TW200808361A - RNAi-mediated inhibition of histamine receptor H1-related conditions - Google Patents

RNAi-mediated inhibition of histamine receptor H1-related conditions Download PDF

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Publication number
TW200808361A
TW200808361A TW096112906A TW96112906A TW200808361A TW 200808361 A TW200808361 A TW 200808361A TW 096112906 A TW096112906 A TW 096112906A TW 96112906 A TW96112906 A TW 96112906A TW 200808361 A TW200808361 A TW 200808361A
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Taiwan
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identification number
sequence identification
sequence
nucleotides
mrna
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TW096112906A
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English (en)
Chinese (zh)
Inventor
John M Yanni
Jon E Chatterton
Daniel A Gamache
Steven T Miller
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Alcon Mfg Ltd
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Publication of TW200808361A publication Critical patent/TW200808361A/zh

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW096112906A 2006-04-13 2007-04-12 RNAi-mediated inhibition of histamine receptor H1-related conditions TW200808361A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79162306P 2006-04-13 2006-04-13

Publications (1)

Publication Number Publication Date
TW200808361A true TW200808361A (en) 2008-02-16

Family

ID=38610324

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096112906A TW200808361A (en) 2006-04-13 2007-04-12 RNAi-mediated inhibition of histamine receptor H1-related conditions

Country Status (6)

Country Link
US (5) US8017592B2 (cg-RX-API-DMAC7.html)
EP (2) EP2674493B1 (cg-RX-API-DMAC7.html)
JP (1) JP5473594B2 (cg-RX-API-DMAC7.html)
AR (1) AR060449A1 (cg-RX-API-DMAC7.html)
TW (1) TW200808361A (cg-RX-API-DMAC7.html)
WO (1) WO2007121156A2 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2674493B1 (en) 2006-04-13 2017-12-27 Arrowhead Research Corporation RNAi-mediated inhibition of histamine receptor H1-related conditions
US10787664B2 (en) * 2015-05-26 2020-09-29 City Of Hope Compounds of chemically modified oligonucleotides and methods of use thereof
MX392754B (es) * 2016-05-09 2025-03-24 Biogaia Ab Seleccion de cepas bacterianas utiles en el tratamiento de la alergia.
CN113604557A (zh) * 2021-08-04 2021-11-05 杭州浙大迪迅生物基因工程有限公司 一种人组胺受体HRH1 mRNA检测引物探针组、试剂盒和应用
US20240158856A1 (en) * 2021-08-04 2024-05-16 Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd Primer probe set for human histamine receptor hrh1 mrna detection, kit and detection method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8090542B2 (en) * 2002-11-14 2012-01-03 Dharmacon Inc. Functional and hyperfunctional siRNA
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
AU2003224132A1 (en) * 2003-04-24 2004-11-19 Galapagos Genomics N.V. Effective sirna knock-down constructs
EP1648997A2 (en) * 2003-07-11 2006-04-26 Oregon Health and Science University Methods of treatment and disgnosis using modulators of virus-induced cellular gene sequences
JPWO2005028667A1 (ja) * 2003-09-19 2006-11-30 独立行政法人理化学研究所 ヒト肥満細胞で発現するg蛋白質共役型受容体を標的とした薬剤およびそのスクリーニング方法
CN101052717A (zh) * 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
US20070213286A1 (en) * 2005-09-12 2007-09-13 The Trustees Of Columbia University In The City Of New York Inhibitors of dynein or lissencephaly 1, and methods of using same for treatment of neuronal disorders
EP2674493B1 (en) * 2006-04-13 2017-12-27 Arrowhead Research Corporation RNAi-mediated inhibition of histamine receptor H1-related conditions

Also Published As

Publication number Publication date
WO2007121156A8 (en) 2011-05-19
JP2009533466A (ja) 2009-09-17
US8222227B2 (en) 2012-07-17
EP2003971A4 (en) 2010-10-27
US9206428B2 (en) 2015-12-08
US8017592B2 (en) 2011-09-13
US20110269822A1 (en) 2011-11-03
US8618278B2 (en) 2013-12-31
US20090274631A1 (en) 2009-11-05
US9745585B2 (en) 2017-08-29
AR060449A1 (es) 2008-06-18
EP2674493A1 (en) 2013-12-18
WO2007121156A2 (en) 2007-10-25
US20120264809A1 (en) 2012-10-18
EP2003971A2 (en) 2008-12-24
WO2007121156A3 (en) 2008-11-06
US20140088172A1 (en) 2014-03-27
JP5473594B2 (ja) 2014-04-16
US20160053270A1 (en) 2016-02-25
EP2674493B1 (en) 2017-12-27

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