TW200800009A - Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure - Google Patents
Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure Download PDFInfo
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- 239000012089 stop solution Substances 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940108485 tenormin Drugs 0.000 description 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
- WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940075528 thiobutabarbital sodium Drugs 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 229960005461 torasemide Drugs 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 238000012920 two-step selection procedure Methods 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
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- 210000004291 uterus Anatomy 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229940099270 vasotec Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229940070384 ventolin Drugs 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Vascular Medicine (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40077402P | 2002-08-01 | 2002-08-01 |
Publications (1)
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| TW200800009A true TW200800009A (en) | 2008-01-01 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| TW096125738A TW200800009A (en) | 2002-08-01 | 2003-07-30 | Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
| TW096144624A TW200815603A (en) | 2002-08-01 | 2003-07-30 | Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
| TW092120775A TWI291555B (en) | 2002-08-01 | 2003-07-30 | Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096144624A TW200815603A (en) | 2002-08-01 | 2003-07-30 | Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
| TW092120775A TWI291555B (en) | 2002-08-01 | 2003-07-30 | Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7611832B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1543025A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005534319A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100473662C (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003259237B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2494607A1 (cg-RX-API-DMAC7.html) |
| TW (3) | TW200800009A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004013285A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100473662C (zh) | 2002-08-01 | 2009-04-01 | 阿瑞那制药公司 | 治疗缺血性心脏病及充血性心衰竭的人类g蛋白偶联受体及其调节物 |
| AU2005301988A1 (en) * | 2004-11-08 | 2006-05-11 | University Of Rochester | Transgenic non-human animal models of ischemia-reperfusion injury and uses thereof |
| WO2015131099A1 (en) * | 2014-02-28 | 2015-09-03 | The General Hospital Corporation | Diagnosis of multiple myeloma and lymphoma |
| CA2945706C (en) * | 2014-04-25 | 2023-10-24 | Libramen Naturals Inc. | G-protein coupled receptor 22 transformed cell lines and uses therefor |
| CN110772636B (zh) * | 2017-08-21 | 2021-03-16 | 武汉大学 | Gpr31抑制剂在制备治疗心脏缺血再灌注损伤及相关疾病药物中的应用 |
| CN114642668B (zh) * | 2020-12-21 | 2024-04-05 | 忻佑康医药科技(南京)有限公司 | 拉坦前列素的药物新用途 |
| CN119351340B (zh) * | 2024-10-31 | 2025-07-08 | 中国食品药品检定研究院(国家药品监督管理局医疗器械标准管理中心、中国药品检验总所) | 一种测定rhTSH药物生物学活性的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335818T1 (de) * | 1995-12-28 | 2006-09-15 | Takeda Pharmaceutical | Ligand polypeptide für hypophyse g-protein gekoppeltes rezeptor-protein, deren herstellung und anwendung |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US5994097A (en) | 1997-08-28 | 1999-11-30 | Incyte Pharmaceuticals, Inc. | Polynucleotide encoding human G-protein coupled receptor |
| EP1297127A2 (en) * | 2000-05-03 | 2003-04-02 | AstraZeneca AB | Gpr22 modulators as appetite-control agents |
| WO2002006445A2 (en) | 2000-07-19 | 2002-01-24 | Deltagen, Inc. | Transgenic mice containing targeted gene disruptions |
| WO2002061432A2 (en) | 2001-02-01 | 2002-08-08 | Lifespan Biosciences, Inc. | Gpr22, a g protein-coupled receptor (gpcr) and compositions and methods related thereto |
| JP2005516605A (ja) | 2002-02-01 | 2005-06-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 心血管疾患を処置するための方法および組成物 |
| CN100473662C (zh) | 2002-08-01 | 2009-04-01 | 阿瑞那制药公司 | 治疗缺血性心脏病及充血性心衰竭的人类g蛋白偶联受体及其调节物 |
| CN101287832A (zh) | 2005-10-14 | 2008-10-15 | 艾尼纳制药公司 | Gpr22和其相关方法 |
-
2003
- 2003-07-25 CN CNB038234882A patent/CN100473662C/zh not_active Expired - Fee Related
- 2003-07-25 US US10/523,100 patent/US7611832B2/en not_active Expired - Fee Related
- 2003-07-25 EP EP03766914A patent/EP1543025A4/en not_active Withdrawn
- 2003-07-25 AU AU2003259237A patent/AU2003259237B2/en not_active Ceased
- 2003-07-25 CA CA002494607A patent/CA2494607A1/en not_active Abandoned
- 2003-07-25 WO PCT/US2003/023296 patent/WO2004013285A2/en not_active Ceased
- 2003-07-25 JP JP2004526159A patent/JP2005534319A/ja active Pending
- 2003-07-30 TW TW096125738A patent/TW200800009A/zh unknown
- 2003-07-30 TW TW096144624A patent/TW200815603A/zh unknown
- 2003-07-30 TW TW092120775A patent/TWI291555B/zh not_active IP Right Cessation
-
2006
- 2006-11-22 US US11/604,179 patent/US20070224127A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200410985A (en) | 2004-07-01 |
| EP1543025A2 (en) | 2005-06-22 |
| US20070224127A1 (en) | 2007-09-27 |
| US7611832B2 (en) | 2009-11-03 |
| EP1543025A4 (en) | 2006-03-15 |
| US20050238579A1 (en) | 2005-10-27 |
| TWI291555B (en) | 2007-12-21 |
| TW200815603A (en) | 2008-04-01 |
| CN100473662C (zh) | 2009-04-01 |
| AU2003259237A1 (en) | 2004-02-23 |
| AU2003259237B2 (en) | 2011-01-06 |
| WO2004013285A3 (en) | 2004-06-10 |
| WO2004013285A2 (en) | 2004-02-12 |
| CA2494607A1 (en) | 2004-02-12 |
| JP2005534319A (ja) | 2005-11-17 |
| CN1684975A (zh) | 2005-10-19 |
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