201004637 九、發明說明： 延緩衰老的食品組飾 【發明所屬之技術領域】 本發明涉及一種食品組合物，特別涉及一種延緩衰老的食品組合 物。 ❹ ❹ 【先前技術】 在本方法發明之前，白藜蘆醇主要作為雌激素調節血液中的膽固醇 水準、抗血小板凝集、抗人體低密度脂蛋白的氧化作用、抗癌作用 方面研究較多，同時也實際應用到藥物和營養保健產品中在市場上 銷售。 也有將抗氧化的白藜蘆醇的用於抗衰老，其每曰服用量低於20mg， 這是因為一是白藜蘆醇價格較高，其二是對白藜蘆醇的特性認識不 足，包括含量大了以後的毒副作用不甚瞭解，所以其作為抗衰老物 是沒有任何實際效果的。就其機里而言，白黎董醇在進入人體的血 液後，停留的時間非常短’大部分馬上就迅速通過尿液排出，來不 及作用於相關抗鮮的生理雜，也就起不到任何抗鮮作用。 【發明内容】 本發明的目的就在於克服上述缺陷，研製一種抗衰老保健藥物。 本發明的技術方案是：延緩衰老的保健組合物，其主雖術特徵在 於每單位劑置基本由白黎蘆醇Resveratrol、漆黃素Fisetin、紫鉚因 Butein、櫟精 Quercetin、卵碟脂 Lecifliin、六鱗酸肌醇 INOSITOL HEXAPHOSPHATE組成，其配伍關係為每單位劑量含白藜蘆醇 resveratrol 4(卜350mg、漆黃素 fisetln 40~350mg、紫鉚因 butein 4(K350mg、櫟精 quercetin 70~ 200mg，卵碟脂 lectthin 80~1500mg， 六碟酸肌醇 Inositol hexapliospluitel0~100mg 〇 其進一步的技術方案是： 5 201004637 在於白黎蘆醇Resveratrol、漆黃素Ffsetin、紫鉚因Buteto的配比為 1:1:1° 本發明的優點和效果在於雖然白藜蘆醇在人體內停留時間短，但加 人櫟精Quercetin、卵碟脂Lecitliiii、六碟酸肌醇Inositol hwapliosphate能使粧人體内停留的時間大大延長，從而充储揮 其抗衰老的作用和功效，並且紫鉚花素Biitein、漆樹黃囿Fisetlii具 有延緩衰老的作用和功效，與白藜蘆醇協同發揮抗衰老作用，效果 更加明顯。而且，增加白藜蘆醇含童並不會帶來毒副作用，即無毒。 【實施方式】 實施例1 : 取白藜蘆醇 Resveratrol 185mg、漆黃素 Flsctin 185nig、紫鉚因 Betein 185mg、櫟精 Quercetin lOOmg，卵碟脂 Lecithin SOOmg，六隣酸肌 醇Inositol hexapliospliate50nig混合均勻；可製成口服液、膠囊、片 酆J、顆粒劑' _ 〇 實施例2 : 取白黎蘆醇 Rcsveratrol 155mg、漆黃素 Fisetln 155mg、紫鉚因 Butein 155mg、櫟精 Quercetin 120mg ,卵碟脂 Lecithin SOOmg，六碟酸肌 ® 醇Inositol he»iphosplu»te70mg，混合均勻；可製成口服液、膠囊、 片劑、顆粒劑、粉劑。 根據實驗證明，通過添加一些特別的成分進行組合後，菊晃白藜蘆 醇有助於延長酵母、線蟲等的壽命，而且也發現這種組合物質對哺 乳動物也有“增壽”的顯著功效。本發明主要使用了三種化合物： 紫鉚花素Butein、漆樹黃酮Fisetln (1，3, 7,3’，4’ -四羥(基)黃酮） 和白藜蘆醇，發現可以使平均壽命增加31%、55%和70%，並且這三 種物質都可顯著增加哺乳動物最大平均壽命。 具體而言： 1 ·增加每日的服用量’使停留在人體血液中的有效成分增加很多，能 夠有足夠量的作用於抗衰老的活性成分。對於增大服用量以後對人 201004637 輕否有毒害作用，通過卿的實驗證明，我們可以頻，白藜蘆 醇的安全劑量為每曰1000mg/kg，遠遠大於我們所設定的服用量， 可以說其是安全無毒的。 2 ·單一的白藜蘆醇其抗衰老的作用畢竟有限，通過添加紫鉚花素201004637 IX. Description of the invention: Food composition for delaying aging TECHNICAL FIELD The present invention relates to a food composition, and more particularly to a food composition for delaying aging. ❹ ❹ 【Prior Art】 Prior to the invention of this method, resveratrol was mainly used as an estrogen to regulate cholesterol levels in the blood, anti-platelet aggregation, anti-oxidation of human low-density lipoprotein, and anti-cancer effects. It is also practically applied to drugs and nutraceutical products for sale in the market. Anti-aging resveratrol is also used for anti-aging, which is less than 20 mg per ounce because of the higher price of resveratrol and the lack of understanding of the characteristics of resveratrol, including The toxic side effects after the large content are not well understood, so it has no practical effect as an anti-aging substance. As far as the machine is concerned, after the blood entering the human body, the staying time is very short. 'Most of the time is quickly discharged through the urine, and it is too late to act on the physiological anti-fresh. Anti-fresh effect. SUMMARY OF THE INVENTION The object of the present invention is to overcome the above drawbacks and to develop an anti-aging health care medicine. The technical proposal of the invention is: a health-care composition for delaying aging, the main feature of which is that each unit of the agent is basically composed of resveratrol, laccase, fisetin, butein, quercetin, eucalyptus, and lecithin. , squamous inositol INNOSOTL HEXAPHOSPHATE composition, the compatibility relationship is resveratrol resveratrol 4 per unit dose (Bu 350mg, flavin fisetln 40~350mg, eucalyptus butein 4 (K350mg, quercetin quercetin 70~ 200mg) , egg fat lectthin 80~1500mg, six-disc acid inositol Inositol hexapliospluitel0~100mg 〇 its further technical solution is: 5 201004637 lies in the ratio of Resveratrol, flavonoid Ffsetin, and pudding to Butte: 1:1° The advantages and effects of the present invention are that although resveratrol has a short residence time in the human body, the addition of Quercetin, Lecitliiii, and Inositol hwapliosphate can make the body stay in the body. It is greatly extended to replenish its anti-aging effect and efficacy, and the Biitein and the lacquer tree Astragalus Fisetlii have the effect and effect of delaying aging, and Resveratrol synergistically exerts anti-aging effect, and the effect is more obvious. Moreover, increasing resveratrol-containing children does not bring toxic side effects, that is, non-toxic. [Embodiment] Example 1: Resveratrol Resveratrol 185mg, lacquer Flavonoid Flsctin 185nig, pebbles Betein 185mg, Quercetin lOOmg, egg fat Lecithin SOOmg, hexamed acid inositol hexapliospliate50nig evenly mixed; can be made into oral liquid, capsule, tablet J, granules ' _ 〇 implementation Example 2: Resveratrol Rcsveratrol 155mg, laccase Fisetln 155mg, Butein 545mg, Quercetin 120mg, egg fat Lecithin SOOmg, six-disc acid muscle alcohol Inositol he»iphosplu»te70mg, evenly mixed; It can be made into oral liquid, capsules, tablets, granules, powders. According to experiments, by adding some special ingredients, Juju Resveratrol helps to prolong the life of yeast, nematodes, etc. This combination of substances also has a significant effect on "life-enhancing" in mammals. The present invention mainly uses three compounds: Bautin, the flavonoid Fisetln (1,3, 7,3',4'-tetrahydroxy) and resveratrol, which are found to increase the average lifespan by 31. %, 55%, and 70%, and all three substances can significantly increase the maximum life expectancy of mammals. Specifically: 1 · Increasing the daily dose' makes the active ingredient staying in the blood of the human body much more, and has a sufficient amount to act on the anti-aging active ingredient. After increasing the dosage, it has no toxic effect on human 201004637. Through the experiment of Qing, we can frequency, the safe dose of resveratrol is 1000mg/kg per ,, which is far greater than the dosage we set. Said it is safe and non-toxic. 2 · The effect of single resveratrol on anti-aging is limited, by adding scutellarin
Butein、漆樹黃酮Fisettn (1，3,7,3,，4,-四羥(基)黃南）這兩麵 哺乳動物有顯著抗衰老作用的成分，可以將本發明延緩衰老的時間 在單一成分的基礎上延長60%以上，增大本發明的效果。 3 ·添加能延長白黎蘆醇在血液中停留時間的成分。通過大量的實驗研 究和查證，添加櫟精Quercetin »卵碟脂Lecithin »六鱗酸肌 醇Inositol hexaphosphate簡稱IP6 (米糠提取物）能顯著延長 白藜蘆醇在血液中的滯留時間，延長到原時間的4〜7倍，所以能 大大提高白藜蘆醇的作用時間，顯著增強本發明延緩衰老的功能。 4 .本發明進行這樣的組合後，能起協同效應，而不是簡單的叠加，經 過相關的試驗研究，本發明能發揮明顯的延緩衰老的作用，而且安 全無毒副作用 實驗證明： 利用一種化合物來增加肥胖的老鼠的壽命，發現這種化合物逆 轉了高熱量飲食老鼠所有基因表達~其中有一些與糖尿病，心臟病 和其它與肥胖有關的所有疾病，並首次發現這種小分子化合物白藜 蘆醇（Resveratrol)對哺乳動物的好處。 老鼠分成三組：第一組給予一^飲食(簡稱SD組）；第二組給 予高熱量的飮食，其中總熱董的百分之60來自脂肪(簡稱HC組）； 第三組給與和第二組相同的食物，並加給食用白藜蘆醇(簡稱HCR 組）。開始做實驗的時候所有的老鼠都是約52周大，相當於中年的 人類0 在60周大時，HC組和HCR組老鼠的的存活率開始分歧並且保 持3至4個月差異。在114周大時，HC組有百分之58死亡，而HCR 組和SD組只有百分之42死亡。發現白藜藤醇能使HC組的死亡率 降低百分之31，SP使與SD組相比死亡率也沒顯著增加〇(注：那些 老鼠都還活著，所以這遺不是最後的資料。）中間壽命增加是大約 百分之15 〇我們要等到所有的老鼠都死亡之後才有精確的數字，這 7 201004637 種老鼠的壽命是兩年半。因此最後的數字還要再等5個月左右’但 是毫無疑問，我們已經看見老鼠能增加壽命。 研究還M HCR組有非常好的體質，在體能測試上遠超遇HC 組的老鼠。餵食白藜蘆醇的老鼠不只長壽，且他們活力更好。體能 測試結果證明老化得到改善。 白藜蘆醇有兩種存在的形式：順式和反式。天然存在的白藜蘆 醇一般為反式，反式白藜蘆醇被吸收進入人體血液後，在沒有櫟 精，磷脂(卵磷脂），六碟酸肌醇簡稱INOSITOLHEXAPHOSPHATE (米 糠提取物）共同存在的時候，在血液中迅速轉變為順式白黎蘆醇， 隨尿液排出體外，而加入櫟精，磷脂(卵磷脂），六碟酸肌醇簡稱 INOSITOLHEXAPHOSPHATE (米糖提取物）共同吸收進入血液後，他 們將抑制反式白黎蘆醇轉變為順式白藜蘆醇，延長粧體内的停留 時間，充分發揮其作用。 白黎藏醇(Resveratrol ’簡稱Res)、漆酮(Flstein)、紫鉚因 (Buteiii)等有較強的抗氧化、抗自由基的作用，主要通過啟動組蛋 白去乙酿化酶的活性來延長細胞的壽命。Res是一種自然產生彡^ 類化學物質，廣泛存在於一些植物中，如葡萄、縣和花生，它是 一種含有芪類結構的非黃酮多酚類化合物，具有重要的生物學作 用。白藜蘆醇通過降低乙醢化底物的JTm值可以對ySir2起到最高的 啟動活性’使其的壽命延長70% 〇而白藜蘆醇在與漆樹黃酮、紫鉚 因共同存在時，白藜蘆醇與SIRT1基因結合時構象將發生费^，調 節pS3*AMC的相豆素基因，從而增加細胞的存活，大大延長人的壽 命0 所用原料都能從市場上購買到，所用的白藜蘆醇原料為反式 白黎董醇。 本發明要求保護有範圍並不僅僅局限於上述實施例的描述。 g 201004637 【圖式簡單說明】 fiE J\\\Butein, lacquer flavones, Fisettn (1,3,7,3,4,4-tetrahydroxy (yellow) Huangnan) have significant anti-aging effects on both mammals, and can delay the aging of the present invention in a single component. The invention is extended by more than 60% to increase the effect of the present invention. 3 · Add ingredients that extend the residence time of resveratrol in the blood. Through a lot of experimental research and verification, adding Quercetin » Lecithin » Inositol hexaphosphate, IP6 (rice extract) can significantly prolong the residence time of resveratrol in the blood and extend it to the original time. 4 to 7 times, so can greatly improve the action time of resveratrol, significantly enhance the function of the invention to delay aging. 4. After the combination of the present invention, a synergistic effect can be exerted, rather than a simple superposition. After relevant experimental research, the present invention can exert a significant anti-aging effect, and the safe and non-toxic side effects test proves: using a compound to increase The lifespan of obese mice found that this compound reversed all gene expression in high-calorie diet mice - some of which were associated with diabetes, heart disease and other diseases associated with obesity, and the first discovery of this small molecule compound resveratrol ( Resveratrol) benefits to mammals. The rats were divided into three groups: the first group was given a diet (referred to as the SD group); the second group was given a high-calorie foraging, in which 60% of the total heat was from fat (referred to as HC group); The same food as the second group was added to the resveratrol (HCR group). At the beginning of the experiment, all the mice were about 52 weeks old, which is equivalent to the middle-aged human 0. At 60 weeks of age, the survival rates of the HC and HCR mice began to differ and remained different for 3 to 4 months. At 114 weeks of age, 58 percent of the HC group died, compared with 42 percent of the HCR and SD groups. It was found that scutellarin reduced the mortality of the HC group by 31%, and SP did not significantly increase the mortality rate compared with the SD group. (Note: Those mice are still alive, so this is not the last data. The increase in intermediate life is about 15 percent. We have to wait until all the mice die to have accurate numbers. The life expectancy of these 7 201004637 mice is two and a half years. So the final number will have to wait another five months or so' but there is no doubt that we have seen mice increase their lifespan. The study also has a very good constitution in the M HCR group, which is far superior to the mice in the HC group in physical fitness testing. Rats fed resveratrol not only live longer, but they also work better. Physical fitness test results show that aging is improved. Resveratrol has two forms of existence: cis and trans. Naturally occurring resveratrol is generally trans, trans-resveratrol is absorbed into human blood, and in the absence of sputum, phospholipids (lecithin), six-disc acid inositol referred to as INOSITOLHEXAPHOSPHATE (rice extract) coexist At the time, it is rapidly converted into cis resveratrol in the blood, excreted with the urine, and added with quercetin, phospholipid (lecithin), and six-disc acid inositol, referred to as INOSITOLHEXAPHOSPHATE (rice extract), into the blood. After that, they will inhibit the conversion of trans-resveratrol to cis-resveratrol, prolong the residence time in the makeup and fully exert its effects. Resveratrol (Res, Resveratrol, Flstein, Buteiii) have strong anti-oxidation and anti-free radical effects, mainly by initiating histones to deactivate enzyme activity. Extend the life of the cell. Res is a naturally occurring chemical substance widely found in some plants, such as grapes, counties and peanuts. It is a non-flavonoid polyphenolic compound containing a terpenoid structure and has important biological functions. Resveratrol can increase the lifetime of ySir2 by reducing the JTm value of the acetylated substrate to increase its lifespan by 70%. When resveratrol coexists with lacquer flavonoids and flavonoids, white When the resveratrol binds to the SIRT1 gene, the conformation will occur, and the phase of the pS3*AMC can be increased, thereby increasing the survival of the cells and greatly prolonging the life of the human. The raw materials used can be purchased from the market. The raw material of ruthenol is trans-white hexanol. The scope of the claimed invention is not limited to the description of the above embodiments. g 201004637 [Simple description of the schema] fiE J\\\
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