CN101484192A

CN101484192A - Methods of inhibiting the distortions that occur during the production of silicone hydrogel ophthalmic lenses

Info

Publication number: CN101484192A
Application number: CNA2007800247360A
Authority: CN
Inventors: J·D·福德; A·阿利; D·杜贝
Original assignee: Johnson and Johnson Vision Care Inc
Current assignee: Johnson and Johnson Vision Care Inc
Priority date: 2006-06-30
Filing date: 2007-06-25
Publication date: 2009-07-15
Also published as: TW200817755A; AR061759A1

Abstract

A method of inhibiting the distortion of silicone hydrogel ophthalmic lenses during sterilization comprising sterilizing said silicone hydrogel ophthalmic lenses in a package, wherein said package is oriented in a substantially horizontal position.

Description

Be suppressed at the distored method that produces in the silicone hydrogel ophthalmic lenses process of producing

Related application

The present invention is the temporary patent application U.S. Patent application No.60/817 that submitted on June 30th, 2006,728 non-interim submission.

The present invention relates to reduce the distored method that in producing silicon hydrogel contact lens (silicone hydrogel contactlenses) process, produces.

Background technology

From nineteen fifties contact lens used to improve vision by commerce.Initial contact lens is made by hard material.Although this eyeglass is still using now,, be unsuitable for all patients because their initial comfortableness is poor.Development in this field subsequently produces the soft contact lens based on hydrogel, and it is very popular now.Further development causes the development of silicone hydrogel lens.This silicone hydrogel lens has known higher oxygen permeability, and compares with the contact lens that hard material is made, and wears usually more comfortable.Yet silicone hydrogel lens is not have problems.

Silicone hydrogel lens may crease in their production processes or otherwise physically distortion.When sterilizing, eyeglass can see this problem.Typically, silicone hydrogel lens is packaged in the one eye that contains with in the container of packaging solution and be heated to about 100 ℃ or higher temperature.During this process, silicon hydrogel is known to be adhered on their packaging material or distortion otherwise.A kind of method that addresses this problem is to add specific surfactant to use in the packaging solution to eye, and another method is the inner surface of the described packing of modification.Even there are these methods, the preferred scope of expanding the scheme that addresses this problem.The invention provides and solve in their production process, the distort replaceability solution of problem of silicon hydrogel.

The accompanying drawing summary

Fig. 1 is the eye lens packing of horizontal alignment.

The specific embodiment

The present invention includes and suppress in sterilization process, the distort method of (distortion) of silicone hydrogel ophthalmic lenses (ophthalmic lenses), its by or form by the described silicone hydrogel ophthalmic lenses of sterilization in packing basically, wherein said packing be oriented to the basic horizontal position.

＂ silicone hydrogel ophthalmic lenses ＂ is meant that those are placed on the eye apparatus in the eyes or on the eyes as used herein.It maybe can be beauty treatment property that these devices can provide vision correction.The term eyeglass includes, but are not limited to soft contact lens, intraocular lens, cover eyeglass (overlay lenses), eye embedded body (ocularinsert) and optics embedded body (optical insert).The preferred eyeglass of the present invention is a U.S. Patent No. 5,710,302, and WO 9421698, and EP 406161, JP 2000016905, U.S. Patent No. 5,998,498, U.S. Patent application No.09/532,943, U.S. Patent No. 6,087,415, U.S. Patent No. 5,760,100, U.S. Patent No. 5,776,999, US Patent No 5,789,461, U.S. Patent No. 5,849,811 and U.S. Patent No. 5,965,631 described silicone hydrogel lens.Above-mentioned list of references is incorporated by reference in full at this.Preferred eyeglass is including, but not limited to silicon hydrogel, as acquafilcon A, balafilcon A, lotrafilconA and U.S. Patent No. 5,998,498, U.S. Patent application No.09/532,943, the U.S. Patent application No.09/532 that on August 30th, 2000 submitted to, 943 part continuity, U.S. Patent No. 6,087,415, U.S. Patent No. 5,760,100, U.S. Patent No. 5,776,999, U.S. Patent No. 5,789,461, U.S. Patent No. 5,849,811 and U.S. Patent No. 5, the silicon hydrogel of preparation in 965,631.Most preferred silicone hydrogel ophthalmic lenses is acquafilcon A.These patents and all other disclosed in this application patents are incorporated by reference in full at this.

Sterilization is meant at the needed temperature and time heating of kill microorganisms silicone hydrogel ophthalmic lenses as used herein.Preferably, temperature is higher than about 100 ℃ and time greater than about 15 minutes.As mentioned above, silicone hydrogel ophthalmic lenses is sterilized in packaging solution at eye.Eye of the present invention can be any group water solution that is used to store contact lens with packaging solution.Typical solutions includes but not limited to saline solution, other buffer solution and deionized water.Preferred aqueous solution is saliniferous saline solution, and described salt includes but not limited to sodium chloride, sodium borate, sodium phosphate, dibastic sodium phosphate, sodium dihydrogen phosphate, or the potassium salt of corresponding acid of the same race.These compositions merge the buffer solution that comprises acid and its conjugate base with formation usually, make the pH aspect that is added on of bronsted lowry acids and bases bronsted lowry only cause relatively little change.Sort buffer solution can also comprise 2-(N-morpholino) ethyl sulfonic acid (MES), sodium hydroxide, 2 in addition, two (methylol)-2 of 2-, 2 ', 2 ＂-nitrilotriethanol, n-three (methylol) methyl-2-aminoethyl sulfonic acid, citric acid, sodium citrate, sodium carbonate, sodium bicarbonate, acetic acid, sodium acetate, ethylenediaminetetraacetic acid etc. and their combination.Preferably, this solution is the saline solution of borate buffered saline solution or phosphate-buffered.

＂ packing ＂ is meant any container that can be used for to the silicone hydrogel ophthalmic lenses sterilization.The example of this container is open in following publication: United States Patent(USP) Nos. D435,966 S; 4,691,820; 5,467,868; 5,704,468; 5,823,327; 6,050,398,, it is incorporated by reference in full at this.

" level " is meant in the residing position of sterilization process intermediate package.Referring to Fig. 1, packing 20Flange 10Orientation are levels with respect to the level surface (level surface) of table top 40.In sterilization process, the silicone hydrogel ophthalmic lenses (not shown) rests in bowl material 30In, the convex surface of silicone hydrogel ophthalmic lenses is near bowl material there 30The concave surface (not shown).

Embodiment 1

The solution A that contains various surfactants

Etafilcon A hydrogel and acquafilcon A contact lens are positioned in the independent polypropylene contact lens packing.In each packing, add the saline packaging solution covering each eyeglass, and with this package encapsulation.The described packing of half is placed in the support of upright position, and second half is placed in the support of horizontal level.These packings be heated to 121 ℃ about 20 minutes.Cooling is also opened these packings, visually checks these eyeglasses.Etafilcon A eyeglass in horizontal level and upright position sterilization all keeps their shape, does not have folding line or other distortion (deformity).Contain folding line and other distortion at the Acquafilcon of vertical orientated sterilization A eyeglass.Acquafilcon A eyeglass in the horizontal level sterilization does not contain these distortion.

Claims

1. suppress silicone hydrogel ophthalmic lenses distored method in sterilization process, comprise that described silicone hydrogel ophthalmic lenses sterilizes in packing, wherein said packing is along the basic horizontal location orientation.

2. the method for claim 1, wherein said silicone hydrogel ophthalmic lenses is selected from by U.S. Patent No. 5,998,498, U.S. Patent application No.09/532, the U.S. Patent application No.09/532 that on August 30th, 943,2000 submitted to, 943 part continuity, U.S. Patent No. 6,087,415, U.S. Patent No. 5,760, and 100, U.S. Patent No. 5,776,999, U.S. Patent No. 5,789, and 461, U.S. Patent No. 5,849,811 and the group formed of U.S. Patent No. 5,965,631 prepared silicon hydrogels.

3. the process of claim 1 wherein that described silicone hydrogel ophthalmic lenses is selected from the group of being made up of acquafilcon A, balafilcon A and lotrafilcon A.

4. the process of claim 1 wherein that described silicone hydrogel ophthalmic lenses is acquafilcon A.

5. the process of claim 1 wherein that described sterilization carries out being higher than about 100 ℃ temperature.

6. the process of claim 1 wherein that described sterilization carries out being higher than about 120 ℃ temperature.

7. the process of claim 1 wherein sterilizes carried out about 10 minutes.

8. the process of claim 1 wherein sterilizes carried out about 20 minutes.

9. the process of claim 1 wherein that sterilization carried out about 18 to about 20 minutes to about 120 ℃ of temperature at about 118 ℃.

10. the method for claim 9, wherein said silicone hydrogel ophthalmic lenses is acquafilcon A.