 5 is actuated to raise the lid 34 to open the notch 314, and then the holder device is cleaned by the cleaning device 7. At this time (refer to FIGS. 4, 5, 6), the operator can pull the lock lever 43 of the bracket device 4 away from the ring 415 and take out the tray 42, and then open the restriction member 422 to take out the finished product in the receiving member 421 (collagen matrix ).

If desired, the carriage device 4 can be removed from the hook 68 of the rocking device 6. It is even possible to further separate the respective frames 41 of the cradle device 4 from the ears 416 to thoroughly clean the frame 41, and then combine the frames 41 as they are and hang them on the hooks 68. Since the longitudinal direction of the groove 413 extends from the fourth side of the frame 41 to the third side, and the third side of the frame 41 is provided with the rib 414, the tray 42 can only be taken from the fourth side of the frame 41. . On the other hand, since the longitudinal direction of the ear portion 416 extends from the fourth side to the third side of the frame 41, and the notch direction of the ear portion 416 located at the top of the frame 41 is opposite to the direction of the notch of the bottom portion 416, Each frame 41 can only be separated from the direction of the third or fourth side and cannot be separated from the direction of the first or second side. Therefore, when the lock lever 43 is inserted into the ring 415 of the fourth side of each frame 41, the frames 41 are firmly combined together, and the tray 42 is also confined within the frame 41.

After washing and combining the tray device 4, a tray 42 containing a new and untreated material 11 can be placed, and the above steps are repeated to produce more collagen matrix.

In summary, the present invention achieves the object of the present invention by including a rocking device, other means for promoting the flow of the solution, and a bracket device that is easy to assemble and disassemble.

The above is only the preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All should remain within the scope of the invention patent.

1. . . Equipment for making collagen

2. . . Isolation room

3. . . Slot device

4. . . Bracket device

5. . . Actuating device

6. . . Shaking device

7. . . Cleaning device

8. . . Solution supply device

9. . . Air suction device

10. . . thermometer

11. . . raw material

12. . . Solution

twenty one. . . Top wall

twenty two. . . Side wall

31. . . Reaction tank

32. . . Heat exchanger

33. . . Vibration machine

34. . . cover

41. . . frame

42. . . tray

43. . . Lock lever

51. . . Fastener

52. . . Moving parts

61. . . driver

62. . . First gear

63. . . guide

64. . . Slider

65. . . Connection piece

66. . . Second gear

67. . . Slider

68. . . hook up

69. . . Blocker

311. . . Side surface

312. . . Bottom surface

313. . . Bevel

314. . . notch

315. . . Discharge

316. . . Convection

341. . . Inspection window

411. . . First convex

412. . . Second convex

413. . . ditch

414. . . rib

415. . . ring

416. . . Ear

421. . . Receiving piece

422. . . Restriction

423. . . hole

Figure 1 is a combined front view of the apparatus of the present invention, wherein a portion of the configuration is shown in cross section;

Figure 2 is a cross-sectional view taken along line II-II of Figure 1, showing the carriage device in a first position above the solution;

Figure 3 is a cross-sectional view taken along line III-III of Figure 1;

Figure 4 is a front elevational view of the bracket assembly of the present invention in which only three trays are placed for illustration;

Figure 5 is a side view of the bracket device of the present invention;

Figure 6 is an exploded perspective view of the tray and the raw material of the present invention;

Figure 7 is a combined side view similar to Figure 2 showing the carriage device in a second position in solution;

Figure 8 is a combined side view similar to Figure 7, showing the third position in which the carriage means is in solution and the second gear is positioned higher;

Figure 9 is a combined side view similar to Figure 8 showing the fourth position in which the carriage means is in solution and the second gear is in a lower position.

1. . . Equipment for making collagen

2. . . Isolation room

3. . . Slot device

4. . . Bracket device

5. . . Actuating device

6. . . Shaking device

7. . . Cleaning device

8. . . Solution supply device

9. . . Air suction device

10. . . thermometer

twenty one. . . Top wall

twenty two. . . Side wall

31. . . Reaction tank

32. . . Heat exchanger

34. . . cover

41. . . frame

51. . . Fastener

52. . . Moving parts

61. . . driver

62. . . First gear

67. . . Slider

68. . . hook up

69. . . Blocker

311. . . Side surface

312. . . Bottom surface

313. . . Bevel

314. . . notch

315. . . Discharge

316. . . Convection

414. . . rib

Claims (20)

An apparatus for manufacturing collagen, comprising: a tank device comprising a reaction tank for supporting a solution; a carrier device for supporting a raw material, the raw material reacting with the solution to form the collagen; and actuating The device interlocks the cradle device; the cradle device is above the solution when the actuating device is in the first position; the cradle device is in the solution when the actuating device is in the second position. The apparatus for producing collagen according to claim 1, wherein the apparatus comprises a shaking device that interlocks the bracket device to repeatedly move the bracket device along the trajectory in the solution to promote This material is reacted with the solution. The apparatus for producing collagen according to claim 2, wherein the tank device comprises a lid for closing the reaction tank; the actuator is coupled to the lid, the lid being linked to the tray device. The apparatus for producing collagen according to claim 3, wherein the rocking device comprises a slide bar slidably passing through the cover, and one end of the slide bar is coupled to the bracket device. The apparatus for manufacturing collagen according to claim 4, wherein the shaking device comprises a driver, a first gear eccentrically fixed to the driver, and a second gear coupled to the slider; when the actuation device is located In the first position, the second gear does not engage the first gear; and when the actuating device is in the second position, the second gear engages the first gear. The apparatus for producing collagen according to claim 5, wherein the shaking device comprises a blocking member fixed to the sliding bar; and when the actuating device moves between the first position and the second position In a part of the stroke, the cover contacts the blocking member to move the sliding bar together with the cover; when the actuating device is in the second position, the cover does not contact the blocking member, so that the sliding bar is opposite to the blocking member The cover moves and the first gear drives the second gear and the slide to reciprocate the carriage arrangement between a higher third position and a lower four position in the solution. The apparatus for manufacturing collagen according to claim 6, wherein the shaking device comprises a connecting member, a slider, and a guide rail; the second gear is pivotally connected to the connecting member, and the connecting member is fixed to the slider and the sliding rod. The slider is slidably coupled to the rail. The apparatus for producing collagen according to any one of claims 1 to 7, wherein the bracket device comprises a plurality of frames; each of the frames includes a first side and a second side opposite to each other And a plurality of ears disposed at the top and bottom of the first side and the second side, wherein the direction of the notch of the ear portion at the top is opposite to the direction of the notch of the ear portion at the bottom; The engagement of the ears prevents the frames from separating in the direction of the first side and the second side. The apparatus for producing collagen according to claim 8, wherein each of the frames further includes a third side and a fourth side opposite to each other, and a ring disposed on the fourth side; The cradle device includes a lock bar that is removably received in the ring, thereby preventing the frames from separating in the direction of the third side and the fourth side. The apparatus for producing collagen according to claim 9, wherein each of the frames further includes a rib disposed on the third side and a third side extending from the fourth side to the third side a tray; the tray device includes a tray for accommodating the material, the tray being received in the groove; the rib and the lock rod respectively restrict movement of the tray toward the third side and the fourth side. The apparatus for producing collagen according to any one of claims 1 to 7, wherein the tank device comprises a heat exchanger adjacent to the reaction tank for heat exchange with the solution. The apparatus for producing collagen according to claim 11, wherein the apparatus comprises an air suction device connected to the cover for extracting gas between the solution and the cover; the bracket device comprises a lock lever and a plurality of frames for receiving the material; each of the frames including ears that detachably engage the frames; the lock bars detachably extend through the frames To prevent the ears from disengaging. The apparatus for producing collagen according to claim 12, wherein the tank device comprises a vibrating machine for vibrating the solution. The apparatus for producing collagen according to claim 12, wherein the reaction tank comprises a convection opening for promoting the flow of the solution. The apparatus for producing collagen according to claim 12, wherein the reaction tank comprises a bottom surface, a slope extending obliquely upward from the bottom surface, a side surface extending upward from the other end of the slope, and a bottom surface provided at the bottom The discharge port of the surface. The apparatus for producing collagen according to claim 12, wherein the cover comprises a transparent inspection window. The apparatus for producing collagen according to claim 12, wherein the apparatus comprises a solution supply device connected to the lid. The apparatus for producing collagen according to claim 12, wherein the apparatus comprises an isolation chamber, the reaction chamber, the bracket device, and the cover are located in the isolation chamber. The apparatus for producing collagen according to claim 18, wherein the actuating device and the shaking device are partially located outside the isolation chamber and another portion thereof is located in the isolation chamber. The apparatus for producing collagen according to claim 18, wherein the apparatus comprises a cleaning device detachably suspended from a side wall of the isolation chamber.