TW200846072A - Microflow device for preparing gelatin fine particles and driving method thereof - Google Patents
Microflow device for preparing gelatin fine particles and driving method thereof Download PDFInfo
- Publication number
- TW200846072A TW200846072A TW96117394A TW96117394A TW200846072A TW 200846072 A TW200846072 A TW 200846072A TW 96117394 A TW96117394 A TW 96117394A TW 96117394 A TW96117394 A TW 96117394A TW 200846072 A TW200846072 A TW 200846072A
- Authority
- TW
- Taiwan
- Prior art keywords
- liquid
- microchannel
- gelatin
- gelatin particles
- flow channel
- Prior art date
Links
- 108010010803 Gelatin Proteins 0.000 title claims abstract description 65
- 239000008273 gelatin Substances 0.000 title claims abstract description 65
- 229920000159 gelatin Polymers 0.000 title claims abstract description 65
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 65
- 235000011852 gelatine desserts Nutrition 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims abstract description 20
- 239000010419 fine particle Substances 0.000 title claims abstract 5
- 239000007788 liquid Substances 0.000 claims abstract description 116
- 239000002245 particle Substances 0.000 claims abstract description 60
- 238000002347 injection Methods 0.000 claims abstract description 36
- 239000007924 injection Substances 0.000 claims abstract description 36
- 239000000499 gel Substances 0.000 claims abstract description 25
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 238000006243 chemical reaction Methods 0.000 claims abstract description 7
- 238000004132 cross linking Methods 0.000 claims abstract description 7
- 239000012071 phase Substances 0.000 claims description 37
- 239000003921 oil Substances 0.000 claims description 32
- 235000019198 oils Nutrition 0.000 claims description 32
- 238000002156 mixing Methods 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 13
- 239000008346 aqueous phase Substances 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 239000011859 microparticle Substances 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 9
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- NNJPGOLRFBJNIW-HNNXBMFYSA-N (-)-demecolcine Chemical compound C1=C(OC)C(=O)C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-HNNXBMFYSA-N 0.000 claims description 2
- 235000019486 Sunflower oil Nutrition 0.000 claims description 2
- 238000010008 shearing Methods 0.000 claims description 2
- 239000002600 sunflower oil Substances 0.000 claims description 2
- 238000013022 venting Methods 0.000 claims 4
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 238000005459 micromachining Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 8
- 238000001879 gelation Methods 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 8
- 238000005520 cutting process Methods 0.000 description 6
- 239000008187 granular material Substances 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 235000008429 bread Nutrition 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 235000017399 Caesalpinia tinctoria Nutrition 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000388430 Tara Species 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000004807 desolvation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW96117394A TW200846072A (en) | 2007-05-16 | 2007-05-16 | Microflow device for preparing gelatin fine particles and driving method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW96117394A TW200846072A (en) | 2007-05-16 | 2007-05-16 | Microflow device for preparing gelatin fine particles and driving method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200846072A true TW200846072A (en) | 2008-12-01 |
| TWI352621B TWI352621B (OSRAM) | 2011-11-21 |
Family
ID=44823028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW96117394A TW200846072A (en) | 2007-05-16 | 2007-05-16 | Microflow device for preparing gelatin fine particles and driving method thereof |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW200846072A (OSRAM) |
-
2007
- 2007-05-16 TW TW96117394A patent/TW200846072A/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI352621B (OSRAM) | 2011-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12416033B2 (en) | Assays and other reactions involving droplets | |
| CA2873958C (en) | Microbubble generation | |
| US20090131543A1 (en) | Method and Apparatus for Forming Multiple Emulsions | |
| WO2007134120A2 (en) | Microfluidic device for forming monodisperse lipoplexes | |
| JP2013255912A (ja) | リポソームおよびその作製方法 | |
| Paknahad et al. | High throughput microfluidic nanobubble generation by microporous membrane integration and controlled bubble shrinkage | |
| Huang et al. | In situ synthesis of twin monodispersed alginate microparticles | |
| US9156189B2 (en) | Systems and methods for high-throughput microfluidic bead production | |
| Xue et al. | Soft-template regulation of magnetic microsphere topology from a microfluidic device | |
| Reineke et al. | On-chip fabrication and in-flow 3d-printing of microgel constructs: from chip to scaffold materials in one integral process | |
| TW200846072A (en) | Microflow device for preparing gelatin fine particles and driving method thereof | |
| KR20240087627A (ko) | 지질 나노 입자 제조용 칩, 및 이를 포함하는 지질 나노 입자 제조 시스템 | |
| Huang | Microfluidic Production and Characterization of Lipid Vesicles, Polymer Vesicles, and Hybrid Polymer/Lipid Vesicles | |
| Förster et al. | On-chip fabrication and in-flow 3D-printing of cell-laden microgel constructs: From chip to scaffold materials in one integral process | |
| Darooeizadeh | The effect of geometry on mixing efficiency for microfluidic device | |
| Young | Achieving monodisperse optical microsensors with co-flow microfluidics | |
| JP5029669B2 (ja) | マイクロミキサー、およびマイクロ流体チップ | |
| Bardin | Microfluidic Methods for Generating Clinical-Scale Quantities of Uniform Fine Emulsions for Applications in Site-Specific Therapeutics | |
| Park | Microfluidic Development of Bubble-templated Microstructured | |
| Hsieh et al. | Monodisperse Lipoplex Generation by Integrated Picoliter Micro Reactor and Incubator | |
| Mitchell | Synthesis of Particles in Microfluidics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |