TW200808360A - RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions - Google Patents
RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions Download PDFInfo
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Classifications
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C07—ORGANIC CHEMISTRY
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Dermatology (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| TW102118618A TW201336514A (zh) | 2006-04-13 | 2007-04-12 | ＲＮＡ干擾（ＲＮＡｉ）所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用（二） |
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| WO2009046059A1 (en) * | 2007-10-01 | 2009-04-09 | Alcon Research, Ltd. | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
| US20110123637A1 (en) * | 2008-05-26 | 2011-05-26 | Universitat Zurich | Protamine/rna nanoparticles for immunostimulation |
| AU2009330458B2 (en) * | 2008-12-22 | 2013-08-22 | Otonomy, Inc. | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| EP2865758A1 (en) * | 2013-10-22 | 2015-04-29 | Sylentis, S.A.U. | siRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene |
| CN104805085A (zh) | 2014-01-29 | 2015-07-29 | 江苏命码生物科技有限公司 | 串联表达的siRNA及其在治疗慢性淋巴细胞白血病中的应用 |
| SG11201705312PA (en) * | 2014-12-29 | 2017-07-28 | Bonac Corp | Composition containing nucleic acid molecule stably |
| US10888391B2 (en) | 2015-05-29 | 2021-01-12 | Ablacon Inc | Optical force sensing assembly for an elongated medical device |
| CA3002786C (en) | 2015-10-30 | 2021-09-07 | Bonac Corporation | Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-.beta.1 gene |
| BR102018001541B1 (pt) | 2018-01-24 | 2021-05-11 | Universidade Federal Do Rio Grande Do Sul | composição farmacêutica nanométrica na forma de lipossomas ou nanoemulsão que contém sequências específicas de rna de interferência |
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| US5360720A (en) | 1993-10-08 | 1994-11-01 | Alcon Laboratories, Inc. | Method of preparing human conjunctival mast cells for mast cell stabilization assays |
| US5545626A (en) * | 1994-01-19 | 1996-08-13 | The Trustees Of Columbia University In The City Of New York | Method of treating glaucoma with oligonucleotides |
| JPH11507824A (ja) * | 1995-06-07 | 1999-07-13 | ユニバーシティー・オブ・ペンシルバニア | 食作用を阻害する方法 |
| CA2526831C (en) * | 2001-05-18 | 2012-07-31 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) |
| US20050227935A1 (en) * | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA) |
| JP4649331B2 (ja) * | 2002-10-01 | 2011-03-09 | エピゲノミクス アーゲー | 乳房細胞増殖障害の改良治療方法および核酸 |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| CN101914532A (zh) * | 2002-11-22 | 2010-12-15 | 生物智囊团株式会社 | Rna干扰的目标碱基序列的搜索方法 |
| AU2003224132A1 (en) * | 2003-04-24 | 2004-11-19 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| EP2371835A1 (en) * | 2003-07-03 | 2011-10-05 | The Trustees Of The University Of Pennsylvania | Inhibition of syk kinase expression |
| CA2546074A1 (en) * | 2003-11-14 | 2005-06-02 | Yale University | Syk-targeted nucleic acid interference |
| GB0404209D0 (en) | 2004-02-25 | 2004-03-31 | Uws Ventures Ltd | Materials and methods for treatment of allergic disease |
| WO2005085443A2 (en) * | 2004-03-01 | 2005-09-15 | Massachusetts Institute Of Technology | Rnai-based therapeutics for allergic rhinitis and asthma |
| EP1904649A2 (en) | 2005-07-18 | 2008-04-02 | Epigenomics AG | Compositions and methods for cancer diagnostics comprising pan-cancer markers |
| WO2007070872A1 (en) * | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| TW200916117A (en) | 2007-08-03 | 2009-04-16 | Alcon Res Ltd | RNAi-related inhibition of TNF α signaling pathway for treatment of ocular angiogenesis |
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| EP2662446A3 (en) | 2014-04-02 |
| CN101972483A (zh) | 2011-02-16 |
| BRPI0709506A2 (pt) | 2011-07-19 |
| CN101443020A (zh) | 2009-05-27 |
| WO2007121347A3 (en) | 2008-12-04 |
| EP3156486A2 (en) | 2017-04-19 |
| US20140357695A1 (en) | 2014-12-04 |
| US20110288157A1 (en) | 2011-11-24 |
| TW201336514A (zh) | 2013-09-16 |
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| EP2004240A2 (en) | 2008-12-24 |
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| CA2649138A1 (en) | 2007-10-25 |
| KR20080110900A (ko) | 2008-12-19 |
| EP2004240A4 (en) | 2010-12-15 |
| US8865671B2 (en) | 2014-10-21 |
| AU2013207601B2 (en) | 2016-11-17 |
| AU2007238027B2 (en) | 2013-08-15 |
| MX2008013068A (es) | 2008-12-16 |
| MX345954B (es) | 2017-02-16 |
| US9371529B2 (en) | 2016-06-21 |
| US8048863B2 (en) | 2011-11-01 |
| CA2649138C (en) | 2018-04-03 |
| US20160257963A1 (en) | 2016-09-08 |
| AR060448A1 (es) | 2008-06-18 |
| JP2009533475A (ja) | 2009-09-17 |
| EP2662446A2 (en) | 2013-11-13 |
| EP3156486A3 (en) | 2017-07-12 |
| US20090324507A1 (en) | 2009-12-31 |
| WO2007121347A2 (en) | 2007-10-25 |
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