TW200940046A - Plastic ampule - Google Patents

Abstract

To provide a plastic ampule, restricting volatilization/scattering of liquid medicine contained in the plastic ampule and elution of compounding agents of plastics into the liquid medicine, and restricting generation of whiskers, and deformation/breakage of an opening part when opening the plastic ampule. The plastic ampule 10 is provided with a liquid medicine containing part 11, a liquid medicine discharge cylinder part 12 communicated with the medicine containing part 11, and extended toward one side, and a top part 13 to close one end part of the medicine discharge cylinder part 12. On the medicine discharge cylinder part 12, a fragile part 14 is thinly formed along the circumference. The medicine containing part 11, the medicine discharge cylinder part 12, and the top part 13 are formed of multi-layer plastic including an intermediate layer including a cyclic olefin-based (co-)polymer of a glass transition temperature of 60-80[deg.]C, an inner layer laminated on the inside of the intermediate layer, an outer layer laminated on the outer side of the intermediate layer, and adhesive layers respectively disposed between the intermediate layer and the inner layer, and between the outer layer and the intermediate layer.

Description

200940046 IX. INSTRUCTIONS: [Technical Field] The present invention relates to a plastic ampule, and a colored plastic container formed by having thermoplastics. In detail, it relates to a method for accommodating a drug in a male seal state. A plastic ampule for liquids, and a colored plastic container for containing a drug which is easily decomposed and deteriorated by purple. [Prior Art]: In the past years, the rice used to hold the liquid in a sealed state has been transformed into a plastic ampule from the viewpoint of impact, ease of operation, and safety. The ampoules are usually constructed in such a manner that the accommodating portion for accommodating the medicinal liquid is connected to the medicinal liquid accommodating portion and extends to the side, and the medicine is sealed. The fragile portion of the ejector portion of the side end portion of the liquid discharge cylinder portion (shaped along the circumferential direction) ^^α. 2 'has a stalk that causes the above-mentioned liquid medicine to discharge from the fragile portion of the tube portion = as 'twisted Or fracture] and used to discharge the discharge of the liquid. Can be: Polycollage ampoules are made by the use of liquid medicines such as polymethylene or polypropylene women in recent years to suppress the volatilization of water contained in plastics, especially the solvent of the liquid medicine. ), or inhibit the (co)polymer contained in the plastic. - and ... also studied the use of cyclically dilute hydrocarbons. Specifically, the material in Patent Document 1 is a plastic ampoule formed from a material of the (10) day of the combination of a ring-type flue-cured tobacco, Patent Document 97110774 5 200940046 2 A plastic ampule formed of a resin containing a polycyclic olefin is described as the innermost layer. Further, as a method of producing a plastic ampule, as described in Patent Document 2, it is known that a step of forming an ampoule by blow molding, a step of filling a liquid in a * bottle, and a sealed ampule are known. The so-called blow molding, filling and sealing (bl0w/fin/seal, BFS) method according to the BFS method can integrally form a plastic ampule, and the medicinal solution can be aseptically contained in a plastic enamel bottle and sealed. . In addition, in such a plastic container, in order to accommodate a drug which is easily decomposed and deteriorated by ultraviolet rays, it has been studied to impart a light-shielding property to a plastic material forming a container, for example, it is proposed to formulate a pigment in a plastic material, or to dispense ultraviolet light absorption. Agent. Patent Document 3 discloses a colored resin composition for an infusion bag, characterized in that 0 to 3 parts by weight of a color index pigment yellow 95 and/or a color index pigment yellow 147 are blended in 100 parts by weight of the thermoplastic resin. Yu Cheng. Further, in the case of the patent document 4, in order to prevent the oily food container from being deteriorated by light, or to improve the preservation of the contents, the inner and outer layers which are mainly composed of the concentrated smoke are interposed with the adhesive resin layer, and the ultraviolet absorber is contained. The ethylene-ethyl chant alcohol copolymer layer was set as an intermediate layer and formed by the resulting laminated body. Patent Document 1: Japanese Laid-Open Patent Publication No. Hei No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. Japanese Patent Laid-Open Publication No. Hei 9-86-57A SUMMARY OF THE INVENTION [Problems to be Solved by the Invention] In the case of forming a plastic ampule by the BFS method, a layer of a cyclic olefin*"/) polymer From the viewpoint of preventing the sealing property or the formability of the ampoule, it is preferable to use it as a layer other than the innermost layer of the ampoule, and to prevent the elution of an additive such as a pigment or an ultraviolet absorber into the liquid medicine. And 5 is preferably used as a layer which is more inner side of the layer to which the additives are formulated. Therefore, the layer of the olefin-based (co)polymer is naturally used as an intermediate layer of the plastic ampoules. A plastic ampule formed of a layer of a cyclic olefin-based (co)polymer has the following disadvantages: for example, in the case of opening an ampoule, the opening which is generated by twisting or breaking is often referred to as "burr". Fine resin ; Or due to damage or deformation of the openings, it is difficult to discharge drug solution from the plastic ampule. Further, in the case of formulating a pigment in a plastic material forming a container, in order to sufficiently shield the wavelength light in the ultraviolet region, a large amount of pigment must be formulated, so that there is a problem that the wavelength light in the visible region is also shielded, so that it is difficult to see The contents of the plastic container. Moreover, in the case where the ultraviolet absorber is blended in the plastic material and the wavelength light in the ultraviolet region is sufficiently shielded, there is also a concern that the problem of an increase in cost is apt to become remarkable due to the large amount of the ultraviolet absorber being dispensed, and the ultraviolet absorber is generated. The dispersion of the dispersion in the plastic material is degraded, or the ultraviolet absorber is exuded from the plastic material (b 1 eed). 97110774 7 200940046 As another method of improving the light-shielding property of a plastic knee container, it is generally considered that the thickness of the plastic is increased. However, in this case, there is a concern that the overall degree of the container increases, which causes an obstacle in the operability of the plastic container. Especially in the case of - the plastic container is a relatively small container such as a relative, etc. • The disadvantage caused by the increase in thickness. Bei Jian = The purpose of the invention is to provide a kind of plastic ampoules, which can inhibit sputum;: the volatilization and loss of the ampoules, or the dissolution of the plastic sputum to the medicinal sputum can inhibit the burrs of the plastic ampoules when they are opened Or deformation or damage of the opening. The other purpose of 1 is to provide a color-colored plastic container. The glutinous rice is easily decomposed and deteriorated by ultraviolet rays, and the inside of the container is observed. j is easy (the means to solve the problem), etc. In order to achieve the above objectives, the researcher repeatedly tried hard to study, and the surname was found to be formed by multi-layer plastics. ❹ ❹ : The layer-used cyclic olefin (common) condensed on the second: 2 is a specific range, the above problems can be solved, and: 遂 completed the present invention. The invention relates to a plastic ampule of the present invention characterized by a liquid chemical storage portion; a communication with the chemical liquid storage portion; a second valley portion; the chemical liquid discharge cylinder portion is provided along : Week out =, weak part; the above liquid medicine containing portion, the brittleness of the above liquid medicine wall is formed by multi-layer plastic kicking, and the multi-layer plastic system is provided with: 97110774 200940046: Medium to: inner: shape (four) layer. , the inner layer, and the laminating outside the outer layer of the above-mentioned intermediate layer = : An bottle 'Because the formation of the chemical liquid containing portion, the liquid medicine polymer, the intermediate layer containing the ring (4) hydrocarbon system (total) loss, red. The volatilization of the liquid in the plastic ampoule. The dispersing agent of the powder or J glue is dissolved into the liquid. And 'the brittle thorn of the working Κ 排出 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆An adhesive layer is provided on the intermediate layer. Between the intermediate layer of θ Β 34 and the outer layer, respectively, the adhesion between the intermediate layer and the inner layer or the adhesion between the intermediate layer and the outer layer can be improved. == The plastic ampoules are further provided with: the above-mentioned liquid trousers discharge cylinder: two fragile portions, the cymbal continuous from the outer peripheral surface of the top side and protruding from the outer side of the second portion, or the outer surface from the top portion The sepals are continuous and the dog is on the outer side of the top. In the case of the present, the above-mentioned cymbal is held by the above-mentioned cymbal to be twisted or twisted, whereby the operation of the kelly discharge cylinder to be broken or broken at the fragile portion becomes easy. (4) The plastic ampule of the present invention is further provided with the fragile portion for enhancing the discharge of the chemical liquid from the cylindrical portion, and the outer surface of the chemical liquid containing the liquid chemical storage unit is 97110774 9 200940046, and the surface of the chemical liquid containing portion is continuously distributed. The chemical liquid discharge tube portion and the chemical liquid storage portion are outside and are in contact with each other. In this case, by the feeding of strong sheets, the rigidity between the discharge of the liquid of the liquid medicine can be increased, so that the twisting or f-curving (four), medicine: deformation of the receiving part or the discharge of the liquid medicine, x It is easy and accurate to break the fragile portion of the discharge portion of the liquid. Therefore, the workability of the plastic ampule can be remarkably improved. Preferably, the plastic ampule of the present invention is used for the thickness of the multilayer plastic of the discharge portion of the chemical liquid, and the force required to rupture the fragile portion is 〇65 N.m/mm or less. # By setting the force required to disintegrate the above-mentioned liquid medicine from the fragile portion of the cylindrical portion to the above range, the workability for unsealing the plastic ampule can be remarkably improved. The plastic ampule of the present invention is preferably such that the inner layer and the outer layer of the multilayered plastic are (i) high-pressure polyethylene having a density of 0.900 to 0.940 g/cm3, or (?) containing a polypropylene resin. In the case of the above (i), it is easy to adjust the force required for cracking the fragile portion, and the feeling of twisting or breaking the fragile portion is good. In the case of the above (11), the heat resistance of the plastic ampule can be improved. Further, in the case of the above (ii), a mixture of the polypropylene resin-based polypropylene, the polypropylene elastomer and the nucleating agent is preferred. 97110774 10 200940046 In this case, the softness and transparency of the inner layer and the outer layer of the multilayered plastic can be improved. The plastic ampule of the present invention is preferably such that the intermediate layer of the above-mentioned multilayer plastic is formed of a --mixed resin. The mixed resin contains a cyclic olefin-based (co)polymer having a glass transition temperature of 60 to 80 ° C, and a density of 0. 900〜〇. 940 g/cm3 of high-pressure polyethylene, or high-density polyethylene having a density of 0.940 to 0.970 g/cm3; high-pressure polyethylene having a density of 0.900 to 0.940 g/cm3 in the above mixed resin, Or the density of 0.940 to 0.970 g/cm3 of the high-density polyacetonitrile is 30% by weight or less. In this case, it is easy to adjust the force required for cracking the above-mentioned fragile portion, and the adhesion between the intermediate layer and the inner layer and the outer layer can be improved. Preferably, the plastic enamel of the present invention is such that the outer layer of the multi-layered plastic contains a coloring agent and/or contains a ultraviolet absorbing agent. In the case of (iii) and (lv) above, the plastic ampule may be appropriately provided with a light-blocking property. In the case of the above (iv), the ultraviolet absorber is preferably a benzotriazole-based ultraviolet absorber. Further, in the case of the above (iv), it is preferable that the outer layer of the multilayered plastic further contains metal oxide fine particles together with the ultraviolet absorber. In order to achieve the above other objects, the colored plastic container of the present invention is characterized in that it is formed of a thermoplastic multilayer plastic comprising: a coloring layer containing a pigment and an ultraviolet absorber; and a direct or clamping/intermediate layer And an inner layer laminated on the side surface of the colored layer; the thickness T of the colored layer 97110774 11 200940046 is 50 to 1000"; the above ratio (4), the thickness of the colored layer is as follows: training; The product of the ultraviolet absorber contains = υϋ), and the thickness Tτ of the thickness of the upper 34 colored layer, in the above 1 SPTS 150..·(1)

5SUTS 160... (2) 20< UTS 160. (3) The colored plastic container according to the present invention maintains moderate visibility to the inside of the container and can efficiently shield wavelength light in the ultraviolet region. Therefore, according to the present invention, it is possible to stably accommodate a drug which is liable to be decomposed and deteriorated by ultraviolet rays. Preferably, the colored plastic container of the present invention is such that the other side surface of the colored layer is the outer side surface of the thermoplastic multilayer plastic. That is, it is preferred that the colored layer 之外 be an outer layer of the colored plastic container. Further, in this case, it is more preferable that the content ratio U of the ultraviolet absorber in the colored layer (the weight « divided by the thickness of the colored layer only satisfies the following formula (4) at a quotient U/T. U/TS 0. 004·. (4) By arranging the colored layer on the outer surface of the thermoplastic multilayer plastic, that is, by using the colored layer as the outermost layer of the thermoplastic multilayer plastic, UV absorption can be efficiently performed. The ultraviolet absorbing effect of the agent. Further, in this case, by setting the content ratio of the ultraviolet absorbing agent in the colored layer to the range of 97110774 12 200940046, the ultraviolet absorbing agent can be prevented from oozing out from the surface of the thermoplastic multilayer plastic. In the colored plastic container of the present invention, it is preferable that the pigment is an azo condensation pigment, and the ultraviolet absorber is a benzotriazole ultraviolet absorber. In this case, the shielding effect on the light in the ultraviolet region is good. Further, in the colored plastic container of the present invention, it is preferable that the transmittance of the thermoplastic multilayer plastic is 5% or less for light having a wavelength of 200 to 380 nm, and 40% of light having a wavelength of 600 nm. The colored plastic container of the present invention is preferably provided between the colored layer and the inner layer, and has a cyclic olefin polymer layer. In this case, the colored layer can be prevented from moving to the inner layer by the pigment or ultraviolet absorber contained therein. Side or coloring, the contents of the plastic container, and can prevent adverse effects on the medicine contained in the colored plastic container. The coloring is included in the series: the liquid medicine contained in the bottomed cylinder a communicating with the open end of the liquid medicine receiving portion: the liquid medicine discharging cylinder portion extending from the two sides; and the colored plastic ampoule of the closing portion of the liquid medicine discharging portion of the liquid medicine chamber; the plastic layer of the above liquid medicine containing portion The thickness is 3〇〇15〇〇” ^, in this case, it is preferably a colored plastic container (coloring by the blow molding, filling and sealing (BFS) method to form a female bottle) (invention effect) = return of the present invention Money can inhibit the containment of (4) (four) the volatilization of the heart. Loss, or the plastic compound dissolves the liquid liquid out of the fragile part of the tube when it is cracked, and 'the drug works well, can inhibit the plastics of 97110774 200940046 when the seal is opened glitch, Deformation and damage of the opening. The plastic ampule of the present invention is suitable for use as, for example, an ampoule which is filled in a sealed state, and is particularly suitable for use as a plastic ampoules produced by the BFS method. Maoyue's colored plastic container has moderate visibility to the inside of the container, and can effectively shield the light from the outside of the container to the ultraviolet area of the inside person. Therefore, the colored plastic container of the present invention is suitable for accommodating the ultraviolet light. The use of the plastic ampoules of the present invention is described in detail below with reference to the drawings, and the embodiment of the plastic ampoules of the present invention is shown in the following paragraphs. ^1 A front view of her form. Further, with respect to the plastic circle shown in Fig. 1, it is a plan view, and the plastic ampoules 10 are viewed from the bottom view, and the rear view is shown together with the front view/, Fig. 1 and the left side view. See the right side as shown in Fig. 1 and Fig. 2, the plastic ampule-shaped liquid medicine for containing the liquid medicine a, · > becomes the open end of the bottomed tube Ua and the direction of the body 1 1; and the liquid medicine receiving portion Pa pa pa ^ ^ ^ 延伸 之 乐 乐 discharged 筒 12 . 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 . . . . . . . . . . . . In the liquid chemical accommodating portion U, the (four) portion U° 7 ¢- is formed in the longitudinal direction of the medicinal liquid accommodating portion U, and is formed at one end side opposite to the mandrel of the bottom MI. There is a 9710774 200940046 mouth end 11a' near the open end 11a, and has a shoulder J 7 whose diameter is smaller from the side i6 lateral opening end 11 a side (one side). The cross-sectional shape of η is formed into a circular shape in the middle view of the plan view. However, the cross-sectional shape of the chemical liquid storage portion u is not limited thereto. For example, it may be formed in an elliptical shape. J. Referring to FIG. 1 and FIG. The discharge cylinder portion 12 is extended in the axial direction of the same wheel * by , ▲ 丄 in the following manner. The top 13 of the liquid phase discharge cylinder portion 12 from the upper side is formed in the chemical liquid discharge cylinder portion 12t and the end portion of the chemical liquid storage portion. Continuously and blocking the drug solution discharge cylinder portion 12 is, for example, a syringe nozzle of the liquid medicine in the insertion 11 for sucking the inner diameter of the liquid medicine receiving portion spray (4), so that it is preferable to have the above Preferably, the nozzle is fixed in the state of the chemical liquid containing portion, and is further sufficiently longer than the 'axis direction. degree. The liquid medicine discharge portion U and the liquid medicine discharge tube portion are integrated together, and are formed to be accommodated and sealed. The top portion 13 is continuous with each other, and the liquid medicine discharge cylinder portion 12 is tied to the closed portion of the liquid solution. . Na to the chemical liquid discharge cylinder portion 12" The open end of the liquid valley portion 11 is provided along the chemical liquid discharge cylinder portion 12: a substantially intermediate portion between the portions, and a portion 14 (see Fig. 5). The ° direction is formed into a thin wall. The fragile hunting, holding the liquid container accommodating portion u, 97110774 /, the top of the liquid discharging cylinder portion 12, 200940046, can easily break the fragile portion or break and split. Kaifeng plastic money. 2: This is the following state: • The drug solution is discharged from the opening of the tube, and the opening formed here is inserted into the drug solution of the drug: nanometer: 再 = ; Next, ... inserting into the liquid medicine row 2 = the liquid medicine contained in the chemical liquid containing portion 11. f. Figure 5 'The liquid medicine containing portion 1 the liquid discharging portion 12 and the top portion 13 are formed of a layer of plastic, which Multi-layer plastics have: Example ° =: anthracene ring (four) hydrocarbon system (co) polymer two = for the intermediate layer 18, and laminated on the inner side of the plastic ampoule 1 于 layer of plastic ampule 1 〇 outside the stomach, with the inner layer 19 adhesive layers 21; and an adhesive layer 22 disposed between the intermediate layers 18; and disposed in the intermediate layer 18 and the outer layer 20, disposed in the intermediate layer 18 The inner layer 19 = the adhesive layer between the two is the only one of the adhesive layer m, and the inner side surface and the outer side surface of the plastic ampoules are arranged in the inner layer 19 and the outer layer 2 塑. 'The direct use of the ring is: in the middle layer 18 of the two, the glass transfer temperature is 6 ° ~ _ < feed olefin system (this), for example, one can be mentioned: in B; with dimer, B A copolymer of a rare and a bribery compound, a cyclopental 97110774 16 200940046, a ring-opening polymer, a plurality of cyclopentadiene derivatives, a whitish outer τ dream + 』 a heart-opening ring, a surface, a Ό, a glass The transfer temperature is 60 to 8 (the range of rc. I think that "+ cyclic olefin system (co)polymer can be used alone" can also be used in combination of two or more types. π is early, as for the female hydrocarbon system 22 The above-mentioned 'preferably' is preferably a hydrogenated product of a copolymer of ethylene and a pentane-based a substance, or a hydrogenated product of a ring-opening (co)polymer of a ring of the above or more.

: Shape, interlayer 18 a temple' By using the ring-shaped thin smoke (co) polymer as described above, the strength or water permeability of the plastic ampule can be made better 'and' can give resistance to plastic ampoules Breathability. Further, as a specific example of the above-mentioned cyclic olefin-based (co)polymer, for example, a copolymer having a repeating unit represented by the formula (A) and a repeating unit represented by the formula (A) can be mentioned. A compound such as a polymer having a repeating unit represented by the formula (B). [Chemical 1]

[Chemical 2]

^ch2ch2·)^- 97110774 (B) 17 200940046 (Formula (A), Equation (A,) and Equation (8) Order, Rl·, r2 3

The same or different 'represents hydrogen, a hydrocarbon residue or a polar group R and R may be bonded to each other to form a ring 1, / R is the same or different, and represents an integer of 1 or more, and η, 乂 and 2 phases represent 〇 or 1 or more. The integer. y is the same or different, and examples of the hydrocarbon residue include an alkyl group.

More preferably, the carbon number is 6%, and the carbon number is W. The polar number is, for example, a (four) atom (for example, a chlorine atom, a desert atom, an argon atom, etc.), The ester, nitrile " fluorenyl group and the like have repeating units represented by the general formulae (4) and (A'): a system of known open-loop polymerization, one or two or more kinds of single: The gasification of the ring-opening polymer thus obtained is carried out according to the usual method, and the polymer can be purchased, for example, under the trade name "Z_0R (lH Ν Co., Ltd. ❹ S_etiC Rubber L)." And "a", "a brand of a product, which has a repeating unit of the formula (B), which is a product of the company's product, which is a method of a known method, which is used to reduce one or more kinds of monomers as a monomer. The olefinic monomeric fish, ethylene, is added and copolymerized, and the soil is buried, the belly sputum, the gas π, and/or it is weathered according to the conventional method. The poly sigma can be bought, for example, by Mitsui Chemicals. The product name "ship (registered trademark)" manufactured by the company, and the trade name "T0PAS (registered trademark) manufactured by TIC0M G_) Wait. Tao Ming 97110774 18 200940046 Among the polymers having the repeating units represented by the above formulas (A), (A') and (B), the hydrides are all saturated polymers, and therefore, in addition to gas shielding properties or moisture shielding properties It is superior in heat resistance, transparency, and stability. - The glass transition temperature (Tg) of the cyclic olefin-based (co)polymer is determined by a power-compensated differential scanning calorimeter (power compensation Dsc) described in JIS K 7121, "Method for Measuring Plastic Transfer Temperature" The intermediate point glass transition temperature (Tmg); and the Tg' of the cyclic olefin system (co)polymer used to form the intermediate layer 18 is set to 60 to 8 (^c, preferably 65 to 8) as described above. In the case where the Tg of the cyclic olefin-based (co)polymer exceeds 8 (rc), there is a problem in that an opening called "burr" remains on the opening due to the cracking of the fragile portion 14. Further, if the Tg of the cyclic olefin-based (co)polymer exceeds 8 (TC), the force required to break the fragile portion 14 by twisting or breaking increases, and it is difficult to open the plastic ampule. On the other hand, when the Tg of the cyclic olefin-based (co)polymer is less than 60 ° C, the water vapor barrier property required for the intermediate layer 18 or the effect of preventing the resin additive or the like from moving to the content liquid is lowered. The desired object of the present invention cannot be achieved. The melting of a cyclic olefin system (co)polymer The melt flow rate (melt f 1〇w rate, MFR) is not particularly limited, and is preferably from 4 to 30 g/l 〇 minutes (26 〇. 〇) in terms of the formability or mechanical properties of the plastic ampule. The molecular weight of the cyclic olefin-based (co)polymer is not particularly limited, and the number average molecular weight <Mn> is preferably 10,000 to 10,000, more preferably 20,000 to 50,000. Further, the average molecular weight is, for example, It is obtained by a gel permeation layer of 9710774 19 200940046 by a method of analysis (GPC) using cyclohexane as a solvent, and is obtained as a styrene equivalent value. The intermediate layer 18 can be, for example, only a glass transition temperature (Tg) of 60 to 80 ° C. The cyclic olefin-based (co)polymer is formed, and may be formed, for example, of a cyclic olefin-based (co)polymer having a Tg of 60 to 80 ° C and a mixed resin of polyethylene. For example, a cyclic olefin-based (co)polymer having a Tg of 60 to 80 ° C and a density of 〇 900 to 940 g/cm 3 (more preferably a density of 0.920 to 0.930 g/cm 3 ) may be mentioned. High-pressure polyethylene or a mixed resin of high-density polyethylene having a density of 0.940 to 0.970 g/cm3. a branched polyethylene produced by a high pressure method. On the other hand, a still-density polyethylene is a linear polyethylene produced by a medium-low pressure method, and the high-density polyethylene may be, for example, a homopolymer of ethylene. For example, it may be a copolymer of ethylene olefin, propylene, butene-p-pentylene, hexamethylene-4-pentene-1, octene-1, decene-1 and the like.藉 By using the above-mentioned mixed resin as the resin forming the intermediate layer 18, the force required to break the fragile portion 14 by twisting or breaking can be easily set, and the intermediate layer 18 can be raised and adjacent to the intermediate layer. The adhesion of the inner layer or the outer layer 20 of the 18 layer. Further, it is preferable that the force material and μ# π are transparent to the above-mentioned fluorene-density polyethylene in the above-mentioned % olefin-based (co)polymer. ^, can fully maintain the mixed resin in the above mixed resin, 斋 Λ Λ 920 ^ 0. 930 ; / cm 3 ^ is 0.940 ~ 0.970 g / cm 3 of the ancient ~ inter-pressure polyethylene, or the density of the above mixture The light weight of the tree 3 (^, _4 polyethylene content ratio, preferably 3 〇 wt% or less, more preferably 5 to 30 weight 97110774 20 200940046% / particularly good 4 5 to 25 wt%. If the above mixed resin When the mixing ratio of the above-mentioned high-pressure method or the above-mentioned male and polyethylene is more than the above range, the above-mentioned performance required for the cyclic olefin-based (co)polymer may be insufficient. 'As the inner layer 19 and the outer layer are formed. For example, a polyalkylene pellet is not particularly limited, and examples thereof include various polyolefins which can be used in a conventional medical plasticizer. Among them, polycondensation is preferred. Ethylene-based resin or polypropylene-based resin. When a heat-resistant plastic container for medical use is used, a polypropylene-based resin can be preferably used. Examples of the polyethylene-based resin include a high-pressure method ( Branched) low density polyethylene (HP-LDPE), straight Low-density polyethylene (LLDPE), medium density polyethylene ⑽PE), high density polyethylene ⑽pE) homopolymers, or polyethylene-based polymers. Examples of the co-monomer other than ethylene in the polyethylene-based copolymer include the same α-olefins as described above. Further, the content ratio of the comonomer other than 6 dilute in the polyethylene-based copolymer is preferably not more than mol%, more preferably 3 to 20 mol%. The nature of the rare tree mites is not particularly limited, and the fragile portion 14 is cleaved by the moldability of the intermediate layer 含有8 containing the cyclic olefin system (8) poly 5 material, by twisting or breaking. From the viewpoints of ease of setting of the required force and mechanical properties of the plastic ampule, it is preferred to select a relatively low density polyethylene resin, specifically, a density of 0.900 to 940.940 g/cm. Preferably, the high-pressure method polyethylene (tetra)ethylene in the range of 930 〇 920 〇 930 g/cm 3 is the same as the two layers forming the intermediate layer 18: two. 97110774 21 200940046 The melt flow rate (10) of the polyethylene resin is not particularly limited, and is preferably Q from the viewpoint of the mechanical properties of the molded plastic of the intermediate layer 18 containing the cyclic olefin system (4) polymer. 2 to minutes (190 ° C). In addition, examples of the polypropylene resin include, for example, a crystalline homopolymer such as an isotactic polypropylene or a syndiotactic polypropylene, or a crystalline copolymer containing a small amount of a comonomer. ° ❹ As a comonomer other than propylene in the above crystalline copolymer, for example, ethylene: butene's pentene-p-hexene + 4-decylpentene-b-sin Wait for women's hydrocarbons. Further, the content ratio of the comonomer other than the propylene compound in the crystalline copolymer is preferably 30 mol% or less, more preferably 2 to 30 mol%, particularly preferably 3 to 25 mol%. In order to impart flexibility to the above polypropylene-based resin, it is preferable to use Γο::: a raw body. In particular, the density produced by using a metallocene catalyst is .870 g/cm3, and the glass transition temperature (Tg) is -1 (TC below =: the physical body' has both heat resistance, transparency and flexibility, so (2) If there is a polypropylene elastomer of the VIII (4) type, for example, the trade name "ΝΟΤΙΟ" manufactured by Mitsui Chemicals Co., Ltd. can be purchased. For other polypropylene elastomers, for example, low crystal polyacryl "T^MER[^ % 'Mitui Chemical Co., Ltd. manufactures the product name 夕卜声20=10 copies of the trademark) "X series, etc.) ° Relative to the formation of the inner layer 19 or the amount of the above-mentioned polypropylene elastomer is preferably adjusted. It is 1 0 to 40% by weight. The swell flow rate (_) of the polypropylene resin is not particularly limited. From the viewpoints of the formability of the intermediate layer 18 containing the cyclic olefin-based (co)polymer and the mechanical properties of the plastic ampule, Preferably 〇2~2〇 \

The minute (230 ° C) « g U inner layer 19 and the outer layer 20 can be formed, for example, only from a polyethylene-based resin or a poly resin, for example, a polypropylene, a polypropylene elastomer, and a nucleating agent: mixture. In this case, the visibility of the inner layer 19 or the outer layer 2 can be improved. ❹ As a nucleating agent, for example, 2,2,-methylenebis(4,6-di-t-butylphenyl)phosphate (NA-11), bis[2,2_methylene Base_bis(4,6_di: tert-butylphenyl)phosphoric acid] is a sulphate-based nucleating agent such as basal (NA-21): Further, the inner layer 19 or the outer layer 20 is not limited to a single layer. For example, a laminate of layers formed of mutually different resins selected from the resins may be mentioned. Between the layers of the T-interlayer 18 and the inner layer 19, and between the layers of the intermediate layer 18 and the outer layer, the adhesive layers 21 and 22 may be separately provided as needed. The resin of the adhesive layer 2, 22, for example, a mixed resin such as LLDpE (a polymer which is polymerized by a single catalyst such as a metallocene catalyst) or a polyethylene. In the resin for forming an adhesive layer, for example, an unsaturated ester copolymer or the like which is known as an adhesive resin may be mentioned. The U-material and the ethylene-vinyl acetate door are not particularly limited to the thickness of the adjacent layer (the middle layer 19, the intermediate layer 18 and the outer layer 20). Specifically, it is preferably about 97110774 23 200940046 2 to 10% with respect to the thickness of the adjacent layer. And so on, in the outer layer 20, for example, a coloring agent can be adjusted, and a coloring agent for the ultraviolet absorbing agent is used to reduce the quality of the plastic ampules of the plastic, and the transparency of the sputum is prevented. Plastic ampoules give creativity: for example, CL Pigment Yellow 95, CI Yan " 7, CI Pigment Yellow 180, CI. Yan Yan == 22 °, "Pigment (4), etc. Red = 1 = pigment. These pigments can be The ❹ ❹ 亦 亦 配 配 配 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 ' ' ' ' ' ' ' (4) In order to reduce the permeability of the wire of the (four) wire and prevent the deterioration of the chemical solution contained in the plastic knee ampule due to ultraviolet rays, 'specifically', for example, 2_(2, -hydroxy_5) , monomethylphenol) benzotriazole (Ciba Specialty Chemicals (trade name "TINUVIN (registered trademark) p" manufactured by Ciba Specialty Co., Ltd.), 2_(2, monohydroxy 3,5 bis (methylbenzyl) Phenol) benzotriazole (made by Ciba Specialty Chemicals Co., Ltd.) Trade name "(registered trademark) 234"), 2-/2'-hydroxy-3'-t-butyl-5'-nonylphenol)_5-gas benzotriazole (>% Bajing Chemical Co., Ltd.) The company's trade name is "TINUVIN (registered trademark) 326"), 2-(2,-hydroxy_3',5'-di-t-butylphenol)-5-chloro 9710774 24 200940046 benzobisazole (steam) Bajing Chemical Co., Ltd. "Τί_ίΝ (registered trademark) 327"), 2-(2, mono-based, 3, 5, trade name triamylphenol) benzotriazole (Ciba Specialty Chemicals Co., Ltd.; "τ 副 简 registered trademark" 328"), 2_(2, m = quotient butyl benzene age) benzotris(s) (Ciba Refinery Limited 4: Product name "Π_ΙΝ (registered trademark) 329" t Receiving agent, etc.

The amount of the ultraviolet absorber is appropriately determined according to the degree of 2G of the outer layer and the degree of ultraviolet shielding required by the plastic money, and can be 'not particularly limited, for example, the resin forming the outer layer 2G = p 0.01 to 0.4 weight. %. Preferably, in the case where the ultraviolet absorber is blended in the resin forming the outer layer 20, it is preferable to adjust the metal oxide to be less than 0 from the viewpoint of improving the ultraviolet absorbing efficiency of the ultraviolet absorbing agent and reducing the amount of the ultraviolet absorbing agent. ❹ The metal oxide of the metal oxide fine particles may, for example, be titanium oxide, zinc oxide, iron oxide, cerium oxide or magnesium oxide. Further, the average particle diameter of the metal oxide fine particles is not particularly limited, and from the viewpoint of maintaining the transparency of the plastic ampoules, it is preferably 5 Å or less, more preferably 30 run or less. The amount of the metal oxide fine particles to be added may be appropriately set depending on the type of the ultraviolet absorber to be used or the amount thereof to be blended, the thickness of the resin forming the outer layer 20, the transparency required for the plastic ampule, or the degree of ultraviolet shielding property, and the like. It is not particularly limited. For example, in the resin forming the outer layer 20, it is preferably 0.0110774 25 200940046, which is 0.01 to 0.4% by weight. The combination of the violet L-line absorber and the metal oxide microparticles is particularly limited, and preferably 2_(2,, base: phenol)-5-gas benzotriazole (described above) The second butyl _5 'A standard ~ and the group of oxidized granules TI bribe 1N (Registrar layer = layer 19 and outer layer 2 〇 each layer thickness, any - ^:::: the layer formed by the multilayer plastic (4) The ratio of 2 degrees to the circumference of the bay can be appropriately set according to the type of liquid contained in the plastic ampoules, the guar, etc. The thickness of the layer plastic is based on the use of the plastic ampoules, the liquid: It is not particularly limited as long as it is appropriately set in the accommodation amount, and the like: For example, in the accommodating portion η, 'Comparatively 3' 〇 15 15 is more preferably 0 # m. The multilayer plastic kick thickness is in the chemical liquid accommodating portion 11, The materials (4) of the same portion 12 and the top portion 13 of the liquid medicine discharge may be different from each other. 所需 The force required to break the weakened portion 14 of the multilayer plastic (twist or fracture), that is, the 'dividing fragile portion 14 as a whole The required torque is preferably set to G.4QN.m or less, and more preferably set to 〇.〇5, from the viewpoint of the operability of the plastic ampule. 〇.4〇Nm. The force required to rupture the fragile crucible 14 relative to the thickness of the multi-layered plastic of the discharge portion 12 of the liquid medicine is preferably 〇·65 N or less, more preferably 〇.〇5~〇. 65 N.m/mm. The force of the fragile portion 14 is split in a portion adjacent to the fragile portion 14 of the liquid discharging portion of the chemical liquid and the thickness of the layer of the plastic layer is substantially uniform (the force per unit length of the thickness of the multilayer plastic) The required force is set to the above range, whereby the operability 97110774 26 200940046 which can be used to rupture the fragile portion 14 is good. 2: The force required for the weak portion 14 to be split can be determined according to the formation of the multilayer plastic The appropriate type of 开 曰 = = 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 The thickness of the intermediate layer formed is preferably 25~, more preferably 30~. ❹ ❹ = and as shown in Fig. 2, the liquid receiving portion u has two: 24 on the outer peripheral surface 23 thereof, the flange 24 Attached to the mandrel holding the chemical liquid containing portion η and 'outside the chemical liquid containing portion η;: extending in the axial direction of the second axis 15' The accommodating portion u is formed on the bottom portion 16 of the bottom portion 16 in the radial direction. The convex portion of the outer protrusion and the edge 25 are continuous with the flange 25 from the bottom portion 16. The flange 24 and the bottom portion 16 of the peripheral surface 23 are the same. It is produced by the method of manufacturing two flanged bottles 10 which are continuous with each other. The present invention (4) 5; is formed by the following plastic surface of the plastic portion U: 23 丄 =:=25 is formed in the liquid medicine and seeks to maintain the shape of the liquid containing the liquid. Each of the y portions 11 is provided with rigidity. As shown in Fig. 1 and Fig. 2, the sputum sheet 28 is provided with a cymbal sheet 28, and the outer peripheral surface 26 of the cymbal sheet is continuous toward the top portion 13 and protrudes on the side of the second = side. 'And' to the outer surface 27 of the top 13 is connected. "2 outside. Continuously protruding from the top portion 13, since the cymbal sheet 28 is formed from the top 13 side and the fragile portion 14 of the second portion: the portion 12 of the top portion 12, a1 is continuously formed, so that the liquid medicine capacity is held 97110774 27 200940046 : In the case where the top 13 of the bulu liquid discharge cylinder portion 12 is turned sideways or ridged, the chemical liquid accommodating portion u and the medicine are twisted and deformed. Μ Γ Γ Γ * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Formed on the flat plate portion 29: circumference::. Corner 30, powder hand η 9» +~ 丨同围倒倒... Borrowing two 8 pieces ^ The rigidity of the office W itself is maintained, and the plastic ampoules are sealed and held in order to open the deformation. It is "under the condition, it can suppress the sputum film, as shown in Figure 1 and the circle? Zhang - ^ external use Μ Η, not in the shoulder 17 of the liquid storage compartment!! On the evening: face 23' and from The liquid medicine accommodating portion of the fragile portion 14 is located on the outer peripheral surface 26 of the two adjacent portions, and is provided with a separate protrusion for the discharge of the chemical liquid: the mouth Μ 2 and the liquid accommodating portion u F are the same, and the reinforcing sheet 31 is on both sides. And the reinforcing sheets 3 connected to each other are discharged from the tubular portion 12:::: continually forming 'that is, across the self-position, and the accommodating portion u: the portion of the wide portion η of the portion " The liquid medicine is discharged from the tube portion 12; the sexual liquid can be used to raise the liquid medicine, for example, the liquid medicine discharge tube portion 12 protruding in the plastic ampoule accommodating portion η; easy to work, the self-medicated liquid is strong: 2: The opening of the plastic rice 10 is accurately performed. Therefore, the sheet 31 has the flat portion 3 chamfered portion 33, and the center of the reinforcing sheet 31 and the inner portion 4 formed around the flat portion 32 are hollow. The wall portion (refer to 97110774 28 200940046 according to Figure 7). Thereby, the reinforcing sheet 31 itself enhances the reinforcing effect, and can be suppressed in order to open the plastic ampoules = temple guard-step film The deformation of the strong piece 31. Moreover, when the weight is increased by 28, the finger can grasp the reinforcing piece well. The twisting of the moon is as shown in Fig. 2, and the addition (four) 31 is formed on the plane. In this case, a uniform appearance can be obtained. And the film = the same ❹ = two T28, the finger is easy to grasp the reinforcement = plastic reinforced sheet 31 can also be formed in the same with the film 28 - in the manufacture of plastic ampoules 10, smashed 28 and enhanced di quaternary Each part of the first liquid medicine discharge tube portion 12 and the σ-le liquid plastic ampule 1 〇 々〇Ρ 同时 同时 同时 同时 J J J J J J J J J J J J J J J J J J J J J J J J J J J Blow molding two methods to manufacture. The formation of the mouth = two:: melt: = more than two - forming, layer 18, adhesive layer adhesion / ^, the middle, w sub-shoulder 20 made of multi-layer semi-finished products. h mold clamping the obtained multi-layer semi-finished product to form each part of the liquid medicine discharge post 12 and the reinforcing sheet 31 (blowing two pairs: liquid mold cooling r housing portion discharging = page portion 13 and handling sheet 28, forming With the chemical liquid step), the closed area of the part 12 and the top 13 (the sealed case can be obtained by filling the plastic ampoule 10 with the liquid medicine sealed.) When the semi-finished product is held in the mold, the two flanges are formed along the closing faces of the pair of molds. 25 97110774 29 200940046 Sealing: 'The formation of plastic ampoules, the filling of liquid medicine, the difference in ampoules, and therefore A molded article (plastic) in which the drug solution (not shown) is filled in the sealed state in the state of the drug solution 1 (and the drug discharge tube portion 12) can be manufactured at a low cost. Ampoule - 丄u). The multilayered semi-finished product can be made according to the usual method in multi-layer blow molding, the shape of the machine or the die, the forming conditions of the multilayered semi-finished product, etc. The usual method in the middle can be set appropriately. The spear i is made of a blow molding filling and sealing method using a multi-layered semi-finished product. The plastic female bottle can be used in addition to the layer structure of the semi-finished product (the number of the semi-finished products is different or the die structure is different). The semi-finished BFS method is used to make plastic ampoules in the same way. Further, the respective layers of the multilayer film may be laminated to each other in the above-described manner, or may be adhered to each other by interposing layers formed of the above-mentioned adhesive resin. The plastic ampoules of the present invention are widely used, for example, in medical applications. Further, an embodiment of the colored plastic container of the present invention will be described in detail with reference to the accompanying drawings. The colored plastic container of the present invention is formed of a thermoplastic multilayer plastic comprising: a coloring layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly or sandwiching an intermediate layer to one side surface of the colored layer. Fig. 8 is a cross-sectional view showing an example of a structure of a thermoplastic multilayer plastic forming a colored plastic container. 97110774 30 200940046, and Fig. g and Fig. 3 are cross-sectional views showing other examples of the layer structure of the thermoplastic multilayer plastic, respectively. Further, in the following description, the same symbol is denoted by the same or the same type in a plurality of layer configuration examples. - The thermoplastic multilayer plastic shown in Fig. 8 is provided with a coloring layer 1 containing a pigment and an ultraviolet absorber (H, a cyclic olefin polymer layer laminated on one side surface of the colored layer 1〇1, 2, laminated in a ring The polyolefin layer 103 of the olefin polymer layer 1 2 opposite to the side surface of the layer ι ι. In the thermoplastic multilayer plastic, the colored layer 101 forms a layer of the outer layer of the colored plastic container, and the cyclic olefin is polymerized. The layer 102 forms a layer of the intermediate layer of the colored plastic container, and the polyolefin layer 103 forms a layer of the inner layer of the colored plastic container. The cyclic olefin polymer layer 102 is designed to prevent the pigment ultraviolet ray adsorbent disposed on the colored layer from moving to The layer contained in the colored plastic container and the layer 5 is placed in any layer of the thermoplastic multilayer plastic forming the colored plastic container of the present invention. The 35 plastic multilayer poem shown by 〇® 9 has: a pigment and an ultraviolet absorber. The coloring layer 01, the intermediate layer 104 of a three-layer structure laminated on one side surface of the colored layer 101, and the polyolefin layer 103 laminated on the opposite side surface of the intermediate layer 1〇4 with the coloring layer 1〇1. 104: a ring-shaped olefin polymer layer 102' and a layer of tantalum layer on one side surface and one side surface of the cyclic olefin polymer layer 102, respectively, and a total of two layers of polyolefin layer 丨〇5, .106 In the thermoplastic multilayer plastic, the colored layer 101 forms a layer of the outer layer of the colored plastic container, and the polyolefin layer 103 forms a layer of the inner layer of the colored plastic container. ^ 97110774 31 200940046 The thermoplastic multilayer layer shown in Fig. The coloring layer HHm of one of the 岬k layer iUd enamels contains pigment and ultraviolet absorbing, "-layered on the colored layer 101 and the polyolefin layer 103 in the polyolefin layer 103. The thermoplastic multilayer mold ::: layer 103 forms a layer of the outer layer of the colored plastic container, and the ring polymer layer 102 forms a layer of the inner layer of the colored plastic container. In addition, the coloring is to form a layer of a layer of the intermediate layer of the colored plastic container. The thermoplastic multilayer plastic shown in Table 2 = 1 , can be applied to each layer of the adhesive layer. In this case, for example, the adhesion of the colored layer m to the object layer 102 can be improved, and the cyclic hydrocarbon polymer should have the following adhesion: the adhesion of the colored layer (8) to the intermediate layer ι 4 = 'intermediate layer The adhesive of the cyclic olefin polymer layer 102 in 104 and the adhesion of each of the polythene J: i〇6, the colored layer 1〇1 and the polythene hydrocarbon layer 1〇3, in the present invention, the layer of the thermoplastic multilayer plastic The configuration is not particularly limited. For example, in order to impart light-shielding properties to the colored plastic container, it is preferable to arrange the colored layer 101 as much as possible on the outer side of the colored plastic container. In particular, it is effective in the case where the colored plastic container is a relatively small container such as an ampoule. The plastic which is a coloring layer is not particularly limited as long as it has a thermoplastic plastic, and specific examples thereof include polyolefin. The polyolefin is not particularly limited, and examples thereof include a polyethylene resin or a polypropylene resin. Further, in the case where the colored plastic container is required to have heat resistance, a polypropylene resin is preferable. 97110774 32 200940046 As the polyethylidene resin, for example, a high-calendar (supported) low-density polyethylene (iiP-LDPE), a linear low-density polyethylene (UDpE), a medium-density polyethylene ( a homopolymer such as MDPE), high-density polyethylene (HDPE), or a poly-glycol, and a t-thin as a co-monomer other than ethylene in the polyethylene-based copolymer, and examples thereof include acrylonitrile and butyl. Alkene-1, pentacene-p-hexene-Bu 4-methylpentazone 4, terpene-i胄α-anthracene hydrocarbon. Further, in the poly(fluorene) ethylene-based copolymer, the content ratio of the comonomer other than ethylene is preferably 20 mol% or less, more preferably 3 to 2 mol%. The properties of the polyethylene-based resin are not particularly limited. For example, it is preferably relatively low in degree, and specifically, the density is preferably in the range of 0.910 to 930.930 g/cm3. . Also, the rate of grafting flow (June) is preferably 〇·2~2〇_min (190. 〇. In terms of improving the mechanical properties of the colored plastic container, the properties of the polyethylene resin are better, especially It is preferable in the case where a cyclic olefin polymer layer is provided between the colored layer and the inner layer. As the polypropylene-based resin, for example, it can be wrapped in a crucible. The core of the sample is 4 gauge polypropylene, and the syndiotactic poly-specific H Or a poly(tetra) copolymer. Examples of the co-monomer other than poly-propylene include ethylene, butadiene-1, hexene-1, 4-methylpentene 4, octene fluorene, and anthracene. Further, in the case of the above-mentioned silk towel, it is preferably 30 mol% or less, more preferably 3 or more than 3 to 25 mol%. More preferably 2 to 3 mol%. %, particularly preferably, the properties of the polypropylene-based resin are not particularly limited in characteristics, and _ is the polyacrylic acid of the above range: 97110774 33 200940046 The case of having a cyclic olefin polymer layer between the colored layer and the inner layer β Further, the colored layer can be formed, for example, from a mixture of polypropylene, polypropylene elastomer, and nucleating agent. In this case, coloring can be improved. The transparency of the layer. As the nucleating agent, for example, 2,2,-methylenebis(4,6-di-t-butylphenyl)phosphate (NA-u), bis[2,2 - a nucleating agent such as a methylene _ bis ( 46 1-2 butyl butyl phenyl phosphate ) hydroxy aluminum (NA_21) or the like. ❹ - pigment system 4 reduces the light transmittance of the colored plastic container and suppresses The ingredients contained in the color plastic container (for example, pharmaceuticals, etc.) are formulated by deterioration of light (especially ultraviolet rays). In addition to the above purposes, for example, in order to impart creativity to the colored plastic container, Adjustable pigments. / As the pigment contained in the colored layer, it can be adjusted according to the type of content contained in the colored plastic container j, in order to improve the preservation of the above contents, δ, the wavelength region of the light to be shielded In the case where the contents of the colored plastic container are mainly used to shield the light in the outer region of the i, the pigment may be, for example, an azo condensation pigment (for example, the following) The expression of c. 丨. pigment yellow, by the following formula匕1·Pigment Yellow 93, C I. Pigment Yellow 94 represented by the following formula, CI Pigment Yellow 128, CI Pigment Red, CI Pigment Red 22〇, c·丨. Pigment Red 221, c.丨.Pigment red) 丨 丨 丨 琳 系 ( ( ( ( ( ( ( ( ( ( ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς C. I·Pigment Orange 61, c丨·Pigment Orange 68, etc.), monoazo-based pigment 97110774 34 200940046 (for example, CI Pigment Yellow 181, etc.), disazo pigment (for example, c. L Pigment Yellow 180 Etc.), brewing pigments (for example, c. I. Pigment Yellow 147, etc.), ii, etc., organic pigments such as well pigments, quinacridone pigments, or, for example, iron oxide, CI Pigment Blue 28 (cobalt blue) Inorganic pigments such as cobalt aluminate), C.I. Pigment Yellow 53 (titanium yellow; yellow). [化3] [化4] h3(

Cl

.3 (C.I. Pigment Yellow 95)

Cl OC-NH CH3 {

Cl ¢1

Coch3 hc-n=n HN-CO

〇C-NH 0〇ch3 H3C\ HN-CO Cl

(C.l. Pigment Yellow 93> 97110774 35 200940046 [Chem. 5]

Cl

COCH3

N=N-CH (C.I·Pigment Yellow 94> [Chem. 6]

COCH3

N=N-CH (C.l. Pigment Yellow 128> 97110774 36 200940046 [Chem. 7]

The pigment is preferably an azo condensation yellow pigment from the viewpoint of efficiently shielding the light in the ultraviolet region. Further, for example, even when the agent contained in the colored yoghurt is an aqueous solution of sodium zagreli (g〇dium 〇zagrei), the pigment is preferably improved from the viewpoint of improving the effect of suppressing deterioration of sodium ozagrel sodium. The azo condensation is a yellow pigment, particularly preferably CI Pigment Yellow 9 5. φ Resodium sodium solution and other ingredients. UV absorbers are formulated to reduce the UV transmission of colored plastics and to inhibit the deterioration of the contents of colored plastic containers (eg, Aegis) due to UV rays.

97110774 g Mouth name "ΤΙΝϋΠΝ (registered supplier methylphenol) benzotriazole (commercial name "TINUVIN (registered trademark) p" manufactured by Cibafin 37 200940046 Chemical Co., Ltd.), 2_(2'-base- 3',5'-bis(methylbenzyl)phenol)benzotriazole (trade name "TINUVIN (registrar's) 234" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2 - (2'-hydroxyl ~3',5,-di-t-butylphenol)-5-chloro benzophenanal (trade name "TINUVIN (registered trademark) 327" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2-(2, -Hydroxy-3,5,2-di-second-pentylbenzene-aged benzotriazole (trade name "TINUVIN (registered trademark) 328" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2_(2, one A benzotriazole-based ultraviolet absorber such as hydroxy-5, _tetramethylbutylphenol) benzotriazole (trade name "TINUVIN (registered trademark) 329" manufactured by Ciba Specialty Chemicals Co., Ltd.). Further, for example, even if the drug contained in the colored plastic container is ozagrel sodium (specifically, 'aqueous solution, monomer, etc.), the ultraviolet absorber is preferably a benzotriazole system, and particularly preferably a product. Name "tinuvin (registered standard) 326". Further, various additives other than the pigment and the ultraviolet absorber may be blended in the colored layer as needed. For example, from the viewpoint of improving the efficiency of absorbing ultraviolet rays of the ultraviolet absorbing agent and reducing the amount of the ultraviolet absorbing agent used, it is possible to further contain an ultraviolet absorbing agent and metal oxide fine particles together. Examples of the metal oxide of the metal oxide fine particles include titanium oxide, zinc oxide, iron oxide, an oxidation sieve, and oxidized town. Further, the combination of the external absorbent and the metal oxide fine particles is not particularly limited. The above-mentioned trade name "ΤΙΝϋνΐΝ (registered trademark plus 6 97110774 38 200940046 and zinc oxide fine particles are preferably used. The inner layer is made of thermoplastic). Specifically, for example, as described above, for example, a polythene hydrocarbon layer, a ring-shaped thin smoke polymer layer, etc. may be mentioned. Examples of the polyene smoke of the olefin layer may be exemplified and formed. The coloring gel is the same. ❹ ❹ The cyclic olefin polymer forming the cyclic thin hydrocarbon polymer layer may, for example, be a copolymer of a cyclic olefin and an olefin, a ring-opening polycondensate of a cyclic olefin, or the like. Specifically, for example, a copolymer of ethylene and a cyclopentadiene, a ring-opening polymer of a berry and a pentane derivative, and a ring of two or more kinds thereof may be mentioned. Η: a biological ring-opening copolymer, or a hydride of the above. Among them, a nitride of a copolymer of ethylene and a compound of a sulphate compound, or a type or a mixture of two or more kinds of f pentadiene is preferable. Hydride of open-loop (co)polymer The straw is provided with an annular thin hydrocarbon polymer layer as an inner layer, which prevents the pigment or ultraviolet absorber in the colored layer from moving to the content of the colored plastic. Further, the mechanical strength or water-proof ability of the colored plastic container can be improved, or the coloring can be improved. The plastic container imparts air permeability. The glass transition temperature of the hydrocarbon polymer (5) is not particularly limited. For example, it is a power compensation differential scanning method by IIS K 71 21.1987 "Transfer temperature measurement method for plastics". The analyzer (power compensation ds〇 measured, intermediate point glass transfer temperature (Trag), preferably 6 65~8〇t: υ more preferably the right % olefin polymer Tg exceeds 8 (rc, then produces as follows Unsatisfactory situation 97110774 39 200940046 Condition: For example, in the case where the colored plastic container is an ampule as described below, a fine resin sheet called "burr" remains on the opening portion which is formed by splitting the ampule, or the force required for the split becomes On the other hand, if the '· Tg of the cyclic olefin polymer is less than 60 c ', there is a concern that the effect of preventing the movement of the pigment or the ultraviolet absorber in the colored layer or preventing The gas and water vapor permeation ability is lowered. The melt flow rate of the cyclic olefin polymer (舯趵 is not particularly limited, and is preferably 4 to 30 g/min in terms of the formability or mechanical properties of the colored plastic container. (26. (:). The molecular weight of the cyclic olefin polymer is not particularly limited, and the number average molecular weight <Mn> is preferably from 10,000 to 10,000, more preferably from 20,000 to 50,000. The molecular weight is determined, for example, by gel permeation chromatography (GPC) using cyclohexane as a solvent, and is obtained as a standard polystyrene equivalent value. The intermediate layer is a layer formed of a thermoplastic plastic. Specific examples thereof include: ❹ (a) a cyclic olefin polymer layer, (b) a cyclic olefin polymer layer ′, and one side surface and the other side surface of the cyclic olefin polymer layer, respectively. a laminated body of a three-layer structure in which one layer of a polyolefin layer of two layers is laminated, (c) a colored layer, and the like. * The cyclic olefin polymer forming the polyolefin layer or the cyclic olefin polymer layer forming the above polyolefin layer may be the same as described above. As shown in the above (a) and (b), even in the case where the cyclic olefin polymer layer is the intermediate layer of 97110774 40 200940046, the same effect as that of the inner layer of the annular smoky polymer layer can be obtained. . That is, it is possible to obtain an effect of preventing the pigment and the absorbing agent in the colored layer from moving to the inside of the colored plastic container, or the effect of the strength of the tirapus container, and further, the ability to prevent water: and gas from being transmitted can be obtained. Effect. In order to improve the adhesion of the system or to reduce the hard production of the colored plastic container, the polyethylene hydride may be appropriately formulated in the cyclic olefin polymer layer as the intermediate layer. ❹ ❹ 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为0. 935~〇. 9 B: Two' relative to 1〇. The content ratio of the polyethylene to the olefinic polymer layer in a part by weight is preferably 5 to 20 parts by weight. Further, in the colored layer, the intermediate layer forming the colored plastic container is selected as the plastic forming the colored layer or the pigment contained in the colored layer: the line absorbent and other additives, which are the same as described above. And, if necessary, for example, a layer such as the above thermoplastic multilayer plastic layer, a gas barrier layer, an oxygen absorbing layer, a sealing layer or the like. As the adhesive layer, the strong saturated carboxy group is compared with the ethylene-acrylic acid copolymer and the ethylene-acid: the layer of the moon. Further, as another example of the adhesive layer, for example, == polyethylene, in particular, a so-called layer such as a metallocene is used as a density. A polyethylene form = In the colored plastic container of the present invention, the thickness 1 of the colored layer can be set to 97110774 200940046 50~1 000. When the thickness T of the colored layer is less than 50 /zm, it is difficult to adjust a sufficient amount of the pigment or ultraviolet absorber required for exerting the effects of the present invention to the colored layer. On the other hand, if the thickness T of the colored layer exceeds 1 000 /zm, the thickness of the thermoplastic multilayered plastic as a whole becomes too large, so that the formability or workability of the colored plastic container is lowered. The thickness T of the colored layer is particularly preferably 50 to 4 Å in the above range, and more preferably 50 to 300. In particular, in the case where the colored plastic container is a colored plastic ampule, the thickness τ of the colored layer is preferably 5 〇 to 3 〇 () in m. In the colored plastic container of the present invention, the product P ratio (P% by weight) of the pigment in the colored layer and the product ρτ of the thickness τ (#m) of the colored layer are set to satisfy the following formula (1). 1 ^ PT^ 150--(1) ❹ 2 is set within the range of the above formula (1), and the ratio of the ultraviolet absorbing agent in the colored layer described below is ϋ (weight illusion, and The product UT of the thickness T(am) of the color layer is set to the following range, and the moderate visibility to the inside of the container can be maintained' and the wavelength light of the ultraviolet region is efficiently shielded. In contrast, the value of _PT < In the above range, the shielding effect of the wavelength light in the outer region is insufficient. On the contrary, if the value of ρτ exceeds the above range, it is difficult to confirm the inside of the colored plastic container. The value of ΡΤ is particularly preferably 5 to 12 in the above range. More preferably, it is 5 to (10). The relationship between the amount of the coloring agent in the layer and the thickness τ of the coloring layer: except that y is set to satisfy the range of the above formula (1), there is no special feature in the colored layer. From the viewpoint of dispersibility and the like, for example, in the colored layer, the content of the composition is preferably from 0. 〇1 to 〇 4% by weight. In the colored plastic container of the present invention, the ultraviolet absorbing agent in the colored layer is used. The content ratio U (% by weight) and the thickness T of the coloring layer ( The product υτ -· of /Zm) is set as follows: when the product ρ (% by weight) of the pigment in the colored layer and the product ΡΤ of the thickness T (#m) of the coloring layer exceed 20, the following formula (2) is satisfied. When the product pT is 2 〇 or less, the following formula (3) is satisfied. 5SUTS 160 (2) 20 < UTS 160 (3) 设定 By setting the value of the product τ to the above formula The range of (2) or (3), and setting the value of the above accumulation to the range of the above formula (1), maintains moderate visibility to the inside of the container, and can efficiently shield the wavelength light in the ultraviolet region. Here, if the value of the product UT is lower than the range of the above formula U) when the accumulation exceeds 20, or is less than the range of the above formula when the product is 2 〇 or less, the shielding effect of the wavelength light in the ultraviolet region is obtained. insufficient. On the other hand, if the value of UT exceeds the above range, there is a concern that the dispersibility of the ultraviolet absorber in the colored layer is lowered. In the case where the accumulation exceeds 20, the value of the accumulation τ is particularly preferably 5 to 120 Å or more preferably 10 to 1 于 in the above range. On the one hand, in the case where the accumulation is less than 20, the value of the accumulation is preferably from 30 to 160, more preferably from 35 to 16, in the above range. The relationship between the amount of the ultraviolet absorbing agent in the color layer and the thickness τ of the colored layer is not particularly limited as long as it is set to satisfy the range of the above formula (2), and is based on the dispersibility in the colored layer.重量重量。 01,0. 4重量%. Further, in the case where the side surface of the colored layer is the outer surface of the thermoplastic multilayer plastic, that is, the colored layer is a layer forming the outer layer of the colored plastic container, it is preferable to use the ultraviolet absorber in the colored layer. The quotient U/T when the content ratio ϋ (% by weight) is divided by the thickness T (/zm) of the colored layer is set to satisfy the following formula (4). U/TS 0· 004 (4) _ If the U/T exceeds the above range, there is a concern that the ultraviolet absorber oozes out from the colored layer to the outside of the colored plastic container. The value of the U/T is particularly preferably 〇·0038 or less, more preferably 〇.0001~〇.〇〇38. In the colored plastic container of the present invention, the thickness of each layer other than the colored layer is preferably set to be in the range of 10' with respect to the entire layer formed of the thermoplastic multilayer plastic. Further, the ratio of the thickness of each layer can be appropriately set depending on the type of the contents of the plastic container accommodated in the layer, the capacity, and the like. ❹ Thermoplastic, the thickness of the overall thickness of the multi-layer plastic, according to the use of the colored plastic container: the content type, the capacity of the contents of the glutinous rice, etc., may be appropriately set, and the value is not limited to, for example, preferably 300 to 1500 〃m, More preferably 400~1 WO #m. The pharmaceutical agent contained in the colored plastic container of the present invention is not particularly limited as long as it is preferably an aqueous solution of sodium ozagrel. For example, the shape of the color plastic container is not particularly limited, and examples include a cow writing bottle, a flexible bag container, and a bottle. Figure U is a front view of a color plastic container as an embodiment of a color plastic 97110774 44 200940046, and Fig. 12 is a side view thereof, and Fig. i3 is a plan view "Fig. 14 is a bottom view" Fig. 15 side Sectional view. As shown in Fig. 11 and Fig. 12, the colored plastic ampule 11 is provided with a liquid chemical storage portion lu for accommodating a chemical liquid in a bottomed cylindrical shape, and communicates with the open end (1)a of the chemical liquid storage portion m. The chemical liquid discharge cylinder portion 112 that extends sideways and the top portion (1) that closes one end portion of the chemical solution discharge cylinder portion 112; and the chemical liquid discharge cylinder portion 112 includes a weak portion 114 that is formed thin in the circumferential direction. In the chemical solution accommodating portion 111, a side end portion opposite to the bottom portion 116 is formed in the vicinity of the opening end 111a along the longitudinal direction of the central axis 115 of the chemical solution accommodating portion (1), and has a diameter from the bottom portion 116. The side surface toward the open end (1) "the shoulder portion m which becomes smaller (one side). = 3 and as shown in Fig. 14, the cross section of the chemical liquid storage portion lu is formed in a circular shape in a plan view or a bottom view, but the chemical liquid containing portion (1) The surface shape is not limited thereto, and may be formed, for example, in an elliptical shape. :: Referring to Fig. 11 and Fig. 12, the chemical liquid discharge cylinder portion 112 is continuous with the opening w11a of the chemical liquid storage portion lu as follows: Valley: The axis of the central axis 115 of the part (1) is the same as the central axis, and extends along the axis of the ς two-axis m. On one side of the drug discharge cylinder portion 112: the end ln f liquid discharges the tube portion 112' with the medicine The end portion of the liquid accommodating portion 111 on the side opposite to the side of the opening a) is discharged from the top 113 of the upper portion of the sealing liquid discharge portion 112. The side portion is continuous, and the forming portion == Μ is inserted, for example, to absorb the liquid medicine. In the case of a liquid injector nozzle, it is preferably as suitable as the above nozzle of 97110774 45 200940046 In order to fix the nozzle in a stable state, it is preferable to have a sufficient length between the chemical liquid accommodating portion ln and the top portion 113 in the axial direction of the chemical liquid discharge cylinder portion 112. The chemical liquid accommodating portion ill and the medicine The liquid discharge cylinder portion 112 and the top portion 113 are continuously integrated with each other, and a closed region for accommodating and sealing the chemical liquid is formed. Further, the chemical liquid discharge cylinder portion 112 is attached to the open end 111a of the chemical liquid storage portion 至 to the medicine. A substantially intermediate portion between the one end portions of the liquid discharge cylinder portion 112 is provided with a weak portion 114 (see FIG. 15) formed in a thin wall along the circumferential direction of the chemical discharge cylinder portion 112. Thereby, the liquid medicine is accommodated. The portion m and the top 113 side of the liquid discharging cylinder portion ι 2 are twisted or bent to each other, whereby the fragile portion (1) can be easily twisted, broken or split, and the colored plastic ampule 110 can be thereby obtained. In this case, the chemical liquid is discharged from the tubular portion 112, and the injection nozzle formed therein is inserted into a syringe nozzle (not shown) to collect the chemical liquid contained in the chemical storage unit U1. Furthermore, the syringe is manufactured in the same manner as: The injection needle is not attached to the front end of the mouth of the (4), and the nozzle is inserted into the opening σ of the drug discharge cylinder portion 112, thereby sucking the liquid medicine in the liquid medicine containing portion 111. As shown in Figs. 11 and 12 The chemical solution accommodating portion lu is provided on the outer peripheral surface thereof with a flange 124' which is located at a position opposite to the mandrel m of the chemical solution accommodating portion iu 2 and along the axis of the central axis 115: To: stretch, and from the chemical liquid volume (4) (1), the outer peripheral surface 123 is increased in the radial direction. The liquid chemical receiving portion ln is on the bottom portion 116 thereof, and the flange 125 is protruded outward from the bottom portion 116, The outer peripheral surface 123^ is convex 97110774 46 200940046 The flange 124 and the flange 125 of the bottom portion 116 are continuous with each other. In the case of 111, the flanges 124 and 125 are formed in the chemical solution accommodating portion and m is supplied to L + , whereby rigidity can be imparted to the chemical solution accommodating portion 111, and the shape of the chemical solution accommodating portion 111 can be maintained. As shown in FIG. 11 and FIG. 12, the liquid medicine discharge cylinder 112 is continuous from the top 113 side and protrudes from the chemical liquid discharge cylinder side and from the outer surface of the top 113. The fragile portion (1) of the portion 112 is formed continuously between the drug:::113 side and the top portion 113. Therefore, in the case where the grip portion ln and the top 113 side of the drug solution discharge tube portion 112 are turned or f-curved, the drug solution is accommodated. Part (1) and the liquid medicine ❹ The fragile part of the tube part m: The opening operation of the ampoules m is discharged from the cleavage liquid. The coloring is easily and accurately performed: the flat portion 129 and the σ 0' cymbal 128 formed around the flat portion 129 form a hollow thick portion. Borrowing two: piece: the rigidity of itself is maintained, and the deformation of the film 128 is held in order to open the colored plastic bottle 110. (4) In the case of the cymbal sheet 128, it is possible to suppress the cymbal sheet and the liquid chemical accommodating portion m from the chemical liquid accommodating portion of the shoulder portion m and the self-weak portion 114 as shown in Figs. 11 and 12 The outer peripheral surface 126 of the side liquid discharge cylinder portion 112 is provided with reinforcing sheets 131 which are respectively protruded from the outer side of the liquid medicine discharge cylinder portion 112 and the chemical liquid storage portion 119 of the 97110774 47 200940046. In this manner, the reinforcing sheet 131 is continuously formed in such a manner as to straddle the side of the liquid chemical containing portion 1U from the fragile portion 114 of the chemical liquid discharge cylindrical portion I12 and the shoulder portion 117 of the liquid chemical containing portion U1. Therefore, the rigidity between the chemical solution accommodating portion 111 and the drug solution discharge tube portion 12 can be remarkably improved. # Thereby, for example, during the conveyance or operation of the colored plastic ampule 110, the liquid medicine discharge cylinder portion i 12 protruding from the chemical liquid accommodating portion 111 is not easily damaged. Further, when the cymbal piece 128 is split and twisted or broken, the finger easily grasps the reinforcing piece 131, and has an effect of stopping the rotation accurately, so that the opening operation of the colored plastic ampule can be easily and accurately performed. The gusset sheet 131 has a flat plate portion 132 and an inverted j portion 133 formed around the flat plate portion 132, and the inside of the reinforcing sheet 131 is formed into a hollow thick portion. Thereby, the rigidity of the reinforcing sheet 131 itself is maintained, the reinforcing effect is further enhanced, and the deformation of the reinforcing sheet 131 can be suppressed in the case where the ytterbium sheet 131 is held in order to open the colored plastic enamel. Moreover, when the cymbal piece 128 is twisted, the finger can grasp the reinforcing piece 1 w ^ well. When the colored plastic ampule 110 is manufactured, the cymbal piece 128 and the reinforcing piece 131 can be combined with the chemical liquid accommodating portion U1, the medicinal liquid discharge tube portion 112, and the top portion. Each part of 113 is formed at the same time. ° The colored plastic ampule 110 can be produced, for example, by a so-called blow molding, a sealing method, or a multilayer blow molding method. Specifically, for example, the above thermoplastic multi-layered plastic is first extruded into a shape, and a multilayered semi-finished product in which the layers are welded to each other is produced. 97110774 48 200940046

That is, the thermoplastic multilayer plastic described below is extrusion-molded to produce a multilayered semi-finished product in which the layers are welded to each other, the thermoplastic multilayer plastic having a coloring layer containing a pigment and an ultraviolet absorber, and directly holding the intermediate layer. The inner layer of one side surface of the colored layer is laminated, and the thickness T of the colored layer is set to be in the range of 50 to 1000 /ζη, and the content ratio of the pigment in the colored layer is p (% by weight) and the thickness of the colored layer. The product PT of T(Am) satisfies the following formula (1), and the outer line in the colored layer = the content ratio U (% by weight) of the collector, and the thickness τ of the colored layer (the product UT of _, in the above product When pT exceeds 20, the following formula (2) is satisfied, and when the above-mentioned accumulation is 20 or less, the following formula (3) is satisfied. 1 s PTS 150..· (1) 5$ UTS 160.·.(2) 20< UTS 160..· (3) Na::; to !, Mo holding the obtained multi-layer semi-finished product to form a liquid preparation step) 1 Discharging each part of the cylindrical portion 112 and the reinforcing sheet 131 (Blowing, 药 液 液111 internal filling liquid (filling step formation with Hua: two,, closed area (closed material) ) Bu Le liquid discharge tube portion 112 and top 113 color plastic money (coloring = ^,, can be filled (four) with liquid medicine, with a plastic container) 110. The layer structure is half into σ. Extruder or mold Head::: The usual method in plastic molding is not particularly limited, and _=, the molding conditions of the semi-finished structure of the eve layer structure, etc. can be appropriately set according to the usual method in the eve layer blow molding, that is, 97110774 49 200940046 The use of multi-layer construction of semi-finished products to blow plastic ampoules, in addition to the semi-finished 岔 岔 法 法 制 数 ( 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四The construction method of plastic paper is the same way: Layer: The layers of the film can be used for the above-mentioned ones, or the P-bends of each of them can be laminated, and the layers can be laminated with the same layer of 'adhesive resin'. The layer formed is effective to shield the light in the ultraviolet region from the viewpoint of the colored plastic ampule (1) 2 Μ Μ incident to the inside, the thickness of the liquid accommodating portion of the colored plastic ampule 11 is preferably 300 to 1500 #m Colored plastic ampoules ( The colored plastic container 110 can be formed by various methods. Among them, a blow molding, filling, and sealing method is preferable. The colored plastic container of the present invention is prepared by blending a pigment and an ultraviolet absorber in a specific range. There is no problem such as bleeding, and the following properties can be imparted: the transmittance of light having a wavelength of 200 to 380 nm is 5% or less, and the transmittance of light having a wavelength of 600 nm is 40% or more. The plastic ampoule can be widely used, for example, for medical purposes, and is particularly suitable for containing a photo-deteriorating agent, specifically an aqueous solution of sodium ozagrel. The present invention has been described with respect to the embodiments of the present invention. However, the embodiments of the present invention are not limited thereto, and the design may be appropriately modified without departing from the scope of the invention. - [Examples] The present invention will now be described based on examples and comparative examples, but the present invention is not limited by the following examples. 97110774 50 200940046 (Manufacturing and opening evaluation of plastic security) [Examples 1 -1 to 1 - 6 and Comparative Example 1 _ 1 to 2 2 (1) The material for forming a multilayer film of plastic ampoules is as follows Show. C0C1: a cyclic dilute hydrocarbon copolymer (ethylene/tetracyclotetradecene) having a glass transition temperature (Tg) of 70. 〇, manufactured by Mitsui Chemicals Co., Ltd., trade name "APEL (registered trademark) APL8008T" "C0C2 · · cyclic olefin copolymer (ethylene / tetracyclododecene copolymer), Tg 80 ° C, Mitsui Manufactured by Chemical Co., Ltd., product * "ApEL (registered trademark) APL6509T" C0C3: a cyclic olefin copolymer (ethylene/tetracyclododecene copolymer), Tg is 105 ° C, manufactured by Mitsui Chemicals Co., Ltd., "APEL (registered trademark) APL6011T" C0P1: a cyclic olefin polymer (hydride of a decene-based ring-opening polymer), Tg 70 c, manufactured by Nippon Zeon Co., Ltd., trade name | "ZE0N0R (registered) Trademark) 750R" C0P2, cyclic olefin polymer (hydride of decene-based ring-opening polymer) 'Tg is 102C 'Manufactured by Nippon Zeon Co., Ltd., trade name "ZE0N0R (registered trademark) 1020R" PE1 . Pressurized low-density polyethylene, density 〇. 928 g/cm3, manufactured by Ube Maruzen Polyethylene Co., Ltd., trade name "UBE POLYETHYLENE (registered trademark) B128H" PE2: UV-dispensed in PE1 Absorbent (2-(2,_carbyl-3'-t-butyl-5'-nonylphenol)-5-chlorobenzotriazole' Ciba Specialty Chemicals Co., Ltd. 97110774 51 200940046 Manufactured, commodity The name "TINUVIN (registered trademark) 326") and the zinc oxide fine particles (average particle diameter: 30 μm), the content ratio of the ultraviolet absorber is set to 0. 218% by weight, and the content ratio of the zinc oxide fine particles is adjusted to be 0. 182% by weight.重量重量。 The PE1 is a UV absorber (trade name r CIBA TINUVIN (registered trademark) 326), the proportion of the above-mentioned ultraviolet absorber is set to 0. 24% by weight.

❹ PE4: High-density polyethylene 'density is 〇. 94〇g/cm3, manufactured by Prune P〇lymer Co., Ltd., trade name "ULT-ZEX (registered trademark) Uz4020B" PE5: high density Polyethylene, density 〇.965 g/cm3, manufactured by Prehman Polymer Co., Ltd., trade name "ΝΕ〇_ΖΕχ(registered trademark) Νζ65150Β" ΡΕ6. Linear chain polymerized by a metallocene catalyst Low density polyethylene with a twist of 0.903 g/cm3 'Manufactured by Preman Polymer Co., Ltd., trade name "Evolue (registered trademark) sp5〇1〇B" [Example 1-1] by blow molding The filling and sealing method is used to manufacture a plastic ampoule for the shape of the ffil 1 to the shape shown in Fig. 7 of 2.5 mL. Furthermore, in a plastic ampoule, 2.5 mL of physiological saline was filled and sealed. In the formation of plastic ampoules, the use of splicing, raw thickness of 640 (four)), Heng 5 layer 2 with a 5-layer structure of multi-layer plastic (total, 5-layer structure of the multi-layer plastic system: the outer layer 20 formed by PE2 ( The thickness Λ 9ηη , "* ” and the horse 200 Mm) are formed on one side surface of the outer layer 20 and are further 彡β 彡# > i into the adhesive layer 22 (thickness 20 #m), product 97110774 52 200940046 layer An intermediate layer 18 (having a thickness of 200 hearts) formed on the adhesive layer 22 side of the outer layer 20 and formed by COCUTU 70. is formed on the opposite side surface of the intermediate layer 18 from the layer of the outer layer 20 and is adhered by the contact. a layer, 21 (thickness of 2 〇 ")', and an inner layer 19 (thickness of 2 〇〇") laminated on the adhesive layer a side of the intermediate layer 18 and formed of PE1. Further, the total thickness of the multilayer plastic The thickness of each layer (the intermediate layer 18, the inner layer 19, the outer layer 20, and the adhesive layers 21 and 22) indicates the thickness of the chemical liquid containing the plastic ampule - β η (hereinafter, the same). [Example 1-2 Using a layer formed of C0C2 (Tg of 80 ° C) (thickness of 200 instead of the layer formed by coci) as the intermediate layer 18, except A plastic ampule filled and sealed with physiological saline was produced in the same manner as in Example 1 to 1. [Example 1-3] A layer formed of PE3 (thickness of 2 〇〇 was replaced by pE2) The layer formed by tantalum is used as the outer layer 2〇, and a layer formed by c〇pi (Tg is 7〇) is used (the thickness is 2〇〇 instead of the layer formed by c〇ci, as the intermediate layer 18' Other than the above, 'plasticized and filled with plastic saline filled and sealed in the same manner as in Example 1. [Example 1-4] Mixing COClCTg in a ratio of 3:1 (weight ratio) It is a layer formed of a mixed resin of 7 (TC) and PE4 (thickness: 200 am), instead of the layer formed by the layer 8 as the intermediate member 8, except that it is the same as the practical example 1 1 The method of 'manufacturing filled and sealed plastic with plastic saline 97110774 53 200940046 ampoule. [Example 1-5] Mixing C〇PKTg with a ratio of 3 . wθ to which mixed tree is used) Forming a layer formed by the household 1 (thickness of 200) instead of θ 朿 as the intermediate layer 18' Example 1-1 the same big bucket, ^, shell ^ _ type '裒 填充 填充 及 及 及 及 塑胶 塑胶 塑胶 塑胶 塑胶 ❹ ❹ 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 ❹ ❹ The ratio of ι to) is mixed with C0Pl (Tg is 7 〇. 〇, E ～ 至 树脂 resin layer (thickness is 2 〇〇, the axe formed by S0C1, the upper thickness is 200 "" In the same manner as in Example 1-1, θ was used as the intermediate layer 18, and ampoules were prepared in the same manner as in Example 1-1. Plastic filled with normal saline and sealed [Comparative Example 1-1] Instead of the layer formed by C0C:r:(J"1〇5C) (thickness 2°0 ") 18, other than this, in the same way as the actual example 1-1, the plastic ampule is stopped. Ik is filled and sealed with physiological saline [Comparative Example 1-2] The use of c〇P2 (Tg is 102t) Instead of the layer formed by C0C1, (the thickness is 200 1 1 r, the operation is as the intermediate layer 18, except that the plastic ampule is cut in the same manner as the real palladium case 1-1. Sealed with saline plastics. The layer composition of the 97110774 200940046 ❹ 瓶 bottle made in Example Η Η Η & & & & & & & & & & [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ Inner layer 19 Total thickness (ym) Example 1-1 PE2 200 PE6 20 /zm COC1 200 PE6 20 /zm PEI 200 //m 640 Example 1-2 Example 1-3 PE2 200 //m ...Li-_ 200 β\Ά PE6 20 ...ϋ... 20 /zm C0C2 200 Aim C0P1 200 PE6 20 PE6 20 μ.\Ά PEI 200 //m ...-...- 200 640 640 Example 1-4 ΡΕ2 200 PE6 20 β\& C0C1+PE4 (3:1) 20 0 PE6 20 PEI 200 640 Example 1-5 PE2 200 //m PE6 20 /zm C0P1+PE5 (3:1) 200 PE6 20扉PEI 200扉640 Example b PE2 200 /zm PE6 20 /zm C0P1+ PE1 (19: 1) 200 PE6 20 /zm PEI 200 Lu ♦ Suspected 畤 鲁 — - 640 Comparative Example 1_1 PE2 PE6 C0C3 PE6 PEI Comparative Example 1-2 - Correction - Complex. PE6 Li-l. PE1 " _200 (4) 640 .2p〇..^m ... 20 /zm 200 PE2 PE6 C0P2 200 //m 20 2ΠΠ nm (2) Evaluation of the opening of plastic ampoules 20 am 640 ❹ For Examples 1-1 to 1-6 and In the comparative example 丨 丨 丨 丨 中 塑胶 塑胶 塑胶 丨 丨 丨 丨 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶After the sheet 28, the liquid liquid accommodating portion of the liquid accommodating portion is used as a rotating shaft, and the cymbal piece 28 is rotated. The twisting device is: the liquid discharges the top portion 13 of the cylindrical portion 12, thereby opening the plastic 8 and using the rotation. Torque meter, measuring the twist 〇. The liquid medicine of the top of the discharge tube portion 12 on the side of the top 13 is shown in Table 2. The force of force (N.m). The result of the measurement is shown, after the opening, the opening of the liquid medicine discharge cylinder 97110774 55 200940046 12 connected to the side of the liquid medicine (10) 11 is inserted into the syringe nozzle for sucking the physiological saline in the liquid medicine receiving portion I, and then the medicine is taken The liquid accommodating portion 11 is placed in a state where the opening of the chemical liquid discharge cylinder portion 12 is downwardly viewed to see whether or not liquid leakage from the opening is generated. The results are shown in Table 2. [Table 2] The force required for each unit of thick force is one---LN · m ]__[ N · m/mm 1 with or without liquid leakage --^~~ --t.3MJ.-2... ... "〇:4〇..............................o'1-o..... .........................f-... '''·〇:35.............. ....-............〇Λ55................-............- ...Γ'1:28"'.........-----------.......〇Λ44 ...................—?-- -...- i^JLX-6 . One; 〇: 32.................................... ....-....................————---Comparative Example 1-1 --- Comparative Example 1-2 ............- ...... According to Table 2, it can be clearly stated that, although the thickness of the intermediate layer 18 is relatively large, the plastic ampules can be opened and the fragile portion 14 can be opened relative to the thickness of the multilayer plastic which is discharged from the same portion 12 of the liquid medicine. The force of 'f' is set to a small value of 065. Further, after the opening, no leakage from the liquid discharge port and the nozzle of the syringe was observed. In the case of the comparative example 2 in which the glass transition temperature of the cyclic olefin system (co) used in forming the intermediate layer 18 exceeds the range of (10) to ah, the liquid discharge cylinder portion 12 is Multi-layer plastic = Kaifeng plastic ampoule i. The force required exceeds Ο.,—:: Thickness The leakage from the above opening is observed. [Examples 1-7 to 1-9] (1) Manufacture of plastic ampoules 97110774 56 200940046 Plastic ampules (multilayer slabs) and the entanglements in the embodiment l+H are as follows. In addition, the same as the PP1·arm (10) is omitted. "Noruiman Polymer Co., Ltd., product ❹ TPi^ . : manufactured by A Division, trade name "TAFMER (registered trademark) XM7070" - 2 elastomers (nano crystal structure control type polypropylene elasticity _ 彳Manufactured by Dry Co., Ltd., trade name "Ν〇τ trademark" PN-3050" E3 thermoplastic elastomer (nano crystal structure control type polypropylene elastomer) manufactured by Ishii Chemical Co., Ltd., trade name "N〇TI〇( Registered trademark) ΡΝ-2070" ΤΡΕ4. Thermoplastic elastomer (polyethylene elastomer), manufactured by Mitsui Chemicals Co., Ltd., trade name "TAFMER (registered trademark) Α0585Χ" [Example 1-7] 藉 By blow molding. 5毫升的塑料瓿。 The filling and sealing method, and the shape of the shape shown in Figure 1 to Figure 7 is 2. 5 mL of plastic ampoules. Furthermore, in the plastic ampule, the filling and sealing of 2.5 mL of physiological saline. In the formation of plastic ampoules, a multi-layer plastic with a 5-layer structure (total thickness 520 # m) is used. The multi-layer plastic system of the 5-layer structure has a mixture of PP1 and TPE2 in a ratio of 3:2 (weight-to-weight ratio). The outer layer '20 (having a thickness of 150 em) formed of the mixed resin' is formed on one side surface of the outer layer 20 and is an adhesive layer 22 formed by mixing a mixed resin of PE6 and TPE 4 in a ratio of 1:1 (weight ratio) ( The thickness is 1 〇 / zm), laminated on the adhesive layer of the outer layer 20 97110774 57 200940046 22 side and formed by c〇Pl (Tg is 70. The intermediate layer 18 (thickness is 2〇〇β m) formed by ' An adhesive layer 21 (thickness of 1 μm) formed by mixing the opposite side surfaces of the layer 18 with the outer layer 20 and mixing the mixed resin of pE6 and TPE4 in a ratio of 1:1 (weight ratio), and The inner layer ι9 (thickness 15 Å/m) formed by laminating the mixed layer of PP1 and TPE 2 at a ratio of 3:2 (weight ratio) on the side of the adhesive layer 21 of the intermediate layer 18 is integrated with the mixed resin as a whole. In the above mixed resin, the nucleating agent (2,2,-methylene double (4,6-di_) is formulated in a ratio of ❹ 0-2% by weight. Tributylphenol) sodium phosphate, manufactured by ADEKA Co., Ltd., product name Adekastab NA-11") [Examples 1-8] Mixed with pp 1 in a ratio of 4:1 (by weight) for mixing A layer formed of a resin (having a thickness of 15 Å instead of a layer formed of a mixed resin containing ρρι and TPE 2 as an outer layer 2 〇 and an inner layer i9, except that a filling was performed in the same manner as in Example 7) And sealing the plastic ampoule with physiological saline. [Examples 1-9] Instead of using a layer (thickness 15 〇 Mm) formed by mixing a mixed resin of ρρι盥τρΕι in a ratio of 9:1 (weight ratio) A plastic ampule filled and sealed with physiological saline is produced in the same manner as in the case of the outer layer 2q and the inner layer 19, and the layer formed of the mixed resin of ρρι and TPE2 is used. Example 1 - 7~1 - 9 congratulations; I eve sleeve coffee main Q A "The composition of the plastic ampules is shown in the table <3 0 97110774 58 200940046 [Table 3] Outer layer 20 Adhesive layer 22 Middle layer 18 Adhesive Layer 21 Inner Layer 19 Total Thickness (/zm) Example 1-7 PP1+TPE2 (3:2) 150 ym PE6+TPE4 (1:1) 10 C0P1 200 PE6+TPE4 (1:1) 10 /zm PP1+TPE2 (3:2) 150 β\Ά 520 Example 1-8 PP1+TPE3 (4:1) 150 β\Ά PE6+TPE4 (1:1) 10 C0P1 200 /zm PE6+TPE4 (1:1) 10 /zm PP1+TPE3 (4:1) 150 /zm 520 ΡΡ1+ΤΡΕ1 PE6+ TPE4 C0P1 200 //m PE6+TPE4 PP1+TPE1 Example 1-9 (9:1) 150 /zm (1:1) 10 /zm (1:1) 10 em (9:1) 150 520 (2) Evaluation of the opening property of the plastic ampoules The plastic ampules filled and sealed with physiological saline manufactured in Examples 1-7 to 1-9 were subjected to the same opening-sealing evaluation as described above. As a result, in any of the examples 1-7 to 1-9, the force required to open the plastic ampoule 1 (the split fragile portion 14) can be set to 0.40 Nm or less (relative to the discharge of the chemical liquid). The thickness of the multilayer plastic of the tubular portion 12 is a small value of 0.65 Nm/mm or less. Further, after the opening, no liquid leakage from the opening of the chemical discharge barrel 12 and the nozzle of the syringe was observed. (Manufacturing and physical property evaluation of colored plastic ampoules) 树脂 The resin materials, pigments, and ultraviolet absorbers used in the following Examples 2-1 to 2-54 and Comparative Examples 2 to 1 to 2-19 are as follows. PE1: High-pressure method low-density polyethylene, density 〇928 g/cm3, manufactured by Ube Maruzen Polyethylene Co., Ltd., trade name r Ube POLYETHYLENE (registered trademark) B128H" PE4: high-density polyethylene, density 〇.94 〇g/cm3, manufactured by Prehman Polymers Co., Ltd., trade name "ULT-ZEX (registered trademark) Uz4020B" PE5: high-density polyethylene, density 〇·965 g/cm3, Preman's polymerization 97110774 59 200940046 Manufactured by Co., Ltd., trade name "ΝΕ〇_ΖΕχ(registered trademark)Νζ65150Β" ΡΕ7. Adhesive low-density polyethylene, density 〇. 9〇3, manufactured by Puri Man Polymer Co., Ltd., "Εν—(Registered Trademark) SP0510B" PP1: Polypropylene, manufactured by Prehman Polymer Co., Ltd., trade name "B205" PP2: Polyolefin-based thermoplastic elastomer, manufactured by Mitsui Chemicals Co., Ltd., trade name "ΝΟΤΙΟ" (registered trademark) pN_3〇5〇", which is the same as τρΕ2 above. ΡΡ3: A polyolefin-based thermoplastic elastomer, manufactured by Mitsui Chemicals Co., Ltd., trade name "TAFMER (registered trademark) χΜ7〇7〇", which is the same as τρΕΐ described above. C0C1 ·•cyclic olefin copolymer (ethylene/tetracyclododecene copolymer),

Tg is 70 ° C, manufactured by Mitsui Chemicals Co., Ltd., trade name "ApEL (registered trademark) APL8 〇 08T" C0P1: cyclic olefin polymer (hydride of decene-based ring-opening polymer), Tg &amp赃'Manufactured by Japan Reion Co., Ltd., trade name "ZE0N0R (registered trademark) 750R" Pigment: yellow pigment, CI pigment yellow 95. UV absorber: manufactured by Ciba Specialty Chemical Co., Ltd., trade name · "TINUVIN (registered trademark) 326" ^Deduction name [Examples 2-1 to 2-8 and Comparative Examples 2-1 to 2-4] (1) Manufacture of ampoules 97110774 60 200940046 The use of f is shown in Table 4 or Table 5. The layer is made of thermoplastic ^fill. In the sealing method, the crucible of the shape shown in Fig. 8 is used for 2.5 mL). In an ampoule, 2.5 0.8% (w/v) aqueous solution of sodium ozagrel was filled. The thickness of each layer of the thermoplastic multilayer plastic shown in Table 4 (the liquid accommodating portion) is repeated. ^ The original example of the text 2 - 2-4 of the example 2] ~ 2 '8 and the comparative example, between the outer layer and the middle layer between the inner layer and the inner layer, respectively, offer $ &amp; 曰 <, and the middle knife Do not configure the 20" polyethylene layer formed by the above pE7 as the adhesive layer. The thickness is ❹ 97110774 200940046 [Table 4]

Outer layer (colored layer) Intermediate layer inner layer total thickness Example 2-1 PE1 T=1 00 β \ά Ρ=0· 63%, ΡΤ: 63 U=0. 4% &gt; UT=40 U/T=0.004 COC1 200 β m PEI 300 β m 640 β m Example 2-2 ΡΕ1 Τ二200 β m Ρ = 0. 06% ' ΡΤ=12 ϋ=0. 24% ' UT = 48 U/T=0.0012 COP1 200 β m PEI 200 β m 640 β m Example 2-3 ΡΕ1 Τ=300 β m Ρ=0.04% , ΡΤ=12 U=0. 12% ' UT = 36 U/T=0.0004 C0C1+PE4 (9:1) 200 β m PEI 100 β m 640 μ m Example 2-4 ΡΕ1 Τ=50 β m Ρ=2.5%, ΡΤ=125 U=0. 1% ' UT=5 U/T=0.002 COP1+PE4 (3:1 200 β m PEI 300 β m 590 β m Example 2-5 ΡΕ1 Τ=300 β m Ρ=0. 04% ' ΡΤ=12 U=0. 4% ' UT=120 U/T=0.0013 C0P1+PE4 (4:1) 200 β m PEI 100 ^ m 640 β m Example 2-6 ΡΕ1 Τ=1 00 ^ m Ρ=0. 04% ' ΡΤ=4 U=0.38% ' UT=38 U/T=0.0038 COC1 200 β m PEI 200 β m 540 β m Example 2-7 PP1+PP2C8 : 2) Τ=200 β m Ρ = 0. 13% ' ΡΤ = 26 U=0. 4% ' UT=80 U/T =0.002 COP1 200 β m , PP1+PP2 (8:2) 200 β m 640 μ, m Example 2-8 PP1+PP3C8 : 2) Τ=1 00 /ζ m Ρ=0. 13% ' ΡΤ = 13 U: 0. 4%, UT=40 U/T=0.004 C0P1+PE4 (4:1) 250 β m PP1+PP3 (8:2) 250 β m 640 β m 97110774 62 200940046 [Table 5] Outer C colored layer) Intermediate drawer inner layer ik ΡΕ1 *———— Comparative Example 2-1 Τ=40 μ m P=0. 13% ' PT=5.2 U=0_1%, UT = 4 U/T=0.0025 COC1 200 μ. m PEI 360 ^ m 640 β m PEI --- Comparative Example 2-2 T=100 ^ m P:0. 1%, PT = l〇U=0. 5%, UT = 50 U/T=0.005 C0C1 200 β m PEI 300 β m 640 [jL m PEI T=100 ^ m Comparative Example 2-3 P=2. 6%, PT=260 U=0. 2% ' UT = 20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m PEI — Comparative Example 2-4 T=100 ^ m P=0.0035% &gt; PT=〇.35 U=0. 13% ' UT=13 U/T=0.0013 C0C1 200 β m PEI 300 β m 640 β m ❹

Further, in the tables shown in Tables 4 and 5 and below, the above-mentioned abbreviations are used for the resin materials forming the respective layers. For the layer formed of the mixed resin, the number of the resin materials to be mixed is indicated by "+" as in "C0C1 + PE4". The ratio in the brackets indicated by the outline of the mixed resin is connected, and the mixing ratio (weight ratio) of the mixed resin is used. For example, in the case of "COCHPE4 (9: 1)", it is indicated that a mixed resin of C0C1 and PE4 is mixed in a weight ratio of g: i. Further, the resin material of each layer (mixing ratio of the mixed resin) is formed, and = the thickness of the layer (//111) is carried. For example, it is described as "pEi _ (4): In the case of the layer, the thickness formed by "PElj is 1 〇... In addition, in the table shown in Table 4, Table 5 and below, "P" and Γρτ") 97110774 63 200940046 The product of the content ratio P (% by weight) of the pigment in the colored layer, and the content ratio P (% by weight) of the pigment and the thickness τ (v in) are also indicated. "U" and "ϋτ U/T" respectively indicate the content ratio of the ultraviolet absorber in the colored layer 'U (% by weight), the content ratio of the ultraviolet absorber U (% by weight) and the thick sound, Τ (in m) The product of the 'product' and the ultraviolet absorbing agent U (weight = thickness T (/zm). ' (2) Observing the appearance change of the ampoules 实施 Example 2-1 shown in Table 4 and Table 5. The ampules of ~2-8 and Comparative Examples 24 to 2-4 were confirmed, and the appearance of the ampoule after 4 days at room temperature was confirmed (no oozing was confirmed). The results are shown in Table 6 below, and the ampule of Comparative Example 2_2, Since the ultraviolet absorber oozes out from the container body, white fine powder is observed on the surface of the container. (3) Determination of the proportion of the cis isomer

The ampules of the above examples and comparative examples (except Comparative Example 2-2 in which the ultraviolet absorber was exuded) were placed under a light source of illuminance of 2000 lx (D65 lamp) for 25 days, and then subjected to high performance liquid chromatography (high). Performance liqind Chr〇mat0graphy, HPLC) Determination of the proportion of cis isomers of similar substances belonging to sodium ozagrel in the content liquid. The measurement was performed in the following order. First, a sample of 25 rainbow was collected, which was diluted with a mobile phase to make a total amount of 4QmL, which was made into a sample solution. The sample solution was collected 5", and the amount of the cis isomer of the similar substance of sodium Ozagrel was determined by the HPLC method in the following conditions. The peak area of the sample solution was determined by an automatic integration method. It is obtained by the percentage method of the area of 9710774 200940046. The HPLC measurement conditions are as follows. Measurement wavelength: 220 nm, · Column: YMC-Pack ODS-A A-302, 150x4. 6 mm i. D., S -5 ' β m Column temperature: approx. 25°c Mobile phase: 〇. 3% ammonium acetate solution/methanol mixture (4: i) Flow rate: 1. 0 mL/min® Measurement time: 20 minutes The measurement results are shown in In the following Table 6, the results of the above analysis were judged to be poor when the content of the cis is more than 3%. (4) Measurement of light transmittance from the above examples and comparative examples (ultraviolet absorber bleed out) Except for Comparative Example 2-2.) The sample solution for the ampoules of the ampoules was cut out for the sample for measuring the transmittance. Using this sample, the light transmittance at a wavelength of 2 〇〇 to 38 〇 nm was measured by a spectrophotometer. And the transmittance of light with a wavelength of 6 〇〇 nm. Also for ampoules in brown glass (within The product is 2. 5 mL with) filled with 2.5 mL of 〇. 8% (w/v) aqueous solution of sodium ozagrel, placed at room temperature for 14 days in the same manner as above. The ratio of the content is used as a control. The measurement results are not shown in the following Table 6. 97110774 65 200940046 [Table 6] Example 2-1 Example 2 9 Appearance of ampoule (with or without exudation) Content of cis isomer 200~ 380 nm No observed 600 nm 02% Maximum 0. 1% No observed 49% 0. 12% Maximum 2. 5% 623⁄4

Light transmittance e According to the results shown in Table 6, with respect to the ampoules of Examples 2-1 to 2-8, the increase amount of the cis isomer is equivalent to or higher than that of the control brown glass ampoule, as opposed to Thus, the ampoules of Comparative Examples 2_丨 and 2_4 were more than 3 times larger than the brown glass ampules of the control. On the other hand, in the ampoule of Comparative Example 2-3, since the light transmittance of light of 6 〇〇 (10) was low, it was difficult to visually observe the content liquid. [Examples 2-9 to 2-16] In the same manner as in the embodiment, a layered structure = thermoplastic multilayer plastic shown in Table 7 was used, and a blow molding, filling and sealing method was used to produce the film shown in Fig. 8. The shape of the 2.5 l exchange ^ ^ 士 * 0 r L each amount with the ampoule. In the ampoules, fill in the broth 5 mL of 0. 8% (w / v) Austrian rain * ^ Xinghao Gero sodium aqueous solution. 97110774 66 200940046 [Table 7] Outer layer (colored layer) The total thickness of the inner layer of the intermediate layer PE1 T = 100 ^ m COC1 + PE5 PEI 300 β m 640 β m Example 2-9 P=0. 63% ' PT = 63 U= 0.4% ' UT=40 (4:1) 200 μ m - U/T=0.004 PEI Example 2-10 T=200 β m P=0.06% , PT=12 U:0. 24%, UT = 48 U /T=0.0012 COP1+PE5 (4:1) 200 β m PEI 200 β m 640 β m PEI 实施 Example 2-11 T=300 β m P = 0. 04% ' PT = 12 U=0. 12% 'UT = 36 U/T=0.0004 COC1+PE5 (4:1) 200 β m PEI 100 β m. 640 β m PEI Example 2-12 T=50 β m P=2.5% &gt; PT=125 U= 0.1% &gt; UT=5 U/T=0.002 COP1+PE5 (4:1) 200 β m PEI 300 β m 590 β m PEI Example 2-13 T=300 β m P: 0. 04%, PT = 12 U=0.4%, UT=120 U/T=0.0013 COP1+PE5 (4:1) 200 μ. m PEI 100 /zm 640 μ m PEI Example 2-14 T= 1 00 β m P=0. 04 % ' PT = 4 U = 0. 38% &gt; UT=38 U/T=0.0038 COC1+PE5 (4:1) 200 β m PEI 200 β m 540 μ m Example 2-15 PP1+PP2 (8: 2) T=200 β m COP1+PE5 PP1+PP2 640 P=0_ 13%, PT=26 (4:1) (8:2) U=0. 4%, UT=80 U/T=0. 002 200 β m 200 β m [jL Π1 PP1+PP3(8 : 2) Example 2-16 T=1 00 ^ m COP1+PE5 PP1+PP3 640 β m P=0. 13%, PT=13 U= 0. 43⁄4 ' UT=40 (4:1) 250 μ. m (8:2) 250 β m U/T=0.004 Examples 2-9 to 2-16 are in Examples 2-1 to 2-8 The material for forming the intermediate layer is changed to C0C1 or a mixed resin of COP1 and PE5 (weight: 67 97110774 200940046, ratio 4:1). - 乂" In the same manner as in the above (2), no change in the appearance of the appearance of the female bottle of the ninth to 216 spectacles was observed. As a result, no ultraviolet ray absorbing agent was observed from the container body. [Examples 2-17 and 2-18 ]

In the same manner as in Example 2-1, the thermoplastic multilayer plastic having the layer structure = shown in Table 8 was used to produce a 2.5 mL capacity by the blow molding, filling, and sealing method. Ampoule. In the money, fill in 2.5 mL of 〇. 8% (w / v) aqueous solution of sodium ozagrel. In the same manner as in the above (7) to (4), the ampule content ratio was measured for the ampoules of Example 2-17, and the light transmittance was measured. The results are shown in Table 9. [Table 8]

-~~^ Μ

ΡΕ1 300 μ m PEI T=100 β m Example 2 -17

P=0. 25%, PT=25 U=0. 4%, UT=40 U/T: 0.004 — ρεΊ COP1 200 β m 640 β πι Example 2-18 PE1 50 // m

Τ=400 β m 690 β m Ρ=0·01% , ΡΤ=4 C0P1 U=0. 15% ' UT=6〇200 ^ m U/T=0.000375 97110774 68 200940046 [Table 9] Ampoule appearance cis Transmittance of the body ------___ (with or without oozing) Content ratio 200~380 nm fi f) Q nm Example 2-17 No observed 0. 04% max. 0.8% ~ 583⁄4 Example 2 18 未0。 02% max. 0% 15% 65% Control - 0. 15% As shown in Table 9, for Examples 2-17~2-18, it is judged to have the same as Example 2-1~ 2-8 the same performance.

[Example 2-1 9~2-24 and Comparative Example 2-5~2-1〇J ❹ , only '%, use thermoplastic multilayer plastic having a layer of Table 10 or Table 11 The sword mf 4 is made of the shape of the shape of Fig. 8 by the blow molding, filling and sealing method', and the inner shape is also used. In the ampule, 2.5 mL of 〇.8% (w/v) is filled, followed by the same as (2) to (4) above. The ampules of ~2-24 were observed for the change in appearance, and the light transmittance was measured for Examples 2-19. The result is shown as the ratio of the cis-form body.

97110774 69 200940046 [Table 1 0 ]

Outer layer (colored layer) Intermediate layer inner layer total thickness PE1 Example 2-19 Τ=400 β m P=0.06% ' PT=24 U=0.05% ' UT=20 U/T=0.000125 COC1 150 β m. PEI 50 &quot m 640 β m PEI Comparative Example 2-5 T = 400 β m P=0. 0375% ' PT=15 U=0. 05% ' UT = 20 U/T=0.000125 C0C1 150 β \ά PEI 50 β m 640 β m PEI Example 2-20 T=400 β m P=0.35% ' PT-140 U = 0. 05% &gt; UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 μ m PEI 50 // m 640 β m PEI Comparative Example 2-6 T=400 β m P = 0. 45% ' PT = 180 U=0.05% ' UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 β m PEI 50 β m 640 β m PEI Example 2-21 T=200 β m P=0.11%, PT=22 U=0.1%, UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m PEI Comparative Example 2-7 T=200 β m P = 0. 075% ' PT=15 U=0.1% &gt; UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m 97110774 70 200940046 [Table 11]

Outer layer (colored layer) Intermediate layer inner layer total thickness Example 2-22 PE1 Τ = 200 β m P=0.7% ' PT=140 U = 0. 1%, UT=20 U/T=0.0005 COC1+PE4 (9: 1) 200 β m PEI 200 β m 640 β m Comparative Example 2-8 PEI T=200 β m P=l. 0% ' PT=200 U = 0. 1% ' UT=20 U/T=0.0005 COC1+ PE4 (9:1) 200 β m PEI 200 β m 640 β m Example 2-23 PEI T=100 β m P = 0.25%, PT = 25 U=0.2% ' UT=20 U/T=0.002 COC1 200 β m PEI 300 β m 640 β m Comparative Example 2-9 PEI T=100 μ m P: 0.15%, PT=15 U=0.2% ' UT=20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m Example 2-24 PEI T=100 μ m P = l. 5% &gt; PT=150 U=0.2% ' UT=20 U/T=0.002 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m Comparative Example 2-10 PEI T = 10 0 β m P=l.8% ' PT=180 U=0. 2% ' UT=20 U/T=0.002 C0C1+PE4 ( 9:1) 200 β m PEI 300 β m 640 β m

[Table 12] Appearance of Ampoule (with or without exudation) Proportion of light content of cis-type body 200~380 nm 600 nm Example 2-19 No observed 0. 28% Maximum 4. 3% 66% Comparative Example 2 - 5 No observed 0. 38% 襄 5. 6% 66% Example 2-20 No 0.02% observed Maximum not above 0. 1% 42% Comparative Example 2 - 6 Not observed - Maximum less than 0.1% 27% Example 2-21 No observed 0. 29% Sharpest 4. 3% 69% Comparative Example 2 - 7 No observed 0. 40% Stupid 5. 5% 66% Example 2-22 Not observed 0. 03% max. 0. 3% 43% Comparative Example 2 - 8 Not observed - Most people are less than 0. 1 % 24% Example 2-23 No observed 0. 29% Most lost 4. 5% 68% Comparative Example 2-9 No observed 0. 41% Stupid 5. 7% 66% Example 2-24 No observed 0. 03% Maximum less than 0. 1% 403⁄4 tls 彳歹丨) 2 -1 0 Not observed - maximum less than 0. 1% 28% control - 0.15% - 97110774 71 200940046 As shown in Table 12, in Examples 2_19 to 2_24 satisfying the above formula (1) and the above formula (3), The performances similar to those of the examples 2-1 to 2-8 are, in contrast, the comparative examples 2_5 to 2_1 in which the above formula (3) is not satisfied. Health conditions · Mf as not to increase the content ratio of the cis form, or a decrease of visible light transmittance, it is difficult to visually observe the contents liquid. [Examples 2-25 to 2-30] In the same manner as in Example 2-1, the thermoplastic multilayer plastic having the layer ❹ shown in Table 13 was used in the manner of the door-to-door, ^ δ ^ , 夕The glue is made by the blow molding, filling and sealing method, and the ampule is used in the ampule. In the ampoules, 5 mL of 〇.8% (w/v) M-Gray sodium solution was added. 10

L Table 13 J

Example 2-25 Τ=400 β m P=〇. 06% &gt; PT = 24 U=〇. 05% ^ UT=2〇-lZIr.0. 000125 Intermediate layer inner layer total thickness Example 2-26 Example 2-27 PET ^=400 β m P=〇. 35% ' PT = l4n U=〇. 05%, UT=2〇u^_o〇〇mMl - T=20〇β m P=〇. 11% ' PT=22 U=0.1%, UT=20 U/T=0,0005 COC1+PE5 (4:1) 150 ^ m

PEI (4 : U 50 640 βΰί COC1+PE5 (4:1) 150 /z m COC1+PE5 50PEh 640

PEI Example 2-28 PEI T=20〇μ m P=〇·7%, PT=14〇U=0.1%, UT=20 U/T=Q.0005 TEl~ 2〇Vl\ 2〇r&quot;m 640 "COC1+PE5 (4:1) 200 β m 20〇E!am 640 ^ m Example 2-29 Example 2-30 T = 1 00 /zm P: 〇.25%, PT=25 U=0 2%, UT = 20 u/t=o.nn^ ΤΕΪ T=100 P = l. 5%, PT=15〇U = 0. 2%, UT = 20 U/T=Q.002_ COC1+PE5 (4:1) 200 β m PEI β yin ,, 300 /zm 640 βΏι COC1+PE5 (4:1) 200 β m PEI c , n 300 640 βίΆ 97110774 72 200940046 Example 2-25~2~30 The material for forming the intermediate layer in Examples 2-19 to 2-24 was changed to a mixed resin of COC1 and PE5 (weight ratio 4:1). In the same manner as in the above (2), the example 2 25~2-30 observed eight appearance changes' results were not observed to seep out of the ultraviolet absorber from the container body. [Examples 2-31 to 2-33 and Comparative Example 2-Π~2-13] ❹ = and Example 2 In the same way, using the layer = thermoplastic multilayer plastic shown in 纟14, by the blow molding, filling and sealing method, the shape of the shape shown in Fig. 8 is 2 5 "9, τ π π female Hey. Within the Anzhen, fill 2.5 mL of 〇.8% (w/v) Ozagray, and then the same as the above (2) ~ (4) ten minutes ~ 2-3 彳 &gt; ~ π &amp;# u In the manner of Example 2-31 Ζ 33, the change in appearance and the ratio of the cis-form of the 佘 ^ 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 The results are shown in Table 5. 97110774 73 200940046 [Table 14] ^Γ¥~(Colored layer) Total thickness of inner layer of intermediate layer Example 2-31 m, width/%%0 厶3 5 0 0 7 oooo 0··= -400T E 11 ==/ ΟΛ Αμα 2 • ο 11 0〇II II 5 ΤΤ7 PU8 C0C1+PE4 (9:1) 150 β v\ £o P5 mm ^u· ο 4 Comparative Example 2-11 4 • ο ο 3 II=5 ΤΤ7 PU8 m , ο /%%ο ΛΜ.1 5 ο 0 7. ο ο ο ο ο_·= 400Τ Ε II 11= / ρ τ ρ υ υ COC1+PE4 (9:1) 150 am

Eo p 5 m ^ 4 6 m ^ Example 2-32 ❹ Comparative Example 2-12 Example 2-33 PE1 Τ=200 β m P = 0. 005%, PT=1, U = 0. 15% ' UT = 30 U/T=Q.00075 ΤΙΊ ' T=200 β m P = 〇. 002%, PT=0. U = 0. 15% ' UT = 30 U/T=Q.00075 PET T=100 ^ m P=〇.015%, PT=1_ U = 0. 3%, UT = 30 U/T=0.003 C0C1+PE4 (9:1) 200 β m 4 6 m =1 1 o Eo P2 m C0C1+PE4 ( 9:1) 200 β m 4 6 m 1 o Eo P2 m C0C1+PE4 (9:1) 200 β m Melon 0 4 6 m 1 o Eo P3 PEI T=100 β m P=〇.0053⁄4 &gt; PT= 0, U=0. 3% ' UT=30 U/T=0.003 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m [Table 15] Light transmittance Ampoule appearance cis-form implementation Example 2-31 K ^ nr UA to observe 1 J ^ ^ PO V*} 0. 27% zuu~ oou nm Maximum 4. 8% buu nm 60% Comparative Example 2-11 to observe the radish 0. 45% Maximum 6 8% 63% Implementation 垧2-32 Unobserved radish 0. 29% Maximum 4. 8% 60% Comparative _ 2-12 to observe 1 0. 5% Jia; Large 6. 8% 61% Example. 2-33 To observe Yin 0. 28% Maximum 4. 8% 583⁄4 ίϊι Comparative Example 2-13 Observed to 1 0. 51% Maximum 7. 0% 60% For Cong 15% As shown in Table 15 Formula (1) and the above formula (2) Example 2 - 31 to 2-33 'has the same performance as the examples 2-1 to 2-8, whereas in the comparative examples 2-11 to 2-13 which do not satisfy the above formula (1), The following unfavorable situation: the proportion of cis-forms increases, or the transmittance of visible light is 97110774 74 200940046, and the rate of radiation drops, and it is difficult to visually observe the content liquid. [Examples 2-34 to 2-36] In the same manner as in Example 2-1, the thermoplastic multilayer plastic material having the layer composition shown in Table 16 was used to be filled by blow molding. . Sealing method, and the 2.5 mL capacity of the shape shown in _ ^ 8 is used in ampoules. In the An's bottle, it is really filled with 2'5 mku% (w/v) aqueous solution of Ou Vilagren. L Table 16 ] ---- _L interlayer - inner layer total thickness 2 —_丨COC1+PE5 (4:1) 150 β m PEI 50 /zm 640 β m 0 ----- C0C1+PE5 (4:1 ) 200 β m PEI 200 β m 640 β in 5 C0C1+PE5 (4:1) 200 β m PEI 300 μ. m 640 β m a small π see a throwing example w~2-33 2-34 Ρτ U=0. 075% ' UT=3h ——-^p^ooilis30 Example 2-35 ?: Count SosV1, Ρτ U=0. 15% n UT=3fl — -^ia〇〇iI30 Implementation Example 2-36 LSMisV1, pT U=〇.3% ^ UT=3〇———1_ZZ1^L_003 1) The material is changed to C混合C1 and mixed resin (weight ratio 4: In the same manner as in the above (2), the results of the examples 2-34~2 to 36, = appearance change were not observed in the UV absorber from the container [Bei Shi Example 2-37~2-42 and comparison Example 2_14 to 2_19] In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a watch or a two-layer structure was used, and the shape of the shape shown in Fig. 8 was produced by blow molding. The amount of the Anc bottle 97110774 75 200940046, filled with 2. 5 mL of 0. 8% (w / v) Ozagrena aqueous solution. Then, with In the same manner as described in (2) to (4), the ampules of Examples 2-37 to 2-42 were observed for changes in appearance, the ratio of cis isomers was measured, and the light transmittance was measured. The results are shown in Table 19. [Table 17] Outer layer (colored layer) Intermediate layer inner layer total thickness Example 2-37 PE1 Τ=400 β m Ρ = 0·1%, PT = 40 U=0.013% &gt; UT=5. 2 U/T =0.0000325 COC1+PE4 (9:1) 150 β \ά PEI 50 // m 640 β m Comparative Example 2-14 ΡΕ1 Τ=400 β m Ρ=0.1% &gt; ΡΤ=40 U = 0. 005% ' UT = 2 U/T=0.0000125 COC1+PE4 (9:1) 150 β \ά PEI 50 β m 640 β m Example 2-38 ΡΕ1 Τ=400 β m Ρ: 0· 1%, ΡΤ = 40 U=0 4% &gt; UT = 160 υ/τ: ο·001 COC1+PE4 (9:1) 150 ^ m PEI 50 ^ m 640 β m Comparative Example 2-15 ΡΕ1 Τ=400 β m Ρ=0.1% &gt; ΡΤ=40 U=0.5% &gt; UT=200 U/T=0.00125 COC1+PE4 (9:1) 150 ^ m PEI 50 β m 640 β m Example 2-39 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ=40 U=0.02% ' UT=5 U/T=0.00008 C0C1+PE4 (9:1) 200 β m PEI 150 μ wi 640 β m Comparative Example 2-16 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ = 40 U = 0. 01%, UT = 2.5 U/T: 0.00004 C 0C1+PE4 (9:1) 200 β m PEI 150 β m 640 β m 97110774 76 200940046 [Table 18] (Colored layer 1 Intermediate layer inner layer total thickness Example 2-40 PE1 Τ=250 β m Ρ = 〇· 16 %, PT=40 U=0.6%, UT=15〇ΙΙ/Τ = 0. 0024 C0C1+PE4 (9:1) 200 β m PEI 150 μ m 640 β m Comparative Example 2-17 ~ρεΤ ~~ Τ= 250 β m Ρ = 〇. 16% ' ΡΤ=40 U=0.8%, UT=2〇〇ϋ/Τ=0.0032 COC1+PE4 (9:1) 200 β m PEI 150 β m 640 β m Example 2 41 τη Τ=200 β m Ρ=0. 2% ' ΡΤ=40 U=0. 03% &gt; UT = 6 If/T=0. 00015 C0C1+PE4 (9:1) 200 β m PEI 200 β in 640 β m Comparative Example 2-18 ~Ffl - Τ=200 β m Ρ=0. 2% ' ΡΤ=40 ϋ=0. 01% ' UT=2 ϋ/Τ=0.00005 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m Example 2-42 ΤΕΐ - Τ=200 β m Ρ=〇. 2% ' ΡΤ=40 U=0.7% ' UT=14〇ϋ/Τ=0.0035 COC1+PE4 (9 :1) 200 β m PEI 200 β m 640 β m Comparative Example 2-19 ΡΕ1 Τ=200 β m Ρ=〇· 2%, ΡΤ=40 U=l% ' UT=200 U/T=0.005 C0C1+PE4 (9:1) 20 0 β m PEI 200 β m 640 β m [Table 19] Outside the ampoule - (with or without exudation, cis-form) Content ratio Light rate 200~380 run 600 nm Example 2-37 bundle view to 1. 0. 25% max 4. 7% 58% Comparative example 2-14 Not observed to ^ 0. 32% max 5. 5% 563⁄4 Example 22-3 No observation to 0. 02% Maximum less than 0. 1% 57% 4 Private j 2 -15 to Guan Qin to L __0. 02% Maximum less than 0. 1 % 57% Example 2 -39 未113⁄4 察3£_j 0. 27% max 4. 83⁄4 56% λ compared to Example 2-16 to observe 0. 33% max 5 43⁄4 53% Example 2-40 to observe 1 0. 02% ~~ Maximum less than 0 1 % 563⁄4 Kun compared to your j 2-17 husband observed to 1 0. 02% maximum to Zhan 0 1% 53% Example 2-41 耒 observation f丨U. 26% maximum 4 83⁄4 53% Comparative example 2-18 to observe the potential... 0. 53⁄4 蛊大 7 93⁄4 543⁄4 Example 2-42 Not observed to 1 07021 Max Fupan 0 1% ^93⁄4 Comparative Example 2-19 Observed ----0.153⁄4 19 shows that in the embodiments 2-37 to 2-42 satisfying the above formula (丨) and the above formula (2), the performance is the same as that of the examples 24 to 2_8, and the phase is 97110774 77 200940046. In Comparative Example 2_i4 to 2_i9 of the above formula (2), the following problem occurs: the content of the cis is increased, or the transmission of visible light The rate is lowered, and it is difficult to visually observe the content liquid. [Examples 2-43 to 2-48] In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a layer structure shown in Table 2A was used, and a pattern was produced by a blow molding, filling and sealing method. The volume of 2 5 mL of 8 shapes is ampoules. In an ampoule, fill 2.5 mL of 〇.8% (w/v) aqueous solution of sodium Ozagrel. [Table 20]

Example 2-43 Τ=400 β m P = 0. 1% &gt; PT = 40 U = 0. 013% ' UT=5 2 U/T=0.〇〇〇〇3?r COC1+PE5 (4 :1) 150 ^ m PEI 50 // m 640 β m Example 2-44 PEI T=400 μ. m P=0. 1% ' PT = 40 U=0. 4%, UT=160 U/T= 〇.001 COC1+PE5 (4:1) 150 β vn PEI 50 ^ m 640 β m Example 2 - 4 5 FE1 T=250 μ. m P=0. 16%, PT=40 U=0. 02% ' UT=5 U/T=0.00008 COC1+PE5 (4:1) 200 β m PEI 150 μ m 640 β m PEI ~~- Example 2 - 4 6 T=250 β m P=0. 16%, PT = 40 U=0. 6% ' UT = 150 U/T=0.0024 COC1+PE5 (4:1) 200 μ. m PEI 150 ^ m 640 β m PK1 Example 2 - 4 7 T=200 β m P= 0. 2% &gt; PT=40 U=0· 03%, UT:6 U/T=0.00015 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m Example 2 - 4 8 _________ PEI T=200 β m P=0. 2%, PT = 40 U = 0. 7% &gt; UT = 140 U/T=0.0035 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m ❹ The material to be formed was changed to a mixed resin of C0C1 and PE5 (weight ratio 4: 97110774 78 200940046 ❹ 1). The appearance change was observed in the same manner as in the above (2), and the appearance of the fruit was as follows: for the example 2-43 to 2-48, the exudation was observed. The σ fruit was not observed from the container body [the actual example 2-49~2~5i J was the same as the thermoplastic multilayer plastic of the composition of Example 2-1, and the H'f has a table as shown. The layer 2 is shown in Figure 8. The volume is filled with 2. 5 mL of 〇/, and I is used by niece. In the Anzheng, the Azigalel steel shovel was followed by the above (2) ~ (Exhibition ~ 2 - 51 ampoules, observing its appearance changed) to Example 2-49 and measuring the luminosity. The results are shown in Table 22. 疋 cis type contains the ratio ' [Table 211

Example 2-49 9Kc〇Pl PP1 实施 Example 2~5〇 Example 2 ~ 51 ΡΕ1 Τ=50 β m P=3 ' PT=150 U=0. 2% ' UT=l〇U/T=0.004 TEl T = 1 00 仁 m P = l. 5% &gt; PT=150 U = 0. 4%, UT=40 U/T=0.004 ΤΕΓ T=200 β m P=0. 75%, PT=150 U = 0. 7% ' UT=140 II/T = Q. 0035 300 640 200 “ni 3〇SE1“m 640 n 2〇C〇〇P- 20^m B40,m 97110774 79 200940046 [Table 22]

---~_______ υ &gt; 1 U7&amp; - --------- As shown in Table 22, '2-49 to 2-51, have the same performance as Examples 2-1 to 2-8 . [Example 2-52 to 2-54] 热塑性 In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a layer structure shown in Table (2) was used, and a pattern was produced by a blow molding, filling and sealing method. The shape of the display is 2 5 and the capacity is in ampoules. In an ampoule, fill 2.5 mL of 〇.8% (w/v) aqueous solution of sodium ozagrel. [Table 23] 实施 Example 2-52 Jim UT = l〇-^^004. Example 2-53ll&amp;r- Example 2-54 -^^1^0035 I3 interlayer C0P1+PE5 (4:1) 250 β m C0P1+PE5 (4:1) 200 β m COP1+PE5 (4:1) 200 β m PEI 300 β ηι 640 μ. m PEI 300 /zm 640 in m PEI 200 ^ m 640 /zm Example 2 -52~2-54 is the case where the compound 2_49~2_51^^ intermediate ^=material is changed to the mixed resin of c0pl and PE5 (weight ratio 4: 丄). The second method was observed, and the examples 2_52 to 2-54 were observed to seep out. The ultraviolet absorbing agent is not observed from the container body 97110774 200940046. Further, although the above invention is provided as an example of the present invention, it is merely an exemplification, and is not intended to be a limitation. Variations of the invention as apparent to those skilled in the art are included in the scope of the following patent. (Industrial Applicability) The plastic ampule formed by the plastic ampule of the present invention is suitable for use as a sterilized accommodating and densely suitable as a blow molding, filling and sealing dimension. The color-colored plastic container of the second color is suitable as a plastic container for the purpose of accommodating the interior of the container and efficiently shielding the ultraviolet 11 field from the container due to the purple to internal #. A plastic container for decomposing and deteriorating chemicals. BRIEF DESCRIPTION OF THE DRAWINGS [Embodiment of the drawings] A front view of an embodiment of a plastic ampoule of the present invention. Figure 1 is a left side view of the plastic ampoules shown in Figure 1. Figure 3 is a top plan view of the plastic ampule shown in Figure 1. Figure 4 is a bottom view of the plastic money shown in Figure 1. Figure 5 is a left side cross-sectional view of the plastic ampoules shown in Figure 1. Figure 6 is a cross-section of the plastic ampule shown in Figure 1. Figure 7 is a Β-Β profile of the plastic ampoules shown in Yan. IT: Section: 97110774 200940046 Fig. 10 is a cross-sectional view showing another example of a layer of a thermoplastic multilayer plastic forming a colored plastic container. Figure 11 is a front elevational view showing an embodiment of a colored plastic container. Figure 12 is a side elevational view of the colored plastic container of Figure 11; Figure 13 is a plan view of the colored plastic container shown in Figure 11. Figure 14 is a bottom plan view of the colored plastic container shown in Figure π. Figure 15 is a side cross-sectional view of the colored plastic container shown in Figure 11. [Description of main component symbols] ❹ 10 Plastic ampule 11 ' 111 Chemical solution housing 11 a, 111 a Open end 12, 112 Chemical liquid discharge cylinder 13 , 113 Top 14 , 114 Fragile 15 , 115 Center shaft 16 , 116 Bottom 17 ' 117 Shoulder 18 , 104 Intermediate layer 19 Inner layer 20 Outer layer 21 ' 22 Adhesive layer 23 , 123 24 , 25 , 124 , 125 of the liquid medicine receiving part Flange 26 , 126 Liquid discharging cylinder part 97110774 82 200940046 27 ' 127 Top outer surface 28, 128 29 29, 32, 129, 132 flat portion - 30, 33, 130, 133 chamfered portion, 31 '131 reinforcing sheet 101 colored layer 102 cyclic olefin polymer layer 103, 105, 106 Polyolefin Layer® 110 Colored Plastic Ampoule 97110774 83

Claims (1)

200940046 X. Patent application scope 1. A plastic ampule, which is provided with a chemical liquid accommodating portion, communicates with the chemical liquid accommodating portion, and discharges the tubular portion to the one side: medicine: and closes the medicine The liquid discharge side of the liquid discharge cylinder portion is provided with a portion along the circumference side = a page portion, and a weak portion; the battle liquid is a brittle wall of the crucible wall. The liquid medicine storage portion, the liquid medicine discharge tube layer plastic The 'multilayer plastic is provided with a layer containing a glass transition top layer = 9 layers' and an outer layer laminated on the outer side of the intermediate layer. Such as the scope of patent application! The plastic ampule of the item has an adhesive layer between the intermediate layer and the inner layer and between the outer layers. In the above-mentioned 3, the plastic ampoules n of the patent range i, and the above-mentioned fragile portion of the it::? tube portion, from the top side of the above-mentioned $ / , continuous 4 to the outside of the above-mentioned liquid medicine discharge cylinder掰片; ^. The plastic ampoules of the first aspect of the invention, wherein the outer surface of the top surface of the liquid medicine is discharged from the chemical liquid discharge portion The outer peripheral surface of the upper liquid liquid storage unit side and the surface of the chemical liquid storage unit are continuously protruded from the chemical liquid discharge cylinder portion and the chemical liquid storage portion, and are connected to each other. ', 5. For example, the plastic ampoules of the scope of the patent scope, wherein the thickness of the above-mentioned multi-layered 刍 刍 刍 layer of the liquid discharged from the cylinder is compared with that of the above-mentioned 97110774 84 200940046 The force required is 〇. 65 N.in/mra or less. 2 The plastic ampule of claim 1, wherein the above-mentioned multilayer inner layer and outer layer comprise a pressure-sensitive polyethylene having a density of ◦. deleting ~ 〇. (d) _3. 7. The plastic ampoules of the first item of the patent scope, wherein the inner and outer layers of the plastic contain polypropylene resin. 8. The plastic ampoules of claim 7, wherein the polypropylene resin is a mixture of polypropylene, a polypropylene elastomer and a nucleating agent. 9. The plastic ampoules of claim i, wherein the intermediate layer of the multilayer plastic is a cyclic olefin (co)polymer containing a glass transition temperature of A to 、, and a density of 0·900~ A high-pressure polyethylene of 0.940 g/cm3 or a mixed resin of a high-density polyethylene having a degree of 〇. 94〇~〇97〇g/cm3 is formed, and the degree after σ 曰月曰 is 〇~0.940 g The content of the high-pressure bismuth polyethylene of /cm3 or the high-density polyethylene having a density of 〇94〇~〇97〇g/cm3 is 30% by weight or less. 10. The plastic ampule of claim </ RTI> wherein the outer layer of the plurality of layers of plastic contains a colorant. 11_ The plastic ampule of claim i, wherein the outer layer of the multi-layer plastic contains an ultraviolet absorber. 12. The plastic ampule of claim 11, wherein the ultraviolet absorbing agent is a benzotriazine-based ultraviolet absorbing agent. 13. For the plastic ampoules of the scope of the patent application, in which the above-mentioned 97110774 85 200940046 layer of plastic outer layer further contains metal vapor microparticles. π.-Colored plastic container, characterized in that it is formed by a thermoplastic multilayer plastic having: a coloring layer containing a pigment and an ultraviolet absorber; and one of the color layers directly or sandwiching the intermediate layer The inner layer of the side surface; I has the thickness of the colored layer dicing from (10) to "(10)em; 积 the content ratio P (% by weight) of the pigment in the colored layer, and the product of the thickness T (/zm) of the colored layer pT In the following formula (1), the product υτ of the content ratio U (% by weight) of the ultraviolet absorber and the thickness TUm of the colored layer in the colored layer satisfies the following formula (2) when the product ρτ exceeds 20 When the product ρτ is 2 〇 or less, the following formula (3) is satisfied, 1SPTS 150·.(I) 5 S UTS 160·(2) 20&lt; UTS 160··. (3). ❿ 15 The colored plastic container of claim 14, wherein the other side surface of the colored layer is the outer surface of the thermoplastic multilayer plastic. 16. The colored plastic container according to claim 15 of the patent application, wherein The content of the ultraviolet absorber in the colored layer In the case of U (T), the quotient U/T of the thickness T (//m) of the above colored layer satisfies the following formula (4): U/TS 0· 004. (4). The colored plastic container of claim 14, wherein the pigment is an azo condensation pigment, and the ultraviolet absorber is stupid = 97110774 86 200940046 azole-based ultraviolet absorber. 18. As claimed in claim 14 The colored plastic container, wherein the transmittance of the thermoplastic multilayer plastic is 5% or less for a light having a wavelength of 2 〇〇 to 38 () nm, and 4% or more for a light having a wavelength of 6 〇〇 (10). The colored plastic container according to claim 14, wherein a colored olefin polymer layer is provided between the colored layer and the inner layer. 20. The colored plastic container according to claim 14 of the patent application, wherein The straight line is provided with: a sputum liquid 2 which is formed into a bottomed cylindrical shape for containing the liquid medicine and which is connected to the open end of the chemical liquid accommodating portion and extends to the side side: a portion; and a closed liquid discharge cylinder The top of the side-side part:: the same as the "test" thermoplastic multilayer plastic The thickness _ 21 • If the patent application system is formed by blow molding, filling, and coloring the plastic seal method of item 20. And its 97110774 87