201216998 六、發明說明： 【發明所屬之技術領域】 本發明涉及化妝品的技術領域。 【先前技術】 基丙烯酸酯）具 文獻1:日本特 本申請者發現了聚（曱氧基聚乙二醇甲 有的保濕性’並申請了化妝品的專利（專利 開 2003-171257 號公報）。 品的技術。 但是’需要進一步提供保濕性高的化妝 現有技術文獻 專利文獻 專利文獻1日本特開2003-171257號公報 【發明内容】201216998 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to the technical field of cosmetics. [Prior Art] Acrylate] Document 1: Japanese Patent Application No. 2003-171257 (Patent No. 2003-171257). However, there is a need to further provide a makeup having a high moisture retention property. Patent Document 1 Patent Publication No. 2003-171257 [Summary of the Invention]
本發明的課題是，提高含有聚（曱氧基聚乙二醇甲基丙 烯酸酯）的化妝品的保濕性。 A 本發明的主要構成如下所述。 (1) 一種化妝品，其特徵在於，含有聚（甲氧基聚乙二 醇曱基丙烯酸酯）（A)和聚氧伸乙基甲基葡萄糖皆（B)。 (2) —種保濕化妝品，其特徵在於，含有聚（甲氧基聚 乙二醇甲基丙烯酸酯）（A)和聚氧伸乙基曱基葡萄糖香（B)。 (3) 根據（1)或（2)所述的化妝品，其特徵在於，聚（甲 氧基聚乙二醇曱基丙烯酸酯）（A)，其基於聚苯乙烯換算的 數均分子量為1000至100000。 (4) 根據（1)至（3)中任一項所述的化妝品，其特徵在 於，聚氧伸乙基曱基葡萄糖苷（B)為曱基葡萄糖的聚乙二醇 323551 3 201216998 醚，用以下化學式表示。 CH3C6Hl0〇5(OCHzCH2)nOH n=5 至 30 本發明可提供··藉由塗抹於皮膚表面上，使角質層的 水分量增高，並抑制皮膚表面的水分蒸散量，因而保濕性 優異的化妝品。藉由將聚（曱氧基聚乙二醇曱基丙烯酸酯） 和聚氧伸乙基甲基葡萄糖苷組合，確認可提高保濕性，具 有改善皮膚粗縫、防止皮膚粗縫的效果。 【實施方式】 適用於本發明的聚（甲氧基聚乙二醇甲基丙烯酸酯）是 使曱氧基聚乙一醇甲基丙烯酸g旨均聚而得到的聚合物。 甲氧基聚乙二醇甲基丙稀酸酯，例如可藉由使聚乙二 醇曱基醚和曱基丙烯醯氯反應而得到。此外，也有一部分 作為試劑而市售。例如可將由新中村化學工業株式會社市 售的 NK Ester M-230G(n〜23)、M Ester M-90G(n〜9), 由日油株式會社市售的Blemmer PME-1000(ne23)、Biemmer* PME-400(n~9)、Blemmer PME-200(n^4)作為單體使用。接 著對於聚合物的製造方法，根據通常方法即可，藉由在容 劑中在聚合起始劑的存在下使單體反應而得到。 以下表示本發明涉及的聚（甲氧基聚乙二 酸酯）的合成例。 烯 乙基 合成例1聚（甲氧基聚乙二醇甲基丙烯酸酯）（聚氧伸 鏈的平均聚合度為4.5) 在100ml茄型燒瓶中稱取聚合起始劑偶氮二異丁腈An object of the present invention is to improve the moisture retention of a cosmetic containing poly(decyloxy polyethylene glycol methyl acrylate). A The main constitution of the present invention is as follows. (1) A cosmetic comprising poly(methoxypolyethylene glycol methacrylate) (A) and polyoxyethylidene methyl glucose (B). (2) A moisturizing cosmetic comprising poly(methoxy polyethylene glycol methacrylate) (A) and polyoxyethylidene glucosamine (B). (3) The cosmetic according to (1) or (2), wherein the poly(methoxypolyethylene glycol methacrylate) (A) has a number average molecular weight of 1,000 in terms of polystyrene. To 100,000. (4) The cosmetic according to any one of (1) to (3), wherein the polyoxyethylidene glucoside (B) is a thioglycolic polyethylene glycol 323551 3 201216998 ether, It is represented by the following chemical formula. CH3C6H10 〇5 (OCHzCH2) nOH n = 5 to 30 The present invention provides a cosmetic which is excellent in moisture retention by being applied to the surface of the skin to increase the moisture content of the stratum corneum and suppress the amount of water evapotranspiration on the surface of the skin. By combining poly(decyloxy polyethylene glycol methacrylate) and polyoxyethylidene ethyl glucoside, it was confirmed that the moisturizing property can be improved, and the effect of improving the rough skin and preventing the skin from being sagged. [Embodiment] Poly(methoxypolyethylene glycol methacrylate) which is suitable for use in the present invention is a polymer obtained by homopolymerizing methoxypolyethyl methacrylate methacrylic acid. The methoxypolyethylene glycol methyl acrylate can be obtained, for example, by reacting poly(ethylene glycol decyl ether) with mercapto acrylonitrile. In addition, some are commercially available as reagents. For example, NK Ester M-230G (n~23) and M Ester M-90G (n~9), which are commercially available from Shin-Nakamura Chemical Co., Ltd., are commercially available from Nippon Oil Co., Ltd., Blemmer PME-1000 (ne23), Biemmer* PME-400 (n~9) and Blemmer PME-200 (n^4) are used as monomers. Next, the method for producing the polymer can be obtained by reacting a monomer in the presence of a polymerization initiator in a solvent according to a usual method. The synthesis examples of the poly(methoxypolyethylenedicarboxylate) according to the present invention are shown below. Ethyl Ethyl Synthesis Example 1 Poly(methoxypolyethylene glycol methacrylate) (average degree of polymerization of polyoxyalkylene chain is 4.5) The polymerization initiator azobisisobutyronitrile was weighed in a 100 ml eggplant type flask.
323551 S 4 201216998 (AIBN)0.0306g，用氬氣將燒瓶内置換3次後，加入30ml 蒸餾苯在室溫下攪拌至AIBN溶解。在其中加入聚乙二醇曱 基醚甲基丙烯酸酯（PEG的平均聚合度為4. 5)5ml，在60°C 加熱48小時，接著在70°C加熱24小時進行聚合。然後停 止聚合回收目標物。 合成例2聚（曱氧基聚乙二醇甲基丙烯酸酯）（聚氧伸乙基 鏈的平均聚合度為9) 在100ml茄型燒瓶中稱取聚合起始劑偶氮二異丁腈 (AIBN)0.0403g，用氬氣將燒瓶内置換3次後，加入30ml 蒸餾苯在室溫下攪拌至AIBN溶解。在其中加入聚乙二醇甲 基醚曱基丙烯酸酯（PEG的平均聚合度為9)5ml，在60°C加 熱48小時，接著在70°C加熱24小時進行聚合。然後停止 聚合回收目標物。 合成例3聚（曱氧基聚乙二醇曱基丙烯酸酯）（聚氧伸乙基 鏈的平均聚合度為22. 7) 在100ml茄型燒瓶中稱取聚合起始劑偶氮二異丁腈 (AIBN)O. 00753g，用氬氣將燒瓶内置換3次後，加入30ml 蒸餾苯在室溫下攪拌至AIBN溶解。在其中加入聚乙二醇甲 基醚曱基丙烯酸酯（PEG的平均聚合度為22. 7)5ml，在60°C 加熱48小時，接著在70°C加熱24小時進行聚合。然後停 止聚合回收目標物。 使用GPC測定得到的聚（甲氧基聚乙二醇甲基丙烯酸 酯）的分子量。其結果為：合成例1的分子量，基於聚苯乙 烯換算的數均分子量Mn=13800、重均分子量Mw=40400 ;合 5 323551 201216998 成例2的分子量，基於聚苯乙烯換算的數均分子量 Mn\15j63、重均分子量Mw=3568〇 ;合成例3的分子量基 於聚苯乙婦換算的數均分子量Mn=83〇〇、重均分子量黯二 10000。 如上所述得到的本發明涉及的聚（甲氧基聚乙二醇甲 基丙烯酸酯）的分子量，可根據其使用目的進行各種調整。 但通常情況下基於聚苯乙烯換算為1〇〇〇以上1〇〇⑽〇以 下，優選為2500以上looooo以下。在本發明的化妝品中， 相對於化妝品總量通常在〇· 〇5至20質量％的範圍含有上述 聚合物。 低於0.05質量％時有時保濕性不充分，大於2〇質量％ 時，由於黏腻故不優選。 本發明中使用的聚氧伸乙基曱基葡萄糖苷為甲基葡萄 糖的聚乙二醇醚，用以下化學式表示。323551 S 4 201216998 (AIBN) 0.0306g, after replacing the inside of the flask three times with argon, 30 ml of distilled benzene was added thereto, and the mixture was stirred at room temperature until the AIBN was dissolved. 5 ml of polyethylene glycol oxime ether methacrylate (having an average degree of polymerization of PEG of 4.5) was added thereto, and the mixture was heated at 60 ° C for 48 hours, followed by heating at 70 ° C for 24 hours to carry out polymerization. Then stop the polymerization to recover the target. Synthesis Example 2 Poly(decyloxy polyethylene glycol methacrylate) (the average degree of polymerization of the polyoxyethylene chain was 9) The polymerization initiator azobisisobutyronitrile was weighed in a 100 ml eggplant type flask ( AIBN) 0.0403 g, after replacing the inside of the flask three times with argon, 30 ml of distilled benzene was added and stirred at room temperature until the AIBN was dissolved. 5 ml of polyethylene glycol methyl ether decyl acrylate (having an average degree of polymerization of PEG of 9) was added thereto, and the mixture was heated at 60 ° C for 48 hours, followed by heating at 70 ° C for 24 hours to carry out polymerization. Then stop the polymerization to recover the target. Synthesis Example 3 Poly(decyloxypolyethylene glycol methacrylate) (the average degree of polymerization of the polyoxyethylene chain was 22.7). The polymerization initiator azobisisoindole was weighed in a 100 ml eggplant type flask. Nitrile (AIBN) O. 00753 g, after replacing the inside of the flask three times with argon, 30 ml of distilled benzene was added and stirred at room temperature until the AIBN was dissolved. 5 ml of polyethylene glycol methyl ether decyl acrylate (having an average degree of polymerization of PEG of 22.7) was added thereto, and the mixture was heated at 60 ° C for 48 hours, followed by heating at 70 ° C for 24 hours to carry out polymerization. Then stop the polymerization to recover the target. The molecular weight of the obtained poly(methoxypolyethylene glycol methacrylate) was measured by GPC. As a result, the molecular weight of Synthesis Example 1 was a polystyrene-equivalent number average molecular weight Mn=13,800, and a weight average molecular weight Mw=40,400; 5,323,551,201216998, the molecular weight of Example 2, a polystyrene-equivalent number average molecular weight Mn \15j63, weight average molecular weight Mw = 3568 〇; the molecular weight of Synthesis Example 3 is based on polystyrene-converted number average molecular weight Mn = 83 〇〇, weight average molecular weight 黯 10000. The molecular weight of the poly(methoxypolyethylene glycol methacrylate) according to the present invention obtained as described above can be variously adjusted depending on the purpose of use. However, in general, it is 1 〇〇〇 or more and 1 〇〇 (10) 基于 or less based on polystyrene, and preferably 2500 or more. In the cosmetic of the present invention, the above polymer is usually contained in an amount of from 5 to 20% by mass based on the total amount of the cosmetic. When the amount is less than 0.05% by mass, the moisture retaining property may be insufficient, and when it is more than 2% by mass, it is not preferable because it is sticky. The polyoxyethylidene glucoside used in the present invention is a polyethylene glycol ether of methyl glucoside, which is represented by the following chemical formula.
CH3C6Hl〇〇5(OCH2CH2)nOH 在此，氧伸乙基的聚合度η優選為5至30。 聚氧伸乙基曱基葡萄糖苷可使用市售品。作為氧伸乙 基的平均聚合度η為10、化妝品的成分表示名稱為甲基葡 糖醇聚醚-10(methyl gluceth-ΙΟ)的聚氧伸乙基曱基葡萄 糖苷，可使用日本油脂製：MACBIOBRIDE MG-10E、Noveon 製：GLUCAME E-10 。 作為氧伸乙基的平均聚合度η為20、化妝品的成分表 示名稱為甲基葡糖醇聚醚-20的聚氧伸乙基甲基葡萄糖 苷，可使用日本油脂製：MACBIOBRIDEMG-20E、Noveon製： 6 323551 g 201216998 GLUCAME E-20 。 聚氧伸乙基曱基葡萄糖苷的調配量，優選相當於總化 妝品為0. 05質量％以上10. 0質量％以下。低於0. 05質量％ 時有時保濕性不充分，大於10.0質量％時，由於黏腻故不 優選。 在本發明的化妝品中可調配通常化妝品中使用的成 分，可含有多元醇、糖、油劑、表面活性劑、水溶性高分 子、有機粉體、無機粉體、香料、pH調節劑、防腐劑、維 生素等美容成分。 本發明的化妝品主要適用於皮膚，具有皮膚保濕效 果，如果是皮膚外用劑也包含醫藥部外品。 作為本發明的化妝品的劑型，可例舉化粧水、乳液、 面霜、水性凝膠、面膜等，關於乳化劑型，可以為水包油 乳化劑、油包水乳化劑中的任一種。 實施例 (角質層水分量測定） 1.實驗方法 用洗手肥皂泡沫擦洗前臂内側部10次，再用溫水沖洗 10秒。 將前臂的水分擦去，在23°C、相對濕度為36%的環境 下安靜保持20分鐘。 在左右前臂上分別標記出3個2. 5cmx2. 5cm的區域， 將表1中記載的6種試樣依次塗布，依次測定在塗布後20 分鐘、40分鐘、60分鐘、80分鐘、100分鐘、120分鐘後 7 323551 201216998 的角質層水分量。此外，將無塗布部位作為對照 質層水分量。 θ 試樣的塗布方法為，將則載於精密電子天平上，稱 取試樣lGmg’使用該刮片將其塗布於2 5αηχ2. 5cm的區域。 使用IBS公司製SKICON-200，在各區域分別測定5次 角質層水分量，進行平均。 表1 (1) 11質量％聚氧伸乙基甲基葡萄糖苷※）水溶液 (2) 10質量％聚氧伸乙基曱基葡萄糖苷※） + 1質量％聚（曱氧基聚乙二醇甲基丙稀酸醋）水溶液 (3) 11質量!《二丙二醇（DPG)水溶液 (4) 10質量％二丙二醇（DPG) + 1質量％聚（甲氧基聚乙二醇甲基丙烯酸酯）※※）水溶液 (5) 11質量％ 1,3-丁二醇（BG)水溶液 (6) 10 質量！1, 3-丁二醇（BG) + 1質量％聚（甲氧基聚乙二醇甲基丙烯酸酯）※※）水溶液 ※:）日本油脂製：MACBIOBRIDE MG-10E ※※）合成例2的高分子 2.結果 改變試樣塗布區域的位置，將相同的試驗重復2次。 測定第1次的結果如表2所示，測定第2次的結果如表3 所示。確認2次具有相同的趨勢。此外，第1次的結果在 第1圖中用坐標圖來表示。 聚氧伸乙基曱基葡萄糖苷、二丙二醇（DPG)、1，3-丁二 8 323551CH3C6Hl〇〇5(OCH2CH2)nOH Here, the degree of polymerization η of the oxygen-extended ethyl group is preferably from 5 to 30. A commercially available product can be used as the polyoxyethylidene glucoside. The average degree of polymerization η of the oxygen-extended ethyl group is 10, and the component of the cosmetic product is a polyoxyethylidene glucoside of the name methyl gluceth-indole, which can be prepared using Japanese fats and oils. : MACBIOBRIDE MG-10E, manufactured by Noveon: GLUCAME E-10. The average degree of polymerization η of the oxygen-extended ethyl group is 20, and the component of the cosmetic represents a polyoxyethylidene methyl glucoside of the name methylglycol-20, which can be made using Japanese fat: MACBIOBRIDEMG-20E, Noveon System: 6 323551 g 201216998 GLUCAME E-20. The content of the polyoxyethylidene glucoside is preferably 0. 05% by mass or more and 1.0% by mass or less. When the amount is less than 0.05% by mass, the moisture retention may be insufficient. When the amount is more than 10.0% by mass, it is not preferable because it is sticky. The component used in the usual cosmetics may be blended in the cosmetic of the present invention, and may contain a polyol, a sugar, an oil agent, a surfactant, a water-soluble polymer, an organic powder, an inorganic powder, a fragrance, a pH adjuster, and a preservative. Beauty ingredients such as vitamins. The cosmetic of the present invention is mainly applied to the skin and has a skin moisturizing effect, and if it is a skin external preparation, it also contains a pharmaceutical external product. The dosage form of the cosmetic of the present invention may, for example, be a lotion, an emulsion, a cream, an aqueous gel or a mask, and the emulsifier may be either an oil-in-water emulsifier or a water-in-oil emulsifier. EXAMPLES (Measurement of water content in the stratum corneum) 1. Experimental method The inner side of the forearm was scrubbed 10 times with hand soap foam and rinsed with warm water for 10 seconds. The moisture of the forearm was wiped off and kept quiet for 20 minutes at 23 ° C and a relative humidity of 36%. Three areas of 2.5 cmx2. 5 cm were marked on the left and right forearms, and the six kinds of samples described in Table 1 were sequentially applied, and the measurement was sequentially performed at 20 minutes, 40 minutes, 60 minutes, 80 minutes, and 100 minutes after application. The water content of the stratum corneum after 12 minutes of 7 323551 201216998. Further, the uncoated portion was used as the control layer moisture content. The θ sample is applied to a precision electronic balance, and the sample is applied to a region of 2 5αηχ2. 5 cm. Using the SKICON-200 manufactured by IBS, the water content of the stratum corneum was measured five times in each region and averaged. Table 1 (1) 11% by mass of polyoxyethylene methyl glucoside ※) Aqueous solution (2) 10% by mass of polyoxyethylidene glucoside *) + 1% by mass of poly(decyloxy polyethylene glycol) Aqueous solution of methyl acrylate (3) 11 mass! "Dipropylene glycol (DPG) aqueous solution (4) 10% by mass of dipropylene glycol (DPG) + 1% by mass of poly(methoxy polyethylene glycol methacrylate) ※※)Aqueous solution (5) 11% by mass 1,3-butanediol (BG) aqueous solution (6) 10 Quality! 1, 3-butanediol (BG) + 1% by mass of poly(methoxypolyethylene glycol methacrylate) ※※) Aqueous solution ※:) Japanese fats and oils: MACBIOBRIDE MG-10E ※※) Synthesis Example 2 Polymer 2. Results The position of the sample application area was changed, and the same test was repeated twice. The results of the first measurement are shown in Table 2, and the results of the second measurement are shown in Table 3. Confirm that 2 times have the same trend. Further, the first result is shown by a graph in Fig. 1 . Polyoxyethylene ethyl glucoside, dipropylene glycol (DPG), 1,3-butyl 2 323551
S 201216998 醇（BG)均為保濕劑，但確認與聚（曱氧基聚乙二醇曱基丙烯 酸醋）並用時的角質層水分量的增加效果卻不同。關於 DPG、BG，即使分別與聚（曱氧基聚乙二醇甲基丙烯酸酯） 並用，角質層水分量也幾乎無變化。認為單獨使用聚（曱氧 基聚乙二醇曱基丙烯酸酯）時沒有增加角質層水分量的效 果。另一方面，將聚氧伸乙基曱基葡萄糖苷和聚（曱氧基聚 乙二醇曱基丙烯酸酯）並用時角質層水分量顯著增大。 表2 試樣 角質層水分量 測定第1次 無塗佈 塗佈30 分錢後 塗佈60 分鐘後 塗佈90 分鐘後 塗佈120 分餚後 (1) 聚氧伸乙基甲基葡萄糖苷 (11¾) 43.6(3.5) 163.0(14.8) 116.2(9.1) 89.0(11.0) 101.2(8. 7) (2) 聚氡伸乙基甲基葡萄糖苷 (10¾) +合成例2的高分子（1%) 54. 0(3. 7) 174.8(17.6) 130.4(8.3) 116.4(7.8) 125. 8(9.8) (3) DPG(m) 55.8(2.3) 131.61(19.4) 72.2(7.5) 67.2(5.5) 73.4(9.1) (4) DPG ⑽） +合成例2的高分子（1¾) 54.0(2.6) 138. 8(5.0) 71.8(6.4) 59.8(6.1) 65.2(6.2) (5) BG(11%) 43.6(0.9) 75.6(5.9) 54.8(3.0) 51.6(2.2) 62.6(2.1) (6) BG(IOK) +合成例2的高分子(1%) 41.2(2.1) 59.6(5. 2) 54.6(3.2) 60.0(1.4) 64.0(2.1) (7) 對照 50.6(2.2) 55.4(2.8) 56.6(1.7) 56.6(3.2) 63. 6(3. 2) 單位： ( )内的數值表示標準偏差 9 323551 201216998 表3 試樣 角質層水分量 測定第2次 無塗佈 塗佈30 分餚後 塗佈60 分錢後 塗佈90 分錄後 塗佈120 分鈸後 (1) 聚氧伸乙基甲基葡萄糖苷 (11¾) 39. 8(1.5) 159.8(17.3) 137.8(10.7) 122.2(9. 9) 107.6(8.2) (2) 聚氧伸乙基甲基葡萄糖苷 (10¾) +合成例2的高分子（1¾) 40.2(2.5) 179.4(12.2) 158(10.7) 142(11.8) 150(29.8) (3) DPG(1196) 42.4(2.3) 45.0(2.2) 48.8(1.9) 51.2(2.1) 52.2(5.8) (4) DPG(IO^) +合成例2的高分子（1¾) 40.6(4.6) 140. 8(17.8) 82.8(4.3) 79.4(10.7) 76.0(7.8) (5) BG01%) 43.0(1.0) 142.8(18.1) 76. 4(3. 7) 68. 8(5.4) 65. 2(7. 2) (6) BG(IOK) +合成例2的高分子（1¾) 34.4(2.8) 62.6(3.8) 50.0(5. 1) 43.6(4.2) 45.8(6.8) (7) 對照 45.6(2.2) 71.6(8.4) 60.2(6.8) 54.6(1.8) 64.6(3.3) 單位： ( )内的數值表示標準偏差 (水分蒸散量測定） 1.實驗方法 在面霜瓶（開口部直徑為4cm)中加入純淨水10mL。 在瓶子的邊緣塗上漿糊後黏接濾紙（No. 2)。 在遽紙的中心部滴入0. 5mL的試樣。試樣在整個濾、紙 上自然展開。試樣如表4所示。 使用精密電子天平測定將試樣滴入濾紙後的面霜瓶的 總重量。 在恆溫恆濕房（23至24°C、相對濕度33°/〇中放置6小 時，測定面霜瓶的總重量，根據與原來重量之差求出水分 蒸散量。 10 323551 201216998 表4 1 水（空白） 2 20質量％聚氧伸乙基曱基葡萄糖苷※） + 0.5質量％合成例1的高分子水溶液 3 20質量％聚氧伸乙基曱基葡萄糖苷※） + 0.5質量％合成例2的高分子水溶液 4 20質量％聚氧伸乙基曱基葡萄糖苷※） + 0. 5質量％合成例3的高分子水溶液 5 20質量％聚氧伸乙基曱基葡萄糖苷※） + 0.5質量％透明質酸※）※）水溶液S 201216998 Alcohol (BG) is a humectant, but it is confirmed that the effect of increasing the water content of the stratum corneum when used in combination with poly(decyloxy polyethylene glycol methacrylate) is different. Regarding DPG and BG, even if they are used together with poly(decyloxy polyethylene glycol methacrylate), the water content of the stratum corneum hardly changes. It is considered that the use of poly(decyloxypolyethylene glycol methacrylate) alone does not increase the effect of the moisture content of the stratum corneum. On the other hand, when the polyoxyethylidene glucoside and the poly(decyloxy polyethylene glycol methacrylate) are used together, the water content of the stratum corneum is remarkably increased. Table 2 Determination of the water content of the stratum corneum of the sample No. 1 coating application after 30 minutes of coating without coating for 60 minutes, coating for 90 minutes and then coating 120 minutes of food (1) Polyoxyethylene methyl glucoside ( 113⁄4) 43.6 (3.5) 163.0 (14.8) 116.2 (9.1) 89.0 (11.0) 101.2 (8. 7) (2) Polyethyl glucoside (103⁄4) + polymer of Synthesis Example 2 (1%) 54. 0(3. 7) 174.8(17.6) 130.4(8.3) 116.4(7.8) 125. 8(9.8) (3) DPG(m) 55.8(2.3) 131.61(19.4) 72.2(7.5) 67.2(5.5) 73.4 (9.1) (4) DPG (10)) + Polymer of Synthesis Example 2 (13⁄4) 54.0 (2.6) 138. 8 (5.0) 71.8 (6.4) 59.8 (6.1) 65.2 (6.2) (5) BG (11%) 43.6 (0.9) 75.6 (5.9) 54.8 (3.0) 51.6 (2.2) 62.6 (2.1) (6) BG (IOK) + Polymer of Synthesis Example 2 (1%) 41.2 (2.1) 59.6 (5.2) 54.6 (3.2 60.0(1.4) 64.0(2.1) (7) Control 50.6(2.2) 55.4(2.8) 56.6(1.7) 56.6(3.2) 63. 6(3. 2) Unit: The value in ( ) indicates the standard deviation 9 323551 201216998 Table 3 Determination of the water content of the stratum corneum of the sample, the second coating without coating, after 30 minutes of application, after coating for 60 cents, after coating 90 minutes, after coating for 120 minutes, (1) polyoxyethylene methyl glucose Glycosides (113⁄4) 39. 8 (1.5) 159.8 (17.3) 137.8 (10.7) 122.2 (9. 9) 107.6 (8.2) (2) Polyoxyethylidene methyl glucoside (103⁄4) + polymer of synthesis example 2 (13⁄4) 40.2 (2.5) 179.4(12.2) 158(10.7) 142(11.8) 150(29.8) (3) DPG(1196) 42.4(2.3) 45.0(2.2) 48.8(1.9) 51.2(2.1) 52.2(5.8) (4) DPG(IO^ + Polymer of Synthesis Example 2 (13⁄4) 40.6 (4.6) 140. 8 (17.8) 82.8 (4.3) 79.4 (10.7) 76.0 (7.8) (5) BG01%) 43.0 (1.0) 142.8 (18.1) 76. 4 (3. 7) 68. 8(5.4) 65. 2(7. 2) (6) BG(IOK) + polymer of synthesis example 2 (13⁄4) 34.4(2.8) 62.6(3.8) 50.0(5. 1) 43.6(4.2) 45.8(6.8) (7) Control 45.6(2.2) 71.6(8.4) 60.2(6.8) 54.6(1.8) 64.6(3.3) Unit: The value in ( ) indicates the standard deviation (measurement of moisture evapotranspiration). Experimental method 10 mL of purified water was added to a cream bottle (opening diameter: 4 cm). Apply paste to the edge of the bottle and glue the filter paper (No. 2). 5毫升的样品。 Drop the 0. 5mL sample in the center of the crepe paper. The sample is naturally spread over the entire filter and paper. The samples are shown in Table 4. The total weight of the cream bottle after dropping the sample into the filter paper was measured using a precision electronic balance. Place in a constant temperature and humidity room (23 to 24 ° C, relative humidity 33 ° / 放置 for 6 hours, determine the total weight of the cream bottle, and determine the amount of water evapotranspiration based on the difference between the original weight. 10 323551 201216998 Table 4 1 Water ( Blank) 2 20% by mass of polyoxyethylidene glucoside *) + 0.5% by mass of aqueous polymer solution of Synthesis Example 3 20% by mass of polyoxyethylidene glucoside *) + 0.5% by mass of Synthesis Example 2 Aqueous polymer solution 4 20% by mass of polyoxyethylidene glucoside *) + 0.5% by mass of aqueous polymer solution of Synthesis Example 5 20% by mass of polyoxyethylidene glucoside *) + 0.5 mass % hyaluronic acid ※) ※) aqueous solution
※:）日本油脂製：MACBIOBRIDE MG-10E ※※:）KIBUN FOOD CHEMIFA 製：透明質酸 FCH-SU 2.結果 水分蒸散量的結果如第2圖所示。將聚氧伸乙基曱基 葡萄糖苷和聚（曱氧基聚乙二醇曱基丙烯酸酯）並用時顯示 出優異的水分蒸散抑制效果。 處方例1柔膚水 (調配成分） （質量％) 1. 合成例2的高分子 0. 5 2. 曱基葡糖醇聚醚-10 5. 0 (聚氧伸乙基甲基葡萄糖苷） 3. 聚甘油-10二硬脂酸酯 0. 2 4. 聚甘油-10硬脂酸酯 0.4 5. 橄欖油 3. 0 11 323551 201216998 6. 1，3-丁二醇 4. 0 7. 黃原膠（xanthan gum) 0. 1 8. 1, 2-戊二醇 1. 0 9. 檸檬酸三鈉 0. 04 10. 檸檬酸 0. 01 11. 苯氧基乙醇 0. 2 12. 純淨水 剩餘 本化妝水的保濕性高，改善、防止皮膚粗糙的效果優 異。 (質量％)※:) Japanese fats and oils: MACBIOBRIDE MG-10E ※※:)KIBUN FOOD CHEMIFA system: hyaluronic acid FCH-SU 2. Results The results of water evapotranspiration are shown in Figure 2. When the polyoxyethylidene glucoside and the poly(decyloxy polyethylene glycol methacrylate) were used in combination, an excellent effect of suppressing water evapotranspiration was exhibited. Formulation Example 1 Toner (mixing component) (% by mass) 1. Polymer of Synthesis Example 2 0.5. 2. Mercapto Glycol-10 - 0.5 (polyoxyethylidene) 3. Polyglycerol-10 distearate 0. 2 4. Polyglycerol-10 stearate 0.4 5. Olive oil 3. 0 11 323551 201216998 6. 1,3-butanediol 4. 0 7. Yellow The original gum (xanthan gum) 0. 1 8. 1, 2-pentanediol 1. 0 9. Trisodium citrate 0. 04 10. Citric acid 0. 01 11. Phenoxyethanol 0. 2 12. Pure water The remaining lotion has a high moisturizing property and is excellent in improving and preventing rough skin. (quality%)
處方例2 美容液 (調配成分） 1. 合成例2的高分子 2. 曱基葡糖醇聚醚-20 3. 聚甘油-10二硬脂酸酯 4. 聚甘油-10硬脂酸醋 5. 純淨水 6. 橄欖油 7. 荷荷巴油（jojoba oi 1) 8. 二丙二醇 9. 聚羧乙烯 10. 1，2-戊二醇 11. 彈性蛋白 12. 透明質酸 13. 膠原蛋白 12 323551 201216998 ‘ 14. 氫氧化鉀 0.03 . 15. 純淨水 剩餘 本美容液的保濕性高，改善、防止皮膚粗糙的效果優 異。 【圖式簡單說明】 第1圖表示角質層水分量的試驗結果。 第2圖表示皮膚的水分蒸散量試驗結果。 【主要元件符號說明】 無。 13 323551Formulation Example 2 Cosmetic liquid (mixing ingredient) 1. Polymer of Synthesis Example 2. 2. Mercapto Glycol-20 - Polyglycerol-10 distearate 4. Polyglycerol-10 stearic acid vinegar 5 Pure water 6. Olive oil 7. Jojoba oi 1 8. Dipropylene glycol 9. Carboxylate 10. 1,2-pentanediol 11. Elastin 12. Hyaluronic acid 13. Collagen 12 323551 201216998 ' 14. Potassium hydroxide 0.03. 15. Remaining pure water This beauty lotion has high moisturizing properties and is excellent in improving and preventing rough skin. [Simple description of the figure] Fig. 1 shows the test results of the water content of the stratum corneum. Fig. 2 shows the results of the test for moisture evapotranspiration of the skin. [Main component symbol description] None. 13 323551