TW200716174A - Anti-MCP-1 antibodies, compositions, methods and uses - Google Patents
Anti-MCP-1 antibodies, compositions, methods and usesInfo
- Publication number
- TW200716174A TW200716174A TW095117600A TW95117600A TW200716174A TW 200716174 A TW200716174 A TW 200716174A TW 095117600 A TW095117600 A TW 095117600A TW 95117600 A TW95117600 A TW 95117600A TW 200716174 A TW200716174 A TW 200716174A
- Authority
- TW
- Taiwan
- Prior art keywords
- mcp
- methods
- compositions
- antibodies
- antibody
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 abstract 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
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- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Endocrinology (AREA)
- Dermatology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68265405P | 2005-05-19 | 2005-05-19 | |
| US68262005P | 2005-05-19 | 2005-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200716174A true TW200716174A (en) | 2007-05-01 |
Family
ID=37432201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095117600A TW200716174A (en) | 2005-05-19 | 2006-05-18 | Anti-MCP-1 antibodies, compositions, methods and uses |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1888114B1 (OSRAM) |
| JP (1) | JP4975020B2 (OSRAM) |
| KR (1) | KR100977823B1 (OSRAM) |
| CN (1) | CN101511869B (OSRAM) |
| AR (1) | AR053470A1 (OSRAM) |
| AU (2) | AU2006247034B2 (OSRAM) |
| BR (1) | BRPI0613164A2 (OSRAM) |
| CA (1) | CA2609349C (OSRAM) |
| CR (1) | CR9606A (OSRAM) |
| EA (1) | EA014229B1 (OSRAM) |
| ES (1) | ES2438193T3 (OSRAM) |
| IL (1) | IL187459A0 (OSRAM) |
| MX (1) | MX2007014610A (OSRAM) |
| NO (1) | NO20076563L (OSRAM) |
| NZ (1) | NZ563516A (OSRAM) |
| PA (1) | PA8675801A1 (OSRAM) |
| PE (2) | PE20110071A1 (OSRAM) |
| TW (1) | TW200716174A (OSRAM) |
| WO (1) | WO2006125202A2 (OSRAM) |
| ZA (1) | ZA200711073B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| CA2692392A1 (en) * | 2007-06-29 | 2009-01-08 | Centocor Ortho Biotech Inc. | Anti- mcp-1 antibodies, compositions, methods and uses |
| CA2734800C (en) * | 2008-08-20 | 2021-02-09 | Probiodrug Ag | Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (mcp-1 n1pe) |
| CA2772488C (en) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Heterocyclic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| US20150158942A1 (en) * | 2012-05-22 | 2015-06-11 | Shire Human Genetic Therapies, Inc. | Anti-ccl2 antibodies for treatment of scleroderma |
| EP2727944A1 (en) * | 2012-10-30 | 2014-05-07 | Universitätsklinikum Regensburg | Depletion of CCR2-positive monocytes for the treatment of inflammatory conditions in the gastrointestinal system |
| EP3108013B1 (en) | 2014-02-18 | 2019-09-18 | Dignity Health | Lkb1 related diagnostics and treatments of cancer |
| EP3613435A1 (en) | 2015-01-28 | 2020-02-26 | Universite De Bordeaux | Chemokine receptor cxcr4 inhibitors for treating and/or preventing chronic obstructive pulmonary disease |
| WO2018014111A1 (en) | 2016-06-22 | 2018-01-25 | Harless William Warren | Cancer treatment and metastasis inhibition using an anti-cancer stem cell agent in combination with a neul sialidase inhibitor or a cytokine inhibitor after primary cancer treatment |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| AU2020259884A1 (en) | 2019-04-17 | 2021-10-07 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
| WO2021122733A1 (en) * | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| CN112358547A (zh) * | 2020-09-30 | 2021-02-12 | 浙江大学 | 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用 |
| CN114990073A (zh) * | 2022-05-27 | 2022-09-02 | 河南农业大学 | 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1319120C (en) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| US5266491A (en) | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| CA2084307A1 (en) | 1990-06-01 | 1991-12-02 | Cetus Oncology Corporation | Compositions and methods for identifying biologically active molecules |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| WO1992005258A1 (en) | 1990-09-20 | 1992-04-02 | La Trobe University | Gene encoding barley enzyme |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| DE4436420C5 (de) | 1994-10-12 | 2009-04-02 | Daimler Ag | Mittelkonsole für ein Kraftfahrzeug |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| KR100575070B1 (ko) | 1997-09-29 | 2006-05-03 | 넥타르 테라퓨틱스 | 안정화된 생활성 제제 및 이의 사용 방법 |
| GB0016138D0 (en) * | 2000-06-30 | 2000-08-23 | Novartis Ag | Organic compounds |
| WO2003002019A2 (en) | 2001-06-27 | 2003-01-09 | Salviac Limited | A catheter |
| DK1461300T3 (da) * | 2001-11-30 | 2011-10-24 | Biogen Idec Inc | Antistoffer mod kemotaktiske monocytproteiner |
| UA87979C2 (ru) * | 2002-08-19 | 2009-09-10 | Астразенека Аб | Человеческое моноклональное антитело, которое нейтрализует моноцитарный хемоатрактантный белок (мср-1) |
| CN1681926A (zh) * | 2002-09-12 | 2005-10-12 | 财团法人化学及血清疗法研究所 | 人的抗人mcp-1抗体和该抗体的片段 |
| EP1716181B1 (en) | 2004-02-19 | 2009-12-16 | Genentech, Inc. | Cdr-repaired antibodies |
| WO2006085961A2 (en) * | 2004-06-30 | 2006-08-17 | Centocor, Inc. | Anti-mcp-1 antibodies, compositions, methods and uses |
-
2006
- 2006-05-18 PE PE2010000028A patent/PE20110071A1/es not_active Application Discontinuation
- 2006-05-18 PE PE2006000524A patent/PE20061444A1/es not_active Application Discontinuation
- 2006-05-18 PA PA20068675801A patent/PA8675801A1/es unknown
- 2006-05-18 TW TW095117600A patent/TW200716174A/zh unknown
- 2006-05-19 NZ NZ563516A patent/NZ563516A/en not_active IP Right Cessation
- 2006-05-19 JP JP2008512576A patent/JP4975020B2/ja not_active Expired - Fee Related
- 2006-05-19 BR BRPI0613164-6A patent/BRPI0613164A2/pt not_active IP Right Cessation
- 2006-05-19 CN CN2006800262915A patent/CN101511869B/zh not_active Expired - Fee Related
- 2006-05-19 ES ES06770770.3T patent/ES2438193T3/es active Active
- 2006-05-19 KR KR1020077029133A patent/KR100977823B1/ko not_active Expired - Fee Related
- 2006-05-19 AU AU2006247034A patent/AU2006247034B2/en not_active Ceased
- 2006-05-19 MX MX2007014610A patent/MX2007014610A/es active IP Right Grant
- 2006-05-19 EP EP06770770.3A patent/EP1888114B1/en active Active
- 2006-05-19 CA CA2609349A patent/CA2609349C/en not_active Expired - Fee Related
- 2006-05-19 EA EA200702532A patent/EA014229B1/ru not_active IP Right Cessation
- 2006-05-19 WO PCT/US2006/019627 patent/WO2006125202A2/en not_active Ceased
- 2006-05-19 AR ARP060102053A patent/AR053470A1/es unknown
-
2007
- 2007-11-18 IL IL187459A patent/IL187459A0/en unknown
- 2007-12-18 CR CR9606A patent/CR9606A/es unknown
- 2007-12-18 ZA ZA200711073A patent/ZA200711073B/xx unknown
- 2007-12-19 NO NO20076563A patent/NO20076563L/no not_active Application Discontinuation
-
2010
- 2010-07-02 AU AU2010202813A patent/AU2010202813B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR100977823B1 (ko) | 2010-08-25 |
| EP1888114A2 (en) | 2008-02-20 |
| WO2006125202A3 (en) | 2009-05-07 |
| PE20110071A1 (es) | 2011-01-31 |
| AR053470A1 (es) | 2007-05-09 |
| CA2609349A1 (en) | 2006-11-23 |
| CN101511869A (zh) | 2009-08-19 |
| AU2006247034B2 (en) | 2010-12-02 |
| EP1888114B1 (en) | 2013-09-18 |
| NO20076563L (no) | 2008-02-05 |
| ES2438193T3 (es) | 2014-01-16 |
| KR20080012968A (ko) | 2008-02-12 |
| AU2006247034A1 (en) | 2006-11-23 |
| PA8675801A1 (es) | 2006-12-07 |
| ZA200711073B (en) | 2009-09-30 |
| CR9606A (es) | 2010-08-18 |
| MX2007014610A (es) | 2008-04-14 |
| JP2008546374A (ja) | 2008-12-25 |
| EP1888114A4 (en) | 2010-02-24 |
| NZ563516A (en) | 2011-04-29 |
| EA200702532A1 (ru) | 2008-06-30 |
| CN101511869B (zh) | 2012-12-12 |
| AU2010202813B2 (en) | 2011-11-03 |
| EA014229B1 (ru) | 2010-10-29 |
| IL187459A0 (en) | 2008-03-20 |
| CA2609349C (en) | 2012-10-30 |
| PE20061444A1 (es) | 2007-01-15 |
| BRPI0613164A2 (pt) | 2010-12-21 |
| JP4975020B2 (ja) | 2012-07-11 |
| AU2010202813A1 (en) | 2010-07-22 |
| WO2006125202A2 (en) | 2006-11-23 |
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