JP2019119706A - Comfort feeling improver - Google Patents

Abstract

To provide a comfort feeling improver that improves a comfort feeling caused by a tactile sense of human.SOLUTION: A comfort feeling improver that improves a comfort feeling caused by a tactile sense contains polyoxyethylene methylglucoside as an active ingredient.SELECTED DRAWING: None

Description

  TECHNICAL FIELD The present invention relates to a pleasant feeling improving agent that improves the pleasant feeling evoked by human touch.

Humans experience various emotions when using daily necessities. In particular, the feeling of applying a cosmetic on the skin evokes feelings such as happiness, satisfaction, luxury, relaxation, refreshment, dissatisfaction and discouragement.
Therefore, in cosmetic development, not only functional values such as moisturizing, but also emotional values that exhibit pleasant feelings such as happiness and satisfaction are required, and development of materials capable of imparting such values is in progress.

  Also, in recent years, emotions such as pleasure and discomfort, sense of security and aversion felt by tactile sensation have been reported to be transmitted to the brain by C fibers called C tactile fibers, which are different from Aβ fibers and Aδ fibers. It is known that, when brushing the skin with a brush member at a speed of 1 to 10 cm / sec and 20 to 40 G, C tactile fibers react to evoke a pleasant feeling (Non-Patent Document 1).

  On the other hand, polyoxyethylene methyl glucoside is a polyhydric alcohol-based synthetic polymer obtained by addition-polymerizing ethylene oxide to methyl glucoside, and has moisturizing action and irritation alleviating action, so it is suitable for moisturizing external preparations for skin such as shampoo and rinse. Alternatively, it is blended as a conditioning component.

  However, it has not been known so far that polyoxyethylene methyl glucoside has an action to improve the pleasure related to C fiber.

Loken et al., NATURE NEUROSCIENCE, Vol. 12, p547-548, 2009

  The present invention relates to providing a pleasant feeling improving agent that improves the pleasant feeling evoked by human touch.

  The inventor of the present invention, from various materials that can be formulated in cosmetics, has the effect of enhancing pleasant feeling evoked by tactile stimulation involving C fiber when polyoxyethylene methyl glucoside is applied to the skin, and this is a human It was found that it is useful as a pleasant feeling improvement agent caused by the sense of touch.

  That is, the present invention provides a tactile sensation-based pleasant feeling improvement agent containing polyoxyethylene methyl glucoside as an active ingredient.

  The tactile-based pleasure-enhancing agent of the present invention can enhance the pleasure-evoked by human touch. For example, by using this for skin external preparations such as cosmetics, it is possible to improve the pleasure obtained when applied to the skin, and to enhance the emotional value of the skin external preparations.

The effect of polyoxyethylene methyl glucoside on tactile sensation after application.

  In the present invention, as "polyoxyethylene methyl glucoside", those having an addition mole number of polyoxyethylene of 5 to 35 are preferable, and those of 10 to 30 are more preferable from the viewpoint of enhancing pleasure. More preferably, it is 20.

  Although polyoxyethylene methyl glucoside can be manufactured by addition-polymerizing ethylene oxide to methyl glucoside, commercial items, such as GLUCAM E-10 and GLUCAM E-20, can also be used.

As shown in the examples described later, polyoxyethylene methyl glucoside is applied to human skin, and when it is given a tactile stimulus that activates C fiber and evokes a feeling of pleasure, it has an action of enhancing the feeling of pleasure. Therefore, polyoxyethylene methyl glucoside can be a pleasant feeling improvement agent attributable to human touch, and can be used to improve the pleasant feeling attributable to human touch.
Here, the human use of polyoxyethylene methyl glucoside of the present invention is mainly non-therapeutic use. "Non-therapeutic" does not include medical practice, that is, does not include methods for surgery, treatment or diagnosis of human beings, or more specifically, a doctor, or a medical worker or a person who has been instructed by a medical doctor to the human being. It is a concept that does not include a method for performing surgery, treatment or diagnosis. In the present invention, as non-therapeutic use, use of polyoxyethylene methyl glucoside for improving comfort due to touch for cosmetic or aesthetic purposes, such as by estheticians, cosmetologists, barbers, trimmers etc. Use etc. are mentioned.

In the present invention, the "pleasant feeling caused by touch" refers to a pleasant feeling evoked by touch in a human. Pleasure includes comfort, happiness / satisfaction, luxury, exhilaration and so on.
Examples of tactile stimuli that evoke pleasant emotions in humans include stimuli that excite C tactile fibers, for example, an act of adapting a skin external preparation for skin care to the skin, a cream or lotion for body care, etc. The act of getting familiar with the skin, the act of gently wiping the skin with fabric products such as towels, etc. may be mentioned.
In addition, it is known that when touching the skin at a speed of 1 to 10 cm and 20 to 40 g per second with a brush member such as a brush, the C tactile fiber is excited to obtain pleasant emotion (Non-Patent Document 1).
In addition, “preferable feeling improvement” includes arousing or enhancing the above described pleasant feeling.

  The tactile sensation-based pleasant feeling enhancer of the present invention may be an external preparation for skin that exerts a feeling of comfort or an enhancement effect due to the tactile sense itself, or it may be combined with the external skin preparation for tactile sense. It may be a raw material or a material for exerting the awakening of the pleasant feeling resulting from or the enhancing effect thereof.

  Specific examples of the above-mentioned external preparation for skin include ointments, emulsified cosmetics, creams, emulsions, lotions, gels, sheets and the like, but skin care products in the form of creams, emulsions, lotions, gels and the like, among others Body care products, massage products are preferred. The skin external preparation may be any of cosmetics, pharmaceuticals, and quasi-drugs.

  The above-mentioned external preparation for skin containing polyoxyethylene methyl glucoside can be produced by a general method widely used in the field. That is, the polyoxyethylene methyl glucoside of the present invention is a pharmaceutically acceptable carrier, such as various oils, surfactants, gelling agents, preservatives, antioxidants, solvents, alcohols, water, chelating agents, thickening agents It can be obtained by processing into a desired form after being mixed and dispersed together with an agent, an ultraviolet light absorber, an emulsion stabilizer, a pH adjuster, a pigment, a flavor and the like. In addition to the polyoxyethylene methyl glucoside of the present invention, the skin external preparation may be a plant extract, a bactericidal agent, a moisturizing agent, an antibacterial agent according to the type of preparation such as cosmetics, quasi-drugs and pharmaceuticals. Various components, such as an agent and a refreshing agent, may be suitably blended. In addition, a medicinal component may be blended to further enhance the pleasant feeling improvement effect.

  The content of polyoxyethylene methyl glucoside in the external preparation for skin is preferably 0.0003% by mass or more, more preferably 0.001% by mass or more, and still more preferably 0.003% by mass, based on the total amount of the external preparation for skin. The content is preferably not less than 1.0% by mass, more preferably not more than 0.3% by mass, and still more preferably not more than 0.1% by mass. Moreover, Preferably it is 0.0003-1.0 mass%, More preferably, it is 0.001-0.3 mass%, More preferably, it is 0.003-0.1 mass%.

The amount of polyoxyethylene methyl glucoside applied may be an amount that can achieve the improvement of pleasant emotion resulting from the sense of touch of the subject. For example, the applied amount may be an amount capable of improving the pleasant feeling in the administration group by 10% or more, preferably 30% or more, more preferably 50% or more with respect to the non-administration group.
For example, per adult (60 kg), the polyoxyethylene methyl glucoside is preferably 0.0003 mg or more, more preferably 0.003 mg or more, and preferably 3 mg or less, more preferably 1 mg or less. Moreover, Preferably it is 0.0003-3 mg, More preferably, it is 0.003-1 mg.

  The target of application of the above-mentioned external skin preparation is, for example, a human who desires to obtain pleasure such as comfort, happiness / satisfaction, luxury feeling, exhilaration, etc. when making the skin external preparation conform to the skin. .

Regarding the embodiment described above, the following aspects are further disclosed in the present invention.
The pleasant feeling improvement agent resulting from the touch which contains <1> polyoxyethylene methyl glucoside as an active ingredient.
Use of polyoxyethylene methyl glucoside for manufacturing the pleasant feeling improvement agent resulting from <2> touch.
Polyoxyethylene methyl glucoside for improving the pleasant emotion resulting from <3> touch.
<4> A method of improving pleasure based on touch, wherein polyoxyethylene methyl glucoside is applied to the skin.
In <5><1> to <4>, the pleasant emotion attributable to the sense of touch is the pleasure of tactile sense via C fiber.
In <6><4>, the application to the skin of polyoxyethylene methyl glucoside applies a skin external preparation containing polyoxyethylene methyl glucoside to the skin to make it conform to the skin.

Example 1 Evaluation of pleasant feeling improvement action by tactile stimulation (1) Method Evaluation was performed on five healthy men in their 20s-30s. After 30 seconds of applying 100 μL of physiological saline to the forearm extensor side, with the same forearm with a cheek brush at a speed of 3-5 cm / sec and a load of 30-50 g for 10 times, the comfort is Visual Analog Scale (VAS; subjectively The degree of emotion was evaluated in a linear manner (the left does not particularly feel anything, the right is very pleasant). Immediately thereafter, 100 μL of physiological saline or 0.01% polyoxyethylene methyl glucoside (20 moles of ethylene oxide added, GLUCAM E-20; manufactured by Lubrizol) is applied to the same forearm, and after 30 seconds, similarly, a cheek brush is applied. The same forearm was evaluated 10 times with VAS for comfort. And the rate of change from the VAS value of comfort upon teak brush stimulation after the first physiological saline application, comfort VAS upon teak brush stimulation after saline or polyoxyethylene methyl glucoside application to the same forearm Each was calculated from the value. Evaluations of tactile comfort before and after the application of saline and polyoxyethylene methyl glucoside were performed on different days.
Stimulation with the cheek brush was performed with a load of about 3-5 cm / sec and a load of 30-50 g, which activates C fibers that receive tactile sensation that evokes comfort (the aforementioned non-patent document 1).

(3) Results As shown in FIG. 1, the rate of change in comfort VAS value before and after application of 0.01% polyoxyethylene methyl glucoside is significantly higher than that before and after application of physiological saline. It was revealed.

Claims (2)

  A tactile sensation-based pleasant feeling enhancer containing polyoxyethylene methyl glucoside as an active ingredient.   The pleasant feeling improving agent according to claim 1, wherein the pleasant feeling due to the sense of touch is a feeling of pleasant feeling of touch via C fiber.

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