TW200817755A - Methods of inhibiting the distortions that occur during the production of silicone hydrogel ophthalmic lenses - Google Patents

Abstract

Methods of reducing the distortion of silicone hydrogel lenses during sterilization are disclosed.

Description

200817755 IX. INSTRUCTIONS: [RELATED APPLICATIONS] This application is a non-provisional application: US Patent Application No. 6〇/817,728, filed June 30, 2006, which is a temporary Patent application. TECHNICAL FIELD OF THE INVENTION The present invention relates to a method of reducing deformation during manufacture of an anthrone ketone hydrogel contact lens. [Prior Art] Contact lenses have been commercially used to improve vision since the 1950s. The first pair of contact lenses are made of hard materials. Although these lenses are still used today, they are less comfortable at first wear, so Not suitable for all patients. In this field, hydrogel-based soft contact lenses have been developed and are nowadays popular. Further research has led to the development of indolone hydrogel lenses, which are known to have a relatively southerous oxygen. It is permeable and is often more comfortable to wear than contact lenses made from hard materials. However, fluorenone hydrogel lenses are not without problems. Anthrone hydrogel lenses may be creased or physically distorted during their manufacture, which is seen when the lens is sterilized. Typically, the fluorenone hydrogel lenses are packaged in individual containers containing ophthalmic packaging solutions and heated to a temperature of about 10 (rc or higher), in which the fluorenone hydrogel is known to adhere to its packaging material. Or be distorted. One solution to this problem is to add some surfactant to the eye solution, and another solution is to modify the surface of the (4) surface. Although iron 200817755 = there are some solutions, it is better to expand this Scope of the Problem Solving Solution The present invention provides another solution to the deformation problem during the manufacture of the fluorenone hydrogel lens. [Summary of the Invention] Figure 1 is a package of an eye lens in a horizontal orientation. The invention includes a method of inhibiting deformation during sterilization of an anthrone hydrogel eye lens, which comprises, or comprises: disinfecting the indolone hydrogel eye lens in a package, wherein the package is placed In a substantially horizontal position. As used herein, an anthrone hydrogel eye lens refers to an eye device that is placed or placed on the eye. These devices provide optical correction. Or as a cosmetic use. The term lens includes, but is not limited to, soft contact lenses, intraocular lenses, cover lenses, eye inserts, and optical inserts. The preferred lens according to the present invention is an anthrone hydrogel lens. , described in U.S. Patent Nos. 5,710,302, WO 9 421 698, EP 406 161, JP 2000 016 905, U.S. Patent 5,998,498, U.S. Patent Application Serial No. 9/532,943, U.S. Patent No. 6,087,415, U.S. Patent 5,760,100, U.S. Patent 5,776,999, U.S. Patent 5,789,461, U.S. Patent No. 5,849,811, issued to U.S. Pat. U.S. Patent No. 5,998,498, U.S. Patent Application Serial No. 09/532,943, filed on Aug. Continuation, U.S. Patent 6,087,415, U.S. Patent 5,760,100, U.S. Patent 5,776,999, U.S. Patent 5,789,461, U.S. Patent 5, 849, 811, and U.S. Patent No. 5,965, 631, the entire entire disclosure of which is incorporated herein by reference. Disinfection refers to heating the fluorenone hydrogel eye lens at a temperature and time required to kill the microorganism, preferably at a temperature above about 100 ° C, and for a period of time greater than about 15 minutes. As discussed previously, the fluorenone hydrogel eye lens is sterilized in an ophthalmic packaging solution which can be any water-based solution for storing contact lenses. Typical solutions include, but are not limited to, salt-containing solutions, other buffer solutions, and deionized water. Preferred aqueous solutions are saline solutions containing salts including, but not limited to, sodium chloride, Sodium borate, sodium phosphate, sodium hydrogen phosphate, sodium hydrogen diphosphate, or the corresponding potassium salt of these. These ingredients are usually combined to form a buffer solution which includes an acid and its conjugate base, so that the addition of acid and base causes only a relatively small change in pH. The buffer solution may additionally include morpholino)ethanesulfonic acid (MES), sodium hydroxide, 2,2-di(hydroxyindenyl)-2,2',2''-nitrile triethanol, n-tri ( Hydroxymercapto)mercapto-2-aminoethanesulfonic acid, citric acid, sodium citrate, sodium carbonate, sodium hydrogencarbonate, acetic acid, sodium acetate, ethyldiaminetetraacetic acid, and the like, and A preferred solution of the composition is a borate buffered or phosphate buffered saline solution. 7 200817755 "Packaging" means any container that can be used to disinfect an indolone hydrogel eye lens. Examples of such containers are disclosed in the following publications: U.S. Patents D435,966 S, 4,691,820, 5,467,868 5, 704, 468, 5, 823, 327, 6, 050, 398, the entire disclosure of which is incorporated herein by reference. "Horizontal" refers to the location where the package is placed during sterilization. Referring to Figure 1, the orientation of the tongue JJL of the package 20 is horizontal relative to the horizontal surface of the tabletop 40. During sterilization, the fluorenone hydrogel eye lens (not Shown) in the bowl welcoming, wherein the convex surface of the fluorenone hydrogel eye lens is adjacent to the concave surface of the bowl Μ«. [Embodiment] Example 1 Solution A containing different surfactants etafilcon A hydrogel and acquafilcon A contact lenses are placed in individual polypropylene contact lens packages, and a salt-containing packaging solution is applied to each package to cover each lens and seal the package. Half of the package is placed in a vertical position. In one bracket, the other half are placed in a bracket in a horizontal position, and the packages are heated to 121 ° C for about 20 minutes, the packages are cooled and opened, and the lenses are visually inspected for disinfection in horizontal and vertical positions. The etafilcon A lenses retain their shape without folding wrinkles or other deformations. The acquafilcon A lenses that are sterilized in a vertical orientation contain creases and other deformations. The acquafilcon A lens disinfected in a horizontal position does not contain such deformation. 8 200817755 [Simple description of the drawing] Figure 1 shows a package of eye lenses in a horizontal orientation. [Main component symbol description] 10 flange 20 package 30 bowls 40 desktop 9

Claims (1)

200817755 X. Patent application garden: 1. A method for inhibiting deformation during sterilization of an anthraquinone hydrogel eye lens, comprising: disinfecting the indolone hydrogel eye lens in a package, wherein the packaging It is placed in a substantially horizontal position. 2. The method of claim 3, wherein the (4) hydrogel eye lens is selected from the group consisting of an anthrone hydrogel prepared as in the following: U.S. Patent No. 5,998,498, U.S. Patent Application Serial No. 9/532,943, the continuation of U.S. Patent Application Serial No. 09/532,943, issued on Aug. 30, the entire disclosure of U.S. Patent No. 6,087,415, U.S. Patent 5,760,1, U.S. Patent 5,776,999, U.S. Patent 5,789,461. U.S. Patent 5,849,811, and U.S. Patent 5,965,631. 3. The method of claim 1, wherein the fluorenone hydrogel eye lens is selected from the group consisting of: (10) A, balafile () n A, and lotrafilcon A. 4. According to the method of claim 帛i, wherein the oleanyl hydrogel eye lens is acquafilcon A. 5. The method of claim 1, wherein the disinfecting occurs at a temperature above about 100 °C. 6. The method of claim 1, wherein the disinfecting occurs at a temperature above about 120 °C. 7. The method of claim </ RTI> wherein the disinfection occurs in about 10 minutes. 8. The method according to the scope of the patent application, wherein the disinfection occurs at about 200817755 for about 20 minutes. 9. The method of claim 1, wherein the disinfecting occurs from about 18 to about 20 minutes at a temperature of from about 118 ° C to about 120 t:. 10. The method of claim 9, wherein the fluorenone hydrogel eye lens is acquafilcon A. 11