TW200418855A - Indolizine compounds - Google Patents

Info

Publication number

TW200418855A

TW200418855A TW092135101A TW92135101A TW200418855A TW 200418855 A TW200418855 A TW 200418855A TW 092135101 A TW092135101 A TW 092135101A TW 92135101 A TW92135101 A TW 92135101A TW 200418855 A TW200418855 A TW 200418855A

Authority

TW

Taiwan

Prior art keywords

substituted

compound

group

unsubstituted

patent application

Prior art date

2002-12-12

Links

• Espacenet
• Global Dossier
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• 125000003406 indolizinyl group Chemical class C=1(C=CN2C=CC=CC12)* 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 182
• 238000000034 method Methods 0.000 claims abstract description 76
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• 108090000695 Cytokines Proteins 0.000 claims abstract description 21
• 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims abstract description 20
• 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims abstract description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 63
• 125000000217 alkyl group Chemical group 0.000 claims description 60
• 125000003118 aryl group Chemical group 0.000 claims description 51
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• 229910003204 NH2 Inorganic materials 0.000 claims description 28
• 239000000126 substance Substances 0.000 claims description 25
• 150000003839 salts Chemical class 0.000 claims description 24
• 238000011282 treatment Methods 0.000 claims description 24
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
• 230000000694 effects Effects 0.000 claims description 17
• 125000003545 alkoxy group Chemical group 0.000 claims description 16
• 229910052794 bromium Inorganic materials 0.000 claims description 15
• 125000001931 aliphatic group Chemical group 0.000 claims description 14
• 229910052740 iodine Inorganic materials 0.000 claims description 14
• 229910052731 fluorine Inorganic materials 0.000 claims description 13
• 125000000623 heterocyclic group Chemical group 0.000 claims description 12
• 230000004968 inflammatory condition Effects 0.000 claims description 12
• JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 11
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• 239000000651 prodrug Substances 0.000 claims description 10
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• 125000004076 pyridyl group Chemical group 0.000 claims description 9
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 8
• 239000000463 material Substances 0.000 claims description 8
• NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 8
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• 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 description 6
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