201244632 六、發明說明： 【發明所屬之技術領域】 本發明係有關有害生物防除組成物及有害生物之防除 方法。 【先前技術】 迄今，已知多種化合物為有害節肢動物防除組成物之 活性成分（參見例如，專利文獻1及2)。 引用文獻表 專利文獻 專利文獻 1 : US 5, 034, 404 專利文獻 2 : US 4, 176, 189 【發明内容】 本發明欲解決之問題 本發明之目的在於提供對有害生物具有優越防除效力 之有害生物防除組成物及有害生物之防除方法。 解決問題之手段 本發明人等精深研究尋找對有害生物具優越防除效力 之有害生物防除組成物’結果發現含有（E)-l-(2 -氯-1,3-噻唑-5-基曱基）-3-曱基-2-硝基胍（下文稱為胍化合物）與 2, 2-二曱基- 3-(2-曱基-I-丙婦基）環丙烧曱酸[2，5 -二綱 基-3-(2-丙快基）-1-味唾唆基]甲i旨（下文稱為醋化合物） 之組合之組成物具有優越之有害生物防除效力，因而完成 本發明。 本發明包括： 324002 201244632 [1] 一種有害生物防除組成物，其含有作為活性成分之脈 化合物與醋化合物之組合。 [2] 根據[1]之有害生物防除組成物，其中該胍化合物與該 4 酯化合物之重量比係在50 : 1至1 : 50之範圍内。 [3] —種有害生物防除方法，該方法包括施加有效量之胍 化合物與S旨化合物。 [4] 根據[3]之有害生物防除方法，其中該胍化合物與該酯 化合物之重量比係在50 : 1至1 : 50之範圍内。 本發明之效力 使用本發明有害生物防除組成物可防除有害生物。 【實施方式】 本發明有害生物防除組成物之特徵為含有胍化合物與 酯化合物之組合。 胍化合物，舉例而言，可利用見述於邶5,〇34,4〇4之 方法製造。 商品名稱為可尼丁（clothianidin ;俗名）之市售化合 物亦可作為胍化合物用。 醋化合物’舉例而言，可利用見述於US 4, 176, 189與 us 4,827,020之方法製造。 於酯化合物中， 的兩個不對稱碳原子之異構物 存在衍生自環丙烷環位置丨及位置 及位置3 各異構物或具有有害 °具有有害生物防除活性之 之混合物均涵蓋於本發明之中。 商品名稱為依普寧（imiDrn, 生物防除活性之彼等異構物任 意比率201244632 VI. Description of the Invention: [Technical Field to Be Invented by the Invention] The present invention relates to a method for controlling a pest control composition and a pest. [Prior Art] Heretofore, various compounds have been known as active ingredients of harmful arthropod control compositions (see, for example, Patent Documents 1 and 2). Citation List Patent Literature Patent Document 1: US 5, 034, 404 Patent Document 2: US 4, 176, 189 SUMMARY OF THE INVENTION Problems to be Solved by the Invention An object of the present invention is to provide a harmful effect against harmful organisms. Biological control methods for controlling composition and pests. Means for Solving the Problem The inventors of the present invention have intensively studied to find a pest control composition having superior control efficacy against harmful organisms, and found that (E)-l-(2-chloro-1,3-thiazol-5-ylfluorenyl group is contained. -3-mercapto-2-nitroindole (hereinafter referred to as hydrazine compound) and 2,2-dimercapto-3-(2-indolyl-I-propyl) propyl propyl citrate [2, A composition of a combination of 5-di-l-yl-3-(2-propanyl)-1-isopropanyl] (hereinafter referred to as a vinegar compound) has superior pest control efficacy, thus completing the present invention . The present invention includes: 324002 201244632 [1] A pest control composition comprising a combination of a pulse compound and an vinegar compound as an active ingredient. [2] The pest control composition according to [1], wherein the weight ratio of the hydrazine compound to the 4-ester compound is in the range of 50:1 to 1:50. [3] A pest control method comprising applying an effective amount of a ruthenium compound and a S compound. [4] The pest control method according to [3], wherein the weight ratio of the hydrazine compound to the ester compound is in the range of 50:1 to 1:50. Efficacy of the Invention The pest control composition of the present invention can be used to control pests. [Embodiment] The pest control composition of the present invention is characterized by containing a combination of an anthracene compound and an ester compound. The hydrazine compound, for example, can be produced by the method described in 邶5, 〇34, 4〇4. A commercially available compound having a trade name of clothianidin (common name) can also be used as a bismuth compound. The vinegar compound' can be produced, for example, by the method described in U.S. Patent Nos. 4,176,189 and 4,827,020. In the ester compound, the isomer of two asymmetric carbon atoms is present in the present invention in the presence of a mixture derived from the cyclopropane ring position and the position and position 3, or a mixture having harmful pest control activity. Among them. The trade name is iprin (imiDrn, any ratio of their isomers for biological control activity)
Prothrin ;俗名）（（〗R)-順式/ 324002 4 201244632 反式-3-(2-曱基-1-丙烯基）-2, 2-二曱基環丙烷甲酸[2, 5- 二酮基-3-(2-丙炔基）-1-咪唑啶基]曱酯）之市售化合物可 作為酯化合物用。 本發明有害生物防除組成物對其具防除效力之有害生 物包括例如有害昆蟲及有害蜱蟎等有害節肢動物，詳言 之’為下述有害生物： 鱗翅目（Lepidoptera)昆；&害物： 模蛾科（Pyralidae)例如二化模 s叩pressalis)、稻敗穩塔QCnaphalocrosis medinalis)、 印度谷螟（PioWa 與地中海粉斑螟 ;夜蛾科（Noctuidae)例如斜紋夜 蛾{Spodoptera litura)、東方黏蟲XPseu(Jaletiaseparata) 與甘藍夜蛾（h/zzesira Arass/cae);粉蝶科（Pieridae)例 如菜粉蝶（户/er/s rapae c/T/cimra);捲葉蛾科 (Tortricidae)例如小捲蛾（di/oxop/ze/es)屬；果姓蛾科 (Carposinidae);潛蛾科（Lyonetiidae);毒蛾科 (Lymantriidae);紋夜蛾科（Antographa);地老虎（/^7Όί2··5) 屬例如黃地老虎（Agrotis segetum)與小地老虎（Agrotj·s ipsilon)’，^^XHelicoverpa)Mi，，^AUIeliothis)Mi·， 菜蛾XPlutella xylostella) ·，直故稻氧義 QParnara guttata) ·，網农蛾（Tinea pellionelja) ·，袋衣蛾（TineoJa 等。 雙翅目（Diptera)昆蟲害物： 庫蚊（6W灯)屬例如尖音庫蚊淡色變種（CWez 324002 5 201244632 pipiens pal lens)與三每幕致XCulex tritaenior/jync/ws);伊蚊（Aedes)屬例如埃及伊蚊（Aedes aegypti)與伊玫（Aedes albopictus) ·，按欢（Anopheles) 屬例如按故（Anopheies sinensis);搖蚊科 (Chironomidae);家蠅科（Muscidae)例如普通家蠅（奶/sca domestica)、蔽腐織（Muscina stabu】ans)與黃腹敗纖 (/5/7/7/^3 ;麗繩科（Calliphoridae);麻繩科 (Sarcophagidae);花罐科（Anthomyiidae)例如種繩 pJjatura)與蔥m(Dena antiQua);實繩科 (Tephritidae);潛葉繩科（Agromyzidae);果繩科 (Drosophilidae);毛蠓科（Psychodidae);蚤繩科 (Phoridae);蚋繩科（Simuliidae);紀科（Tabanidae);螫 繩科（Stomoxyidae);蠓科（Ceratopogonidae)等。 蜚蟣科（Blattaria)昆蟲害物： 德 M 'l· 織{Blattella germanica)、後色；K 竭: {Periplaneta fuliginosa)、美淋九碟{Periplaneta americana)、竭匕:K 罐:{Periplaneta brunnea)、A 方轚竭： (Blatta orientalis)專0 膜翅目（Hymenoptera)昆蟲害物： 蟻科（Formicidae)例如日本弓背蟻即〇77〇i£AS japonicus)、津 鑷道場XTetramorium tsushimae)、場毛 壤（Lasius niger)、華 I 粗封缚XPachycondyJa chinensis)、k侵琢家缚XMonomorium intrudens)、富士 毛場XLasius fuji)、4、专家場XMonomorium pharaonis)、 324002 6 201244632 B 本山缚XFormica fusca japonica)、弩琉璃織 QOchetellus glaber)、堅硬雙錡缚XPristomyrmex punctatus)、％ 節:K镇家織{Pheidole noda)與 H根达織 //£/y^Ve);胡蜂科（Vespidae)例如馬蜂 QPol istes^)M)\_々聲馬锋：ΙΡ〇ΐ istes chinensis)、铸·線馬蜂 QPolistes riparius)、％ 馬绛{p〇iistes jadwigae)、和 馬蜂iPolistes rothneyi、、l吻馬舞{p〇iistes 、斯馬蜂與日本馬蜂 W/sies /apo/^ci/s)]、中國大虎頭蜂（Fespa mandarinia)、a 苯绛{Vespa simillima xanthoptera)、擬大氮頭蜂（Vespa anaiis)、黃邊胡锋 (Fespa oraZ?/O)、黑尾虎頭蜂（Fespa也⑶/以）、細黃胡蜂 CVespula flaviceps lewisi)、ψ夤胡蜂CVespula shidai) 與長黃胡蜂（仇>7ic/?〇Fespi//a咖心3);腫腿蜂科 (Bethylidae);葉蜂科（Tenthredinidae)例如黃翅菜葉蜂 {Athalia rosae ruficornis)專。 蚤目（Siphonaptera)昆蟲害物： 狗櫛頭蚤cam's)、描御頭蚤 {Ctenocephalides felis)、k^QPulex irritans)蓴。 乱目（Anoplura)昆蟲害物： kM^Pediculus humanus)、德^XPhthirus pubis')、 藏 UPedi cuius humanus capti s')、後 ^{Pedi cuius humanus corporis)蓴。 嚙蟲目（Psocoptera)昆蟲害物： 324002 7 201244632 喷蟲（psocid) 等翅目（Isoptera)昆嘉害物： 地棲性白蟻例如犀白蟻（及e iy/以/*此5 speratus)、会灣家台缚XCoptotermes formosanus')、責氣 散白蟻（及ei//aWpesO、黃肢散白蟻 {Reticulitermes hesperus)、南方散白犧 {Reticulitermes virginicus')、瑕 白織 {Reticulitermes tibialis)、金奄色 t 白嗓 (ie/Ό ie/Twes awrei/s);乾木白蟻例如小楹白蟻 (//7c/s/ ie/7Z7es· π//7ατ);與腐木白蟻例如内華達濕木白蟻 {Zootermopsis nevadensis)。 半翅目（Hemiptera)昆蟲害物： 飛虱科（De 1 phac i dae )例如稻灰飛虱（Za〇i/e/p/?5z s in a ie//"s)、稻褐飛 IL (W/aparpa/'a 與白背飛 虱（5b辟/i//ry/e_ra);葉蟬科（Deltocephalidae)例 如黑尾葉蟬（yVep/7〇 ί ii·尤iycej^s)與微綠葉蟬 ;蚜科（Aphididae);蝽科 (Pentatomidae)例如稻綠墙象（yvieza/'a a73ie/3/3aia)、點蜂 緣锋象 iRiptortus clavatus)、二 l锋{Eysarcoris lewisi)、白 l蝽（Eysarcoris parvus)、'1、珀锋（Plautia stall)、茶翅锋 Walyomorpha mista)、赤條氣言锋 (Stenotus rubrovittatus)毵赤須 t 蝽iTrigonotylus cae/esh/·"/»);粉風科（Aleyrodidae);纷科 (Coccidae);臭蟲科（Cimicidae)例如臭蟲（C/zwez 324002 8 201244632 /ecb/aW仍）；網蝽科（Tingidae);木虱科（Psyllidae) 等。 鞘翅目（Coleoptera)昆蟲害物： •黑地毯曱蟲（d itgge/7i/s i//?ic<9/or);紅斑皮蠹 (如;玉米食根蟲例如玉米根葉曱 iDiabrotica virgifera)與十一 葉 ψ (J)iabrotica i//^ecy/wpi//2ciai<9 Λ〇ί^/Ά·);金龜曱科（Scarabaeidae)例 如大綠氮金^XAnomaia cuprea)與九豆姬金象（Anomla /•£//oc"jorea);象鼻蟲科（Curculionidae)例如玉米象 (Si tophi Jus zeamais) - ^ {Lissorhoptrus oryzophiIlls')、構铸象气{Anthonoms grandis grandis、 與綠豆象 ψ (CaJJosobruchus cheninsis) ·，擬步 f 義科 (Tenebrionidae)例如黃粉曱與赤擬 谷盜;葉甲科（Chrysomelidae)例 如稻負泥A(0uJe/na oryzae)、黃條跳蟲XPhyJJotreta striolata)與黄守瓜（Aulacophora feinoraJis);竊蠢科 (Anobiidae);瓢蟲屬例如二十八星瓢蟲 (Henosepilachna vigintioctopunctata).，粉蠢料 (Lyctidae);長蠢科（Bostrychidae);蛛甲科（Ptinidae); 天牛科（Cerambycidae);長袍甲蟲（Paei/e/TAS /£/sc/pe5) 等。 缕翅目（Thysanoptera)昆蟲害物： 南養 Μ 馬 iThrips palmi)、售辕範 MjiFrankUniella occidental is)、I氣ΑΆ ^j{Thrips hawai 1 iensis)專。 324002 9 201244632 直翅目（Orthoptera)昆轰害物： 螻蛄科（Gryllotalpidae)、蝗科（Acrididae)、蟋蟀科 (Gryllidae)等。 蜱蜗目（Acarina): 塵蜗科（Py rog 1 y ph i dae )例如粉塵瞒 {Dermatophagoides farinae)與良態織 ;粉蟎科（Acaridae) 例如腐食酪蟎（pi/ iresce/? i/ae)與橢圓嗜粉蟎 (Wei//O^7/p/7i/soyaii/s);食甜蟎科（Glycyphagidae)例如 隱秘食甜蟎（67yc/p/7ap/s pWraii/s)、食甜家蟎 iGlycyphagus domesticus)與垃敗唆化蔽粉亀織 ;肉食蟎科（Cheyletidae)例如 馬六，芮 I錄iCheyletus malaccensis)與 Cheyletus /z/aiaccesys;跗線蟎科（Tarsonemidae);嗜草蟎科 (Chortoglyphidae);甲蟎總股（Oribatei);葉蟎科 (Tetranychidae)例如棉葉蟎（reira/77c/^s i/riicae)、神 澤氏葉蟎如77烈呢/)、柑橘全爪蟎 (Panonychus citri)與蘋果全爪蟎（Panonychus u!mj) ·，赤 蟎科（Erythraeidae);硬蜱科（Ixodidae)例如長角血蜱 (^e/wap/zysa/ysyo/^ycor/i/sO ;皮刺蟎科（Dermanyssidae) 例如林禽刺蜗（s/7Fa2·/7//ζ〇與雞皮刺蜗 {Dermanussus galinae)專。 蚰挺目（Scutigeromorpha)，唇足綱（Chilopoda)例如 少緣铁給iScolopendra subsipnipes mutiIans).，倍足綱 324002 10 201244632 (D i p 1 opoda )例如溫室馬陸（处/^s f ac/ / ys)與腹馬陸屬 之化办ορι/s·；球婦科（Armad i 11 d i i i dae )與鼠 婦蟲科（Porcellionidae)例如球鼠婦（如咖心///心娜 ywkare) ·’腹足綱（Gastropoda)例如緣龍蛞蝓（^/历狀 與黄虫舌輸，及虫知蛛目（Araneae) 例如橫帶人面i知蛛（yVep/?//a c7araia)、日本紅螯蛛 iCheiracanthiwn japonicund 與紅嘴蜘象{Latrodectus hasselti)等·。 於本發明有害生物防除組成物中，胍化合物對酯化合 物之重量比通常為50 : 1至1 : 50，較佳為20 : 1至1 : 20， 更佳為20 : 1至1 : 1〇，尤其更佳為2〇 : 1至1 : 1，最佳 為20· 1至5: 1之範圍内。 本發明有害生物防除組成物可為胍化合物與酯化合物 之單純混合物；然而，其通常可呈各種調配物形式使用。 彼等調配物實例包括油溶液、可乳化濃縮物、可濕性粉劑、 可濕性分散粒劑、懸浮濃縮物（例如於水中之懸浮劑、於水 中之乳劑）、微膠囊調配物、凝膠調配物、細粉劑、粒劑、 錠劑、塗覆（coating)調配物、氣溶膠、二氧化碳調配物、 加熱蒸發調配物（例如蚊香、電蚊香與液體吸收燈芯型殺蟲 劑）、壓電式噴霧殺蟲劑、加熱型燻蒸劑（例如自行燃燒型 燻蒸劑、化學反應型燦蒸劑與多孔性磁板燦蒸劑）、非加熱 型燻蒸劑（例如樹脂燦蒸劑、紙燦蒸劑、非織造織物燦蒸 劑、'編織物燻蒸劑與可昇華錠劑）、煙燻調配物（例如霧狀 物）、直接接觸調配物（例如片狀接觸調配物、帶狀接觸調 324002 11 201244632 配與網狀接觸調配物）、ULV調配物、毒餌。 調配物，舉例而言，可利用下述方法製備。 (1)使胍化合物和酯化合物與固體載劑、液體載劑、氣 體載劑或飼料及視需要之其他調配用輔助劑（例如界面活 性劑）混合。 (2 )使基材與胍化合物和自旨化合物一起浸潰。 (3) 使胍化合物、酯化合物與基材混合，然後模製。 (4) 使胍化合物與固體載劑、液體載劑、氣體載劑或飼 料及視需要之其他調配用輔助劑，例如界面活性劑混合， 得到含有胍化合物之水中之懸浮劑；及使酯化合物與固體 載劑、液體載劑、氣體載劑或飼料及視需要之其他調配用 輔助劑（例如界面活性劑）混合，得到含有酯化合物之於水 中之乳劑；接著使含有胍化合物之該水中之懸浮劑與含有 画旨化合物之該水中之乳劑混合。 (5 )使胍化合物和g旨化合物與固體載劑、液體載劑、氣 體載劑或飼料及視需要之其他調配用輔助劑（例如界面活 性劑）混合；接著研磨該混合物。 彼等調配物通常含有總量0.001至90重量％之胍化合 物與酯化合物。 用於調配物之固體載劑之實例包括細粉劑與粒劑例如 黏土 [例如高嶺土、矽藻土、膨土、富巴沙米黏土（Fubasami clay)與酸性白黏土]、合成之水合二氧化石夕、滑石、陶瓷 類、其他無機礦物（例如絹雲母、石英、硫、活性碳、碳酸 鈣與水合矽石）、化學肥料（例如硫酸銨、磷酸銨、硝酸銨、 324002 12 201244632 氣化銨與尿素）；常溫為固體之物質（例如2, 4, 6-三異丙基 -1，3, 5-三噚烷、萘、對二氯苯、樟腦與金剛烷）以及氈製 品、纖維、布、織物、片料、紙、線、泡沐物、多孔性材 料及由下述一或多種材質構成之複絲：羊毛、絲、棉、麻、 紙漿、合成樹脂（如聚乙烯樹脂例如低密度聚乙烯、線型低 密度聚乙烯、高密度聚乙烯；乙烯-乙烯酯共聚物類例如乙 烯-乙酸乙烯酯共聚物；乙烯-甲基丙烯酸酯共聚物例如乙 烯-曱基丙烯酸甲酯共聚物與乙烯-甲基丙烯酸乙酯共聚 物；乙烯-丙烯酸酯共聚物例如乙烯-丙烯酸曱酯共聚物與 乙烯-丙烯酸乙酯共聚物；乙烯-乙烯羧酸共聚物例如乙烯-丙烯酸共聚物；乙烯-四環十二碳烯共聚物；聚丙烯樹脂類 例如丙烯均聚物、丙烯-乙烯共聚物；聚-4-甲基戊烯-1 ; 聚丁烯-1 ;聚丁二烯；聚苯乙烯；丙烯腈-苯乙烯樹脂；苯 乙烯彈性體例如丙烯腈-丁二烯-苯乙烯樹脂、苯乙烯-共軛 二烯嵌段共聚物、氫化苯乙烯-共軛二烯嵌段共聚物；氟塑 料；丙烯酸樹脂例如聚曱基丙烯酸曱酯；聚醯胺樹脂例如 尼龍6與尼龍66 ;聚酯樹脂例如聚對苯二曱酸乙二酯、聚 萘二曱酸乙二酯、聚對苯二曱酸丁二酯與聚對苯二曱酸伸 環己基二曱酯；聚碳酸酯；聚縮醛；聚丙烯砜；聚芳基酸 酯；聚羥苯曱酸酯；聚醚醯亞胺；聚酯碳酸酯；聚苯醚樹 脂；聚氯乙烯；聚偏氯乙烯；聚胺酯（polyurethane);及 多孔性樹脂例如發泡聚胺酯、發泡聚丙烯與發泡聚乙烯）、 玻璃、金屬與陶瓷類。 液體載劑之實例包括芳族或脂族烴（例如二曱苯、曱 324002 13 201244632 苯、烧基萘、苯基二曱苯乙烧、煤油、輕油、己烧與環己 烷）；鹵化烴（例如氯苯、二氣曱烷、二氣乙烷與三氯乙烷）； 醇類（例如曱醇、乙醇、異丙醇、丁醇、己醇、苄醇與乙二 醇）；醚類（例如乙醚、乙二醇二曱醚、二乙二醇單甲醚、 二乙二醇單乙醚、丙二醇單曱醚、四氫呋喃與二噚烷）；酯 類（例如乙酸乙酯與乙酸丁酯）；酮類（例如丙酮、曱基乙基 酮、甲基異丁基酮與環己酮）；腈類（例如乙腈與異丁腈）； 亞砜類（例如二曱亞砜）；醯胺類（例如N，N-二甲基曱醯胺、 N，N-二曱基乙醯胺與N-曱基吡咯啶酮）；碳酸烷二酯類（例 如碳酸丙二酯）、植物油（例如大豆油與棉籽油）；植物精油 (例如橙皮油、牛膝草油與擰檬油）及水。 氣體載劑之實例包括丁烷氣體、氣氟碳氣體、液化石 油氣（LPG)、曱醚與二氧化碳。 界面活性劑之實例包括烧基硫酸酯鹽、烧基續酸鹽、 烷芳基磺酸鹽、烷芳基醚類、聚氧乙基化烷芳基醚類、聚 乙二醇醚類、多元醇酯類、糖醇衍生物、木質磺酸鹽（例如 木質續酸納）與聚叛酸鹽（polycarloxylate)。 於本發明之有害生物防除組成物中，胍化合物對木質 磺酸鹽之重量比通常在50: 1至1: 1，較佳為20 : 1至1 ·· 1，更佳為20 : 1至5 : 1之範圍内。 於本發明之有害生物防除組成物中，胍化合物對聚羧 酸鹽之重量比通常在50 : 1至1 : 1，較佳為20 : 1至1 : 1， 更佳為20 : 1至2 : 1之範圍内。 其他調配用輔助劑之實例包括黏著劑、分散劑、安定 324002 14 201244632 劑，其詳細實例包括酪蛋白、明膠、多醣（例如澱粉、阿拉 伯樹膠、纖維素衍生物與海藻酸）、木質素衍生物、膨土、 醣類、合成之水溶性聚合物（例如聚乙烯醇與聚乙烯吡咯啶Prothrin; common name) ((R)-cis/324002 4 201244632 trans-3-(2-mercapto-1-propenyl)-2,2-dimercaptocyclopropanecarboxylic acid [2, 5-diketone A commercially available compound of -3-(2-propynyl)-1-imidazolidinyl] oxime ester can be used as an ester compound. The pests of the pest control composition of the present invention have pest control effects, including harmful arthropods such as harmful insects and harmful cockroaches, and are described as 'the following pests: Lepidoptera Kun; & Pyralidae such as s叩pressalis, QCnaphalocrosis medinalis, Indian gluten (PioWa and Mediterranean pink pupa; Noctuidae such as Spodoptera litura), Oriental Mutant XPseu (Jaletiaseparata) and Brassica chinensis (h/zzesira Arass/cae); Pieridae such as Pieris rapae (Europe/er/s rapae c/T/cimra); Tortricidae (Tortricidae) (di/oxop/ze/es) genus; Carposinidae; Lyonetiidae; Lymantriidae; Antographa; Earth tiger (/^7Όί2··5) For example, Agrotis segetum and Agrotj·s ipsilon', ^^XHelicoverpa) Mi, ^AUIeliothis) Mi·, XPlutella xylostella), straight rice Oxygen QParnara guttata) ,Netea moth (Tinea pellionelja) ·, bag (TineoJa et al. Diptera insect pests: Culex mosquitoes (6W lamps) are, for example, Culex pipiens var. (CWez 324002 5 201244632 pipiens pal lens) and three per curtains XCulex tritaenior/jync/ws); Aedes are genus Aedes aegypti and Aedes albopictus, for example, Anopheies sinensis; Chironomidae; Muscidae For example, common housefly (milk/sca domestica), Muscina stabu (ans) and yellow-belly fiber (/5/7/7/^3; Calliphoridae; Sarcophagidae; Anthomyiidae (such as pJjatura) and onion m (Dena antiQua); Tephritidae; Agromyzidae; Drosophilidae; Psychodidae; Phoridae; Simuliidae; Tabanidae; Stomoxyidae; Ceratopogonidae. Blattaria insect pests: De M 'l· weaving {Blattella germanica), after color; K exhaust: {Periplaneta fuliginosa), Mering 9 disc (Periplaneta americana), exhausted: K can: {Periplaneta brunnea ), A side exhausted: (Blatta orientalis) special 0 Hymenoptera insect pests: Formicidae (Japanese Forked ants, 〇 77〇i£AS japonicus), Tsutsumi Dojo XTetramorium tsushimae), Fields (Lasius niger), Hua I coarsely bound XPachycondyJa chinensis), k 琢 琢 缚 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X ), woven glass QOchetellus glaber), hard double shackles XPristomyrmex punctatus), % section: K town woven {Pheidole noda) and H genda woven / / £ / y ^ Ve); Vespaidae (Vespidae) such as wasp QPol Istes^)M)\_々声马锋:ΙΡ〇ΐ istes chinensis), cast line bee QPolistes riparius), % horse 绛{p〇iistes jadwigae), and wasp iPolistes rothneyi, l kiss horse dance {p〇 Iistes, sima and japanese horse W/sies /apo/^ci/s)], China's Fespa mandarinia, a benzoquinone {Vespa simillima xanthoptera), Vespa anaiis, and Huangbian Hufeng (Fespa oraZ? /O), black-tailed tiger head bee (Fespa also (3) / to), fine yellow wasp CVespula flaviceps lewisi), bee wase CVespula shidai) and long yellow wasp (venge > 7ic /? 〇 Fespi / / a café 3 ); Bethylidae; Tenthredinidae, such as the yellow-winged bee {Athalia rosae ruficornis). Siphonaptera insect pests: dog 蚤 蚤 cam's), C 蚤 {Ctenocephalides felis), k^QPulex irritans) 莼. Anoplura insect pests: kM^Pediculus humanus), De XPhthirus pubis'), Tibetan UPedi cuius humanus capti s'), post ^{Pedi cuius humanus corporis). Psocoptera insect pests: 324002 7 201244632 oc 虫 (psocid) Isoptera Kunjia pests: terrestrial termites such as rhinoceros termites (and e iy / to / 5 this 5 speratus), will Bay family Taiwan XCoptotermes formosanus'), blame for termites (and ei//aWpesO, Reticulitermes hesperus, Reticulitermes virginicus), Reticulitermes tibialis, golden ochre t 白嗓 (ie/Ό ie/Twes awrei/s); dry wood termites such as cockroach termites (//7c/s/ie/7Z7es·π//7ατ); and rot wood termites such as Nevada wet wood termites {Zootermopsis nevadensis). Hemiptera insect pests: De 1 phac i dae such as the rice planthopper (Za〇i/e/p/?5z s in a ie//"s), rice brown fly IL (W/aparpa/'a and white-backed planthopper (5b/i//ry/e_ra); Deltocephalidae (for example, black-tailed spider mites (yVep/7〇ί ii· especially iycej^s) and Aphididae; Aphididae; Pentatomidae such as yvieza/'a a73ie/3/3aia, iRiptortus clavatus, E1 (Eysarcoris lewisi), white l蝽(Eysarcoris parvus), '1, Plautia stall, Walyomorpha mista), Stenotus rubrovittatus, red whisker t 蝽iTrigonotylus cae/esh/·"/»);Aleyrodidae;Coccidae; Cimicidae such as bed bugs (C/zwez 324002 8 201244632 /ecb/aW still); Tingidae; Psyllidae et al. Coleoptera insect pests: • Black carpet aphids (d itgge/7i/si//?ic<9/or); red spotted mites (eg, corn rootworms such as corn root bud iDiabrotica virgifera) and Eleven leaves (J) iabrotica i//^ecy/wpi//2ciai<9 Λ〇ί^/Ά·); Scarabaeidae (such as large green nitrogen gold ^XAnomaia cuprea) and Jiudou Ji Jinxiang (Anomla /•£//oc"jorea); Curculionidae such as Si tophi Jus zeamais - ^ {Lissorhoptrus oryzophiIlls'), constructing elephant qi {Anthonoms grandis grandis, with mung bean ψ ( CaJJosobruchus cheninsis) ·, Tenebrionidae such as yellowfly and red cockroach; Chrysomelidae such as rice negative mud A (0uJe/na oryzae), yellow worm (XPhyJJotreta striolata) and yellow squash (Aulacophora feinoraJis) Anobiidae; Ladybugs such as Henosepilachna vigintioctopunctata., Lyctidae; Bostrychidae; Ptinidae; Cerambycidae ); robe beetle (Paei / e / TAS / £ / sc / pe5) and so on. Thysanoptera insect pests: Southern Μ horse iThrips palmi), sold out MjiFrankUniella occidental is), I ΑΆ ^j{Thrips hawai 1 iensis). 324002 9 201244632 Orthoptera Kunqun: Gryllotalpidae, Acrididae, Gryllidae, etc. Acarina: Py rog 1 y ph i dae such as Dustmatophagoides farinae and benign weave; Acaridae such as rot kens (pi/ iresce/? i/ae ) and elliptic toadstools (Wei / / O ^ 7 / p / 7i / soyaii / s); Glycyphagidae (Gycyphagidae) such as hidden sweets (67yc / p / 7ap / s pWraii / s), sweet螨iGlycyphagus domesticus) and 唆 唆 ; ;;Cheyletidae (for example, Ma Liu, 芮I recorded iCheyletus malaccensis) and Cheyletus /z/aiaccesys; Tarsonemidae; (Chortoglyphidae); Oribatei; Tetranychidae such as cotton leafhopper (reira/77c/^si/riicae), Shenze's leafhopper such as 77 lie/), citrus full claw 螨 ( Panonychus citri) and Panonychus u!mj · Erythraeidae; Ixodidae such as long-horned blood clam (^e/wap/zysa/ysyo/^ycor/i/sO) Dermanyssidae such as forest bird snail (s/7Fa2·/7//ζ〇 and chicken skin spurs {Dermanussus galinae). Scutigeromorpha, Chilopoda such as Shaoyuan For iScolopendra subsipnipes mutiIans)., 324002 10 201244632 (D ip 1 opoda ) such as greenhouse Malu (where / ^sf ac / / ys) and the genus Ophiopogon ορι / s ·; ball gynecology (Armad i 11 Diii dae ) and the rat cellulite (Porcellionidae) such as the ball rat (such as the heart of the heart / / / heart na ywkare) · 'gastropoda (Gastropoda) such as the edge dragon 蛞蝓 (^ / calendar and yellow insect tongue, and Araneae, for example, is a human face spider (yVep/?//a c7araia), a Japanese red-winged spider iCheiracanthiwn japonicund, and a red-billed spider (Latrodectus hasselti). In the pest control composition of the present invention, the weight ratio of the hydrazine compound to the ester compound is usually from 50:1 to 1:50, preferably from 20:1 to 1:20, more preferably from 20:1 to 1:1. More preferably, it is 2: 1 to 1: 1, and the best is in the range of 20·1 to 5: 1. The pest control composition of the present invention may be a simple mixture of an anthraquinone compound and an ester compound; however, it may be usually used in various formulations. Examples of such formulations include oil solutions, emulsifiable concentrates, wettable powders, wettable dispersible granules, suspension concentrates (eg, suspensions in water, emulsions in water), microcapsule formulations, gels Formulations, fine powders, granules, lozenges, coating formulations, aerosols, carbon dioxide formulations, heated evaporative formulations (eg mosquito coils, electric mosquito coils and liquid-absorbent wick-type insecticides), piezoelectric Spray insecticide, heated fumigant (such as self-burning fumigant, chemical reaction type steaming agent and porous magnetic plate can be steamed), non-heated fumigant (such as resin can be steamed, paper can be steamed, Non-woven fabrics, steaming agents, 'knitted fumigants and sublimable lozenges', smoked formulations (eg, mist), direct contact formulations (eg sheet contact formulations, strip contact 324002 11 201244632) Contact with mesh contact), ULV formulation, bait. Formulations, for example, can be prepared by the methods described below. (1) The hydrazine compound and the ester compound are mixed with a solid carrier, a liquid carrier, a gas carrier or a feed, and optionally other adjuvants (e.g., an interface active agent). (2) The substrate is impregnated with the hydrazine compound and the self-specific compound. (3) The hydrazine compound and the ester compound are mixed with a substrate and then molded. (4) mixing the hydrazine compound with a solid carrier, a liquid carrier, a gas carrier or a feed, and optionally other adjuvants, such as a surfactant, to obtain a suspending agent in water containing a hydrazine compound; and an ester compound Mixing with a solid carrier, a liquid carrier, a gas carrier or a feed, and optionally other adjuvants (for example, a surfactant) to obtain an emulsion containing an ester compound in water; and then allowing the water containing the hydrazine compound The suspending agent is mixed with an emulsion of the water containing the graphic compound. (5) mixing the hydrazine compound and the gram compound with a solid carrier, a liquid carrier, a gas carrier or a feed, and optionally other adjuvants (e.g., an interface active agent); and then grinding the mixture. These formulations typically contain a total of from 0.001 to 90% by weight of the ruthenium compound and the ester compound. Examples of the solid carrier used in the formulation include fine powders and granules such as clay [e.g., kaolin, diatomaceous earth, bentonite, Fubasami clay and acid white clay], synthetic hydrated sulphur dioxide Xi, talc, ceramics, other inorganic minerals (such as sericite, quartz, sulfur, activated carbon, calcium carbonate and hydrated vermiculite), chemical fertilizers (such as ammonium sulfate, ammonium phosphate, ammonium nitrate, 324002 12 201244632 Urea); solids at room temperature (eg 2, 4, 6-triisopropyl-1,3,5-trioxane, naphthalene, p-dichlorobenzene, camphor and adamantane) and felts, fibers, cloth , fabric, sheet, paper, thread, foam, porous material and multifilament composed of one or more of the following materials: wool, silk, cotton, hemp, pulp, synthetic resin (such as polyethylene resin such as low density Polyethylene, linear low density polyethylene, high density polyethylene; ethylene-vinyl ester copolymers such as ethylene-vinyl acetate copolymer; ethylene-methacrylate copolymers such as ethylene-methyl methacrylate copolymer and ethylene -methyl propyl Ethyl acetate copolymer; ethylene-acrylate copolymer such as ethylene-vinyl acrylate copolymer and ethylene-ethyl acrylate copolymer; ethylene-ethylene carboxylic acid copolymer such as ethylene-acrylic acid copolymer; ethylene-tetracyclododecan Ene copolymer; polypropylene resin such as propylene homopolymer, propylene-ethylene copolymer; poly-4-methylpentene-1; polybutene-1; polybutadiene; polystyrene; acrylonitrile-benzene Vinyl resin; styrene elastomer such as acrylonitrile-butadiene-styrene resin, styrene-conjugated diene block copolymer, hydrogenated styrene-conjugated diene block copolymer; fluoroplastic; acrylic resin Polydecyl methacrylate; polyamine resin such as nylon 6 and nylon 66; polyester resin such as polyethylene terephthalate, polyethylene naphthalate, butylene terephthalate With poly-terephthalic acid, cyclohexyl dinonyl ester; polycarbonate; polyacetal; polysulfone; polyarylate; polyhydroxybenzoic acid ester; polyether quinone imine; polyester carbonate; Polyphenylene ether resin; polyvinyl chloride; polyvinylidene chloride; polyurethane; and porosity Lipid e.g. foamed polyurethane, foamed polyethylene, foamed polypropylene), glass, metal and ceramic. Examples of the liquid carrier include aromatic or aliphatic hydrocarbons (for example, diphenylbenzene, cesium 324002 13 201244632 benzene, alkyl naphthalene, phenyl diphenyl benzene, kerosene, gas oil, hexane and cyclohexane); Hydrocarbons (eg chlorobenzene, dioxane, di-ethane and trichloroethane); alcohols (eg decyl alcohol, ethanol, isopropanol, butanol, hexanol, benzyl alcohol and ethylene glycol); ethers Classes (eg, diethyl ether, ethylene glycol dioxime ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene glycol monoterpene ether, tetrahydrofuran and dioxane); esters (eg ethyl acetate and butyl acetate) Ketones (such as acetone, mercaptoethyl ketone, methyl isobutyl ketone and cyclohexanone); nitriles (such as acetonitrile and isobutyronitrile); sulfoxides (such as disulfoxide); Classes (eg, N,N-dimethyldecylamine, N,N-dimercaptoacetamide and N-decylpyrrolidone); alkylene carbonates (eg, propylene carbonate), vegetable oils (eg, Soybean oil and cottonseed oil); plant essential oils (such as orange peel oil, hyssop oil and lemon oil) and water. Examples of gaseous carriers include butane gas, gas fluorocarbon gas, liquefied petroleum gas (LPG), oxime ether and carbon dioxide. Examples of the surfactant include alkyl sulfate, alkyl sulfonate, alkyl aryl sulfonate, alkyl aryl ether, polyoxyethylated alkyl aryl ether, polyethylene glycol ether, and plural. Alcohol esters, sugar alcohol derivatives, lignosulfonates (such as wood sodium chlorate) and polycarloxylate. In the pest control composition of the present invention, the weight ratio of the cerium compound to the lignosulfonate is usually from 50:1 to 1:1, preferably from 20:1 to 1··1, more preferably from 20:1 to Within 5:1 range. In the pest control composition of the present invention, the weight ratio of the cerium compound to the polycarboxylate is usually from 50:1 to 1:1, preferably from 20:1 to 1:1, more preferably from 20:1 to 2 : Within the scope of 1. Examples of other adjuvants for formulation include adhesives, dispersants, and diazepam 324002 14 201244632, and detailed examples thereof include casein, gelatin, polysaccharides (such as starch, gum arabic, cellulose derivatives and alginic acid), and lignin derivatives. , bentonite, sugar, synthetic water-soluble polymers (such as polyvinyl alcohol and polyvinylpyrrolidine)
酮）、聚丙烯酸、BHT (2, 6-二-第三丁基-4-甲基苯酚）、BHA (2-第三丁基-4-甲氧基苯酚與3_第三丁基_4一曱氧基苯酚 之混合物）。 蚊香基材之實例包括植物粉末（例如木材粉末與除蟲 勒西T )與黏合劑[例如紅楠（勤c々"似a⑽心厂貧yy )粉末、澂 粉與麵筋]之混合物。 電蚊香基材之實例包括棉短絨，纏結、壓實成板狀、 及混合棉短絨與紙聚，纏結、壓實成板狀。 自行燃燒型燦蒸劑基材之實例包括燃燒發熱劑例如石肖 酸鹽、亞硝酸鹽、胍鹽、氣酸鉀、硝基纖維素、乙基纖維 素與木材粉末；熱解促進劑例如鹼金屬鹽、鹼土金屬鹽、 重鉻酸鹽與鉻酸鹽，供氧劑例如硝酸釺；助燃劑例如三聚 氰胺與小麥澱粉；填料例如矽藻土；黏合劑例如合成之黏 著劑。 化學反應型燻蒸劑基材之實例包括發熱劑例如鹼金屬 之硫化物、多硫化物與硫氫化物、氧化鈣；觸媒例如含碳 物質、碳化鐵與活性黏土；有機發泡劑例如偶氮二甲醯胺、 苯磺醯肼、二硝基伸戊基四胺、聚苯乙烯與聚胺酯；及填 料例如天然纖維與合成纖維。 ' 用於，例如，樹脂燻蒸劑，之樹脂實例包括聚乙烯樹 脂例如低密度聚乙烯、線型低密度聚乙烯與高密度聚乙烯 324002 15 201244632 類；乙烯-乙烯酯共聚物類例如乙烯-乙酸乙稀酯共聚物； 乙烯-曱基丙烯酸酯共聚物類例如乙烯-曱基丙豨酸曱酯共 聚物與乙烯-甲基丙烯酸乙酯共聚物；乙烯〜丙烯酸酯共聚 物類例如乙烯-丙烯酸曱酯共聚物與乙烯—丙稀酸乙酯共聚 物；乙烯-乙烯羧酸共聚物例如乙烯-丙烯酸共聚物；乙烯-四環十二碳烯共聚物；聚丙烯樹脂例如丙烯均聚物與丙烯-乙稀共聚物；聚-4-曱基戊稀-1 ;聚丁缚-1 ;聚丁二稀；聚 苯乙烯；丙烯腈-苯乙烯樹脂；苯乙烯彈性體例如丙烯腈-丁二烯-苯乙烯樹脂、苯乙烯-共軛二烯嵌段共聚物與氫化 苯乙烯-共軛二烯嵌段共聚物；氟塑料；丙烯酸系樹脂例如 聚曱基丙烯酸甲酯；聚醯胺樹脂例如尼龍6與尼龍66 ;聚 酯樹脂例如聚對苯二曱酸乙二酯、聚萘二曱酸乙二酯、聚 對苯二曱酸丁二酯與聚對苯二甲酸伸環己基二甲酯；聚碳 酸酯；聚縮醛；聚丙烯颯；聚芳基酸酯；聚羥苯甲酸酯； 聚醚醯亞胺；聚酯碳酸酯；聚苯醚樹脂；聚氯乙烯；聚偏 氯乙烯；及聚胺酯。彼等可單獨使用或呈其混合物使用。 進一步，若需要，則可添加增塑劑例如苯二甲酸酯類（例如 苯二曱酸二曱酯與苯二曱酸二辛酯）、己二酸酯類與硬脂酸 於彼等基材。樹脂燻蒸劑之製法為將胍化合物與酯化合物 揑合入基材中，隨後利用射出模製、擠壓模製或模壓使其 成型。若需要，則可使所得樹脂調配物進行例如模製及切 割等進一步處理，加工成為板狀、薄膜、帶狀、網狀或線 狀。彼等樹脂調配物可加工成為，例如，動物用項圈、動 物用耳籤、片狀調配物、引導帶及園藝支撐物。 324002 16 201244632 毒餌基材之實例包括飼料成分例如榖粉、植物油、糖 類與結晶纖維素；抗氧化劑例如二丁羥甲苯與原二氫癒創 木酸；防腐劑例如脫氫乙酸；防止小孩及寵物誤食之製劑 例如紅辣椒粉；及吸引有害生物之香料例如乳酷香料、洋 蔥香料與花生油。 本發明之有害生物防除方法係藉由施加本發明有害生 物防除組成物於有害生物及/或有害生物棲息處而進行；本 發明之有害生物防除方法亦藉由分別施加胍化合物及酯化 合物於有害生物及/或有害生物棲息處而進行。 詳言之，下述方法可為本發明有害生物防除組成物之 例示施加方法，彼等方法可根據本發明有害生物防除組成 物形式、施加位置等適當選定。 (1) 將本發明有害生物防除組成物就原樣施加於害蟲 或害蟲樓息處。 (2) 以溶劑（例如水）稀釋本發明有害生物防除組成 物，然後施加於害蟲或害蟲棲息處。 於此情形下，通常係將呈，例如，可乳化濃縮物、可 濕性粉劑、懸浮濃縮物或微膠囊製劑之本發明有害生物防 除組成物稀釋，俾使胍化合物與酯化合物之總濃度成為0. 1 至 50000 ppm。 (3) 於害蟲棲息處加熱本發明有害生物防除組成物，使 有效成分蒸發。 於此情形下，胍化合物及酯化合物之施用率與濃度可 根據，例如，本發明有害生物防除組成物之形式、施用期、 324002 17 201244632 施用位置、施用方法、受損狀況等適當決定。 使用本發明有害生物防除組成物供預防用途時，其施 用率於施加於空間之情形下，就胍化合物與酯化合物總量 而δ ’通*為o.oooi至mg/m3 ;於施加於平面之時， 為0.0001至1〇〇〇 mg/m、加熱蒸發調配物例如蚊香及電蚊 香片係根據調配物形式適當加熱使有效成分蒸發而施用。 非加熱型燻蒸劑例如樹脂燻蒸劑、紙燦蒸劑、可昇華錠劑、 非織造織物燻蒸劑、編織物燻蒸劑與片狀燻蒸劑，舉例而 5，可令其靜置於欲施加之空間，或朝調配物吹風予以使 用0 供預防用途時，施加本發明有害生物防除組成物之位 置之實例包括壁櫥、梳妝台、五斗櫃、衣櫃、櫥櫃、廁所、 浴室、貯藏室、客廳、餐廳、倉庫與車内。此外，本發明 有害生物防除組成物亦可施加於戶外敞開空間。 於使用本發明有害生物防除組成物以防除家畜（例如 牛、馬、豬、綿羊、山羊與雞，及小動物例如狗、貓、大 鼠與小鼠）體表之寄生生物時’可採用獸醫學上已知之方 法。詳言之，於供全身性防除用時，係使調配物呈例如錠 劑、混合於飼料中、栓劑及注射劑（包括肌内、皮下、靜脈 内與腹膜内注射劑）投與；另一方面，於供非全身性防除用 時，係經由喷霧油溶液或水性溶液、傾倒或沾點處理、以 洗髮精調配物洗滌動物、或於動物身上放置樹脂調配物製 成之項圈或耳籤。胍化合物與酯化合物之總劑量通常為每 公斤動物體重在0.01至1〇〇〇 mg之範圍内。 324002 201244632 實施例 茲於下文藉由調配例及試驗例更詳細地敘述本發明， 惟本發明不擬受限於彼等實施例。 首先，敘述本發明有害生物防除組成物之調配例。於 調配例中，除非另行陳述’否則“份數”均以重量計。 調配例1 於37. 5份二曱苯與37. 5份N, N-二曱基曱醯胺中，使 0. 9份胍化合物與9份酯化合物溶解。於所得溶液中，添 加9. 1份聚氧伸乙基苯乙烯基苯基醚與6份十二基笨橫酸 鈣鹽，然後充分混合，製得可乳化濃縮物。 調配例2 於20份胍化合物與20份酯化合物中，添加5份S0RP0L 5060 (TOHO Chemical Industry Co.，Ltd.之註冊商標）， 然後充分混合。於所得混合物中，添加32份CARPLEX #80 (Shionogi & Co·，Ltd.之註冊商標；合成之水合二氧化矽 細粉）與23份300篩目石夕藻土 ’然後以果汁機充分混合， 製得可濕性粉劑。 調配例3 ，於3份脈化合物與0. 3份i旨化合物中，添加5份合成 之水合二氧化矽細粉、5份十二基苯磺酸鈉鹽、30份膨土 與56. 7份黏土’然後充分攪拌及混合。接著，於所得混合 物中添加適量水；進一步攪拌此混合物，以造粒機造粒，. 風乾，製得顆粒狀調配物。 調配例4 324002 19 201244632 於研缽中，使4. 5份胍化合物、0. 5份酯化合物、1份 合成之水合二氧化矽細粉、1份D0RILESB(商標名’Daiichi Sankyo Co.，Ltd.製造）凝聚劑與7份黏土充分混合，然後 以果汁機攪拌及混合。於所得混合物中，添加85· 5份切割 黏土，然後充分攪拌及混合，製得細粉調配物。 調配例5 8份胍化合物、3份酯化合物、35份含半量聚氧伸乙 基烷基醚硫酸銨鹽之白碳與54份水之混合物以濕磨法細 磨，製得調配物。 調配例6 於10份二氯曱烷中，使0.05份胍化合物與0. 1份酯 化合物溶解，所得溶液與89.85份異烧烴（isoparaffin) 溶劑（ISOPAR M，Exxon Chemical Co.，Ltd.之註冊商標） 混合，製得油溶液。 調配例7 將0.1份胍化合物、0.05份酯化合物與49.85份 Neothiozole (Chuo Kasei Co.，Ltd.)置入氣溶膠罐中。 安裝氣溶膠閥後，裝填25份二曱醚與25份LPG，然後振 盪及進一步安裝促動器，製得油性氣溶膠。 調配例8 將0. 5份胍化合物、0. 05份酯化合物、0. 01份BHT、 5份二曱苯、3. 44份脫臭煤油與1份乳化劑（Atmos 300， Atomos Chemical Co. Ltd.之註冊商標）之混合物，及50 份蒸餾水裝填入氣溶膠容器中，附接閥部件。接著，於加 324002 20 201244632 堅下、、生由該閥裝填40份推進劑（LPG)，製得水性氣溶膠。 調配例9 將於適量丙酮中溶解60 mg胍化合物與40 mg酯化合 物所製備之溶液與多孔陶瓷板（4. 〇cmx/|. 〇cm，厚度1. 2cm) 一起浸潰，得到加熱型燻蒸劑。 下述試驗例證實本發明有害生物防除組成物對有害生 物具有優越之防除效力。 試驗例1 撥拌〇. 1重量份KELZAN S (CP Kelco之商標，黃原 膠）、0.2 重量份 VEEGUM Granules (R.T. VanderbiltKetone), polyacrylic acid, BHT (2,6-di-tert-butyl-4-methylphenol), BHA (2-tert-butyl-4-methoxyphenol and 3_t-butyl _4 a mixture of monooxyphenols). Examples of the mosquito-repellent base material include a mixture of a vegetable powder (e.g., wood powder and a pesticidal Lexi T) and a binder [e.g., red nan (a), a powder of gluten and gluten. Examples of the electric mosquito-repellent substrate include cotton linters, entangled, compacted into a plate shape, and mixed cotton linters and paper gathered, entangled, and compacted into a plate shape. Examples of the self-burning type of flue gas-curing agent substrate include combustion-generating agents such as oleic acid salt, nitrite, cerium salt, potassium oxychloride, nitrocellulose, ethyl cellulose, and wood powder; pyrolysis accelerators such as alkali Metal salts, alkaline earth metal salts, dichromates and chromates, oxygen donors such as cerium nitrate; combustion improvers such as melamine and wheat starch; fillers such as diatomaceous earth; binders such as synthetic adhesives. Examples of the chemically reactive fumigant substrate include a heat generating agent such as an alkali metal sulfide, a polysulfide and a sulfur hydride, a calcium oxide; a catalyst such as a carbonaceous material, iron carbide and activated clay; and an organic foaming agent such as azo Dimethylamine, benzenesulfonamide, dinitro-amyltetramine, polystyrene and polyurethane; and fillers such as natural fibers and synthetic fibers. 'Examples of resins used for, for example, resin fumigants include polyethylene resins such as low density polyethylene, linear low density polyethylene and high density polyethylene 324002 15 201244632; ethylene vinyl ester copolymers such as ethylene-acetic acid B a dilute ester copolymer; an ethylene-mercapto acrylate copolymer such as an ethylene-mercaptopropionate copolymer and an ethylene-ethyl methacrylate copolymer; an ethylene-acrylate copolymer such as ethylene-decyl acrylate Copolymer and ethylene-ethyl acrylate copolymer; ethylene-ethylene carboxylic acid copolymer such as ethylene-acrylic acid copolymer; ethylene-tetracyclododecene copolymer; polypropylene resin such as propylene homopolymer and propylene-B Dilute copolymer; poly-4-mercapto pentazol-1; polybutene-1; polybutylene; polystyrene; acrylonitrile-styrene resin; styrene elastomer such as acrylonitrile-butadiene-benzene a vinyl resin, a styrene-conjugated diene block copolymer and a hydrogenated styrene-conjugated diene block copolymer; a fluoroplastic; an acrylic resin such as polymethyl methacrylate; a polyamide resin such as nylon 6 and Nylon 66; polyester tree For example, polyethylene terephthalate, polyethylene naphthalate, butylene dibutylene terephthalate and poly(p-phenylene terephthalate); polycarbonate; polyacetal; Polypropylene phthalate; polyarylate; polyhydroxybenzoate; polyether oximine; polyester carbonate; polyphenylene ether resin; polyvinyl chloride; polyvinylidene chloride; and polyurethane. They may be used alone or in a mixture thereof. Further, if necessary, plasticizers such as phthalic acid esters (for example, dinonyl phthalate and dioctyl phthalate), adipates and stearic acid may be added to the substrates. . The resin fumigant is prepared by kneading a ruthenium compound and an ester compound into a substrate, followed by injection molding, extrusion molding or molding. If necessary, the obtained resin formulation can be further processed by, for example, molding and cutting, and processed into a sheet shape, a film, a belt shape, a mesh shape or a wire shape. These resin formulations can be processed into, for example, animal collars, animal ear tags, sheet formulations, guide tapes, and horticultural supports. 324002 16 201244632 Examples of bait substrates include feed ingredients such as tantalum powder, vegetable oil, sugars and crystalline cellulose; antioxidants such as dibutylhydroxytoluene and pro-dihydroguaiac acid; preservatives such as dehydroacetic acid; preventing children and pets Ingested preparations such as red pepper powder; and spices that attract harmful organisms such as milky spices, onion flavors and peanut oil. The pest control method of the present invention is carried out by applying the pest control composition of the present invention to a pest and/or a pest habitat; the pest control method of the present invention is also harmful by separately applying a hydrazine compound and an ester compound. Biological and/or pest habitats are carried out. In particular, the following methods can be exemplified as the application method of the pest control composition of the present invention, and the methods can be appropriately selected according to the pest control composition form, application position, and the like of the present invention. (1) The pest control composition of the present invention is applied as it is to a pest or a pest. (2) The pest control composition of the present invention is diluted with a solvent (e.g., water) and then applied to a pest or pest habitat. In this case, the pest control composition of the present invention, which is, for example, an emulsifiable concentrate, a wettable powder, a suspension concentrate or a microcapsule preparation, is diluted, so that the total concentration of the hydrazine compound and the ester compound becomes 0. 1 to 50000 ppm. (3) Heating the pest control composition of the present invention in a pest habitat to evaporate the active ingredient. In this case, the application rate and concentration of the hydrazine compound and the ester compound can be appropriately determined depending on, for example, the form of the pest control composition of the present invention, the administration period, the application position of 324002 17 201244632, the application method, the damage condition, and the like. When the pest control composition of the present invention is used for preventive use, the application rate is in the case of application to the space, and the total amount of the bismuth compound and the ester compound is δ'* is o.oooi to mg/m3; At this time, it is 0.0001 to 1 〇〇〇mg/m, and a heating evaporation formulation such as a mosquito coil and an electric mosquito-repellent patch is applied by appropriately heating the formulation to evaporate the active ingredient. Non-heated fumigants such as resin fumigants, paper cans, steamed tablets, non-woven fabric fumigants, knit fumigants and flake fumigants, for example, can be placed in the space to be applied , or when using the hair supply for a preventive use, examples of the location where the pest control composition of the present invention is applied include a closet, a dressing table, a chest of drawers, a closet, a cabinet, a toilet, a bathroom, a storage room, a living room, a dining room, Warehouse and car. Further, the pest control composition of the present invention can also be applied to an outdoor open space. Veterinary use can be used when using the pest control composition of the present invention to prevent parasites on the surface of livestock such as cattle, horses, pigs, sheep, goats and chickens, and small animals such as dogs, cats, rats and mice. The method known above. In particular, when used for systemic control, the formulation is administered, for example, in the form of a lozenge, mixed in a feed, a suppository, and an injection (including intramuscular, subcutaneous, intravenous, and intraperitoneal injections); For non-systemic control, a collar or ear tag made by spraying a spray solution or an aqueous solution, pouring or spotting, washing the animal with a shampoo formulation, or placing a resin formulation on the animal. The total dose of the guanidine compound and the ester compound is usually in the range of 0.01 to 1 mg per kg of animal body weight. 324002 201244632 The present invention is described in more detail below by means of a formulation and a test example, but the invention is not intended to be limited to the embodiments. First, a formulation example of the pest control composition of the present invention will be described. In the formulation, unless otherwise stated, 'the number of copies' is by weight. Formulation Example 1 In 3 parts of diphenylbenzene and 37.5 parts of N,N-didecylguanamine, 0.9 parts of an anthracene compound and 9 parts of an ester compound were dissolved. To the resulting solution, 9.1 parts of polyoxyethylidene phenyl ether and 6 parts of calcium dodecanoate were added, followed by thorough mixing to obtain an emulsifiable concentrate. Formulation Example 2 To 20 parts of the hydrazine compound and 20 parts of the ester compound, 5 parts of SORP0L 5060 (registered trademark of TOHO Chemical Industry Co., Ltd.) was added, followed by thorough mixing. To the resulting mixture, 32 parts of CARPLEX #80 (registered trademark of Shionogi & Co., Ltd.; synthetic hydrated cerium oxide fine powder) and 23 parts of 300 mesh Shishizao soil were added, and then thoroughly mixed with a juice machine. , a wettable powder is prepared. 5。 In the compounding example 3, in 3 parts of the pulse compound and 0.3 parts of the compound, adding 5 parts of synthetic hydrated cerium oxide fine powder, 5 parts of sodium dodecyl benzene sulfonate, 30 parts of bentonite and 56.7 Part of the clay' is then thoroughly stirred and mixed. Next, an appropriate amount of water was added to the resulting mixture; the mixture was further stirred, granulated by a granulator, and air-dried to obtain a granulated preparation. Formulation Example 4 324002 19 201244632 In the mortar, 4.5 parts of hydrazine compound, 0.5 parts of ester compound, 1 part of synthetic hydrated cerium oxide fine powder, 1 part of D0RILESB (trade name 'Daiichi Sankyo Co., Ltd. . Manufacture) The coagulant is thoroughly mixed with 7 parts of clay and then stirred and mixed with a juice machine. To the resulting mixture, 85 5 parts of the cut clay was added, followed by thorough stirring and mixing to prepare a fine powder preparation. Formulation Example 5 A mixture of 8 parts of an anthraquinone compound, 3 parts of an ester compound, 35 parts of a white carbon containing a half amount of a poly(ethyloxyethyl ether) ammonium sulfate and 54 parts of water was finely ground by a wet grinding method to prepare a formulation. Formulation Example 6 In 10 parts of dichloromethane, 0.05 part of the hydrazine compound and 0.1 part of the ester compound were dissolved, and the resulting solution and 89.85 parts of isoparaffin solvent (ISOPAR M, Exxon Chemical Co., Ltd.) Registered trademark) Mix to prepare an oil solution. Formulation Example 7 0.1 part of a hydrazine compound, 0.05 part of an ester compound and 49.85 parts of Neothiozole (Chuo Kasei Co., Ltd.) were placed in an aerosol can. After the aerosol valve was installed, 25 parts of dioxane and 25 parts of LPG were charged, then oscillated and further mounted with an actuator to produce an oily aerosol. Formulation Example 8 0.5 parts of hydrazine compound, 0.05 part of ester compound, 0.01 part of BHT, 5 parts of diphenylbenzene, 3.44 parts of deodorized kerosene and 1 part of emulsifier (Atmos 300, Atomos Chemical Co. A mixture of the registered trademark of Ltd., and 50 parts of distilled water are filled into the aerosol container, and the valve parts are attached. Next, Yu Jia 324002 20 201244632 Kensui, and the valve was filled with 40 parts of propellant (LPG) to prepare an aqueous aerosol. Formulation Example 9 A solution prepared by dissolving 60 mg of an anthracene compound and 40 mg of an ester compound in an appropriate amount of acetone was impregnated with a porous ceramic plate (4. 〇cmx/|. 〇cm, thickness 1.2 cm) to obtain a heated fumigation. Agent. The following test demonstrates that the pest control composition of the present invention has superior control effects against harmful organisms. Test Example 1 Mixing 〇. 1 part by weight of KELZAN S (trademark of CP Kelco, xanthan gum), 0.2 parts by weight VEEGUM Granules (R.T. Vanderbilt
Company Inc.之註冊商標，矽酸鋁鎂）、〇· 2重量份Pr〇xel GXL (Avecia Inc.之註冊商標，防腐劑）與14. 5重量份離 子父換水之混合物1小時以製備溶液，於該溶液中添加 重量份離子交換水及1.5重量份Reax 910 (MeadWestvaco Coloration之商標，木質磺酸鈉）、ιι·45重量份離子交 換水、2 重量份 Soprophor FLK (Rhodia Japan Co. Ltd. 之商標’聚氧伸乙基二苯乙婦基苯基趟填酸鉀）、〇·〇5重 量份 ANTIFOAM C EMULSION (Dow Corning Corporation 之 商標，石夕酮系消泡劑）與10重量份脈化合物之混合物，混 合至得到含有10重量％胍化合物之稀釋液（下文稱為稀釋 液A) 〇 擾拌0.1重量份KELZAN S (CP Kelco之商標，黃原 膠）、0.2 重量份 VEEGUM Granules (R.T. Vanderbilta registered trademark of Company Inc., magnesium aluminum silicate), 〇 2 parts by weight of Pr〇xel GXL (registered trademark of Avecia Inc., preservative) and 14. 5 parts by weight of a mixture of ionomers for 1 hour to prepare a solution, To the solution were added parts by weight of ion-exchanged water and 1.5 parts by weight of Reax 910 (trademark of MeadWestvaco Coloration, sodium lignosulfonate), ιι·45 parts by weight of ion-exchanged water, and 2 parts by weight of Soprophor FLK (Rhodia Japan Co. Ltd.) Trademark 'Polyoxyethylidene diphenylethyl phenyl phenyl hydrazone potassium hydride, 〇·〇 5 parts by weight of ANTIFOAM C EMULSION (trademark of Dow Corning Corporation, sulphuric acid defoamer) and 10 parts by weight of pulse compound The mixture was mixed until a dilution containing 10% by weight of a ruthenium compound (hereinafter referred to as diluent A) was obtained, and 0.1 part by weight of KELZAN S (trademark of CP Kelco, xanthan gum), 0.2 parts by weight of VEEGUM Granules (RT Vanderbilt) was mixed.
Company Inc.之註冊商標’石夕酸鋁鎂）、〇· 2重量份proxei 324002 21 201244632 GXL (Avecia Inc.之註冊商標，防腐劑）與ι4. 5重量份離 子交換水之混合物1小時以製備溶液，於該溶液中添加25 重量份離子交換水及4重量份G〇hsen〇1 GL_〇5 (TheNipp〇nCompany Inc.'s registered trademark 'Aluminum Magnesium Aluminate', 〇· 2 parts by weight of proxei 324002 21 201244632 GXL (registered trademark of Avecia Inc., preservative) and ι. 5 parts by weight of ion-exchanged water mixture for 1 hour to prepare Solution, adding 25 parts by weight of ion-exchanged water and 4 parts by weight of G〇hsen〇1 GL_〇5 (TheNipp〇n)
Synthetic Chemical Industry Co.，Ltd.之註冊商標，聚 乙烯醇）、40. 98重量份離子交換水、5重量份丙二醇、〇 〇2 重量份 ANTIFOAM C EMULSION (Dow Corning c〇rp〇rati〇n 之商標，矽酮系消泡劑）、5重量份酯化合物與5重量份肉 豆蔻酸異丙酯之混合物，混合至得到含有5重量％酯化合物 之稀釋液（下文稱為稀釋液B)。 將稀釋液A、稀釋液b及/或純水混合，以製備含有指 定濃度（參照表1)胍化合物及/或酯化合物之各測試液組成 物。 在已於内壁塗覆奶油之測試容器（直徑：8.75cm，高： 7.5 cm，底部：16篩目金屬網）中放入十隻德國小蠊 ger/z/a/nca)成蟲（5隻公蠊與5隻母蝶成蟲）。 放置該容器於測試室（底面積：46 cm X 46 cm，高70 cm) 底部。使用喷霧槍（喷霧壓：0.4 kg/cro2)，從容器上側上 方60 cm高度處噴霧該液體組成物（0.7ml)。喷霧3〇秒後， 自測試室中取出容器。經一定時間後，計算被擊倒之見蟲 數及擊倒率。 結果，如表1之實施例1至4所示，於噴霧2分 之擊倒率顯示高達80。/“ .如表1之參考例！與參考例2所 示，於噴霧2分鐘後之擊倒率分別顯示3·3 %與37 %。 324002 22 201244632 [表l] 活性成分濃度 項目 (%(重量/容積）） 胍化合物 酉旨化合物 實施例1 0.2 0. 05 實施例2 0.2 0. 1 實施例3 0. 2 0. 2 實施例4 0. 5 0. 05 參考例1 0. 2 — 參考例2 0. 05 試驗例2 製備經丙酮稀釋之溶液，俾使得玻璃板上係施用表2 所示預定劑量之胍化合物與目旨化合物。於直徑7 cm之玻璃 培養皿底面均勻處理該經丙酮稀釋之溶液（0.5 ml)，予以 風乾。以袋狀吸氣器收集十隻常見蚊[尖音庫蚊淡色變種 母蚊成嘉，將其置入該培養皿 中，蓋上聚氯乙烯製透明板，強迫其與經處理之玻璃培養 孤底面接觸。 覆蓋三分鐘後，將該等常見蚊釋入尼龍籠（大小：16. 5 cmxl5. 5cmx22cm)中。釋放一定時間後，計算被擊倒之昆蟲 數及擊倒率。 45分鐘後之擊倒率示於表2。 324002 23 201244632 [表2] 項目 脈化合物之劑量 (mg/板） 酯化合物之劑量 (mg/板） 45分鐘後之 擊例率（％) 實施例5 0. 002 0.0001 70 實施例6 0.0005 0.0001 60 實施例7 0.0003 0.0001 30 實施例8 0.00225 0.0001 40 參考例3 0.0002 — 20 參考例4 — 0.0001 20 工業應用性 由於本發明有害生物防除組成物具有優越之防除效 力，因此本發明對業界有所助益。 【圖式簡單說明】 無。 【主要元件符號說明】 無。 324002 24Synthetic Chemical Industry Co., Ltd. registered trademark, polyvinyl alcohol), 40.98 parts by weight of ion-exchanged water, 5 parts by weight of propylene glycol, 〇〇 2 parts by weight of ANTIFOAM C EMULSION (Dow Corning c〇rp〇rati〇n A mixture of 5 parts by weight of an ester compound and 5 parts by weight of isopropyl myristate was mixed to obtain a diluted solution containing 5% by weight of an ester compound (hereinafter referred to as diluent B). The diluent A, the diluent b, and/or the pure water are mixed to prepare a test liquid composition containing the quinone compound and/or the ester compound at a specified concentration (refer to Table 1). In the test container (diameter: 8.75 cm, height: 7.5 cm, bottom: 16 mesh metal mesh) which has been coated with cream on the inner wall, put ten German cockroaches ger/z/a/nca) adults (5 males)蠊 with 5 female butterflies adults). Place the container in the bottom of the test chamber (bottom area: 46 cm X 46 cm, height 70 cm). The liquid composition (0.7 ml) was sprayed from a height of 60 cm above the upper side of the container using a spray gun (spray pressure: 0.4 kg/cro2). After spraying for 3 seconds, the container was taken out of the test chamber. After a certain period of time, the number of knocked down insects and the knockdown rate are calculated. As a result, as shown in Examples 1 to 4 of Table 1, the knockdown rate at the spray of 2 points was as high as 80. / " As shown in Table 1! As shown in Reference Example 2, the knockdown rate after 2 minutes of spraying showed 3% and 37%, respectively. 324002 22 201244632 [Table 1] Active ingredient concentration item (% ( Weight/volume)) 胍 compound 酉 compound Example 1 0.2 0. 05 Example 2 0.2 0. 1 Example 3 0. 2 0. 2 Example 4 0. 5 0. 05 Reference Example 1 0. 2 - Reference Example 2 0. 05 Test Example 2 A solution diluted with acetone was prepared, and the predetermined amount of the ruthenium compound and the target compound shown in Table 2 were applied to the glass plate. The acetone was uniformly treated on the bottom surface of a glass culture dish having a diameter of 7 cm. The diluted solution (0.5 ml) was air-dried. Ten common mosquitoes were collected in a bag-shaped aspirator [K. sinensis, a light-colored mutant mother mosquito, which was placed in the petri dish and covered with polyvinyl chloride. The plate is forced to contact the isolated bottom surface of the treated glass culture. After covering for three minutes, the common mosquitoes are released into a nylon cage (size: 16.5 cmxl 5. 5 cm x 22 cm). After a certain period of time, the calculation is knocked down. The number of insects and the knockdown rate. The knockdown rate after 45 minutes is shown in Table 2. 324002 23 20 1244632 [Table 2] Dose of the compound vein compound (mg/plate) Dose of the ester compound (mg/plate) Shot rate after 45 minutes (%) Example 5 0. 002 0.0001 70 Example 6 0.0005 0.0001 60 Example 7 0.0003 0.0001 30 Example 8 0.00225 0.0001 40 Reference Example 3 0.0002 - 20 Reference Example 4 - 0.0001 20 Industrial Applicability The present invention is advantageous to the industry because of the superior control effect of the pest control composition of the present invention. Simple description of the schema] None. [Key component symbol description] None. 324002 24