TW455628B - Contact lenses with aqueous solution including phosphonic compounds and cleaning aqueous solution thereof - Google Patents

Abstract

The present invention provides non-oxidative methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a phosphonic acid compound. In preferred embodiments of the invention, the subject phosphonic compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein deposits.

Description

A7 455628 ___B7 ______ V. Description of invention (1) Field of invention ϋ. I-.— 111 II H. 1 -1 -HI-i-IX,.-· Ν · (Please read the precautions on the back before filling in this The present invention relates to a method for treating contact lenses and a composition thereof. The present invention includes the use of an aqueous solution containing a certain phosphonic acid compound. Preferred embodiments of the present invention include methods and compositions for cleaning and disinfecting contact lenses simultaneously. BACKGROUND OF THE INVENTION Generally, contact lenses are broadly divided into three categories: (1) hard contact lenses formed from materials such as polymethyl methacrylate (PMMA) polymerized by acrylates, and (2) silicone acrylates and fluorine RGP contact lenses formed by silicone methylacrylate and (3) gels made by polymerizing hydrophilic or hydrophobic monomers such as 2-hydroxyethyl methacrylate (HEMA) Glue, hydrogel or soft contact lenses. Hard acrylic contact lenses are characterized by a low water vapor diffusion constant, are resistant to light, oxygen and hydrolysis and absorb only a small amount of water. Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs During the normal wearing of contact lenses, tear film and debris composed of protein-based oily fats and related organic substances are easily deposited and piled on the surface of contact lenses. Many factors can affect the formation of deposits, including tolerance changes, lens material 'care methods, and environment. Generally, ionic lenses with high water content are more likely to adsorb proteins than low-water or non-ionic lens materials. In the routine maintenance method, contact lenses need to be washed to remove these tear film deposits and debris. If these deposits are not removed properly, the wettability and optical transparency of the lens will be substantially reduced, causing the wearer to feel uncomfortable. Traditionally, contact lenses are cleaned with one or two cleaning agents. Surfactant cleaner (commonly called "Daily Cleaner" because it is recommended for daily use) can effectively remove most of the carbohydrates and lipids. But it cannot effectively remove -4-This paper is for China National Standard (CNS) A4 specification (210X297 mm) 4 5 5 6 2 B A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (2) In addition to proteinaceous substances such as lysozyme. Generally, they come from plants, Animal and microbial-derived enzymes are used to remove more stubborn protein deposits. These " enzyme " cleaning agents are generally recommended for use weekly and enzyme tablets are usually first dissolved in a suitable aqueous solution. Furthermore, contact lenses need to be sterilized to kill harmful micro-organisms that may exist or grow on the lenses. Several methods have been used to disinfect contact lenses, such as contact lenses with oxidizing chemicals (such as peroxide atmosphere) or anti- The aqueous solution of the microbial agent is contacted at normal temperature. Or the lens can be exposed to high temperature for a certain period of time to complete the disinfection. The latter disinfection technology requires general electricity to be disinfected. Equipment. The conventional method for cleaning and disinfecting contact lenses, especially soft contact lenses, generally includes an initial step including a cleaning phase, in which the lenses are scrubbed with a daily cleaning agent to remove debris and then immersed in an enzyme cleaning solution at room temperature, That is, soaking for at least 15 minutes to effectively remove protein deposits. In this method, the lens must be subsequently disinfected after the cleaning phase. At present, methods have been developed that can remove proteinaceous materials from contact lenses and disinfect lenses simultaneously. For example, USP 4,614,549 discloses a single-step method for cleaning and disinfecting contact lenses with an aqueous solution of lysozyme at a temperature between 60 ° C and 100 ° C. Unfortunately, this method requires the use of electricity to disinfect equipment and high temperatures. Another method is to simultaneously clean and disinfect The method of contact lenses is described in USP Application No. 32,672, which discloses a method for immersing contact lenses in a solution containing peroxide and a peroxide-active enzyme B. However, this method needs to neutralize residual peroxide before wearing the contact lenses. Extra steps. In an effort to provide more convenient ways, new maintenance methods have been developed. I_____ ___ -5- This paper size applies to the SIS home standard (CNS) A4 specification (2! 〇 > < 297 male thin) ''-(Please read the precautions on the back before filling in this card) -1 I mi 455628 No. S6103303 Patent Application Chinese Specification Revision Sheet (September 87) Α7 Β7- 3

.L-玄 * ^ will be revealed next year (eg, USP 5,096,607, approved on March 17, 2009) reveals a cleaning and disinfection system in which contact lenses are impregnated with a multi-purpose solution in the presence of enzyme tablets under certain osmotic conditions The lens is cleaned and disinfected at the same time. This system provides the benefit of a single "EJ" cleaning and disinfection solution, which can be used in combination with enzyme cleaning agents, thereby reducing the number of steps required to effectively clean and disinfect contact lenses. . Although the latter patent provides more important improvements in cleaning contact lenses than previous systems, it still seeks more convenient methods. More specifically, it is still desirable to provide a cleaning system that uses only a single solution without the need to supplement enzyme cleaning agents. The cleaning system can provide a cleaning power comparable to a system using an enzyme cleaning agent. ^ SUMMARY OF THE INVENTION The present invention includes a non-fluorinated method for treating contact lenses and a composition thereof. The present invention includes contact lenses and phosphine containing the following formula Contact with an aqueous solution of an acid or a physiologically compatible salt thereof:

(Please read the notes on the back before filling in this page) Order printed by the Employees' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, where Z is the linking group whose price is equal to η, where η is 1 to 6, preferably Z contains I to 1 2 carbon atoms. The z group may include, for example, a substituted or unsubstituted saturated hydrocarbon group or an amine-containing group = "substituted or unsubstituted, meaning unsubstituted or mesogen, hydroxyl, amino, carboxyl, alkylcarbonyl, alkoxycarbonyl, or Substituted or unsubstituted -Q-The size of the paper method is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 4 5 56 2 8 Α7 Β7 Printed by the Central Proof Bureau of the Ministry of Economic Affairs Η Printed by Consumer Cooperatives 5. Substituted by a phenyl group, wherein the substituent on the phenyl group may be an autogen, a hydroxyl group, an amine group, a carboxyl group, a carbonyl group, or an alkyl group, wherein the alkyl or alkoxy group contains 1 to 4 carbon atoms. The method comprises washing with an aqueous solution containing at least 003% by weight of the target phosphonic acid, preferably 0.005 to 1.0% by weight of the target compound, more preferably 0.001 to 025% by weight of the compound in an aqueous solution. In the preferred embodiment of the contact lens β, the 'targeted phosphonic acid compound can be used in combination with an antimicrobial agent to provide simultaneous disinfection and cleaning of the contact lens. In a more preferred embodiment of the present invention, the target contact lens maintenance solution provides completely non-contact contact lenses. Of oxidation Washing method without the need for any other solution or supplemental enzyme cleaning agent. This cleaning method provides protein removal that is comparable to other cleaning methods that include the use of enzyme cleaning agents. Therefore, the present invention can provide more than known cleaning and disinfection The method has more obvious advantages. Detailed description of the invention The invention can be used for all contact lenses such as traditional hard, soft, hard and soft breathable and silicone (including hydrogel and non-hydrogel) contact lenses, but it is better to use In soft contact lenses. Such contact lenses are generally composed of monomers such as hydroxyethyl methacrylate, hydroxyethyl methyl methacrylate, vinyl pyridone, glyceryl methacrylate, methacrylic acid or acid. It is made from esters, etc. This contact lens can absorb a sufficient amount of water from about 4 to 80 weight 0/0. As mentioned above, the present invention includes a phosphonic acid or Its physiologically compatible salts: This paper size applies to Chinese National Standard (CNS) A4 specifications 210X297 mm) ----- ^ ------ ¥ ------, tr ----- -^ (Please read the note $ on the back before filling in this purchase) 丨 repair Play A7 B7- 4 5 56 2 8 303 vehicles benefit fr amended application page (87 September) V. description of the invention / I! \

z— P—OH \ 〇H / / n (I) where Z is a linking group having a valence equal to n, where n is 1 to 6, preferably J to 3, and preferably Z contains 1 to 12 carbon atoms And more preferably 1 to 10 carbon atoms. The 2 group includes a substituted or unsubstituted saturated hydrocarbon group or an amine-containing group, and the amine-containing group is a saturated group in which the Angstrom atom is inserted by at least one nitrogen atom, preferably 1 to 3 nitrogen atoms to form a secondary or tertiary amine. The hydrocarbon group a when 2 is an amine-containing group including one or more secondary or tertiary amines, and the number of carbon atoms in Z is at least n + 1. Hydrocarbyl means "branched, unbranched, non-cyclic or cyclic moiety consisting of carbon and hydrogen atoms, substituted or unsubstituted" means unsubstituted or via a molybdenum, molybdenum, amine, or thiol group , Alkylcarboxy, alkoxycarbonyl, or substituted or unsubstituted phenyl, wherein the substituent on the phenyl can be a pixel, a hydroxyl, an amino, a carboxyl, an alkylcarbonyl, or an alkyl group, wherein the alkyl or alkyl group Oxygen contains from 4 to 4 carbon atoms. The preferred element is gas, and the preferred substituents are amine, hydroxyl, and substituted or unsubstituted phenyl. Accordingly, suitable Z groups include substituted or unsubstituted forks Alkyl, substituted or unsubstituted alkylene, aminotri (alkylene) having at least η + 1 carbon atom, aminodi (alkylene) having at least η + 1 carbon atom, alkylene Diamine tetra (alkylene) or dialkylene triamine penta (alkylene), in which each alkylene group is connected to a phosphonic acid group. Preferably, all alkylene groups each contain from 4 to 4 Carbon atoms. Examples of compounds in which the Z group is amine tri (alkylene) include amine tri (ethyl-8- _____________ This paper size 逋Use China National Standard (CNS) Α4 specification (2 丨 0 > < 297 mm) (read the notes on the back of the book before filling out this page)-order the Ministry of Economic Affairs Central Standards Bureau employee consumption cooperation Du 455628 A7 B7 Printed by the Shellfish Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the invention (6) Phosphonic acid 'amino tris (isopropylidene phosphonic acid), amino di (methylene phosphonic acid) mono (isopropylidene phosphine) Acid) 'and amine mono (fluorenylphosphonic acid) bis (ethylidenephosphonic acid). Compounds in which the Z group is a substituted or unsubstituted alkylidene group Examples include methylenedipic acid' ethylidene monoscale Acid '1- # to propylidene dilinoleic acid. Examples of compounds where the Z group is butanediamine tetra (alkylene) or dialkylene triamine penta (alkylene) include hexamethylene diamine tetra (Methylenephosphonic acid) and diethylenetriaminepenta (methylenephosphonic acid). The compounds of the present invention are commercially available or can be prepared by methods known in the art, including the method disclosed in USP 3,671,644. Halo substitution The phosphonic acid compounds can be prepared from the corresponding hydroxyl substituted phosphonic acid compounds using, for example, PCI3 or PBr2. The solution of the present invention is physiologically compatible. In particular, the solution needs to be "ophthalmologically safe" for contact lenses, meaning that contact lenses treated with this solution are usually uncleaned. It is suitable and safe when placed directly on the eyes, that is, this solution is safe and comfortable when contacting the contact lenses wetted with this solution with the eyes every day. Ophthalmically safe solutions are compatible with the isotonicity of the eyes and pH 'JL includes substances and amounts that are non-cytotoxin according to ISO standards and US. FDA (Food and Drug Administration) regulations. This solution needs to be sterile and free of microbial contamination before release, and statistical evidence is required until this month The necessary degree of the product. The aqueous solution of the present invention preferably includes a phosphonic acid or a physiologically compatible salt thereof within the range of the formula (I) and represented by the following formula (IΪ), -9- --------- ^ --- 1 ---— 1T (please read the note ^^ on the back to save this page) A7 OH ί r——? OH c II ο (Π) 455628 ________ B7 V. Description of the invention (7) X2 (Bu b X '~ ^ CH2) a ~' C— (CH2) where a, b 'c and d are each selected from 0 to 4 An integer, preferably b or 1; X1 is a phosphonic acid group (that is, P (〇H) 2〇) 'hydroxyl (0H), amine (Nh2) or hydrogen (H); and X2 and X3 are each selected from _ prime A group consisting of hydroxy, amine, carboxy 'alkylcarbonyl, alkoxycarbonyl or substituted or unsubstituted phenyl, and methyl. Examples of substituents on phenyl are halogen, hydroxy, amine, oxo and / or alkyl. It is preferred that the aforementioned alkene group and the ethoxy group contain 1 to 4 carbon atoms, and more preferably contain 1 carbon atom. As mentioned above, the total number of carbon atoms in the formula (II) is preferably 1 to 12, more preferably 1 to 10. Other preferred compounds used in the solution of the present invention include compounds represented by the following formula (III) and their physiologically compatible salts in the range of formula (η): 0Η (_2) b H2〇3P— (CH2) a— C— (CH2) c——P〇3H3 (CH2) d CH3 (HI), where a ′ b, c, and d are each selected from integers 0 to 4 and the total number of atoms in formula (in) It is preferably 1 to 12 ′, more preferably 1 to 10. (In other words, formula (I 工 I) ------------ ^ ------ :: ir (please read the notes on the back before filling in the original)) Staff of the Central Standards Bureau of the Ministry of Economic Affairs Printed by a consumer cooperative ___ '-10- 4 5 562 8 A7 B7 5. In the description of the invention (8), the sum of a + b + c + d is preferably 1 to U, more preferably 2 to 9). Particularly preferred species are those where a, b, c, and d in formula (Π) are all 0, especially the tetrasodium salt of 1-lightethinyl-1,1-diphosphonic acid, also expressed as hydroxyethylenediphosphonic acid Tetrasodium salt 'DeQuest® 2016 sodium phosphonate or phosphonate from Monsanto. Organic phosphonic acids and their salts (collectively referred to as "phosphonic acid compounds" are known to those skilled in the art). This salt is sometimes referred to as a phosphonate. The known uses of this phosphonic acid compound include inhibiting scale formation in cookers. Others Known uses include the stabilization of hydrogen peroxide. For example, US Pat. No. 4,812,173 to Tsao et al. Discloses the use of phosphonic acid compounds for the stabilization of contact lenses. This method requires subsequent neutralization Examples of "oxidative" disinfection methods. An example of oxidative disinfection is the detoxification method using peroxides. This reference does not indicate a general "cleaning" or the removal of proteins from contact lenses. This Other known uses of this phosphonic acid compound include the use as a potent agent in antiseptic compositions containing phenols or quaternary ammonium bactericides. This composition has been found to be applicable to drilling mud compositions, pelletized compositions (Such as teeth cleaning 'hand and hair cleaners) and heavy-duty antiseptic cleaner compositions (such as for professional laundry, laundry fabrics, dairy farming equipment, hospital equipment, etc.) Employees of the Central Standards Bureau of the Ministry of Economic Affairs The cost-effective printed aqueous solution of the target should preferably contain at least 0.003% by weight of the standard phosphonic acid in the total solution, preferably 0.005 to 1.0 ° /% by weight, more preferably 0.01 to 0.25% by weight. The target aqueous solution is also May contain a variety of other ingredients, including (but not limited to): antimicrobials' buffers, chelating and / or sequestering agents, isotonic regulators and surfactants. This solution includes at least one surfactant. Suitable Surfactant can be -11- this paper ^ size is applicable to China National Standard (CNS) A4 specifications (210X297 publicly available 1 " printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs 455628 A7 -------- 51 5 2. Description of the invention (9) Group of anionic or non-ionic, the amount (individual amount or tongue two) can reach 15% by weight of the total composition (solution), preferably up to 5% by weight (the interface with better potential) The active agent is amphoteric or non-ionic interfacial active agent, which can be used to impart cleaning and conditioning properties when used. The surfactant needs to be soluble in contact lens solution but not irritating to the eye tissue. Many non-ionic surfactants include-or multiple With oxygen stretch (-0-R-) repeating single = chain or polymer component 'where ^ 2 to 6 complete atoms. Preferred non-isolated :: surfactants include two or more different oxygen-like alkylene repeating units. Polymer. The proportion of different repeating units determines the HLB of the surfactant. Satisfactory non-ionic surfactants include polyethylene glycol esters of fatty acids, such as sorbitan esters of high carbon alkanes (Cim), and polysorbates. Sugar alcohol esters, polyoxyethylene ethers or polyoxypropylene ethers. Preferred examples include polysorbate 20 (supplied under the trade name Tween® 20), polyoxyethylene (23) lauryl ether (Brije 35), Polyoxyethylene (40) stearate (Myrj®52), polyoxyethylene (25) glyceryl stearate (Atlas® G2612). A poly (oxypropylene) _poly (oxyethylammonium) adduct, in particular at least 40% by weight of the adduct, is a poly (oxyethylene) having a molecular weight of from about 7,500 to 27,000. The non-ionic surfactants, when used at about 5% to 5% by weight, are particularly beneficial for cleaning and adjusting both soft and hard contact lenses. The CTFA Cosmetic Ingredient Dictionary The name used is poloxamine »This surfactant can be registered trademark " Tetronic " commercially available from BASF Wondo Company, Wanda, Michigan. A similar series of surfactants suitable for use in the present invention is Pro Roma (Pol〇xamer) series, which is a poly (oxyethylene) poly-12 supplied under the trademark " Pluronic " (purchased from B ASF)-This paper is applicable to the national standard (CMS) A4 specification (2 丨 0 X 297 mm) ^ ---- ^ -------- ίΐτ ------ t-:-(Please read the notes on the back before filling this page) 455628 Ministry of Economic Affairs A7 printed by Bureau Shelley Consumer Cooperatives _______B7 V. Description of Invention (1〇) (oxypropylene Block polymers. A variety of other ionic and amphoteric and anionic surfactants suitable for use in the present invention can be easily published from "North American Editor, McCutchr Division, MC Publishing Company, McCutchr," of Glen Rock NJ07452 in view of the foregoing description. This and the CTFA International Cosmetic Ingredient Handbook published by the Washington DC, Granulated Products, Toiletries, and Fragrances Association are known ^ The amphoteric surfactants suitable for use in the composition of the present invention include those sold under the trade name " Miranol " Other types of amphoteric surfactants that can be used, such as cocoaamine propyl betaine, are purchased from a variety of sources. The aforementioned surfactants are generally total in the range from 0.0 to 50% by weight (w / v) 'better. .d50 0%, and preferably 〇 丨 to 〖50 / 〇. The pH of this solution needs to be maintained in the range of 5.0 to 8.0, more preferably from about 60 to 8.0, and most preferably from about 6.5 to 7.8, Appropriate buffering agents such as butterfly acid, sodium rotate, potassium citrate, sodium citrate, sodium bicarbonate, RIS and various mixed phosphate buffers (including Na2HP04, NaH2P04 and KH2P04 combination) and mixtures thereof can be added. Borate buffer "Good" especially for enhancing the effect of biguanide. Generally the amount of buffering agent is from about 0.05 to 2.5 weight%, more preferably from 0.01 to 1.5%. The disinfection / preservation solution of the present invention contains borate or Mixed phosphate buffering agent ', which contains one or more boric acid' sodium borate 'tetraborate clock, potassium metaborate, or mixtures thereof. In addition to the buffering agent, in some cases, a sequestering agent may be included in the solution. It is preferable to surround metal ions, otherwise, it will react with the lens and / or protein deposits and collect on the lens. Dextral ethylenediaminetetraacetic acid (EDTA) and its salt (disodium) are the preferred examples. The amount of addition is usually from about 0. 〇ι 至 〇3 重量 ％. Other suitable sequestrants include gluconic acid and citric acid 'tartaric acid ______ ^ 13- This paper is manufactured by Siljia County (CNS) 44th position (210X297 mm) ~~-(Please read the notes on the back first (Fill in this page again). Binding A7 B7 made by employees of the Central Standards Bureau, Ministry of Economic Affairs, Consumer Cooperatives. 5. Description of the invention ...) and its salts, such as sodium salt. Typically, the aqueous solution of the present invention used to treat contact lenses is also isotonicized to about the osmotic pressure of normal tears, which is equal to 0.9% sodium vaporized solution or 2.5 /. Glycerin drops. This solution can be made isotonic virtually by using physiological saline alone or in combination. Otherwise, if it is simply blended with sterile water, the contact lenses will become hypotonic or hypertonic and lose their required optical parameters. In contrast, excess salt solution can cause the formation of hypertonic solutions, which can cause stinging and eye irritation. Examples of suitable tonicity modifiers include (but are not limited to): sodium and potassium chloride, dextrose, glycerol, calcium and magnesium. These pharmaceuticals are generally used in individual amounts ranging from about 0.001 to 2.5% (w / v) and preferably from about 0.2 to 1.5% (w / v). The preferred isotonicity is used in an amount that provides a final osmotic pressure of between 200 and 450 mOsm / kg and more preferably between about 250 and 350 mOsm / kg and most preferably between about 280 and 320 mOsm / kg between. Yes, it is desirable to include a water-soluble viscosity-constituting agent in the solution of the present invention. Due to its soothing effect, the viscosity-constituting agent has a tendency to improve the comfort of the wearer, and the film on the surface of the lens cushions the impact on the eyes. Such water-soluble constituents include cellulose polymers such as hydroxyethyl or hydroxypropyl cellulose, carboxymethyl cellulose and the like. Such a viscosity-constituting agent is used in an amount of from about 0.01 to 40% by weight. The present invention may also contain a moderator as needed. The target solution preferably contains at least one antimicrobial agent. As used herein, an antimicrobial agent means a non-oxidizing organic drug that can derive its antimicrobial activity through chemical or physicochemical interactions with microorganisms. Preferred antimicrobials are quaternary ammonium compounds and biguanides. ^ _____________- 14 * The size of this paper is applicable to the national standard (CNS) Α4 specification (2 丨 〇 > < 297 mm) ---- ^ ----- = 丨 installed --- ^- --1 Order ------ Ball-* ·-* (Please read the notes on the back before filling out this page) 455628 A7 B7 Imprint by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (12) IV Representative examples of graded compounds are compositions composed of sulfonium ammonium ammonium or a balanced mixture such as vaporized n-alkyldimethylbenzyl ammonium ^ Other examples include polymeric quaternary ammonium salts for ophthalmic use, such as Poly [(dimethylimine) · 2-butene-1,4-diyl], [4-tris (2-hydroxyethyl) amino] -2-butenyl-w- [舂 (2 -Hydroxyethyl) ammonia] digas (chemical registration number 75345_27_6), which is usually purchased from ONYX Corporation as polyquaternium 1 (Polyquaternium 1) ®. Representative double arcs are big (biguanides), such as alexidine or chlorhexidine or their salts, and polymeric biguanides such as polymerized hexamethylene biguanide (PHMB). To polymerize hexamethylene biguanides (Zeneca from Wilmington DE), the polymers and water-soluble salts are the best. Generally hexamethylene biguanide polymers (also known as polyaminopropyl biguanide (PAPB) have molecular weights up to about 100,000. Such compounds are known as JL disclosed in USP 4,758,595, which is disclosed and incorporated herein by reference. Disinfection Amount The antimicrobial agent is to at least partially reduce the amount of micro organisms in the formula used. Preferably, the disinfection amount is to reduce the accumulation of microorganisms by 2 logarithmic stages within 4 hours and better to reduce i logarithms within 1 hour. The number of levels. The best disinfection amount is the amount that can eliminate the accumulation of microorganisms on contact lenses when used in the maintenance recommended for the immersion time (FDA chemical disinfection efficiency test-July 1985 draft guidelines for contact lens solutions). Generally, Such agents are present at a concentration of from about 0.00001 to about 0.5% (w / v), and more preferably from about 0.0003 to about 05% (v // v). A second disinfectant can be used as a solution preservative , But also has the antibacterial active bacteria spectrum that enhances, supplements or expands other fungicides. This contains anti-micro-15- (please read the precautions on the back before filling this page) οδ 2 8 Α7 Β7 Staff of the Central Standards Bureau of the Ministry of Economic Affairs Consumption Cooperation Du Printing 16- 5 、 Explanation of the invention (13 raw doses of biocides that are miscible in solution and will not precipitate, the concentration is from about 0.00001 to about 0.5% by weight and more preferably from about 0 0001 to about 0 ^% by weight. Suitable complementary bactericides Contains (but is not limited to) thimerosal or other phenylmercury salts, sorbic acid, alkyltriethanolamine, and mixtures thereof. The acid addition salts of the bactericides used in the compositions of the present invention can be derived from inorganic or organic acids. Most cases It is preferably a salt derived from an acid that is easily soluble in water and can provide an anion suitable for human use (such as a pharmaceutically acceptable anion). Examples of such acids are hydrogen acid, hydrobromic acid, phosphoric acid, sulfuric acid, Acetic acid, D-gluconic acid, 2-pyrrolidine-5-carboxylic acid, methanesulfonic acid, carbonic acid, lactic acid, and glutamic acid. Hydrogen acid is preferred. In this application, the fungicide or other ingredients in the solution of the present invention Amount refers to the amount formulated and introduced into the solution when it is made into a solution. The solution of the present invention can be formulated into specific contact lens maintenance products, such as Fengrun solution, diffused bubble solution 'cleaning and conditioning solution, and functional lens maintenance solution, etc. , And mixed The invention is preferably formulated into a "multifunctional solution", which means a solution that can be used to clean, chemically disinfect, store and rinse contact lenses. This solution can be a multifunctional solution system "or" multifunctional solution packaging " Part of the procedure. The use of a multi-functional solution, system or packaging is expressed as "multi-functional disinfection method". Multi-functional: Cereal does not exclude certain wearers such as being particularly sensitive to chemical disinfectants or their chemicals The wearer can use other solutions such as the possibility of rinsing the lenses with a sterile salt solution before placing it in the eyes. The multifunctional solution does not exclude the use of regular detergents for daily use or for protein removal The possibility of supplementary cleansers such as enzyme cleansers that are generally used weekly. ,, cleaning "This paper offers the standard of household towel making (CNS) Α4 · (21GX297) while taking ------ ^ ---- batch clothes ---_--- ^-ΐτ.,. {Please Read the precautions on the back before filling out this page) 455628 A7 _______B7 V. Description of the invention (14) '— The word means that the solution contains enough to loosen the deposits that are tightly held on the lens and other contaminants on the surface of the contact lens. One or more cleaning agents to be removed, especially when used in conjunction with hand-washing (for example, gently rubbing the lens with a solution) or with auxiliary devices (such as mechanical cleaning aids) that come into contact with the lens fluid. The critical cell concentration of the solution of the agent is a method to evaluate its cleaning efficiency. The viscosity of the multifunctional solution is less than 75 cps, preferably 1 to 50 cps, and more preferably 1 to 25 cps, and more in the total composition. It is preferably at least 95% by weight of water. As stated, contact lenses can be cleaned by contacting the lens with the target aqueous solution. Although this can be achieved by simply immersing the contact lens in the solution ', if a few drops are made first Solution drips on both sides of the lens and scrubs the lens for a period of time, such as about 20 seconds A greater cleaning effect can be achieved. Then the lens can be immersed in a few milliliters of the standard solution, preferably the lens is immersed in the solution for at least 4 hours. Furthermore, after the scrubbing step and after immersed in the solution, the lens is more Rinse with a fresh solution. If the target solution contains an antimicrobial agent, the target solution can not only clean the lenses but also sterilize. However, it should be understood that other "non-chemical" disinfection methods, such as heat sterilization, can also be used. Printed by the Consumer Standards Cooperative of the Central Bureau of Standards of the Ministry of Economics Although it is usually not necessary, it is also possible to use a combination of enzyme cleaners and target solutions to treat contact lenses, especially for patients who are prone to large amounts of protein deposits. The use of enzyme tablets allows the enzyme tablets to be placed directly in the target solution in a manner similar to that described in USP 5,096,607. In a first specific example of the method of the present invention, the method includes at least one phosphine containing 1 to 12, preferably 1 to 10 carbon atoms in an amount of 0.05 to 1.0% by weight. Caiguan Jiaxian (CNS) Congxiu (21 () > < 297 public directors) ------ printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs ^ 56 2 8 A7 ------- B7 V. Description of the invention (15) '-Cleaning contact lenses with an aqueous solution of an acid or a physiologically compatible salt thereof. The $ atom may be in the t-state of a nine-substituted or unsubstituted branched or unbranched aliphatic, cyclic aliphatic or aromatic group, or a combination thereof. The phosphonic acid compound is preferably one of the above formula (), preferably the one of the formula (II), and more preferably the formula (m). The phosphonic acid compound preferably has one or two phosphonic acid groups in a salt state. Without wishing to be bound by theory, the phosphonic acid group in this compound is believed to attach to the protein # molecule and release it from the contact lens material, and this attachment effect may or may not be caused by the presence of calcium or other ions in the vicinity. Interaction. Preferably, the method includes scrubbing the contact lens with the multifunctional solution of the present invention, and then immersing in the solution for a total of 10 minutes to 4 hours, and then directly wearing the lens in the eye. "Direct wearing" means that the solution is not diluted or the lens is not rinsed with a different contact lens solution before the contact lens is placed in or worn in the eye. In another embodiment of the method of the present invention, 'the applied solution is available The long-wearing contact lenses (FRL), which are expected to be worn for no more than about 3 months or for less than about 30 days, or for not more than about 2 weeks, are washed out. Preferably, contact lenses are composed of About 00 to 5 mol% of repeat units derived from fluorenyl acrylic acid (MAA), 10 to 99 mol% of repeat units derived from methyl ethyl methacrylate and about 0 to 5 to 5 mol% of cross-linked repeats It is made from a polymer of units, and the cross-linked repeating unit can be derived from monomers such as ethylene glycol dimethacrylate, divinylbenzene, and trimethyldiacetic acid. When the eyes are clear, the contact limit lens can be diffused separately or supplemented in the contact lens solution of the present invention, and the solution can be used as the eye drop -18 · This paper size applies the Chinese National Standard (CNS) ΑΊ size (210X297 Mm} (碕 Read the notes on the back before filling (This page) Binding '5 2 8 A7 B7 V. Description of the invention (16) agent to further avoid protein accumulation on hydrophilic contact lenses. · Therefore, ophthalmologically safe solutions including the clear compounds can be packaged suitable for application in eye drops In the container in the eyes. Several examples are provided below to illustrate the present invention, these examples are only used to illustrate the present invention and are not intended to limit its scope. Example 1 A preferred formulation of the target solution is shown in Table I below. The required amount of tetrasodium salt of 1-hydroxyethyl-1,1-diphosphonic acid (also referred to as tetrasodium salt of hydroxyethylene diphosphonic acid) was weighed in a beaker and was purchased from Monsanto Corporation (St. Louis as DeQuest® 2016). (MO, MO), followed by adjusting the solution to the total volume with ReNu® multifunctional solution. The pH of the resulting solution is between about 7.1 to 7.3 (if necessary, it can be adjusted with an appropriate amount of hydrogen acid or sodium oxide) The pH of the solution is shown in Table I). The final product has the composition shown in Table I below. ----- ^ --- ^ ---- ^ ---:-~ lir (Please read first (Notes on the back, please fill in this page) Polyhexamethylene biguanide HC1 (purchased from ICI Chemicals Cosmocil CQ as a 20% w / w solution. 0.00047 Boric acid 0.64 Sodium borate 0.12 Disodium ethylenediamine tetraacetate 0.11 Sodium gasification 0.49 Promine (Tetronic® 1107 purchased from BASF Company) 1.00 Tetrasodium salt of hydroxyethylene diphosphonic acid (purchased from Monsanto as a 30% (w / w) solution under the DeQuest® 2016 trademark) 0.10 Hydrochloric acid, 1N If needed for pH adjustment Sodium oxide, 1N If required For adjusting the pH of pure water to 100 -19- This paper size is applicable to China National Standard (CMS) A4 (210X25 »7mm) 45 56 2 8 a7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Description of the invention (17) Example 2 In order to further illustrate the present invention, several soft hydrogel contact lenses (FDA, class III, bufilcon A, 45% water contact lenses) were coated with protein deposits, followed by several tests Treatment with one of the solutions (as shown in Table I above, but containing various amounts of the DeQuest® 2016 compound). These contact lenses were then compared with contact lenses treated with a control solution consisting of ReNu® MSP and ReNu® single-step enzyme tablets. Contact lenses were treated with the following in vitro protein deposition procedure. An electrolytic electrolyte solution was prepared, which was composed of about 0.70% sodium gaseous, 0.17% potassium chloride, 0.22% sodium bicarbonate, and 0.0005% calcium carbonate dihydrate. An electrolyte solution is prepared by adding vapors and carbonates to about 90% of the total volume of the desired distilled water, followed by sufficient mixing of the solutions. Measure pH JL if necessary. Adjust to 7.2 ± 0.1 with 1N HC1 or IN NaOH. The osmotic pressure of the solution is between 280 and 320 mOsm / kg. Next, an approximate amount of protein was added to the electrolyte solution, so that the lysozyme concentration of the solution was 0.10%. The resulting solution was mixed at a moderate speed for about 30 minutes and the pH was measured (adjusted to IN HC1 or IN NaOH to 7.2 ± 0.1 if necessary). A borate buffered common salt solution including about 0.85% boric acid, 0.09% sodium borate, and 0.45% sodium chloride was also prepared, and the pH was measured (and adjusted to IN HC1 or IN NaOH to 7.2 ± 0.1 if necessary). The osmotic pressure of the solution is between 280 and 320 mOsm / kg. Protein deposits were deposited on several soft hydrogel lenses by placing each contact lens in a glass vial and then immersing the lens in about 5 ml of an electrolyte (containing protein) solution. Then, the vial was sealed and shaken at 40 rpms in a hot water bath at about 80 ° C for about 20 minutes, and then the lens was cooled to normal temperature, and then the Chinese national standard (CN'S > A4 specification (CN4) ( 210X297 mm) I ~ I fc II. I ΊI I ϋ ^ • ·-. (Read the precautions on the back before filling in this page) ab b6 2 8 Printed by the Consumer Cooperatives of the Central Interpretation Bureau of the Ministry of Economic Affairs A7 Fifth, Description of the invention (18)-;--The lens buffered saline solution gently scrubs the lens to remove any loose binding protein. After the protein is accumulated, the lens is treated with the target solution or control group solution. The treatment of the solution is to drop a few drops of test solution on both sides of the lens', then scrub the lens for about 2G seconds, then rinse the lens with the test solution and soak it in β 5 ml test solution for 4 hours, and then the lens is buffered with salt by rotten salt The treatment of the control solution is to place a few drops of ReNu® MPS on both sides of the lens and then scrub the lens for about 20 seconds. Then, the lens is washed with fresh ReNu® MPS; 〇mL⑧MPS Approximately 4 hours. The lenses are then scrubbed and rinsed with fresh ReNu® Mps, and finally rinsed with borate buffered saline. Following the above treatment, the lenses are evaluated using microscope imaging analysis to determine the amount of protein removed after the treatment. Microscopic imaging analysis This is a digital image of the lens and analysis of surface debris with grayscale analysis. This procedure involves placing each lens under a microscope with a "dark field" background and then passing light through the lens. Surface debris on the lens will Scatter the light and show a larger area than a clean surface of a contact lens. Obtain a digital photo of the luminescent lens and use} ^ 1 {1 Imaging V, 1.46 software (National Health Care Association) to calculate / separate pixels based on their light intensity. Use The gray scale quantitative coverage of 0-255 covers 値 824 pixels in the circle diagram of the lens. 0 値 is defined as " white " and 255 値 is defined as " black, " (due to the scattered light from the deposits, it is brighter. "値" means _the less clean the surface). The percentage difference before and after 'recording the average (average density) of such 値' before and after the treatment of each group (0 lenses each). The higher the percentage change in the density of protein, the more the protein is removed. Compare the density of the lens treated with the test solution to the positive _______- 21- This paper size applies to China National Standards (CNS) with specifications < 2 丨 〇X297 Liyi ------- (Read the notes on the back first and then fill out this page)

56 2 8 A7 B7 V. Description of the invention (19) The density of the lens treated with the solution of the control group is 値. From these data, the relative protein removal of each lens was determined. The evaluation results are listed in Table II, where the relative protein removal in Table II indicates the percentage change in pixel density when compared to the control solution. --------- t --- ^ --------- ^-. ·-(锖 Please read the notes on the back before filling in this I) Cooperative printing is implemented based on data collected from the 10 lenses processed in the same way. As the data cited in Table II shows, taking the average of each concentration, the target solution and method for treating lenses can provide protein removal compared to the control solution (including the use of enzyme cleaning), although its activity at lower concentrations reduce. In addition to providing excellent cleaning, the target solution also provides a disinfecting effect comparable to that of the control group. -twenty two-

Table II% change in pixel density of the example number relative to the control group (control group = 100%) 1 (0.01% DeQuest® 2016) 82% 2 (0.01% DeQuest® 2016) 59% 3 (0.01% DeQuest® 2016) 0.0 % 4 (0.05% DeQuest® 2016) 83% 5 (0.05% DeQuest® 2016) 76% 6 (0.10% DeQuest® 2016) 76% 7 (0.10% DeQuest® 2016) 91% 8 (0.10% DeQuest® 2016) 133 % 9 (0.25% DeQuest® 2016) 79% 10 (0.25% DeQuest® 2016) 167% This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 455628 A7 _________B7 V. Description of the Invention (20) Example 3 This example further illustrates the present invention and tests the ability of other phosphonic acid compounds to avoid or remove protein deposits on lenses. Using the in vitro protein deposition procedure described in Example 2, the soft hydrogel lens (FDA, Class I, bufilccm A) was used for protein deposition, and then treated with various test solutions similar to the solutions in Table 1 above, but the solution contained Various amounts of various instant acid compounds. After the protein is deposited, the lenses are treated with the target solution or the positive control solution (comparative), which is also composed of ReNu® 1 ^? $ And 1 ^ 1 ^ 11® single-step enzyme tablets and subtilisin, sodium carbonate, Composed of vaporized sodium and boric acid. After this treatment ', the lens was evaluated using microscope imaging analysis to determine the amount of protein removed after the treatment. As described above, the microscope imaging analysis system digitally photographs the lenses and analyzes the surface debris with gray-scale imaging analysis, in which each lens is placed under a microscope with a "dark area" background and the incident light passes through the lens to obtain light emission. The lenses are digitally developed and pixels are calculated / separated based on their light intensity. Comparison of the density of lenses treated with the test solution with lenses treated with the front control solution is shown in Table III, which shows the percentage change in pixel density. The table shows (1) the percentage change in pixel density using a target solution containing a given phosphonic acid compound, (2) the percentage change in pixel density using a comparison enzyme solution, and the last stop, (3) comparing (1) to (2 ) Relative percentage change in pixel density. The compounds in Table III are manifested by test results that meet at least one of the following two criteria:-Protein removal activity. (1) exhibit a relative percentage change of approximately 80% or greater, and / or (2) exhibit Compounds vary by more than 15%. The percentage change in the negative control group (ReNu® MPS solution) averaged approximately 15%. 23- The size of this paper is applicable to China National Standard for Ladder (CNS) A4 (210X; 297 mm) " --- ----- ^ --- ^ ---- installation ------ order- ----- Ice '*: / (Please read the notes on the back before filling in this card) 4 5 56 2 8 A7

B. V. Description of the invention (21) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs. Table III. Test No. Lepidic acid compound Wt.% (W / v). Change in the compound from the compound.% Change in the enzyme. Relative change% 1 1-Hydroxyethylene-1,1-diphosphonic acid tetra nano salt 0.075 10 6 167 2 Methylene diphosphonic acid trisodium salt tetra-permanganate 0.10 10 6 167 3 2-methylbenzylphosphonic acid 0.10 27 18 150 4 1-Hydroxyethylidene-1,1-diphosphonic acid tetra sodium salt 0.030 8 6 133 5 Trimethylene diphosphonic acid trisodium salt tetrahydrate 0.01 8 6 133 6 2-aminoethylphosphonic acid 0.10 23 19 121 7 2-Aminoethylphosphonic acid 0.01 23 19 121 8 2-Methylphosphonophosphonic acid 0.10 53 58 91 9 1-Hydroxyethylidene-1,1-diphosphonic acid tetra nano salt 0.030 30 JJ 91 10 1-Hydroxyethylidene-1,1-bisphosphonic acid tetra sodium salt 0.015 5 6 83 11 1-Hydroxyethylene-1,1-bisphosphonic acid tetra nano salt 0.003 27 33 82 12 Aminomethanephosphonic acid 0.10 26 32 81 13 (4-Aminophosphono) phosphonic acid 0.10 26 39 67 14 Phosphonoacetic acid 0.01 24 37 65 15 DL-2-Amino-4-phosphinophosphonic acid 0.10 18 28 64 16 n-decylphosphonic acid 0.10 20 32 63 17 phosphonium acetic acid 0.10 23 37 62 18 fluorenyl fluorene 0.10 19 31 61 -24- I ----- ^ ----- Loading ------- Order ------ Ice- 4 '' (Please read the precautions on the back before filling (This page) The paper's specifications apply to China National Standards (CNS) A4 (210 X 297 mm) 45562 8 Λ7 B7 Five 'invention description (22) Test number Phosphonic acid compound Wt_% (w / v) Compound to compound % Of change 1 *-Relative change of enzyme% relative change of control group 19 1-Hydroxyethylene-1,1-diphosphonic acid tetra sodium salt 0.003 20 34 59 20 2-Phosphinothiopropionic acid 0.10 18 31 58 21 4-Phosphonobutyric acid — * ------_ 0.10 17 31 55 22 Hexamethylenediamine tetra (methylenephosphonic acid) six bell salt 0.10 ~~ '27 53 51 23 Propanoic acid 0.10 14 28 50 24 Aminomethanephosphonic acid 0.10 14 32 44 25 2-Phosphonic acid butyric acid ------- 0.10 ~ ----. 0.10 11 31 35 26 Diethylene glycol triamine penta (methylene Phosphonic acid) hexananosalt 18 53 34 27 methylene bisphosphonic acid 0.10 10 31 32 28 3-scale brewing propionic acid --------- 0.10 ------ 8 28 29 ------- ----- Equipment --- ^ ---- j Order ------ Yong (please read the precautions on the back before filling in this page) Staff Consumption of Central Bureau of Standards, Ministry of Economic Affairs All compounds in the table printed by the cooperative are commercially available. For example, compounds…, 9, 10, 11 and 19 were purchased from Monsanto Company ”(Louis); Compounds 2, 5 and 13 were manufactured by Company B (Wisconsin) , 8, 12, and 24 # Special company (Pennsylvania Γ; compounds 14, 17 and 23 were purchased from Sigma Chemical Company (St. Louis); and compounds 20, 21, 25, 27 and 28 were purchased from oak Research Chemical Company (South Carolina). According to the data in Table Π !, the target solution containing phosphonic acid compounds and its treatments are applicable to the standard of the National Solid State (^ Π ^ 72; χ297 公 455455628 A7 B7) The method of eyeglasses, in at least one test score, the noodle " group provides better protein removal. The selected or better compound provides ^ compared with or even more than the positive control solution using an enzyme cleaning agent Best protein removal. I --- ^ --- ^ ----- pack --- ^ ---: 丨 order ------ 沭-.;. (Please read the note on the back before (Fill in this page) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 26- This paper size applies to Chinese national standards (CNS > A4 size (2IOX297 mm)

Claims (1)

4 5 b 6 2 8:, Field Ϊ 3 Qin Nian ~ Li H patent application 0 patent Fanyuan ^ original (87 ¥ September) A8 B8 Cg D8 — supplementary 87. 『3 · Γ 之 Handling of contact lenses A non-oxidizing method comprising contacting a contact lens with an ophthalmologically safe aqueous solution containing the following formula: phosphonic acid or a physiologically compatible salt thereof: Z— 〇d (where Z is a linking group having a valence equal to η, where η is an integer of 1 to 6 and Z contains 1 to 12 carbon atoms' and wherein the ζ group is selected from a substituted or unsubstituted saturated nicotyl group or a group containing An amine-based group, the amine-containing group is a saturated hydrocarbon group in which a carbon atom is inserted by at least one gas atom to form a secondary or tertiary amine, and the amine-containing group has at least η + ι carbon atoms, and the substituted The saturated hydrocarbyl group may be substituted by a group selected from the group consisting of a functional group, a hydroxyl group, an amino group, a carboxyl group, an alkoxycarbonyl group, an alkoxycarbonyl group, and / or a substituted or unsubstituted epitope, and the substituted phenyl group may be 'Hydroxy, amine', dialkyl, alkanoyl, and / or alkyl substitutions, where the alkyl or alkoxy group contains 1 to 4 carbon atoms. -2. Used to deal with invisibility according to item 1 of the scope of patent application The non-oxidizing method of eyeglasses includes contacting an ophthalmically safe aqueous solution containing a phosphonic acid compound represented by the following formula with contact lenses: (Please read the precautions on the back before filling in the clothing page) Yindong X2, Consumer Cooperative of Employees, Central Standards Bureau (CH,) ·, — 0H X '— (CH,) — C-CCH,) — P-OH (CH,) d X3 Μ > This paper size uses Chinese National Standard (CNS) M specifications (210x297 public epidemic) 0Β2 8 Α8 Β8 C8 'Scope of patent application ~ where a' b 'c and d are each selected from integers of 0 to 4; X1 Is a phosphonic acid group, a hydroxyl group, an amine group, or hydrogen; and X2 and χ3 are respectively selected from the group consisting of a prime, a hydroxyl group, an amino group, a carboxyl group, an alkoxycarbonyl group, an alkoxycarbonyl group, or a substituted or unsubstituted phenyl group and a methyl group. Group; wherein the substituent on the phenyl group is one or more halogen, hydroxyl, amine, carboxyl and / or alkyl group, and wherein the alkyl group and alkoxy group contain 1 to 4 carbon atoms. A non-oxidizing method for treating contact lenses includes contacting a contact lens with an aqueous solution containing a phosphonic acid compound represented by the following formula and a physiologically compatible salt of the phosphonic acid compound: OH this H2) b H2O3P- (CH2) a—C— (CH2) c—P〇3H2 (b) d CH3 where a′b′c and d are each selected from integers of 0 to 4 = -4 · Method according to item i of the scope of patent application Where Z contains! to! 〇 carbon atoms. ^ Method according to item 2 or 3 of the scope of patent application, where a, b, c and d are all 0. • The method according to item 1, 2 or 3 of the scope of patent application, which further includes an antimicrobial agent 7_ The method according to item 6, scope of the patent application, wherein the antimicrobial agent is selected from the group consisting of polymerized biguanide, biguanide, polymerized Quaternary ammonium compound and its salt institute-2- This paper is correct from CNS (21 () > < 297 male thin) (Please read the precautions on the back before filling in this tribute)- ---- * Order "!-Printed by the Consumers' Cooperative of the Central Ministry of Economic Affairs of the Ministry of Economic Affairs, printed by the Consumers ’Cooperative of the Central Bureau of Economics, Ministry of Economic Affairs; 〇 Ο 2 8 Α8 Ββ C8 DL · _____ VI. Scope of Patent Application _ Composition Group. 8. The method according to item i, 2 or 3 of the patent application park, where the solution ρ Η is 6 to 8 and the permeability is between 250 and 350 mOsm / kg = 9. According to the scope of patent application No. 1, 2 or The method of 3 items, including the steps of scrubbing the contact lens with the solution, and then immersing the contact lens with the solution. 10.-A method for treating contact lenses with a buffer pH of 5 to 8 and an osmotic pressure of 200 to 450 mOsm / kg.眼科 安全 # An oxidizing aqueous solution, including a phosphonic acid compound represented by the following formula: 1? 1 \ Z— P—OH \ 〇H / 11 〇〇 {Where Z is a linking group with a valence equal to η, where η is 1 to An integer of 6 and Z containing 1 to 12 carbon atoms, and wherein the Z group is selected from a substituted or unsubstituted saturated hydrocarbon group or an amine-containing group, wherein the amine-containing group is formed by the insertion of a carbon atom by at least one nitrogen atom A saturated hydrocarbon group of a secondary or tertiary amine, and the number of broken atoms of the amine-containing group is at least η + 1, wherein the substituted saturated hydrocarbon group may be selected from the group consisting of a prime, a hydroxyl group, an amine group, a few groups, and a storage group. Substituted with oxocarbonyl and / or substituted or unsubstituted phenyl groups, and Substituted by halogen, hydroxyl, amine, carboxy'alkylcarbonyl and / or alkyl, wherein the alkyl or alkyl group contains 1 to 4 carbon atoms, and an effective amount of at least one non-oxidizing antimicrobial contact lens Treat the solution. -3- The paper size is in accordance with China National Standards (CNS) Α4 size (210X297mm) '~ (Please read the precautions on the back before filling this page) »-Order! 8 2 6 5 5 Δ 8 8 8 0 ^ ABCD VI. Application scope of patent 11_According to item 10 of the scope of patent application, a non-oxidizing aqueous solution with a pH of 6 to 8 for treating contact lenses, including phosphine shown in the following formula Acid compound:] χ Η ο Η -ο——pnuo IC -c ·-(ςX ί I -a CCI A where a, b, c and d are each selected from integers of 0 to 4; χΐ is a phosphonic acid group, Via an amino group or hydrogen; and X2 and X3 are respectively selected from the group consisting of a prime group, a light group, an amine group, a carboxyl group, an alkyl group, an alkoxy group, a substituted or unsubstituted phenyl group, and a methyl group; Group; wherein the substituent on the phenyl group is one or more halogens, hydroxyl groups, amine groups, and / or polyl groups, and wherein the alkyl and alkoxy groups contain 1 to 4 carbon atoms 3] 2. — Species The non-oxidizing aqueous solution used to handle contact lenses includes the phosphonic acid compound and the physiologically compatible salts of the phosphonic acid compound as shown in the following formula: (Please read the precautions of the back first and fill in the book.) Order by the Ministry of Economic Affairs Standards of Employees' Cooperatives of Standards Bureau 〇 隼 (iH2) b H2O3P— (CH2) a—i — (CH2) c—PO3H2 (iH2) d where a, b, c, and d are each selected from the integers of 0 to 4. Numbers, and advancement ~ step package -4- The paper scale is applicable to the Chinese National Standard (CNS) Α4 specifications (21〇 > < 297 public directors) 455628 Printed by A8 B8 CS of the Central Labor Bureau of the Ministry of Economic Affairs Scope of patent application_ Including the disinfection amount of fungicides selected from the group consisting of biguanide and polymerized quaternary ammonium and its salts. U Solutions according to item 11 or 12 of the scope of patent application, where a, b, C and d is 0 3 14. The solution according to item 10, 11 or 12 of the scope of the patent application, wherein the concentration of the phosphonic acid compound is at least 0.003% by weight volume. 15. According to item 10 or 11 of the scope of patent application A solution in which the osmotic pressure is between 25 and 3 50 mOsm / kg and the antimicrobial agent is selected from the group consisting of biguanide and polymerized quaternary salt. 16. A non-functional solution for cleaning and disinfecting contact lenses An oxidation method comprising: (a) contacting a contact lens with an ophthalmologically safe solution containing at least one phosphonic acid compound or a physiologically compatible salt thereof in an amount of 0.005 to 1.0% by weight, wherein the compound has at least one phosphonic acid group and contains 1 to 12 carbon atoms: and (b) The treated contact lens is placed in the eye of the wearer. _ 17 'A method for disinfecting or cleaning and disinfecting soft contact lenses with a multifunctional solution, the method includes: (a) immersing the contact lens in an ophthalmic safety solution, In the shortest recommended immersion time to obtain sterilizable contact lenses, the solution formula contains the following ingredients: (i) 0.005 to 1.0% by weight of at least one phosphonic acid compound or a physiologically compatible salt thereof, the compound having at least An acidic group containing 1 to 12 carbon atoms, -5- This paper-shaped Αϋ uses a paper towel (CNS) margin (2! Gx2 "centimeter) ~ --- f Please read the note on the back first Recurve this page)-I ·! 8 2 5 5 Ο 8 8 8 ^ ABCD VI. Patent application scope (ii) effective amount of surfactant, (iii) effective amount of non-oxidizing microbicide, and (iv) effective amounts of buffering and isotonicity agents, and (b) placing the treated contact lenses directly in the wearer's eyes, so no need to rinse with different solutions and no other jellyfish before placing in the eyes Daily cleaning of contact lenses 3 18. According to patent application scope No. 1 6 17. The method according to item 17, wherein the solution is used for cleaning from 0.0 to 5 mol% of repeating units derived from methacrylic acid (MAA), and 10 to 99 mol% of hydroxyethyl methacrylate is derived. Contact lenses made from repeating units and polymers with 0.5 to 5 mole% cross-linked repeating units, and wherein the contact lenses are expected or set to be worn for no more than 14 days Method 6 or 丨 7 'This method can provide complete cleaning of contact lenses and thus eliminate the enzyme cleaning of contact lenses 3 20. Method according to item 6 or 17 of the patent application park' where the phosphonic acid compound contains a Or more hydroxyl and / or amine groups. (Please read the notes on the back before filling out this page) / Λ The paper size printed by the Employees' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is applicable to China's national standards (CNS > Human Resources (2 〖0 × 297mm) f ^ m 6.2? The application date is 86.3.17. Case No. 86103303 Category — each network is to be filled by this bureau) Λ4 C4 455G28 Chinese Manual Correction Page (June 89) Invention of Sword Works 1 、 Person in the Invention || Patent Instructions Chinese noon, a non-oxidizing method for cleaning contact lenses with an aqueous solution containing a phosphonic acid compound and its cleaning water-based solution English CONTACT LENSES WITH AQUEOUS SOLUTION INCLUDING PHOSPHONIC COMPOUNDS AND CLEANING AQUEOUS SOLUTION THEREOF Name 1. Wanda G. Richard 2. David J. Heller has a U.S. residence and domicile 1 279 Stonehenge Avenue, Fort Phillip, New Jersey, USA 2. 173 Wazworth Street, Avon, New York, USA Bausch & Lomb Company of the United States of America J American residence, domicile (crowded office), United States, New York, Rochester, Chiss Square, No. 54 mailbox representative name ! \ i J Stefan Ai Silang-1-1 (r \ S 'ί->! [) >: 1 ~ 1—1 Gutter 455628 No. S6103303 Patent Application Chinese Specification Correction Page (87 September 1997) Α7 Β7- 3 .L -Xuan * ^ will be announced next year (eg " USP 5,096,607 approved on March 17th, 2015) reveals a cleaning and disinfection system, in which the presence of enzyme tablets under certain osmotic conditions Immerse contact lenses in a multi-purpose solution while cleaning and disinfecting lenses. This system provides the benefit of a single "EJ" cleaning and disinfecting solution, which can be used in combination with enzyme-based cleaners, thereby reducing effective cleaning and Number of steps required to disinfect contact lenses. Although the latter patent provides more important improvements in cleaning contact lenses than previous systems, it still seeks more convenient methods. More specifically, it is still desirable to provide a single solution without the need for A cleaning system supplemented with an enzyme cleaning agent, which can provide a cleaning power comparable to a system using an enzyme cleaning agent. ^ SUMMARY OF THE INVENTION The present invention includes a non-chemical method for treating contact lenses and its method. Composition. The present invention comprises contacting a contact lens with an aqueous solution containing a phosphonic acid or a physiologically compatible salt of the formula: (Please read the notes on the back before filling in this page) Order printed by the Employees' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, where Z is the linking group whose price is equal to η, where η is 1 to 6, preferably Z contains I to 1 2 carbon atoms. The z group may include, for example, a substituted or unsubstituted saturated hydrocarbon group or an amine-containing group = "substituted or unsubstituted, meaning unsubstituted or mesogen, hydroxyl, amino, carboxyl, alkylcarbonyl, alkoxycarbonyl, or Substituted or unsubstituted -Q-The size of the paper method is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 丨 Amendment as A7 B7- 4 5 56 2 8 No. 303 Cheli application fr amendment page (9 of 1987) Month) 5. Description of the invention / I! \ Z— P—OH \ 〇H / / n (I) where Z is a linking group having a valence equal to n, where n is 1 to 6, preferably J to 3, and Preferably, Z contains 1 to 12 carbon atoms, more preferably 1 to 10 carbon atoms. The 2 group includes a substituted or unsubstituted saturated hydrocarbon group or an amine-containing group, wherein the amine-containing group is one in which the Angstrom atom is replaced by at least one nitrogen atom. Preferably, 1 to 3 nitrogens are inserted to form a saturated hydrocarbon group a of a secondary or tertiary amine. When 2 is an amine-containing group including one or more secondary or tertiary amines, the number of carbon atoms in Z is at least Is n + 1. Hydrocarbyl means "branched, unbranched, non-cyclic or cyclic moiety consisting of carbon and hydrogen atoms, substituted or unsubstituted" means unsubstituted Substituted by a prime, a radical, an amine, a tertiary group, an alkoxy group, an alkoxycarbonyl group, or a substituted or unsubstituted phenyl group, wherein the substituent on the phenyl group may be a pixel, a hydroxyl group, an amine group, a carboxyl group, or an alkane group. A carbonyl or alkyl group, wherein the alkyl or alkoxy group contains from 1 to 4 carbon atoms. The preferred element is gas, and the preferred substituents are amine, hydroxy, and substituted or unsubstituted phenyl. Accordingly, suitable Z groups include substituted or unsubstituted forked alkyl groups, substituted or unsubstituted alkylene groups, amine tris (alkylene groups) having at least η + 1 carbon atom, and having at least η + 1 Carbon atom amine di (alkylene), alkylene diamine tetra (alkylene) or dialkylene triamine penta (alkylene), in which each alkylene group is connected to a phosphonic acid group . Preferably, all the alkylene groups each contain from 1 to 4 carbon atoms. Examples of compounds in which the Z group is amine tri (alkylene) include amine tri (ethylene-8- _____________ This paper size uses China National Standards (CNS) A4 Specification (2 丨 0 > < 297 mm> (Read the notes on the back of Min Min before you fill out this page)-Ordered by the Central Bureau of Standards of the Ministry of Economic Affairs of the People's Republic of China for consumption cooperation; 1 2 Form Trout 4 5 56 2 8: m ^ 86103303_ Patent Application ---- —Φ to say it belongs to the 4½ front page (January 89) Α5 Β5 四 'Chinese Abstract (the name of the invention: a non-oxidizing method for cleaning contact lenses with an aqueous solution containing a phosphonic acid compound) and a cleaning aqueous solution thereof A non-oxidizing method for treating contact lenses and a composition thereof. The present invention includes contacting an aqueous solution including a phosphonic acid compound with a contact lens. In a preferred embodiment of the present invention, the subject phosphonic acid compound is used in combination with an antimicrobial for simultaneous use Disinfect and clean contact lenses, including avoiding or removing protein deposits. I ^^ 1— ^^^ 1 f — m · (Please read the notes on the back before filling in the columns on this page) English Abstract of Invention (Name of the Invention: ec) N TACT LENSES w 丨 τή Agurous soujt 丨 on INCLUDING PHOSPHONIC COMPOUNDS AND CLEANING AQUEOUS SOLUTION THEREOF IT includes contacting a lens with an aqueous solution comprising a phosphonic acid compound. In preferred alternative examples of the invention, the subject phosphonic compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein deposits. -2- This paper is long and applicable to China's National Standards (CNS) A4 specification (210X297 mm) Line 4 5 b 6 2 8:, Field Ϊ 3 Qin Nian ~ Li H patent application 0 patent fan garden ^ original ( (87 ¥ September) A8 B8 Cg D8 — Supplement 87. "3 · Γ 之 Non-oxidizing method for treating contact lenses, including contact lenses and ophthalmologically safe aqueous solution containing the following formula of phosphonic acid or its physiologically compatible salt Pick up Touch: Z— 〇d (where Z is a linking group having a valence equal to η, where η is an integer of 1 to 6 and Z contains 1 to 12 carbon atoms' and wherein the ζ group is selected from a substituted or unsubstituted saturated nicotyl group or a group containing An amine-based group, the amine-containing group is a saturated hydrocarbon group in which a carbon atom is inserted by at least one gas atom to form a secondary or tertiary amine, and the amine-containing group has at least η + ι carbon atoms, and the substituted The saturated hydrocarbyl group may be substituted by a group selected from the group consisting of a functional group, a hydroxyl group, an amino group, a carboxyl group, an alkoxycarbonyl group, an alkoxycarbonyl group, and / or a substituted or unsubstituted epitope, and the substituted phenyl group may be 'Hydroxy, amine', dialkyl, alkanoyl, and / or alkyl substitutions, where the alkyl or alkoxy group contains 1 to 4 carbon atoms. -2. Used to deal with invisibility according to item 1 of the scope of patent application The non-oxidizing method of eyeglasses includes contacting an ophthalmically safe aqueous solution containing a phosphonic acid compound represented by the following formula with contact lenses: (Please read the precautions on the back before filling in the clothing page) Yindong X2, Consumer Cooperative of Employees, Central Standards Bureau, Ministry of Economic Affairs (CH,) ·, — 0H X '— (CH,) — C-CCH,) — P-OH (CH,) d X3 Μ > This paper size uses China National Standard (CNS) M specifications (210x297 public epidemic)