JP5078594B2 - Colored plastic containers - Google Patents

Description

  The present invention relates to a colored plastic container made of multilayer plastic having thermoplasticity, and more particularly to a colored plastic container for containing a drug that is easily decomposed and deteriorated by ultraviolet rays.

In recent years, drug containers such as ampoules have shifted from glass containers to plastic containers from the viewpoint of strength against impact, ease of handling, safety, and the like.
In addition, in such plastic containers, in order to accommodate drugs that are easily decomposed and deteriorated by ultraviolet rays, it has been studied to provide light shielding properties to the plastic material forming the container. It has been proposed to blend a UV absorber or a UV absorber.

Patent Document 1 discloses an infusion bag characterized by blending 0.02 to 3.0 parts by weight of Color Index Pigment Yellow 95 and / or Color Index Pigment Yellow 147 with 100 parts by weight of a thermoplastic resin. A colored resin composition is described.
Patent Document 2 discloses that an ethylene vinyl alcohol copolymer layer containing an ultraviolet absorber is mainly composed of polyolefin for the purpose of preventing adhesion deterioration due to light of oily food containers and improving the storage stability of contents. It has been proposed that the inner and outer layers are formed of a laminate provided as an intermediate layer via an adhesive resin layer.
JP-A-8-193149 JP-A-9-86570

However, in order to sufficiently shield the wavelength in the ultraviolet region by blending the pigment into the plastic material, it is necessary to blend a large amount of pigment, so the wavelength in the visible region is also shielded and the contents of the plastic container can be visually confirmed. The trouble that becomes difficult arises.
In addition, when an ultraviolet absorber is blended in a plastic material to sufficiently block the wavelength in the ultraviolet region, a large amount of the ultraviolet absorber is compounded, so that the problem of cost increase becomes prominent. There is also a possibility of causing problems such as a decrease in dispersibility of the ultraviolet absorber in the resin and oozing (bleeding) of the ultraviolet absorber from the plastic material.

As another method for improving the light shielding property of the plastic container, it is conceivable to increase the thickness of the plastic. In this case, however, the thickness of the entire container is increased, which may hinder the operability of the plastic container. . In particular, when the plastic container is a relatively small container such as an ampoule, an adverse effect due to an increase in thickness is likely to appear significantly.
An object of the present invention is to provide a colored plastic container that can stably store a drug that is easily decomposed and deteriorated by ultraviolet rays and that allows the inside of the container to be easily seen.

  In order to achieve the above object, the colored plastic container of the present invention comprises a colored layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly on one surface of the colored layer or with an intermediate layer interposed therebetween. The colored layer has a thickness T of 50 to 1000 μm, a pigment content ratio P (% by weight) in the colored layer, and a thickness T (μm) of the colored layer. Product PT satisfies the following formula (1), and the product UT of the content ratio U (% by weight) of the ultraviolet absorber in the colored layer and the thickness T (μm) of the colored layer is the above product. When PT exceeds 20, the following formula (2) is satisfied, and when the product PT is 20 or less, the following formula (3) is satisfied.

1 ≦ PT ≦ 150 (1)
5 ≦ UT ≦ 160 (2)
20 <UT ≦ 160 (3)
According to the colored plastic container of the present invention, it is possible to efficiently shield wavelengths in the ultraviolet region while maintaining appropriate visibility with respect to the inside of the container. Therefore, according to the present invention, a drug that is easily decomposed and deteriorated by ultraviolet rays can be stably contained.

In the colored plastic container of the present invention, the other surface of the colored layer is preferably the outer surface of the thermoplastic multilayer plastic. That is, the colored layer is preferably an outer layer of a colored plastic container.
In this case, the quotient U / T obtained by dividing the content ratio U (% by weight) of the ultraviolet absorber in the colored layer by the thickness T (μm) of the colored layer is expressed by the following formula (4 ) Is more preferable.

U / T ≦ 0.004 (4)
By arranging the colored layer on the outer surface of the thermoplastic multilayer plastic, that is, by making the colored layer the outermost layer of the thermoplastic multilayer plastic, the ultraviolet absorbing effect by the ultraviolet absorber can be efficiently exhibited. Moreover, in this case, by setting the content ratio of the ultraviolet absorber in the colored layer within the above range, it is possible to prevent the ultraviolet absorber from bleeding (bleeding) from the surface of the thermoplastic multilayer plastic.

In the colored plastic container of the present invention, it is preferable that the pigment is an azo condensation pigment, and the ultraviolet absorber is a benzotriazole ultraviolet absorber. In this case, the shielding effect against light in the ultraviolet region is good.
In the colored plastic container of the present invention, the transmittance of the thermoplastic multilayer plastic is 5% or less with respect to light having a wavelength of 200 to 380 nm and 40% or more with respect to light having a wavelength of 600 nm. Is preferred.

The colored plastic container of the present invention preferably includes a cyclic olefin polymer layer between the colored layer and the inner layer. In this case, the pigment and UV absorber contained in the colored layer can be prevented from migrating to the inner layer side or the contents contained in the colored plastic container, thereby preventing adverse effects on the chemical contained in the colored plastic container. it can.
The colored plastic container of the present invention includes a chemical solution storage portion for storing a chemical solution formed in a bottomed cylindrical shape, a chemical solution discharge tube portion that communicates with the opening end of the chemical solution storage portion, and extends toward one side, and a chemical solution It is preferable that the colored plastic ampule includes a top portion that closes one end portion of the discharge tube portion, and the thickness of the thermoplastic multilayer plastic in the chemical solution storage portion is 300 to 1500 μm.

  In this case, the colored plastic container (colored plastic ampoule) is preferably formed by a blow fill seal method.

  The colored plastic container of the present invention has moderate visibility with respect to the inside of the container, and can efficiently block the incidence of light in the ultraviolet region from the outside to the inside of the container. Therefore, the colored plastic container of the present invention is suitable for applications that contain drugs that are easily decomposed and deteriorated by ultraviolet rays.

The colored plastic container of the present invention is formed of a thermoplastic multilayer plastic comprising a colored layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly on one surface of the colored layer or with an intermediate layer interposed therebetween. ing.
FIG. 1 is a cross-sectional view showing an example of a layer structure of a thermoplastic multilayer plastic forming a colored plastic container, and FIGS. 2 and 3 are cross sections showing other examples of the layer structure of the thermoplastic multilayer plastic, respectively. FIG. In the following description, the same or similar parts are denoted by the same reference numerals through a plurality of layer configuration examples.

  The thermoplastic multilayer plastic shown in FIG. 1 includes a colored layer 1 containing a pigment and an ultraviolet absorber, a cyclic olefin polymer layer 2 laminated on one surface of the colored layer 1, and a colored layer of the cyclic olefin polymer layer 2. 1 and a polyolefin layer 3 laminated on the opposite surface. In this thermoplastic multilayer plastic, the colored layer 1 is a layer forming the outer layer of the colored plastic container, the cyclic olefin polymer layer 2 is a layer forming the intermediate layer of the colored plastic container, and the polyolefin layer 3 is It is a layer which forms the inner layer of a colored plastic container.

Ring-shaped olefin polymer layer 2, the pigment and the ultraviolet absorber to be blended in the colored layer, a layer provided in order to prevent the shift to the contents contained in the colored plastic container, the present invention In a thermoplastic multilayer plastic that forms a colored plastic container, any layer.
The thermoplastic multilayer plastic shown in FIG. 2 includes a colored layer 1 containing a pigment and an ultraviolet absorber, an intermediate layer 4 having a three-layer structure laminated on one surface of the colored layer 1, and a colored layer 1 of the intermediate layer 4. And a polyolefin layer 3 laminated on the opposite surface. Further, the intermediate layer 4 includes a cyclic olefin polymer layer 2 and a total of two polyolefin layers 5 and 6 laminated on the one side surface and the other side surface of the cyclic olefin polymer layer 2 respectively. ing. In this thermoplastic multilayer plastic, the colored layer 1 is a layer that forms the outer layer of the colored plastic container, and the polyolefin layer 3 is a layer that forms the inner layer of the colored plastic container.

  The thermoplastic multilayer plastic shown in FIG. 3 includes a polyoff olefin layer 3, a colored layer 1 containing a pigment and an ultraviolet absorber laminated on one surface of the poly off olefin layer 3, and a polyolefin layer 3 of the colored layer 1. And a cyclic olefin polymer layer 2 laminated on the opposite surface. In this thermoplastic multilayer plastic, the polyolefin layer 3 is a layer forming the outer layer of the colored plastic container, and the cyclic olefin polymer layer 2 is a layer forming the inner layer of the colored plastic container. The colored layer 1 is a layer that forms an intermediate layer of the colored plastic container.

  In addition, any of the thermoplastic multilayer plastics shown in FIGS. 1 to 3 may include an adhesive layer between the layers. In this case, for example, adhesiveness between the colored layer 1 and the cyclic olefin polymer layer 2, adhesiveness between the cyclic olefin polymer layer 2 and the polyolefin layer 3, adhesiveness between the colored layer 1 and the intermediate layer 4, and in the intermediate layer 4 Adhesiveness between the cyclic olefin polymer layer 2 and the respective polyolefin layers 5 and 6 and adhesiveness between the colored layer 1 and the polyolefin layer 3 can be improved.

In the present invention, the layer structure of the thermoplastic multilayer plastic is not particularly limited. For example, in order to efficiently impart light shielding properties to the colored plastic container, the colored layer 1 is disposed as far as possible outside the colored plastic container. Is preferred. In particular, such measures are effective when the colored plastic container is a relatively small container such as an ampoule.
The plastic forming the colored layer is not particularly limited except that it is a plastic having thermoplasticity, and specific examples thereof include polyolefin.

Although it does not specifically limit as polyolefin, For example, Preferably, polyethylene-type resin and polypropylene-type resin are mentioned. When heat resistance is required for the colored plastic container, a polypropylene resin is preferable.
Examples of the polyethylene resin include homopolymers such as high pressure method (branched) low density polyethylene (HP-LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), and high density polyethylene (HDPE). And polyethylene-based copolymers. Examples of the comonomer other than ethylene in the polyethylene copolymer include α-olefins such as propylene, butene-1, pentene-1, hexene-1,4-methylpentene-1, octene-1, and decene-1. . Moreover, in this polyethylene-type copolymer, the content rate of comonomer other than ethylene becomes like this. Preferably it is 20 mol% or less, More preferably, it is 3-20 mol%.

The property of the polyethylene-based resin is not particularly limited, but for example, it is preferably a relatively low density, and specifically, the density is preferably in the range of 0.910 to 0.930 g / cm ³ . The melt flow rate (MFR) is preferably 0.2 to 20 g / 10 minutes (190 ° C.). These properties of the polyethylene-based resin are suitable for improving the mechanical properties of the colored plastic container, and are particularly suitable when a cyclic olefin polymer layer is provided between the colored layer and the inner layer. .

  Examples of the polypropylene resin include homopolymers such as isotactic polypropylene and syndiotactic polypropylene, and polypropylene copolymers. Examples of the comonomer other than propylene in the polypropylene-based copolymer include α-olefins such as ethylene, butene-1, pentene-1, hexene-1,4-methylpentene-1, octene-1, and decene-1. . In addition, the content of the comonomer other than propylene in the copolymer is preferably 30 mol% or less, more preferably 2 to 30 mol%, and still more preferably 3 to 25 mol%.

Although the property of a polypropylene resin is not specifically limited, For example, MFR becomes like this. Preferably it is 0.2-20 g / 10min (230 degreeC). A polypropylene resin having an MFR in the above range is suitable for improving the mechanical properties of the colored plastic container, and particularly suitable for a case where a cyclic olefin polymer layer is provided between the colored layer and the inner layer. It is.
The colored layer may be formed from, for example, a mixture of polypropylene, a polypropylene elastomer, and a nucleating agent. In this case, the transparency of the colored layer can be improved.

Examples of the nucleating agent include 2,2′-methylenebis (4,6-di-t-butylphenyl) phosphate sodium (NA-11), hydroxyaluminum-bis [2,2-methylene-bis (4,6 -Di-t-butylphenyl) phosphate] (NA-21) and the like.
The pigment is a component that is blended to reduce the light transmittance of the colored plastic container and to suppress the deterioration of the contents (for example, drugs) contained in the colored plastic container due to light (particularly, ultraviolet rays). . In addition to the above-mentioned purpose, the pigment may be blended for the purpose of imparting design properties to a colored plastic container, for example.

As the pigment contained in the colored layer, in accordance with the type of content contained in the colored plastic container, that is, in order to improve the storage stability of the content, according to the wavelength region of the light to be shielded, Set as appropriate.
Specifically, when the contents contained in the colored plastic container are mainly to shield light in the ultraviolet region, examples of the pigment include azo condensation pigments (for example, C.I. Pigment Yellow 95, CI Pigment Yellow 93 represented by the following formula, CI Pigment Yellow 94 represented by the following formula, CI Pigment Yellow 128 represented by the following formula, CI Pigment Red 144, CI Pigment Red 220, CI Pigment Red 221, CI Pigment Red 242, and the like, isoindolinone pigments (for example, CI Pigment Yellow 110 represented by the following formula, CI Pigment Yellow 109, CI Pigment Yellow 139, CI Pigment Yellow 173, C Pigment Orange 61, CI Pigment Orange 68, etc.), monoazo pigments (for example, CI Pigment Yellow 181), disazo pigments (for example, CI Pigment Yellow 180), anthraquinone Organic pigments such as CI pigments (for example, CI Pigment Yellow 147), dioxazine pigments and quinacridone pigments, for example, iron oxide, C.I. I. Pigment blue 28 (cobalt blue; cobalt aluminate), C.I. I. And inorganic pigments such as CI Pigment Yellow 53 (titanium yellow; nickel yellow).

  Among these, an azo condensed yellow pigment is preferable as the pigment from the viewpoint of efficiently shielding light in the ultraviolet region. In addition, for example, even when the medicine contained in the colored plastic container is an ozagrel sodium aqueous solution, the pigment is preferably an azo condensed yellow pigment from the viewpoint of improving the effect of suppressing the alteration of ozagrel sodium, C. I. Pigment Yellow 95 is preferred.

The ultraviolet absorber is a component that is blended to reduce the ultraviolet light permeability of the colored plastic container and to suppress the deterioration of the contents (for example, a drug such as ozagrel sodium aqueous solution) contained in the colored plastic container due to ultraviolet rays. is there.
Examples of the ultraviolet absorber contained in the colored layer include benzophenone series, benzotriazole series, triazine series, oxalic acid anilide series, and cyanoacrylate series. Among these, a benzotriazole type is preferable as the ultraviolet absorber.

  Examples of the benzotriazole ultraviolet absorber include 2- (2′-hydroxy-3′-tert-butyl-5′-methylphenyl) -5-chlorobenzotriazole (product of Ciba Specialty Chemicals Co., Ltd.). Name “Tinuvin (registered trademark) 326”), 2- (2′-hydroxy-5′-methylphenol) benzotriazole (trade name “Tinuvin (registered trademark) P” manufactured by the same company), 2- (2′-hydroxy -3 ′, 5′-bis (methylbenzyl) phenol) benzotriazole (trade name “Tinuvin (registered trademark) 234” manufactured by the same company), 2- (2′-hydroxy-3 ′, 5′-di-tert-) Butylphenol) -5-chlorobenzotriazole (trade name “Tinuvin (registered trademark) 327” manufactured by the same company), 2- (2′-hydroxy-3 ′, 5 ′) Di-tert-amylphenol) benzotriazole (trade name “Tinuvin (registered trademark) 328” manufactured by the same company), 2- (2′-hydroxy-5′-tetramethylbutylphenol) benzotriazole (trade name “Tinuvine manufactured by the same company”) (Registered trademark) 329 ") and the like.

In addition, for example, even when the drug contained in the colored plastic container is ozagrel sodium (specifically, its aqueous solution, simple substance, etc.), the ultraviolet absorber is preferably a benzotriazole type, and in particular, the trade name “Tinubin (registered trademark) 326” is preferable.
In the colored layer, various additives other than the pigment and the ultraviolet absorber can be blended as necessary.

For example, from the viewpoint of improving the efficiency of ultraviolet absorption by the ultraviolet absorber and reducing the amount of the ultraviolet absorber used, metal oxide fine particles may be further contained together with the ultraviolet absorber.
Examples of the metal oxide of the metal oxide fine particles include titanium oxide, zinc oxide, iron oxide, cerium oxide, and magnesium oxide. Further, the combination of the ultraviolet absorber and the metal oxide fine particles is not particularly limited. For example, the combination of the above-mentioned trade name “Tinuvin (registered trademark) 326” and the zinc oxide fine particles is preferable. It is done.

The inner layer is a layer made of a plastic having thermoplasticity. Specifically, for example, as described above, a polyolefin layer, a cyclic olefin polymer layer, and the like can be given.
Examples of the polyolefin that forms the polyolefin layer include the same plastics that form the colored layer.
Examples of the cyclic olefin polymer forming the cyclic olefin polymer layer include a copolymer of cyclic olefin and olefin, a ring-opened polymer of cyclic olefin, and hydrogenated products thereof. Specifically, for example, copolymers of ethylene and dicyclopentadiene, copolymers of ethylene and norbornene compounds, ring-opening polymers of cyclopentadiene derivatives, and ring-opening copolymers of two or more types of cyclopentadiene derivatives. Examples thereof include polymers and hydrogenated products thereof. Among these, preferably, a hydrogenated product of a copolymer of ethylene and a norbornene compound, or a hydrogenated product of a ring-opening (co) polymer of one or more cyclopentadiene derivatives is used.

By providing the cyclic olefin polymer layer as the inner layer, it is possible to prevent the pigment and ultraviolet absorber in the colored layer from moving to the content of the colored plastic. Furthermore, the mechanical strength and moisture permeation preventing ability of the colored plastic container can be improved, or the gas permeation preventing ability can be imparted to the colored plastic container.
The glass transition temperature (Tg) of the cyclic olefin polymer is not particularly limited. For example, the glass transition temperature (Tg) is measured by input-compensated differential scanning calorimetry (input-compensated DSC) described in JIS K _7121-1987 “Method for Measuring Plastic Transition Temperature”. The intermediate glass transition temperature (T _mg ) is preferably 60 to 80 ° C, more preferably 65 to 80 ° C.

  When the Tg of the cyclic olefin polymer exceeds 80 ° C., for example, when the colored plastic container is an ampoule described later, a fine resin piece called “beard” remains in the opening generated by the ampoule cleavage or the cleavage occurs. There arises a problem that the force required for is too large. On the other hand, when the Tg of the cyclic olefin polymer is less than 60 ° C., the effect of preventing the migration of the pigment and the ultraviolet absorber in the colored layer and the gas and water vapor permeation preventing ability may be reduced.

The melt flow rate (MFR) of the cyclic olefin polymer is not particularly limited, but is preferably 4 to 30 g / 10 min (260 ° C.) from the viewpoints of moldability and mechanical properties of the colored plastic container.
The molecular weight of the cyclic olefin polymer is not particularly limited, but the number average molecular weight <Mn> is preferably 10,000 to 100,000, more preferably 20,000 to 50,000. The average molecular weight is obtained as a standard polystyrene equivalent value, for example, by gel permeation chromatography (GPC) analysis using cyclohexane as a solvent.

The intermediate layer is a layer made of a plastic having thermoplasticity. As a specific example of the intermediate layer, for example,
(I) a cyclic olefin polymer layer,
(Ii) a laminate having a three-layer structure comprising: a cyclic olefin polymer layer; and a total of two polyolefin layers each laminated on the one side surface and the other side surface of the cyclic olefin polymer layer,
(Iii) colored layer,
Etc.

Examples of the polyolefin forming the polyolefin layer and the cyclic olefin polymer forming the cyclic olefin polymer layer include the same as described above.
As shown in the above (i) and (ii), even when the cyclic olefin polymer layer is an intermediate layer, the same effects as those obtained when the cyclic olefin polymer layer is an inner layer can be obtained. That is, the effect of preventing the pigment and the UV absorber in the colored layer from moving into the colored plastic container, the effect of improving the strength of the colored plastic container, and the ability to prevent moisture and gas permeation are obtained. The effect to improve is acquired.

In the cyclic olefin polymer layer as the intermediate layer, polyethylene can be appropriately blended for the purpose of improving the adhesion between the layers and reducing the hardness of the colored plastic container.
The polyethylene blended in the cyclic olefin polymer layer as the intermediate layer is preferably a relatively high-density one from the viewpoint of maintaining the transparency of the thermoplastic multilayer plastic. Specifically, for example, polyethylene having a density of 0.935 to 0.970 g / cm ³ is suitable. Moreover, it is preferable that the content rate of polyethylene is 5-20 weight part with respect to 100 weight part of total amounts of a cyclic olefin polymer layer.

In the case where the colored layer is a layer forming the intermediate layer of the colored plastic container, the plastic forming the colored layer, the pigment contained in the colored layer, the ultraviolet absorber, and other additives include the above The same as those mentioned above.
For example, an adhesive layer, a gas barrier layer, an oxygen absorption layer, or a sealant layer may be laminated on the thermoplastic multilayer plastic as necessary.

Examples of the adhesive layer include a layer made of an adhesive resin such as unsaturated carboxylic acid-modified polyethylene, ethylene-acrylic acid copolymer, and ethylene-vinyl acetate copolymer. Other examples of the adhesive layer include, for example, a layer made of low density polyethylene, particularly polyethylene having a density of 0.890 to 0.920 g / cm ³ polymerized by a so-called single site catalyst such as metallocene. .

In the colored plastic container of the present invention, the thickness T of the colored layer is set to 50 to 1000 μm.
When the thickness T of the colored layer is less than 50 μm, it becomes difficult to add a sufficient amount of pigment or ultraviolet absorber to the effect of the present invention in the colored layer. On the other hand, if the thickness T of the colored layer exceeds 1000 μm, the thickness of the entire thermoplastic multilayer plastic becomes too large, and the moldability and handleability of the colored plastic container are lowered.

The thickness T of the colored layer is preferably 50 to 400 μm, more preferably 50 to 300 μm, particularly in the above range. In particular, when the colored plastic container is a colored plastic ampoule, the thickness T of the colored layer is preferably 50 to 300 μm.
In the colored plastic container of the present invention, the product PT of the content ratio P (% by weight) of the pigment in the colored layer and the thickness T (μm) of the colored layer is set to satisfy the following formula (1). .

1 ≦ PT ≦ 150 (1)
While setting the value of the product PT in the range of the above formula (1), the product UT of the content ratio U (% by weight) of the ultraviolet absorber in the colored layer described later and the thickness T (μm) of the colored layer Is set to the following range, the wavelength in the ultraviolet region can be efficiently shielded while maintaining appropriate visibility with respect to the inside of the container. On the other hand, when the value of the product PT is less than the above range, the effect of shielding the wavelength in the ultraviolet region becomes insufficient. On the contrary, if the value of PT exceeds the above range, it is difficult to confirm the inside of the colored plastic container.

The value of the product PT is preferably 5 to 120, more preferably 5 to 60, particularly in the above range.
The blending amount of the colorant in the colored layer is not particularly limited except that it is set so as to satisfy the range of the above formula (1) in relation to the thickness T of the colored layer. From the viewpoint of dispersibility, for example, the content ratio in the colored layer is preferably 0.01 to 0.4% by weight.

In the colored plastic container of the present invention, the product UT of the ultraviolet absorber content ratio U (% by weight) in the colored layer and the colored layer thickness T (μm) is the pigment content ratio P ( Wt%) and the thickness T (μm) of the colored layer when the product PT exceeds 20, the following formula (2) is satisfied, and when the product PT is 20 or less, the following formula (3) It is set to satisfy.
5 ≦ UT ≦ 160 (2)
20 <UT ≦ 160 (3)
By setting the value of the product PT within the range of the above formula (1) while setting the value of the product UT within the range of the above formula (2) or (3), moderate visibility to the inside of the container can be obtained. While maintaining, the wavelength in the ultraviolet region can be efficiently shielded.

On the other hand, if the value of the product UT falls below the range of the above formula (2) when the product PT exceeds 20, or falls below the range of the above formula (3) when the product PT is 20 or less, The shielding effect of the wavelength in the region becomes insufficient. On the contrary, when the value of UT exceeds the above range, the dispersibility of the ultraviolet absorbent in the colored layer may be lowered.
In the case where the product PT exceeds 20, the value of the product UT is preferably 5 to 120, more preferably 10 to 100, particularly in the above range.

On the other hand, when the product PT is 20 or less, the value of the product UT is preferably 30 to 160, more preferably 35 to 160, particularly within the above range.
The blending amount of the ultraviolet absorber in the colored layer is not particularly limited except that it is set so as to satisfy the range of the above formula (2) in relation to the thickness T of the colored layer. From the viewpoint of the dispersibility of the colorant, for example, the content ratio in the colored layer is preferably 0.01 to 0.4% by weight.

Further, when the other surface of the colored layer is the outer surface of the thermoplastic multilayer plastic, that is, when the colored layer is a layer forming the outer layer of the colored plastic container, the ultraviolet absorber is contained in the colored layer. The quotient U / T when the ratio U (% by weight) is divided by the thickness T (μm) of the colored layer is preferably set so as to satisfy the following formula (4).
U / T ≦ 0.004 (4)
If the quotient U / T exceeds the above range, the ultraviolet absorbent may bleed out from the colored layer to the outside of the colored plastic container.

The value of the quotient U / T is preferably 0.0038 or less, more preferably 0.0001 to 0.0038, particularly in the above range.
In the colored plastic container of the present invention, the thickness of each layer other than the colored layer is preferably set in the range of 10 to 50% with respect to the entire layer formed from the thermoplastic multilayer plastic. In addition, the ratio of the thickness of each layer can be set as appropriate in accordance with the type and amount of contents stored in the multilayer plastic container.

The thickness of the entire thermoplastic multilayer plastic may be appropriately set according to the use of the colored plastic container, the type of contents to be stored, the amount to be stored, and the like, and is not particularly limited. For example, the thickness is preferably 300 to 1500 μm. More preferably, it is 400-1200 micrometers.
Although it does not specifically limit as a chemical | medical agent accommodated in the colored plastic container of this invention, For example, Preferably, an ozagrel sodium aqueous solution is mentioned.

Although it does not specifically limit as a form of the colored plastic container of this invention, For example, an ampoule, a flexible bag container, a bottle etc. are mentioned.
4 is a front view showing an example of a colored plastic ampule as an embodiment of the colored plastic container, FIG. 5 is a side view thereof, FIG. 6 is a plan view thereof, and FIG. 7 is a bottom view thereof. FIG. 8 is a side sectional view.

  As shown in FIGS. 4 and 5, the colored plastic ampule 10 communicates with a chemical solution storage portion 11 for storing a chemical solution formed in a bottomed cylindrical shape, and an opening end 11 a of the chemical solution storage portion 11, and is on one side. And a top portion 13 that closes one end of the chemical solution discharge cylinder portion 12, and the chemical solution discharge cylinder portion 12 is formed thinly along the circumferential direction. A fragile part 14 is provided.

An opening end 11 a is formed in the chemical solution storage portion 11 at one end facing the bottom portion 16 in the longitudinal direction along the central axis 15 of the chemical solution storage portion 11, and in the vicinity of the opening end 11 a, the bottom portion 16 is formed. It has a shoulder portion 17 whose diameter decreases from the side toward the opening end 11a side (to one side).
As shown in FIGS. 6 and 7, the cross-sectional shape of the chemical solution storage portion 11 is formed in a circular shape in plan view or bottom view, but the cross-sectional shape of the chemical solution storage portion 11 is not limited to this. For example, it may be formed in an elliptical shape.

  4 and FIG. 5 again, the chemical liquid discharge cylinder 12 is continuous from the opening end 11a of the chemical liquid storage part 11, and the central axis is the same axis as the central axis 15 of the chemical liquid storage part 11. It is formed so as to extend along 15 axial directions. The one end of the chemical liquid discharge cylinder 12 (that is, the end of the chemical liquid discharge cylinder 12 opposite to the opening end 11a side of the chemical liquid storage part 11) is continuous from the one end. A top portion 13 for sealing the chemical solution discharge cylinder portion 12 is formed.

For example, when a syringe nozzle for sucking the chemical solution in the chemical solution storage unit 11 is inserted, the chemical solution discharge cylinder unit 12 fits the nozzle so that the nozzle is fixed in a stable state. It is preferable to have a sufficient inner diameter, and it is preferable to have a sufficient length in the axial direction of the chemical solution discharge cylinder portion 12 between the chemical solution storage portion 11 and the top portion 13.
The chemical liquid storage part 11, the chemical liquid discharge cylinder part 12 and the top part 13 are continuous and integrated with each other, and form a closed region for storing and sealing the chemical liquid.

Further, the chemical liquid discharge cylinder portion 12 is thin-walled along the circumferential direction of the chemical liquid discharge cylinder portion 12 at a substantially intermediate portion between the opening end 11 a of the chemical liquid storage portion 11 and the one end portion of the chemical liquid discharge cylinder portion 12. The fragile portion 14 is formed (see FIG. 8).
As a result, the fragile portion 14 can be easily twisted or broken by gripping the chemical solution storage portion 11 and the top portion 13 side of the chemical solution discharge tube portion 12 and twisting or bending them together. Can be cleaved. Thereby, the colored plastic ampule 10 can be opened.

  In addition, the chemical liquid discharge cylinder 12 is thereby opened, and a syringe nozzle (not shown) is inserted into the opening thus generated, so that the chemical liquid stored in the chemical liquid storage section 11 can be collected. The syringe is, for example, inserted in the opening of the chemical solution discharge cylinder 12 with the injection needle not attached to the tip of the nozzle so as to aspirate the chemical stored in the chemical storage unit 11. used.

  As shown in FIGS. 4 and 5, the chemical liquid storage part 11 extends along the axial direction of the central axis 15 at a position opposed to each other across the central axis 15 of the chemical liquid storage part 11 on the outer peripheral surface 23 thereof. And the rib 24 which protrudes toward the radial direction outward from the outer peripheral surface 23 of the chemical | medical solution storage part 11 is provided. Moreover, the chemical | medical solution storage part 11 equips the bottom part 16 with the rib 25 which protrudes outward from the bottom part 16, and the rib 24 of the above-mentioned outer peripheral surface 23 and the rib 25 of the bottom part 16 are mutually continuous. doing.

The two continuous ribs 24 and 25 are formed on the outer peripheral surface 23 of the chemical solution storage unit 11, whereby rigidity is given to the chemical solution storage unit 11 and the shape of the chemical solution storage unit 11 is maintained.
As shown in FIGS. 4 and 5, the outer peripheral surface 26 of the chemical liquid discharge cylinder part 12 continuously extends from the top 13 side of the weak part 14 of the chemical liquid discharge cylinder part 12 and protrudes to the outside of the chemical liquid discharge cylinder part 12. In addition, a knob 28 is provided continuously from the outer surface 27 of the top portion 13 so as to protrude to the outside of the top portion 13.

  Thus, since the knob 28 is formed continuously between the apex 13 side and the apex 13 from the fragile part 14 of the medicinal liquid discharge cylinder part 12, the medicinal liquid storage part 11 and the medicinal liquid discharge cylinder part 12 are formed. When the top portion 13 side is gripped and twisted or bent together, the chemical solution storage portion 11 and the chemical solution discharge tube portion 12 are not easily deformed. Thereby, the opening operation of the colored plastic ampule 10 by twisting or breaking the fragile portion 14 of the chemical liquid discharge cylinder portion 12 can be easily and reliably performed.

The knob piece 28 has a flat portion 29 and a chamfered portion 30 formed around the flat portion 29, and the inside of the knob piece 28 forms a hollow thick portion. Thereby, since the rigidity of the knob 28 itself is maintained and the colored plastic ampule 10 is opened, deformation of the knob 28 can be suppressed when the knob 28 is gripped.
Further, as shown in FIGS. 4 and 5, the outer peripheral surface 23 of the chemical solution storage portion 11 in the shoulder portion 17 and the outer peripheral surface 26 of the chemical solution discharge cylinder portion 12 on the side of the chemical solution storage portion 11 with respect to the fragile portion 14 are Reinforcing pieces 31 are provided that protrude to the outside of the chemical solution discharge cylinder 12 and the chemical solution storage unit 11 and are connected to each other.

In this way, the reinforcing piece 31 is continuously formed so as to straddle between the portion closer to the chemical solution storage portion 11 than the fragile portion 14 of the chemical solution discharge tube portion 12 and the shoulder portion 17 of the chemical solution storage portion 11. Therefore, the rigidity between the chemical solution storage part 11 and the chemical solution discharge cylinder part 12 is remarkably improved.
Thereby, for example, during transportation or handling of the colored plastic ampule 10, the chemical solution discharge cylinder portion 12 protruding from the chemical solution storage portion 11 is not easily damaged.

Further, when picking the knob 28 and twisting or breaking it, it becomes easy to put fingers on the reinforcing piece 31 and has a reliable detent action, so that the colored plastic ampule 10 can be opened. Can be done easily and reliably.
The reinforcing piece 31 has a flat part 32 and a chamfered part 33 formed around the flat part 32, and the inside of the knob piece 28 forms a hollow thick part. Thereby, the rigidity of the reinforcing piece 31 is maintained, the reinforcing effect is further improved, and the colored plastic ampoule 10 is opened. Therefore, when the reinforcing piece 31 is gripped, deformation of the reinforcing piece 31 can be suppressed. Moreover, when the knob piece 28 is twisted, the finger contact with the reinforcing piece 31 is good.

The knob piece 28 and the reinforcing piece 31 can be molded together with the respective parts of the chemical liquid storage part 11, the chemical liquid discharge cylinder part 12, and the top part 13 when the colored plastic ampule 10 is manufactured.
The colored plastic ampule 10 can be manufactured by, for example, a molding method that combines a so-called blow fill seal (BFS) method and a multilayer blow molding method.

Specifically, for example, first, the above-described thermoplastic multilayer plastic is extruded to produce a multilayered parison in which the layers are fused and laminated.
That is, a colored layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly on one surface of the colored layer or sandwiching an intermediate layer, and the thickness T of the colored layer is 50 to 1000 μm The product PT of the content ratio P (% by weight) of the pigment in the colored layer and the thickness T (μm) of the colored layer satisfies the following formula (1), and in the colored layer: When the product UT of the ultraviolet absorber content ratio U (% by weight) and the thickness T (μm) of the colored layer satisfies the following formula (2) when the product PT exceeds 20, and When the product PT is 20 or less, a thermoplastic multilayer plastic satisfying the following formula (3) is extruded to produce a multilayered parison in which the layers are fused together.

1 ≦ PT ≦ 150 (1)
5 ≦ UT ≦ 160 (2)
20 <UT ≦ 160 (3)
Next, the obtained multilayer parison is sandwiched between split molds, and each part of the chemical liquid storage part 11, the chemical liquid discharge cylinder part 12 and the reinforcing piece 31 is formed (blow process), and then inside the chemical liquid storage part 11 Filled with a chemical solution (filling step), and further sandwiched by a split mold to form a top portion 13 and a knob 28, and a closed region composed of the chemical solution storage portion 11, the chemical solution discharge cylinder portion 12, and the top portion 13. Form (sealing process). In this way, a colored plastic ampule (colored plastic container) 10 filled with a chemical solution and sealed is obtained.

A multilayered parison can be produced according to a conventional method in multilayer blow molding. The shape of the extruder or die, the molding conditions of the multilayered parison, etc. are not particularly limited, and may be appropriately set according to a conventional method in multilayer blow molding.
In addition, the production of plastic ampules by the blow-fill-seal (BFS) method using a multi-layer parison is different from the layer structure of the parison (the number of extruders forming the parison and the structure of the die are different). Can be performed in the same manner as in the production of a plastic ampule by the BFS method using a parison having a single layer structure. As described above, the layers of the multilayer film may be fused and laminated together, or may be bonded to each other by interposing a layer made of the above-described adhesive resin between the layers.

The thickness of the chemical solution housing portion of the colored plastic ampule 10 is preferably 300 to 1500 μm from the viewpoint of efficiently shielding the ultraviolet light from the outside to the inside of the colored plastic ampule 10.
The colored plastic ampule (colored plastic container) 10 can be molded by various methods. Of these, a blow-fill-seal method is preferable.

  The colored plastic container of the present invention has a light transmittance of 5% or less at a wavelength of 200 to 380 nm without causing problems such as bleeding by blending a pigment and an ultraviolet absorber in a specific range. The performance that the transmittance of light of 600 nm is 40% or more can be imparted. Thereby, the plastic ampule of the present invention can be widely used, for example, in medical applications, and is particularly suitable for accommodating a photodegradable drug, specifically, an ozagrel sodium aqueous solution.

  As mentioned above, although embodiment of this invention was described, embodiment of this invention is not limited to this, A design can be suitably changed in the range which does not change the summary of this invention.

Next, an Example and a comparative example are given and this invention is demonstrated.
The resin materials, pigments and ultraviolet absorbers used in the following examples and comparative examples are as follows.
PE1: High pressure method low density polyethylene, density 0.928 g / cm ³ , trade name “B128H”, manufactured by Ube Maruzen Polyethylene Co., Ltd. PE2: high density polyethylene, density 0.940 g / cm ³ , trade name “Ultzex (Registered trademark) Uz4020B ", manufactured by Prime Polymer Co., Ltd. PE3: adhesive low density polyethylene, density 0.903 g / cm ³ , trade name" Evolue (registered trademark) SP0510B ", manufactured by Prime Polymer Co., Ltd .: PE4: High density polyethylene, density 0.965 g / cm ³ , trade name “Neozex (registered trademark) Nz65150B”, made by Prime Polymer Co., Ltd .: PP1: polypropylene, trade name “B205”, made by Prime Polymer Co., Ltd. • PP2: polyolefin Thermoplastic elastomer, trade name “NOTIO® PN” 3050 ", Mitsui Chemicals Co., Ltd. PP3: Polyolefin thermoplastic elastomer, trade name" Tuffmer (registered trademark) XM7070 ", Mitsui Chemicals Co., Ltd. COC1: Cyclic olefin polymer (ethylene tetracyclododecene system) Copolymer), trade name “Apel (registered trademark) 8008T”, Tg 70 ° C., manufactured by Mitsui Chemicals, Inc./COP1: cyclic olefin polymer (norbornene-based ring-opening polymer hydrogenated product), trade name “ZEONOR (registered) Trademark) 750R ", Tg 70 ° C, manufactured by Nippon Zeon Co., Ltd. Pigment: Yellow pigment, C.I. I. Pigment Yellow 95
UV absorber: trade name “Tinubin (registered trademark) 326”, manufactured by Ciba Specialty Chemicals Co., Ltd. <Examples 1 to 8 and Comparative Examples 1 to 4>
1. Manufacture of Ampoule An ampoule having the shape shown in FIG. 1 (for an internal volume of 2.5 mL) was made of a thermoplastic multilayer plastic having the layer structure shown in Table 1 or Table 2 by a blow-fill-seal method. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  The thickness of each layer of the thermoplastic multilayer plastic shown in Table 1 is the thickness in the main body portion (chemical solution housing portion) of the ampoule. In any of the examples and comparative examples, a polyethylene layer having a thickness of 20 μm made of PE3 was disposed as an adhesive layer between the outer layer and the intermediate layer and between the intermediate layer and the inner layer.

  In Tables 1 and 2 and the tables shown below, the abbreviations described above were used as the resin materials forming each layer. For the layer made of the mixed resin, for example, the abbreviation of the resin material to be mixed is described as “+”, such as “COC1 + PE2.” The ratio in parentheses described following the abbreviation indicating the mixed resin is the mixing ratio (weight ratio) of the mixed resin. For example, “COC1 + PE2 (9: 1)” indicates that a mixed resin in which COC1 and PE2 are mixed at a weight ratio of 9: 1 is used.

Moreover, the thickness (micrometer) of the applicable layer was described following the resin material (mixing ratio of mixed resin) which forms each layer. For example, “PE1 100 μm” indicates that the corresponding layer is a layer of “PE1” having a thickness of 100 μm.
In Tables 1 and 2 and the tables shown below, “P” and “PT” are the pigment content ratio P (% by weight) and the pigment content ratio P (weight) in the corresponding colored layer, respectively. %) And thickness T (μm). “U”, “UT” and “U / T” are respectively the content ratio U (wt%) of the ultraviolet absorber, the content ratio U (wt%) and the thickness T (weight%) of the corresponding colored layer. μm) and the quotient obtained by dividing the UV absorber content ratio U (% by weight) by the thickness T (μm).

2. Observation of Ampoule Appearance Change For the ampules of Examples 1 to 8 and Comparative Examples 1 to 4 shown in Tables 1 and 2, the ampoule appearance after 14 days at room temperature was confirmed (bleed confirmation).
The results are shown in Table 3 below. In the ampoule of Comparative Example 2, the ultraviolet absorbent bleeded from the container body, and white fine powder was observed on the container surface.

3. Measurement of cis-body content ratio The ampules of the above Examples and Comparative Examples (excluding Comparative Example 2 where bleeding of the ultraviolet absorber occurred) were left in a content liquid after being left for 25 days under a light source with an illuminance of 2000 lx (D65 lamp). The content of cis-isomers, which are related substances of ozagrel sodium, was measured by high performance liquid chromatography (HPLC).

  The measurement was performed according to the following procedure. First, 2.5 mL of a sample was collected and diluted with a mobile phase to make a total volume of 40 mL, which was used as a sample solution. 5 μL was sampled from this sample solution and analyzed by the HPLC method under the following conditions. The amount of cis-isomer, which is a related substance of ozagrel sodium, was determined by the area percentage method by measuring the peak area of each sample solution by the automatic integration method.

The measurement conditions of HPLC are as follows.
Measurement wavelength: 220 nm
Column: YMC-Pack ODS-A, A-302 150 × 4.6 mmI. D. , S-5μm
Column temperature: about 25 ° C
Mobile phase: 0.3% ammonium acetate solution / methanol mixture (4: 1)
Flow rate: 1.0 mL / min Measurement time: 20 minutes The measurement results are shown in Table 3 below. In addition, as a result of the said analysis, what the content rate of a cis body exceeded 0.3% was determined to be bad.

4). Measurement of light transmittance A sample for light transmittance measurement was cut out from the chemical solution storage part in the ampule of the above-mentioned Examples and Comparative Examples (excluding Comparative Example 2 where bleeding of the UV absorber occurred), and this sample was used. The transmittance of light having a wavelength of 200 to 380 nm and the transmittance of light having a wavelength of 600 nm were measured with a spectrophotometer.

In addition, a brown glass ampule (with an internal volume of 2.5 mL) filled with 0.8 mL (w / v) of ozagrel sodium aqueous solution was allowed to stand at room temperature for 14 days as in the above example. The content ratio of the cis isomer later was measured and used as a control.
The measurement results are shown in Table 3 below.

From the results shown in Table 3, for the ampoules of Examples 1 to 8, the increase in cis-form was equal to or higher than that of the control brown glass ampule, whereas the ampules of Comparative Examples 1 and 4 Was more than 3 times higher than the control brown glass ampoule.
On the other hand, the ampoule of Comparative Example 3 had a low transmittance of 600 nm light, so that it was difficult to visually observe the content liquid.

<Examples 9 to 16>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having a layer structure shown in Table 4 by the blow-fill-seal method. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

In Examples 9 to 16, the material for forming the intermediate layer in Examples 1 to 8 is changed to a mixed resin (weight ratio 4: 1) of COC1 or COP1 and PE4.
Regarding Examples 9 to 16, the above 2. In the same manner as above, the change in the appearance of the ampoule was observed, and as a result, no bleeding of the ultraviolet absorber from the container body was observed.
<Examples 17 and 18>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having a layer structure shown in Table 5 and having a layer structure. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  Next, with respect to the ampules of Examples 17 and 18, the above 2. ~ 4. In the same manner as above, the change in the appearance of the ampule, the measurement of the cis-isomer content ratio, and the light transmittance were measured. The results are shown in Table 6.

As shown in Table 6, it was found that Examples 17-18 also had the same performance as Examples 1-8.
<Examples 19 to 24 and Comparative Examples 5 to 10>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having the layer structure shown in Table 7 or Table 8. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  Next, for the ampules of Examples 19 to 24, the above 2. ~ 4. In the same manner as above, the change in the appearance of the ampule, the measurement of the cis-isomer content ratio, and the light transmittance were measured. The results are shown in Table 9.

As shown in Table 9, the example satisfying the above formula (1) and the above formula (3) has the same performance as the examples 1 to 8, whereas the comparative example not satisfying the above formula (3). Then, the malfunction that the content rate of a cis body became high, and the transmittance | permeability of visible light fell and the visual observation of the content liquid became difficult.
<Examples 25-30>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having the layer structure shown in Table 10. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

In Examples 25 to 30, the intermediate layer forming material in Examples 19 to 24 was changed to a mixed resin (weight ratio 4: 1) of COC1 and PE4.
Regarding Examples 25 to 30, the above 2. In the same manner as above, the change in the appearance of the ampoule was observed, and as a result, no bleeding of the ultraviolet absorber from the container body was observed.
<Examples 31-33 and Comparative Examples 11-13>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having the layer configuration shown in Table 11 and the layer configuration. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  Next, for the ampules of Examples 31 to 33, the above 2. ~ 4. In the same manner as above, the change in the appearance of the ampule, the measurement of the cis-isomer content ratio, and the light transmittance were measured. The results are shown in Table 12.

As shown in Table 12, the examples satisfying the above formula (1) and the above formula (2) have the same performance as the first to eighth embodiments, but the comparative example not satisfying the above formula (1). Then, the malfunction that the content rate of a cis body became high, and the transmittance | permeability of visible light fell and the visual observation of the content liquid became difficult.
<Examples 34 to 36>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having a layer configuration shown in Table 13 and having a layer structure. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

In Examples 34 to 36, the intermediate layer forming material in Examples 31 to 33 was changed to a mixed resin (weight ratio 4: 1) of COC1 and PE4.
Regarding Examples 34 to 36, the above 2. In the same manner as above, the change in the appearance of the ampoule was observed, and as a result, no bleeding of the ultraviolet absorber from the container body was observed.
<Examples 37 to 42 and Comparative Examples 14 to 19>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having the layer structure shown in Table 14 or Table 15. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  Next, for the ampules of Examples 37 to 42, the above 2. ~ 4. In the same manner as above, the change in the appearance of the ampule, the measurement of the cis-isomer content ratio, and the light transmittance were measured. The results are shown in Table 16.

As shown in Table 16, the examples satisfying the above formula (1) and the above formula (2) have the same performance as the first to eighth embodiments, but the comparative example not satisfying the above formula (2). Then, the malfunction that the content rate of a cis body became high, and the transmittance | permeability of visible light fell and the visual observation of the content liquid became difficult.
<Examples 43 to 48>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having the layer configuration shown in Table 17 and the layer configuration. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

In Examples 43 to 48, the intermediate layer forming material in Examples 37 to 42 is changed to a mixed resin (weight ratio 4: 1) of COC1 and PE4.
Regarding Examples 43 to 48, the above 2. In the same manner as above, the change in the appearance of the ampoule was observed, and as a result, no bleeding of the ultraviolet absorber from the container body was observed.
<Examples 49 to 51>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having a layer structure shown in Table 18 and having a layer structure. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

  Next, for the ampules of Examples 49 to 51, the above 2. ~ 4. In the same manner as above, the change in the appearance of the ampule, the measurement of the cis-isomer content ratio, and the light transmittance were measured. The results are shown in Table 19.

As shown in Table 19, the examples satisfying the above formula (1) and the above formula (2) had the same performance as the examples 1 to 8.
<Examples 52 to 54>
In the same manner as in Example 1, a 2.5 mL accommodating ampoule having the shape shown in FIG. 1 was manufactured by a blow-fill-seal method using a thermoplastic multilayer plastic having a layer structure shown in Table 20 and having a layer structure. The ampoule was filled with 2.5 mL of 0.8% (w / v) ozagrel sodium aqueous solution.

In Examples 52 to 54, the intermediate layer forming material in Examples 49 to 51 was changed to a mixed resin (weight ratio 4: 1) of COP1 and PE4.
Regarding Examples 52 to 54, the above 2. In the same manner as above, the change in the appearance of the ampoule was observed, and as a result, no bleeding of the ultraviolet absorber from the container body was observed.
The present invention is not limited to the above description, and various design changes can be made within the scope of the matters described in the claims.

It is sectional drawing which shows an example of the laminated constitution of the thermoplastic multilayer plastic which forms a colored plastic container. It is sectional drawing which shows the other example of the layer structure of the thermoplastic multilayer plastic which forms a colored plastic container. It is sectional drawing which shows the further another example of the laminated constitution of the thermoplastic multilayer plastic which forms a colored plastic container. It is a front view which shows one Embodiment of a colored plastic container. It is a side view of the colored plastic container shown in FIG. It is a top view of the colored plastic container shown in FIG. It is a bottom view of the colored plastic container shown in FIG. It is a sectional side view of the colored plastic container shown in FIG.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 Colored layer, 2 Cyclic olefin polymer layer, 4 Intermediate layer, 10 Colored plastic ampule, 11 Chemical solution storage part, 12 Chemical solution discharge cylinder part, 13 Top part

Claims (8)

Formed of a thermoplastic multilayer plastic comprising a colored layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly on one surface of the colored layer or sandwiching an intermediate layer,
The colored layer has a thickness T of 50 to 1000 μm,
The product PT of the content ratio P (% by weight) of the pigment in the colored layer and the thickness T (μm) of the colored layer satisfies the following formula (1):
When the product UT of the content ratio U (% by weight) of the UV absorber in the colored layer and the thickness T (μm) of the colored layer satisfies the following formula (2) when the product PT exceeds 20: And when the said product PT is 20 or less, the following formula (3) is satisfy | filled, The colored plastic container characterized by the above-mentioned.
1 ≦ PT ≦ 150 (1)
5 ≦ UT ≦ 160 (2)
20 <UT ≦ 160 (3)   The colored plastic container according to claim 1, wherein the other surface of the colored layer is an outer surface of the thermoplastic multilayer plastic. The quotient U / T when the content ratio U (% by weight) of the ultraviolet absorber in the colored layer is divided by the thickness T (μm) of the colored layer satisfies the following formula (4): The colored plastic container according to claim 2.
U / T ≦ 0.004 (4)   The colored plastic container according to claim 1, wherein the pigment is an azo condensation pigment, and the ultraviolet absorber is a benzotriazole ultraviolet absorber.   The transmittance of the thermoplastic multilayer plastic is 5% or less with respect to light having a wavelength of 200 to 380 nm and 40% or more with respect to light having a wavelength of 600 nm. A colored plastic container according to any one of the above.   The colored plastic container according to claim 1, further comprising a cyclic olefin polymer layer between the colored layer and the inner layer.   A chemical solution storage portion for storing a chemical solution formed in a bottomed cylindrical shape, a chemical solution discharge cylinder portion that communicates with the opening end of the chemical solution storage portion, and extends toward one side, and an end portion on one side of the chemical solution discharge cylinder portion And a thickness of the thermoplastic multilayer plastic in the chemical solution storage portion is 300 to 1500 μm. The colored plastic container as described.   The colored plastic container according to claim 7, wherein the colored plastic container is formed by a blow fill seal method.

Images