200925700 九、發明說明： 【發明所屬之技術領域】 本發明係屬於隱形眼鏡之製造技術方法領域者。 【先前技術】 關於隱形眼鏡自1950年初發明後經商品化至今已有6〇年之久，最初 之隱形眼鏡係採用硬材（如：PMMa聚曱基丙稀酸甲醋）所製成，由於其 材質較硬’加上其本體之親能力與親水性均不佳，致使該隱形眼鏡之配 ❹戴時間較短，且會產生有明顯之異物不適感。 又，於70年代中’即有一軟式隱形眼鏡之發明，可謂一進步之改革， 其是以:_ΜΑ(2·經乙基丙烯酸甲脂）為主之水賴質所製成 ，由於其 吸水性南，水化後形成軟式、高含水性之特性，即增進了配戴之舒適性， 但其透氧力仍低’每日僅能配戴8至12小時，久戴後常有發生編氧性 水腫及新生血管增生之病變。 .❹年代初’雖有了具高透氧性硬式隱形眼鏡之產品，透氧力超高但 以致無法 /、硬W，晰_職㈣㈣編法突破改善， 普遍化為消費者接受。 戴之需求，麵隱顧«界不2“透氧性、高舒玻射長時間配 或石夕水谬為—魏域。 —，秋㈣高透雛軟式之石夕夥 以其所製紅2目料’由树為—觀樣傾定之成份， 5 200925700 時’雖有同透氧力’但眼球仍易有不適感。為了令石夕膝隱形眼鏡能夠配戴 舒適，故業界即不斷研究其改進之道，形成有所謂_職縣膠隱形眼 鏡表面以電麟财式來結合親樣(如：证嫩、GMA、G_、 NVP、MAA、MMA、PVA…等），以增進石娜或石夕水膠隱形眼鏡之親水性 並保有其高透氧之目的。 但’此方法之設備成本高，製程繁靖，且於實施製造時，該親水性材 - 料結合於石娜或妙水賴形眼鏡表面之品質極不穩定，導致量產不良率過 〇 高’無法降低製造成本。 另有種方法，係先形成梦膠及水膝之預聚合物為主材料，以供製造 生產石夕水膠隱形眼鏡，其中，預聚合物之主要成份為具高透氧之疏水性石夕 膠（POLYSILOXAME)或含氟石夕膠為主’結合以親水性生醫材料（如： ΗΕΜΑ、GMA、GMMA、NVP、ΜΑΑ、ΜΜΑ、PVA…等），以增進隱形眼 鏡之保水性與配戴之舒適感。 此方法之製程亦極為繁瑣，且其預聚合物之製造成本極高，於生產製 ·©造隱形眼鏡時，其品質較難以控制，且由於預聚合物亦含有碎之不穩定成 分，雖藉以其與水膠相互聚合可增其親水性，但其僅可謂係一種藉疏水性 及親水性不同材性結合取其各別之優點，雖可增隱形眼鏡之親水性，但因 矽膠不穩定之特性，同樣致使隱形眼鏡之鏡片表面仍產生有多量之疏水性 碎乾點’故仍無法完全的解決隱形眼鏡配戴不適感之情形。 鑑於上述之缺失亟待改進，故發明人依業界多年之經驗不斷的思考， 如何改進前述之缺失，以達到具高透氧性及親水性來增進隱形眼鏡之配戴 6 200925700 -· 時間與舒適感，經多次的研究與實驗，終求得一精進之方法者。 至於本發明之目的、方法與精神，請參照下列之依附圖與說明即可完 全的了解本發明者。 ※註： 1、 本說明書中所述之 HEMA=2-Hydroxy Ethyl Methacrylate 2-羥乙基丙烯酸曱脂 2、 本說明書中所述之GMA=Glycerol Methacrylate甘油丙稀酸甲酯 3、 本說明書中所述之 GMMA=Glycerol Methyl Methacrylate 甘油甲基丙烯酸曱酯 4、 本說明書中所述之NVP=N-Vinyl Pyrrolidone N-乙稀β比嘻烧酮 5、 本說明書中所述之MAA=Methacrylic acid 甲基丙稀酸 6、 本說明書中所述之MMA=Methyl Methacrylate 曱基丙烯酸甲酯 7、 本說明書中所述之PVA=Poly Vinyl Alcohol聚乙烯醇 8、 本說明書中所述之PU=Polyurethane聚胺基曱酸乙酯 -〇 9、本說明書中所述之HA=Hyaluronic Acid玻尿酸 10、 本說明書中所述之Collagen膠原蛋白 11、 本說明書中所述之Chitosan幾丁聚醣 12、 本說明書中所述之Polydextrose聚葡萄糖 【發明内容】 一種表面具親水性之矽材隱形眼鏡之製造方法，主要係指可將親水性 生醫材料結合於矽膠或矽水膠材表面形成三明治夾層結構之隱形眼鏡本 7 200925700 - 體’其中之方法可將親水性生醫材料完全包覆石夕踢或碎水勝材表面，並可 將因矽膠祕轉材所含的疏水性魏分所產生之表面疏水，时乾點予以 完全包覆，形成隱形眼鏡表面可完全的親水與具高透氧性，達成配戴隱形 眼鏡之高舒適感，可增長隱形眼鏡配戴時間者。 本發明之綠’制是可以原有之隱魏賴造設備、模具結合本發 明之精要製造方法，即可大量生產具親水性與高透氧性之隱形眼鏡者，其 中’製作使狀模具仙現有之频触制難魏合本㈣之方法實 Ο 施生產者。 【實施方式】 (第一實施例） 本發明為—種表面魏雜之雜隱祕鏡之製造方法，其主要步驟 如下（請參照第一圖）： 步顿一：係於鵠模之公模10與母模1〇a表面覆著一層親水性生醫材料2〇 ❾ 之薄膜’再經紫外光或及熱源設備加工令親水性生醫材料之薄 、形成半固化者，其中’公模1〇、母模收表面覆著之親水性生 醫材料2〇之厚度約〇.!至1〇微米㈤瞻），該親水性生醫材料 之薄膜係可藉以印刷、喷印、噴墨印、移印、旋轉印、超音波 印...等方式平職著於公模1G、母模心之表面者；又，該親水 &生醫材料2G係可依隱形眼鏡之功能需求，先行混合細聚合以 /、匕之材料’如.色素、顏料、抗w材、角膜變色顏料、角膜 變色色素…等。 8 200925700 其中，親水性生醫材料2G均加人有雜継啟始劑者。 步驟二：係將其表面覆著有一層親水性生醫材料2〇薄膜之母模伽注入鏡 片主原料3〇,再蓋壓以表面覆著有親水性生醫材料2〇薄膜之公模 10 ’並經紫外光或及熱源設備力σ工令公模'母模胸表面之親 水性生醫材料20薄膜與鏡片主原料3〇結合固化成型。 步驟三：再行脫模將結合成型之鏡片取出，置入液槽中進行水化膨漲淬取， 肖卩形成-二明治夾層結構具高透氧與高親水性之隱形眼鏡_ ® 者。其巾，主補3G係可树膠或是轉與水狀預聚合物 者。 (第二實施例） 本發明為-種表面具親水性之⑦材隱形眼鏡之製造方法，其主要步驟 如下（請參照第二圖）： 蚩驟一：係於旋轉母模40表面覆著一層親水性生醫材料2〇之薄膜，再經 Q 由紫外光或及熱源設備加工令親水性生醫材料20之薄膜形成半固 化者；其中，旋轉母模40表面覆著之親水性生醫材料20之厚度 約0.1至10微米（micron)，該親水性生醫材料20之薄膜係可藉 以旋動模具產生離心力的原理令親水性生醫材料2〇能平均覆著於 旋轉母模40表面之旋模法、或以印刷、喷印、喷墨印、移印、旋 轉印、超音波印…等方式平均覆著於旋轉母模4〇表面者；又，該 親水性生醫材料20係可依隱形眼鏡之功能需求，先行混合或預聚 合以其它之材料，如：色素、顏料、抗UV材、角膜變色顏料、 9 200925700 角膜變色色素…等。 其中，親水性生醫材料20均加入有膠黏劑與啟始劑者。 步驟二：係將其表面覆著有一層親水性生醫材料2〇薄膜之旋轉母模4〇注 入鏡片主原料30,藉以旋模法轉動旋轉母模4〇產生離心力令鏡片 主原料30形成一光學鏡片於旋轉母模4〇所覆著之親水性生醫材 料20之表面上，並經紫外光或及熱源設備加工令鏡片主原料3〇 固化。 〇 步驟三：再於其上覆著一層親水性生醫材料20 (可以印刷、喷印、喷墨印、 移印、旋轉印、超音波印…等方式覆著），並經紫外光或及熱源設 備加工令其各層材料相結合固化。 步驟四：再行脫模將結合成型之鏡片取出，置入液槽中進行水化膨漲浮取， W成-三·夾層賴具高透輸與高财性謂觀鏡· 者。其中’鏡片主· 3〇係可树戦妙顯轉之預聚合物 者0 綜合以上所述，本發明之方法確可達到預設之功效，且未見諸公開 用者’符_實用性、新馳之要件，爰依法向鈞局提咖申請， 4釣局委員逮予惠審並准予本案專利權，實感德便。 需崎，以上所述乃是本發明之較佳㈣， 作之改變，其產生之功能、侧仍未超出說明書與圖式所涵蓋 一切應屬本創作之範_，合找明。 i之精神時 200925700 【圖式簡單說明】 第一圖為本發明一種表面具親水性之矽材隱形眼鏡之製造方法之第一實施 例方法之簡易示意圖 第二圖為本發明一種表面具親水性之矽材隱形眼鏡之製造方法之第二實施 例方法之簡易示意圖 【主要元件符號說明】 公模-----------------------10 Ο 母模-----------------------10a 親水性生醫材料--------20 鏡片主原料--------------30 旋轉母模-----------------40 隱形眼鏡-----------------100200925700 IX. Description of the invention: [Technical field to which the invention pertains] The invention belongs to the field of manufacturing technology methods for contact lenses. [Prior Art] Contact lenses have been commercialized since the early 1950s and have been commercialized for 6 years. The original contact lenses were made of hard materials (such as PMMa polyacrylic acid methyl vinegar) due to The material is harder, and the pros and the hydrophilicity of the body are not good, so that the contact lens is worn for a short period of time, and there is a significant foreign body discomfort. Moreover, in the mid-1970s, there was a invention of soft contact lenses, which was a progressive reform. It was made of water-based lysium based on _ΜΑ (2·ethyl methacrylate) due to its water absorption. South, after hydration, it forms soft and high water-containing characteristics, which enhances the comfort of wearing, but its oxygen permeability is still low. It can only be worn for 8 to 12 hours a day. Oxygen is often produced after wearing for a long time. Sexual edema and lesions of neovascularization. At the beginning of the ’ ́s time, although there were products with high oxygen permeability and hard contact lenses, the oxygen permeability was so high that it could not be/hard W, and the _ occupation (4) (4) was improved and standardized, and accepted by consumers. Dai Zhi's needs, face-to-face care «Boundary 2' oxygen permeability, Gaoshu glass long-term match or Shi Xishui 谬--Wei domain. —, Autumn (four) high transparent soft stone Shi Xibang with its red 2 eye material 'from the tree - the composition of the observation, 5 200925700 'although the same oxygen permeability' but the eyeball is still easy to feel uncomfortable. In order to make the Shi Xi knee contact lens comfortable to wear, the industry is constantly researching The way to improve is to form a so-called _ prefecture plastic contact lens surface to combine the physical sample (such as: Zheng Nen, GMA, G_, NVP, MAA, MMA, PVA, etc.) to promote Shi Na or The hydrophilicity of Shixi hydrogel contact lens maintains its high oxygen permeability. However, the cost of this method is high, the process is versatile, and when it is manufactured, the hydrophilic material is combined with Shina or Mishui. The quality of the surface of the spectacles is extremely unstable, resulting in a high rate of mass production failure. 'The manufacturing cost cannot be reduced. Another method is to form the pre-polymer of the dream rubber and the water knee to make the production stone. Xishui plastic contact lens, wherein the main component of the prepolymer is hydrophobic with high oxygen permeability POLYSILOXAME or fluorine-containing shijiao-based as a combination of hydrophilic biomedical materials (such as: ΗΕΜΑ, GMA, GMMA, NVP, ΜΑΑ, ΜΜΑ, PVA, etc.) to enhance the water retention of contact lenses The wearing process is extremely cumbersome, and the manufacturing cost of the prepolymer is extremely high. When manufacturing the contact lens, the quality is difficult to control, and the prepolymer also contains the broken product. The unstable component, although it can be polymerized with water gel, can increase its hydrophilicity, but it can only be said to be a combination of hydrophobicity and hydrophilicity, which can increase the hydrophilicity of the contact lens. However, due to the unstable nature of the silicone rubber, the surface of the lens of the contact lens still produces a large amount of hydrophobic dry spots. Therefore, it is still impossible to completely solve the problem of wearing the contact lens. In view of the above-mentioned defects, it is in need of improvement. People rely on the industry's many years of experience to continuously think about how to improve the aforementioned lack of high oxygen permeability and hydrophilicity to improve the wearing of contact lenses. 6 200925700 -· Time and comfort After many studies and experiments, we will finally find a way to improve the method. For the purpose, method and spirit of the present invention, please refer to the following drawings and descriptions to fully understand the inventors. HEMA=2-Hydroxy Ethyl Methacrylate 2-hydroxyethyl acrylate rouge as described in the present specification 2. GMA=Glycerol Methacrylate glyceryl methacrylate 3 as described in the present specification 3. GMMA=Glycerol described in the present specification Methyl Methacrylate Glyceryl Methacrylate 4, NVP=N-Vinyl Pyrrolidone N-Ethyl β-pyrrolidone 5 as described in the present specification, MAA=Methacrylic acid methyl acrylate 6 as described in the present specification MMA=Methyl Methacrylate Methyl methacrylate 7 as described in the present specification, PVA=Poly Vinyl Alcohol polyvinyl alcohol 8 described in the present specification, PU=Polyurethane polyamine decanoate described in the present specification- 〇9, HA=Hyaluronic Acid hyaluronic acid 10 described in the present specification, Collagen collagen 11 described in the present specification, Chitosan chitosan 12 described in the present specification, Poly described in the present specification Dextrose polyglucose [Summary] A method for manufacturing a contact lens with hydrophilic surface, mainly refers to a contact lens which can combine a hydrophilic biomedical material on the surface of a silicone rubber or a hydrophobic adhesive to form a sandwich structure. 7 200925700 - Body' method in which the hydrophilic biomedical material can completely cover the surface of the stone or kicked water, and the surface generated by the hydrophobic Wei branch contained in the gelatinous material can be made hydrophobic. It is completely covered, and the surface of the contact lens can be completely hydrophilic and highly oxygen permeable, achieving a high comfort of wearing contact lenses, and can increase the wearing time of the contact lens. The green 'system of the invention can be used to manufacture the contact lens of the invention with the hydrophilicity and high oxygen permeability of the original manufacturing method, and the mold can be combined with the essential manufacturing method of the invention. The existing method of frequency touch is difficult to implement the method of Weihe (4). [Embodiment] (First Embodiment) The present invention is a method for manufacturing a surface miscellaneous mirror, and the main steps thereof are as follows (please refer to the first figure): Step 1: a model 10 attached to a model The surface of the mother mold 1〇a is covered with a layer of hydrophilic biomedical material 2〇❾, and then processed by ultraviolet light or heat source equipment to make the hydrophilic biomedical material thin and form a semi-cured person, wherein 'male model 1〇 The thickness of the hydrophilic biomedical material covered by the female mold surface is about 〇.! to 1 〇 micrometer (five), the film of the hydrophilic biomedical material can be printed, printed, inkjet printed, moved Printing, rotating printing, ultrasonic printing, etc. are used to work on the surface of the male model 1G and the mother model; in addition, the hydrophilic & biomedical material 2G system can be mixed according to the functional requirements of the contact lens. Polymerized with /, 匕 materials such as pigments, pigments, anti-w materials, corneal color-changing pigments, corneal color-changing pigments, and the like. 8 200925700 Among them, 2G of hydrophilic biomedical materials are added to people with cockroach starter. Step 2: The mother mold gamma coated with a layer of hydrophilic biomedical material is injected into the main material of the lens 3 〇, and then covered with a male mold with a hydrophilic biomedical material 2 〇 film. 'And through the ultraviolet light or heat source equipment force σ workmanship model 'mother model chest surface hydrophilic biomedical material 20 film and lens main raw material 3 〇 combined curing molding. Step 3: After demoulding, the combined lens is taken out and placed in a liquid tank for hydration expansion and quenching. The xiaoyu formation-two Meiji sandwich structure has high oxygen permeability and high hydrophilicity contact lens _ ® . Its towel, the main complement 3G can be gum or transferred to water-like prepolymer. (Second Embodiment) The present invention is a method for producing a contact lens having a hydrophilic surface, and the main steps thereof are as follows (please refer to the second figure): Step 1: Attaching a layer to the surface of the rotating mother mold 40 a film of a hydrophilic biomedical material, which is then processed by ultraviolet light or a heat source device to form a semi-cured film of the hydrophilic biomedical material 20; wherein the surface of the rotating mother mold 40 is coated with a hydrophilic biomedical material The thickness of 20 is about 0.1 to 10 micrometers, and the film of the hydrophilic biomedical material 20 can be used to rotate the mold to generate centrifugal force, so that the hydrophilic biomedical material can be evenly coated on the surface of the rotating mother mold 40. Rotary molding method, or printing, printing, inkjet printing, pad printing, rotary printing, ultrasonic printing, etc., on the surface of the rotating mother mold 4 平均, in addition, the hydrophilic biomedical material 20 series can According to the functional requirements of contact lenses, first mix or pre-polymerize other materials, such as: pigments, pigments, anti-UV materials, corneal color-changing pigments, 9 200925700 corneal color-changing pigments, etc. Among them, the hydrophilic biomedical material 20 is added with an adhesive and a starter. Step 2: Injecting a rotating master mold 4 having a surface of a hydrophilic biomedical material into a lens main material 30, and rotating the rotating master mold 4 by a rotary mold method to generate centrifugal force to form a main raw material 30 of the lens. The optical lens is on the surface of the hydrophilic biomedical material 20 covered by the rotating master mold 4, and is processed by ultraviolet light or heat source equipment to cure the main lens material 3〇. 〇Step 3: Cover it with a layer of hydrophilic biomedical material 20 (can be printed, printed, inkjet, pad printed, rotary printed, ultrasonic printed, etc.), and UV or The processing of the heat source equipment allows the layers of the materials to be combined and cured. Step 4: After demoulding, the combined lens is taken out and placed in a liquid tank for hydration expansion and floating, and the W-three-layer interlayer is highly transparent and high-precision is considered to be a mirror. Among them, the method of the present invention can achieve the preset effect, and the public use of the lens is not as practical as described above. The requirements of Xinchi, 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提 提The above is the preferred (four) of the present invention, and the function and side of the invention are not beyond the scope of the specification and the drawings. The spirit of i is 200925700 [Simple description of the drawings] The first figure is a simple schematic diagram of the method for manufacturing the contact lens with hydrophilic surface of the present invention. The second figure is a hydrophilic surface of the present invention. A simplified schematic diagram of a method for manufacturing a contact lens of a coffin (a description of the main component symbols) - a public model-----------------------10 Ο Mother mold-----------------------10a Hydrophilic biomedical materials--------20 Lens main raw material------- -------30 Rotating Master Model-----------------40 Contact Lens-----------------100
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