201010713 * * 七、發明說明： [發明所屬之技術領域] 本發明涉及一種m?口或營養品，特別涉及一觀緩鮮及預防鞋 相關疾病的營養或保健組合物。 [先前技術] 在本方法發明之前，白藜蘆醇(Resverairol庄要作為雌激素調節血液 中的膽固醇水準、抗血/Jl凝集、抗人體低密度脂蛋白的氧化作用、 抗癌作用方面研究較多，同時也實際應用到藥物和營養保健產品中在 市場上銷售。 也有將抗氧化的白藜蘆醇(Resverateol)的用於抗衰老，其每日服用量 低於20mg，這是因為一Μ白藜蘆醇(Resveratool)ffi格較高，其二是對 白藜蘆醇(Resveratrol)的特性認識不足，包括含量大了以後的毒副作 用不甚瞭解，所以其作為抗衰老物是沒有任何實際效果的。就其御S 而言，白藜蘆醇(Resveratrol)在進入人體的臟後’停留的時間非常 短，大部分因為其構想的變^馬上就迅速通過尿出，來不及作用 於相關抗鞋的生理纖，也就起不到任何抗鞋作用。 【發明內容】 本發明的目的就在於克服上述缺陷，硏製一衰老保健藥物。 本發明的技術方案是：延緩衰老的保健组合物，其主雖術特徵在 i 201010713 於基本由白藜蘆醇(Resveratrol)、櫟精(Quercetin)組成，其配比關係為 fi^M^(Resveratrol)40~350mg ' (Quercetin)8~200mg ° 其進一步的技術方案是： 櫟精可以用磷脂(卵磷脂Lecithin),六麵肌醇（Inositol Hexaphosphate )簡稱画 P6 (米糠提取物 Rice Bran Extract)中的仓E^f— 種來替代也具有相同的效果。 本發明的優點和效果在於雖然白黎蘆醇(Resveratrol)^人體內停留時 ❿ 間短，但加入櫟精(Quercetin)、磷脂(卵磷脂Lecithin)，六碟酸肌醇 (Inositol Hexaphosphate)簡稱 IP6 (米糠提取物 Rice Bran Extract) 後能抑制其有效活性結構的變化使他在人體内停留的時間大大延 長，從而充分發揮其抗衰老的作用和功效，與白藜蘆醇(Resveratrol) 協同發揮抗衰老作用，效果更加明顯。而且，增加白藜蘆醇(Resveratrol) 含量並不會帶來毒副作用，即鱗。 實施例1 : ❷ 取白藜蘆醇(Resveratrol)4amg、櫟精(Quercetin)8.5mg，混合均勻； 可製成口服液、膠囊、片劑、顆粒劑、粉劑。 實施例2 : 取白藜盧醇(Resveratrol)60mg、櫟精(Quercetin)25mg，混合均勻； 可製成口服液、膠囊、片劑、顆粒劑、粉劑。 5 201010713 實施例3: 取白黎蘆醇(Resveratr〇l)155mg、櫟精(〇uercetin)120mg，混合均 勻；可製成口服液、膠囊、片劑、顆粒劑、粉劑。 根據實驗證明，通過添加一些特別的成分進行組合後，發現白藜 蘆醇(ReSVeratrol_於延長酵母、線蟲等的壽命，而且也發現這種 組合物質對哺乳瞧也有“增壽”的顯著功效。本發明主要使用了一 ❿ 種化合物白藜蘆醇(Resveratrol) ’發現可以使平均壽命增加70X ’並且 這種物質都可顯著增加哺乳動物最大平均壽命。 具體而言： 1. 增加每曰的服用量，使停留在人體血液中的有效成分增加很多，能 夠有足夠量的作用於抗衰老的活性成分。對於增大服用量以後對人 體是否有毒害作用，通過科學的實驗證明，我們可以發現，白藜蘆 • 醇(Resveratrol)的安全劑量為每日1000mg/kg，遠遠大於我們所設定 的服用量，可以說其是安全無毒的。 2. 添加能延長白藜蘆醇(Resveratrol)在血液中停留時間的成分。通過大 量的實驗研究和文獻查證，添加櫟精(Quercetin)能抑制其活性結構的 變化，從而顯著延長白藜蘆醇(Resveratrol)在血液中的滞留時間，延 長到原時間的4〜7倍，所以能大大提高白藜蘆醇(Resveratrol)的作 用時間，顯著增強本發明延緩衰老的功能。 201010713 3.本發明進行這樣的組合後，不是簡單的疊加，而是協同保護細胞線 粒體中的DNA (去氧核糖核酸)免遭化學損害而延長細胞的壽命，經過 相關的試驗研究，本發明能發揮明顯的延緩衰老的作用，而且安全 無毒副作用。 實驗證明： 白藜蘆醇(resveratrol，Res)、櫟精(QuCTcetin)等強的抗氧 化、抗自由基的作用，主要通過啟動組蛋白去乙醒Ϊ滿的活性來延 ® 長細胞的壽命〇 Res是一種自然產生多酸類化學物質，廣泛存在於 一些植物中，如葡萄、獎果和花生，它是一種含有芪類結構的非黃 酮多酚類化’具有重要的生物_用。白藜蘆醇(Resveratrol)通 過降低乙醯化底物的Ain值可以對Si r2起到最高的啟動活性，便其 壽命延長70X。利用白藜蘆醇(Resvemtrol)來增加肥胖的老鼠的壽 命，發現他逆轉了高熱量飮食老鼠所有基因表達中有一些與糖尿 病，心臟病和其它與肥胖有關的所有疾病，並首次發現這種小分子 ❹ 化合物白藜蘆醇（resveratro丨）對哺乳動物的好處，近年來先後有一 些研究表明，白藜蘆醇(Resvemtrol南助於延長酵母、線蟲等的壽命。 白藜蘆醇(Resveratrol洧兩種存在的形式：順式（Cis-)和反式 (Trans-)。天然存在的白藜蘆醇(Resveratrol)—般為反式，反式白 藜蘆醇(Trans-Resveratrol)^吸收進入人體血液後，在沒有櫟精共同 存在的時候，在血液中迅速轉變為順式白藜蘆醇(Cis-Resveratrol)， 隨尿液排出體外，而加入櫟精共同吸收進入血液後，他們將抑制反 201010713 式白藜蘆醇(Tr ans-Resveratrol)||變為順式白黎蘆醇 (Cis-Resveratrol)，並延長其在體内的停留時間，充分發揮其作用。 而且白黎蘆醇(Trans-Resveratrol)在與櫟精(Quercetin)共同存在時， 白藜蘆醇(Trans-Resveratrol澳SIRT1基因結合時將發生變化，調節 P53-AMC的相豆素基因’從而增加細胞的存活，大大延長細胞的壽命。 發表于「自然」科學期刊網站的最新研究發現指出，白藜蘆醇 (Resveratrol)和櫟精(Quercetin)協同，可啟動生物體內古老的生存反 射機制，加速活細胞製造抗老化酵素，啟動Sirtuins抗衰老酶，穩 定DNA，延長細胞壽命。白黎蘆醇(Resveratrol)和櫟精(Quercetin)協同 能提高酵母菌壽命，它同時也能延長果蠅的壽命，讓原本一般上只 活約一個月的果蠅多活上十天。當施用予酵母菌時，原本分裂廿五 次就死了的酵母菌可以再多分裂十五次。還未發表的研究顯示白藜 蘆醇(Resveratrol)對線蟲和老鼠也撤，猴子的實驗正在進行中。 義大利神經學研究所的亞曆山德羅切萊里諾和同事在 <當代生 物學》雜誌上發表論文說’白藜蘆醇(Resveratrol)和櫟精(Quercetin) 協同有助於延長脊椎動物非洲齒鯉的壽命，並且隨著簾食的白黎蘆 _ 醇(Resveratrol靡I量和櫟精(Quercetin)的增加，這種小魚壽命可以被 顯著延長。切萊里諾等人給這種原產於辛巴威的小魚餵食了三種不 同劑量的白藜蘆醇(Resveratrol) 〇只有白藜蘆醇(Resveratrol)的中高 劑量組對這種平均壽命只有9個星期的魚沒有效果，而中等劑量的 白麵醇(Resveratn>_入櫟精(Quercetin锻讓這種魚的壽命延長了 三分之一，而攝入了高劑量白藜蘆醇(Resveratrol)和櫟精(Quercetin) 的魚的壽命則延長了 50%以上。此外，鶴食了白黎灌醇(Resveratrol) 和櫟精(Quercetin)的非洲齒鯉即使達到了 10周的“高齡”，仍然表 現出旺盛的生命力，不但遊動活躍，對光線也十分敏感。 201010713 在對老鼠的研究中，將實驗老鼠分成三組：第一組給予一般飮 食(簡稱SD組）；第二組給予高熱量的飮食，其中總熱量的百分之60 來自脂肪(簡稱HC組）；第三組給與和第二組相同的食物，並加給食 用白藜蘆醇(Resveratrol)和櫟精(Quercetin)(簡稱HCR組）。開始做實 驗的時候所有的老鼠都是約52周大，相當於中年的人類。 在60周大時，HC組和HCR組老鼠的的存活率開始分歧並且保持 3至4個月差異。在114周大時，HC組有百分之58死亡，而HCR 組和SD組只有百分之42死亡。發現白藜蘆醇(Resveratrol)能使HC 組的死亡率降低百分之31，即使與SD組相比死亡率也沒顯著增加 (注：那些老鼠都還活著，所以這還不是最後的資料。）中間壽命增 加是大約百分之15 〇我們要等到所有的老鼠都死亡之後才有精確的 數字，這種老鼠的壽命是兩年半。因此最後的數字還要再等5個月 左右，但是毫無疑問，我們已經看見老鼠能增加壽命。 研究還發現HCR組有非常好的體質，在_能測試上遠超過HC組 的老鼠。韻食白藜蘆醇(Resveratrol)的老鼠不只是長壽’且他們活力 更好。體能測試結果證明老化得到改善。 研究表明，白藜藍醇(Resveratrol)和櫟精(Quercetin：te同即可以 抑制白藜藍醇(Resveratrol)的構象發生變化延長其在血液中的停留 時間，也可協同保護細胞線粒體中的DNA (去氧核糖核酸)免遭化學損 害而發揮延緩衰老功效。 本發明所用原料都能從市場上購買到，所用的白藜蔴醇 (Resveratrol)原料為反式白藜蘆醇(Trans-Resveratrol) ’様精 201010713 (Quercetin)的有效成分為槲皮素（Meletin) 〇 本發明要求保護有範圍並不僅僅局限於上述實施例的描述。 參201010713 * * VII. OBJECTS OF THE INVENTION: [Technical Field to which the Invention Is Applicable] The present invention relates to an m-mouth or a nutraceutical, and more particularly to a nutritional or health-care composition for preventing and preventing shoe-related diseases. [Prior Art] Resverairol (Resverairol) is used as an estrogen to regulate cholesterol levels in the blood, anti-blood/Jl agglutination, anti-human low-density lipoprotein oxidation, and anti-cancer effects. It is also widely used in medicines and nutraceutical products. It is also used in the anti-aging treatment of anti-aging resverateol, which is less than 20mg per day. Resveratool has a higher ffi lattice, and the second is insufficient understanding of the characteristics of Resveratrol. The toxic side effects after the large content are not well understood, so it has no practical effect as an anti-aging substance. As far as its Royal S is concerned, Resveratrol's time to stay in the body's dirty is very short, and most of it is quickly passed through the urine because of its conception, and it is too late to act on the relevant anti-shoes. The physiological fiber does not have any anti-shoe effect. SUMMARY OF THE INVENTION The object of the present invention is to overcome the above drawbacks and to prepare an aging health care medicine. : The health-prevention composition for delaying aging, whose main feature is composed of Resveratrol and Quercetin in i 201010713, the ratio of which is fi^M^(Resveratrol) 40~350mg ' (Quercetin) 8~200mg ° The further technical solution is: 栎 可以 can use phospholipid (lecithin Lecithin), hexahedositol (Inositol Hexaphosphate) referred to as P6 (rice extract Rice Bran Extract) in the warehouse E ^ f - The same effect is obtained by the substitution. The advantages and effects of the present invention are that although Resveratrol ^ is short in the human body, it is added with Quercetin, Lecithin (Lecithin), Six Inositol Hexaphosphate, referred to as IP6 (Rice Bran Extract), inhibits the change of its effective active structure, which greatly prolongs its residence time in the human body, thereby fully exerting its anti-aging effect and efficacy. Resveratrol synergistically exerts anti-aging effects, and the effect is more obvious. Moreover, increasing the content of Resveratrol does not bring toxic side effects, ie scales. Example 1: ❷ Take white peony Resveratrol 4amg, Quercetin 8.5mg, evenly mixed; can be made into oral liquid, capsules, tablets, granules, powder. Example 2: Take Resveratrol 60mg, quercetin (Quercetin) 25mg, evenly mixed; can be made into oral liquid, capsules, tablets, granules, powder. 5 201010713 Example 3: Take 155 mg of Resveratr(R) and 120 mg of 〇uercetin, and mix well; it can be made into oral liquid, capsule, tablet, granule and powder. According to experiments, it was found that by adding some special ingredients, resveratrol (ReSVeratrol_ was used to prolong the lifespan of yeast, nematodes, etc., and it was also found that this combination substance has a significant effect on "giving life" for mammals. The present invention mainly uses a compound of resveratrol (Resveratrol) which is found to increase the average lifespan by 70X' and this substance can significantly increase the maximum life expectancy of mammals. Specifically: 1. Increase the dose per sputum The amount of active ingredient that stays in the human blood is increased a lot, and it can have a sufficient amount of active ingredients for anti-aging. For increasing the dose, it is toxic to the human body. Through scientific experiments, we can find that The safe dose of Resveratrol is 1000mg/kg per day, which is much larger than the amount we set. It can be said to be safe and non-toxic. 2. Adding can extend resveratrol in blood. The composition of the residence time. Through a large number of experimental studies and literature verification, the addition of Quercetin can inhibit its active structure. Change, thereby significantly prolonging the residence time of resveratrol in the blood, prolonging to 4 to 7 times of the original time, so can greatly increase the action time of resveratrol, and significantly enhance the anti-aging of the present invention. 201010713 3. After the combination of the present invention, it is not a simple superposition, but synergistically protects the DNA (deoxyribonucleic acid) in the mitochondria of cells from chemical damage and prolongs the life of the cells. After relevant experimental research, The invention can play a significant role in delaying aging, and is safe and has no toxic and side effects. Experiments prove that: resveratrol (Res), quercetin (QuCTcetin) and other strong antioxidant and anti-free radical effects, mainly through the start-up group The protein is deactivated to extend the activity of long cells. Res is a naturally occurring polyacid chemical widely found in some plants, such as grapes, fruit and peanuts. It is a non-steroidal structure. Flavonoid polyphenols have important biological properties. Resveratrol can maximize Si 2 by reducing the Ain value of the acetylated substrate. High start-up activity, extending its lifespan by 70X. Resvemtrol was used to increase the lifespan of obese mice, and he was found to reverse some of the high-calorie feeding mice with some of the gene expression associated with diabetes, heart disease and others. All diseases related to obesity, and for the first time, the benefits of this small molecule sputum compound resveratro (resveratro) have been found in mammals. In recent years, some studies have shown that resvermtrol (Resvemtrol South helps to prolong yeast, nematodes) Life expectancy. Resveratrol (resveratrol 洧 two forms: cis (Cis-) and trans (Trans-). Naturally occurring resveratrol (Resveratrol) is generally trans, trans-Resveratrol (trans-Resveratrol) ^ absorbed into the human blood, in the absence of sputum coexistence, quickly turned into smooth in the blood Resveratrol (Cis-Resveratrol), excreted in the urine, and added to the blood, they will inhibit the anti-201010713 resveratrol (Tr ans-Resveratrol)|| into cis white Cis-Resveratrol, and prolong its residence time in the body to fully play its role. Moreover, when Re-Resveratrol coexists with Quercetin, resveratrol (Trans-Resveratrol will change when SIRT1 gene binds, and regulates P53-AMC's soy-bean gene' to increase The survival of cells greatly prolongs the lifespan of cells. The latest research published in the journal Nature Science found that Resveratrol and Quercetin synergistically activate the ancient living reflex mechanism in vivo and accelerate Living cells make anti-aging enzymes, activate Sirtuins anti-aging enzymes, stabilize DNA, and prolong cell life. Resveratrol and Quercetin synergistically increase yeast life, and it also prolongs the lifespan of fruit flies. Let the fruit flies, which normally only live for about one month, live for ten days. When applied to yeast, the yeast that died after splitting five times can be split up to fifteen times. Unpublished studies show that Resveratrol is also withdrawn from nematodes and mice, and experiments with monkeys are underway. Alessandro Celerino of the Institute of Neurology at the Italian Institute and colleagues in the contemporary A paper published in the journal Biology says that 'Resveratrol and Quercetin work synergistically to extend the lifespan of the vertebrate African gingiva, and with the white pecans (Resveratrol靡I) With the increase in the amount of Quercetin, the life of this small fish can be significantly prolonged. Celerino et al. fed three different doses of resveratrol to the small fish native to Zimbabwe (Resveratrol 〇 Only the medium-high dose group of Resveratrol has no effect on this fish with an average lifespan of only 9 weeks, while the medium dose of leucovorin (Resveratn> _ 栎 栎 (Quercetin forging the life of this fish) One third of the fish, and those who ingested high doses of Resveratrol and Quercetin have a life expectancy of more than 50%. In addition, the crane eats Resveratrol and cockroaches. Quercetin's African gingiva, even after reaching 10 weeks of “old age”, still shows strong vitality, not only active in swimming, but also sensitive to light. 201010713 In the study of mice, experimental mice were divided into three groups: First group given General foraging (SD group); the second group is given high-calorie foraging, in which 60% of total calories are derived from fat (referred to as HC group); the third group is given the same food as the second group, and is added to Resveratrol and Quercetin (HCR group) were eaten. All the mice were about 52 weeks old when they started the experiment, which is equivalent to middle-aged humans. At 60 weeks of age, the survival rates of mice in the HC and HCR groups began to differ and remained different for 3 to 4 months. At 114 weeks of age, 58 percent of the HC group died, compared with 42 percent of the HCR and SD groups. Resveratrol was found to reduce mortality in the HC group by 31%, even though there was no significant increase in mortality compared with the SD group (Note: those mice are still alive, so this is not the final data) The increase in intermediate life is about 15 percent. We have to wait until all the mice have died. The exact life of the mouse is two and a half years. So the final number will have to wait another five months, but there is no doubt that we have seen mice increase their lifespan. The study also found that the HCR group had a very good constitution and could test far more than the HC group. Rats of Resveratrol are not just long-lived and they are more energetic. Physical fitness test results show that aging is improved. Studies have shown that Resveratrol and Quercetin: can inhibit the conformation of Resveratrol and prolong its residence time in the blood, and also synergistically protect DNA in cell mitochondria. (Deoxyribonucleic acid) exerts anti-aging effects against chemical damage. The raw materials used in the present invention are commercially available, and the raw material of Resveratrol used is trans-Resveratrol. 'The active ingredient of Quercetin 201010713 (Quercetin) is Meletin. The scope of the claimed invention is not limited to the description of the above embodiments.
1010