TW201124414A - Trisubstituted derivatives of 9H-beta-carboline (or 9H-pyridino[3,4-b]indole), preparation thereof and therapeutic use thereof - Google Patents

Trisubstituted derivatives of 9H-beta-carboline (or 9H-pyridino[3,4-b]indole), preparation thereof and therapeutic use thereof Download PDF

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Publication number
TW201124414A
TW201124414A TW099143088A TW99143088A TW201124414A TW 201124414 A TW201124414 A TW 201124414A TW 099143088 A TW099143088 A TW 099143088A TW 99143088 A TW99143088 A TW 99143088A TW 201124414 A TW201124414 A TW 201124414A
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TW
Taiwan
Prior art keywords
alkyl
substituted
optionally substituted
branched
trisubstituted
Prior art date
Application number
TW099143088A
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English (en)
Chinese (zh)
Inventor
Didier Babin
Olivier Bedel
Thierry Gouyon
Serge Mignani
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW201124414A publication Critical patent/TW201124414A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW099143088A 2009-12-10 2010-12-09 Trisubstituted derivatives of 9H-beta-carboline (or 9H-pyridino[3,4-b]indole), preparation thereof and therapeutic use thereof TW201124414A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0958831A FR2953838B1 (fr) 2009-12-10 2009-12-10 Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
TW201124414A true TW201124414A (en) 2011-07-16

Family

ID=42062314

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099143088A TW201124414A (en) 2009-12-10 2010-12-09 Trisubstituted derivatives of 9H-beta-carboline (or 9H-pyridino[3,4-b]indole), preparation thereof and therapeutic use thereof

Country Status (5)

Country Link
AR (1) AR079613A1 (fr)
FR (1) FR2953838B1 (fr)
TW (1) TW201124414A (fr)
UY (1) UY33100A (fr)
WO (1) WO2011070299A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105330665B (zh) * 2015-11-04 2017-10-03 衡阳师范学院 一种抑制激肽释放酶klk7的化合物、制备方法和用途
WO2020072675A1 (fr) 2018-10-02 2020-04-09 Northwestern University Bêta-carbolines servant de modulateurs allostériques positifs du récepteur humain de la sérotonine 2c (5-ht2c)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
DE3540653A1 (de) * 1985-11-13 1987-05-14 Schering Ag Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3608089A1 (de) * 1986-03-08 1987-09-10 Schering Ag Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
AU619203B2 (en) * 1987-08-28 1992-01-23 Schering Aktiengesellschaft Isoxazole-beta-carboline derivatives
WO1996034865A1 (fr) * 1995-05-05 1996-11-07 Novo Nordisk A/S Nouvelle chimie heterocyclique
JP2002542246A (ja) * 1999-04-20 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 新規な化合物、それらの製造及び使用
US6492406B1 (en) * 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
EP1209158A1 (fr) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Bêta-carbolines subtituées
JP4599501B2 (ja) * 2001-11-07 2010-12-15 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体
FR2869540B1 (fr) * 2004-04-30 2008-05-16 Centre Nat Rech Scient Cnrse Compositions pharmaceutiques contenant des derives de b-carboline, et leur utilisation pour le traitement des cancers
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2008124323A1 (fr) * 2007-04-03 2008-10-16 Array Biopharma Inc. Composés imidazo[1,2-a]pyridine utilisés comme inhibiteurs des récepteurs à activité tyrosine kinase
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
AR072084A1 (es) * 2008-06-12 2010-08-04 Sanofi Aventis Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim

Also Published As

Publication number Publication date
FR2953838B1 (fr) 2012-02-24
FR2953838A1 (fr) 2011-06-17
UY33100A (es) 2011-07-29
AR079613A1 (es) 2012-02-08
WO2011070299A1 (fr) 2011-06-16

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