TW200404573A - Cosmetic compositions containing salts of malonic acid - Google Patents

Abstract

A cosmetic composition is provided which includes as an active material a salt of malonic acid in a cosmetically acceptable carrier, wherein the composition exhibits a Flexibility Value greater than 1 according to the Porcine Skin Test.

Description

200404573 (1) Description of the invention: [Technical field to which the invention belongs] The present invention relates to a cosmetic composition containing malonates and the use of these compositions for controlling signs of skin aging. σ: Soft, tender and flexible skin has a significant cosmetic charm and is a normal life of the epidermis. Because human skin ages with age, the epidermis can be wrinkled, wrinkled, or uneven to form wrinkles. These symbols have lost their youthful appearance and forecasts have shifted to old age. Exposure to excess = will speed up the transfer process. At the same time, the outer layer of the epidermis (ie, the dead skin layer) can become dry and peeling after being exposed to cold weather or excessive contact with cleaning agents or solvents. As a result, the skin loses its wetness and the skin begins to lose its soft, tender, and flexible characteristics. Emollients such as fats, phospholipids, and sterols have been used to soften wrinkled or dry skin. As a treatment for unhealthy skin, these softeners are only partially effective. It has been known for a long time to improve human skin using citric acid. Undoubtedly, «-acrylic acid is far more effective than ordinary softeners. [Prior Art] U.S. Patent No. 4,424,234 (Alderson et al.) Discloses a variety of skins incorporating ο: -hydroxyhexanoic acid and α-hydroxyoctanoic acid or mixtures thereof in compositions having a pH value less than 7 (often 2 to 4) Therapeutic composition. ¥ 11 and Van Scott are widely patented in this field. For example, U.S. Patent No. 4,05,782 proposes amines or salts of ammonium α-hydroxycarboxylates for the treatment of acne or dandruff. In U.S. Pat. No. 4,105,783 and U.S. Pat. No. 4,197,3,16, it is proposed that this compound 85632 200404573 treats dry skin. U.S. Patent No. 4, m discloses the use of:-via weiwei acid, its g-type or amine salts to treat keratin. Recently, U.S. Patent No. 5'091,171 has focused on the effectiveness of these compounds against age spots, wrinkles and aging-related skin changes. However, cis-acids have many treatment guarantees, but when repeated topical application, it is found that the material will irritate human skin. The irritation can range from feeling tingling, itching and burning to silicon &…, redness and peeling of the bed. The cause of such irritation is that the pH in the cortex is reduced by being connected to the human skin. We have suggested that the low ρΗ is the cause of the hindrance between the keratinocytes and the bond J. The cause, which causes harmful skin reactions, especially individuals with sensitive skin. Organic acids other than "-hydroxy-functionalized" are disclosed in the cosmetic literature. U.S. Patent No. 5,641,495 (Jok et al.) Jointly reveals a type of ceramide or pseudoneramine, a second Acid and a salt of dikisheric acid. This example exemplifies the sodium and potassium salts of oleic acid. It is also possible to use the 'a ^ complete acid' in the lower molecule, such as ginseng, ginseng / sa I. Although the excellent degree of wetness is accompanied by a slight irritation, the husband and wife are beautiful. This system counteracts the loss of skin flexibility, suppleness, and flexibility. Heart aging prostitutes. Improvements in these areas are still unmet needs. 'Oral_ The advantage of the present invention is to provide several novel cosmetic ingredients in the composition' This ingredient effectively controls or even removes signs of aging, especially regarding improvement Skin softness, suppleness and flexibility. [Summary] The present invention provides a cosmetic composition comprising: (1) about 0.0001 to about 30% by weight of a salt of malonic acid; 443 85632 200404573 (ii ) About 1 to about 99.9% by weight An acceptable carrier; wherein the composition exhibits a flexibility value greater than that in a pig skin test. In addition, the present invention provides a method for controlling signs of aging, which includes providing a cosmetic composition including: (i ) About 0.0001 to about 30% by weight of a salt of malonic acid; (η) about 1 to about 99.9% by weight of a cosmetically acceptable carrier; wherein the composition exhibits flexibility in pig skin tests The degree value is greater than j; and the cosmetic composition is applied to the skin. [Embodiment] We have found that malonates are at least as effective as anti-aging signs of skin as alpha hydroxycarboxylic acid. Most particularly, malondi Acid salts are shown to be important in improving skin softness, suppleness, and flexibility. One feature of the present invention is that malonates are a positive flexibility value that allows the composition to counterbalance water in pig skin tests It is at least one (preferably at least one). This test uses a thermodynamic analyzer that loads 20 grams on a pig skin disc with a diameter of 1 cm and records the instant deviation from the analyzer in millimeters. As a control, skin samples were monitored before treatment and 24 hours after primary, secondary, and tertiary treatments. These treatments included applying microliters of each group a substance to the skin for 5 minutes, and then removing but not rinsing After that, drying was performed at 2 ^ and the relative humidity was lower than 1G%. Data conversion included determining the ratio of the skew value to the skew value of the water standard after applying the test composition three times. This ratio was defined as the flexibility value The salt can be formed using the counter cations of various malonate cations. The salts can be incompletely or completely neutralized malonic acid or a combination thereof 85632 200404573, such as the general formula (I) and ( II) Represented

[H02CCH2C02] '[XJ

I

[Xj2 [〇2CCH2C02J

II where X is a cationic counter ion. Appropriate cationic resistance is inseparable from 4 k A p-f butyl I organic ions including those belonging to alkali metals and alkaline earth metals. 2 Illustrative examples include tritium, nanom, ammonium cations and combinations thereof. Not only inorganic ', but also organic cations can be used. Particularly useful are quaternized nitrogen cations with 1 to 1, carbon atoms (preferably, optimal = carbon atoms). Examples are cations derived from amines, which include triethanol :, monoethanolamine, propanolamine, monoethanolamine, methylamine, ethylamine, propylamine, H, butylamine, isobutylamine, tertiary butylamine, amidine, isopropylamine Amylamine, hexylamine: diamine: cyclopentylamine, norbornelamine, octylamine 'ethylhexylamine, nonylamine, sebac :: pyridone, amino acids (lysine, glutamic acid, alanine, Noodles ... histamine, amine), 2-amino-2-methylpropanol, dimethyl A = amine, polyethyleneimine, tris (fluorenyl) aminomethyl, and combinations thereof . 222: Ammonia, dimethylethanolamine, and tris (fluorenyl) amino methylbenzene, propylene glycol: Some: Good "Typical malonates include ammonium malonate and ammonium malonate), propylene V Methyl ethanol, bis (dimethylethylammonium malonate) .— Acid fen (hypermethyl) methanine and bis (shenmethyl) formate, "about (M to about 15%, more preferably About 0.5 to about 10%, most preferably 44S 85632 200404573 to about 8% by weight. This month is enough to use salt I, salt tincture or a mixture of these salts as active knives. The molar ratio of the di-salt π may be about 1000.1 to about 1: 1000 (preferably about 10: 1 to about 丨: 500, more preferably about 2: 1 to about 1: 200, and most preferably about 1: 1 To about 1:20). The composition of the present invention will also include a cosmetically acceptable carrier. The carrier may contain 1 to 99.9% (preferably about 70 to about 95%, and most preferably about 80 to about 90). % Among the useful carriers are water, softeners, fatty acids, fatty alcohols, moisturizing agents, thickeners, and combinations thereof. The carrier can be aqueous, non-aqueous, or an emulsion. Preferably, the composition is aqueous, especially w / 〇 or 〇 / w or triple chat water and oil When water is present, the amount may be from about 5 to about 95% by weight (preferably about 2 () to about 5%, most preferably about 35 to about 6 ()% by weight).: Ketones: synthetic, synthetic Forms of S and hydrocarbons. The amount of softener is no matter where. In the range of about 1 °, 1 to about 95% by weight, preferably about 1 to about 50% by weight. The term "volatile" means nr hair. As used here, M, Ding has a measurable vapor pressure material. = Raw stone evening oil is preferably selected from 3 to 9 stone Xi atom (preferably 4 to 5 ring group (cyclomethyl phase) or linear polydimethylene sintering of Shixahara ^.): In: non-volatile at first glance softener materials ... oils include polysintering Base = ben Γ: Jifang-Posaki-fired copolymer. The Benben useful here is non-volatile about 5 x 1 (),... Tu Xishen includes, for example, the polyhedron U at 25t: which is useful for viscosity. Siloxane, of which in the present invention is χ 10.5. ^ 4 85632 -10- 200404573 x 10 · 4 m2 / s polydifluorenylsiloxane. Another type of non-volatile silicone emulsification and non-emulsification Silicone elastomer. The representative of this class is dioxin Ketone / vinyl dimethyl silicone cross-linked polymers such as

Dow Corning 9040, General Electric SFE 839, and Shin-Etsu KSG-18. Silicone waxes such as Silwax WS-L (Dimethicone Copolyol Laurel) are also useful. Wherein the ester softener is: (1) an alkenyl or alkyl ester of a fatty acid having 10 to 20 carbon atoms. Examples thereof include isococyl pivalate, isoprenyl isononanoate, oleyl myristate, oleyl stearate, and oleyl oleate. (2) Ether-esters, such as fatty acid esters of ethoxylated fatty alcohols. (3) Polyol esters. Glycol mono- and di-fatty acid esters, di-menthol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, Polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glycoside mono- and di-fatty acid esters, polyglycol poly-fatty acid esters, ethoxylated Oleyl monostearate, 1,3-butanediol monostearate, 3, butanediol distearate, polyethylene oxide polyol fatty acid ester, lantana fatty acid Esters and polyethylene oxide lantana fatty acids are satisfactory polyol esters. Particularly useful are pentaerythritol, an alcohol, pentaerythritol, trimethyl ether, and neopentyl glycol esters. (4) Wax esters, such as beeswax, whale wax and pure dagger wax. (5) Sterol esters, of which cholesterol protects the daytime * T [U fatty acid esters are examples of carbonates and sucrose polycotton seed. (6) Sweet and sour fatty acids, such as strict sugar polydi + 497 85632 -11-200404573 The purpose of acid. Suitable for use in cosmetic acceptable carriers. Including petroleum, mineral oil, Cn-Cu isoparaffin, poly alpha olefins, and especially isohexadecane, commercially available as Permethyl 101A from Presperse Inc. Fatty acids having 10 to 30 carbon atoms may also be suitable as cosmetically acceptable carriers. Examples of this class are nonanoic acid, lauric acid, myristic acid, panic acid, stearic acid, isostearic acid, hydroxystearic acid, oleic acid, linoleic acid, ricinoleic acid, arachidic acid, twenty-two Acid and erucic acid. Fatty alcohols having 10 to 30 carbon atoms are another useful cosmetically acceptable carrier. Examples of this class are stearyl alcohol, lauryl alcohol, myristyl alcohol and chlorophyllol. Polyol-type humectants can be used as cosmetically acceptable carriers. Typical polyols include: y: oleyl esters, polyalkylene glycols, and better polyalkylene glycols and their derivatives, including propylene glycol. , Dipropylene glycol, polypropylene glycol, polyethylene glycol and its derivatives, sorbitol, hydroxypropyl sorbitol, hexanediol, i, 3-butanediol, isoamyl glycol, 丨, 2,6_hexane Triol, ethoxylated glycerol, propylene oxide, and propylene glycol, and mixtures thereof. The amount of the humectant may be 无论, wherever it is, and the weight ratio of the mouthpiece is from 0.5 to 50% by weight, preferably from i to 15% by weight. It is sufficient to be used as part of the cosmetically acceptable carrier according to the present invention. Typical thickeners include cross-linked acrylates (such as Carbopol 982, biodegradable acrylates (such as Car bop 〇1 1 3 82®)), cellulose derivatives far from natural gums. Among them, useful cellulose Derivatives are carboxymethyl fiber, internal hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose ethyl cellulose, and hydroxymethyl cellulose. Natural gums suitable for the present invention 49 «85632- 12- 200404573 Including guar gum, xanthan, sclerotia, carrageenan, pectin and combinations of these gums. Inorganic substances can also be used as thickeners, especially clays (such as bentonite and hectorite), tobacco Fumed silica and silicates (such as Veegum®). The amount of thickener can be 0.0001 to 10% by weight, often 0. 0 0 1 to 1% by weight, the best 0. 〇1 to 5% by weight. The cosmetic composition of the present invention may be in any form. These forms may include liquids, creams, ball formulations, sticks, foams, aerosols and non-aerosol sprays and fabrics. (Eg non-woven textiles) formed by application. The agent may also be present in the cosmetic composition of the present invention. When present, the total concentration of the surfactant may be from about 0.1 to about 20% by weight of the composition (preferably from about 1 to about 20% by weight). , The best about work to about "/. Weight ratio). The surfactant can be selected from the group consisting of anionic, nonionic, cationic and zwitterionic actives. Particularly preferred nonionic surfactants have C1G-C2 () fatty alcohols or acid hydrophobes with 2 to 100 moles of ethylene oxide or propylene oxide per mole of hydrolysates; C2_ClQ alkylphenols of 2 to moles of alkylene oxides; ethylene glycol Alcohol mono- and di-fatty acid vinegar; fatty acid mono-ole vinegar; lantana, mono- and di-like 20 fatty acids; and polycyclo j ethane lantana and combinations thereof. Burnt-based polyglucose and saccharin Fats (such as methylglucamine) are also suitable nonionic surfactants.

/ Cross-linking: Anionic surfactants include alkyl ether, sulfuric acid alkyl esters and sulfonyl esters, sulphuric acid sulfate esters and lutein acid esters, pyrobenzyl lutein acid esters, silk and U: woven acid vinegar, c8-c202 deletes the acid ethyl vinegar, the C8 ethyl ether, the C8-C20 cinnamate and the combination thereof. Of the composition. Particularly preferred sunscreen activators may also be included in the present invention 499 85632 -13- 200404573: materials such as ethyl p-methoxycinnamate hexanoate (commercially available as p⑽. M, vobenZene (commercially available as Pars) 〇1! 78, and diphenylene (also 嗣). Inorganic antifungal actives can be used, such as micronized titanium dioxide, zinc oxide, polyethylene, and various other polymers. %, The content of the sunscreen is (M to weight ratio (preferably 2 to 20% by weight, most preferably 4 to 10% by weight). If necessary, the preservative can be replaced and incorporated into the makeup of the present invention. The composition is protected against the growth of potentially harmful microorganisms. A suitable traditional preservative for the composition of the present invention is p-based benzoic acid vinegar. Other preservatives that have recently been used include allantoin derivatives Compounds, propionates and various quaternary ammonium compounds. Cosmetic chemists are familiar with the appropriate preservatives! And usually choose this preservative to meet the preservative poisoning test and provide product stability. Particularly preferred preservative phenoxyethanol , Methyl paraoxoate, propyl paraoxane Benzoate vinegar " Mitarium urea, sodium dechloroacetate and benzyl alcohol. The preservative should be selected based on the use of the composition and possible incompatibilities between the preservative and other ingredients in the emulsion. Preservatives It is preferably used in an amount of 0.001% to 2% by weight of the composition. The composition of the present invention may include vitamins. Examples of vitamins are vitamin A (retinol), vitamin B2, vitamin B6, vitamin C, Vitamin E and biotin. Derivatives of vitamins can also be used. For example, vitamin c derivatives include ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate, and ascorbyl glucose VII. Derivatives of vitamin E include Tocopheryl acetate, tocopheryl palmitate, and tocopheryl linoleate. DL-panthenol and derivatives can also be used. When present, the total amount of vitamins in the composition according to the invention can be from 0.001 to • 14 -200404573 ㈣ weight ratio (preferably 0.001% to 1%, most preferably 0.001 to 5% by weight). Another type of useful substance can be-enzymes such as oxidase, protease, lipase and Conjugates. Super-specialists are superoxide Dimolybase, sold by Brooks, USA, under the name of Bicells SOD. Skin brightening compounds can be included in the combination of the present invention: Medium. Real placenta extract, lactic acid, cyperamide, arbutin, gallic acid Ferulic acid: isophthalic acid includes 4. substituted isophenylene derivatives and combinations thereof. The amount of these agents may be about 0 to about 5% by weight of the composition, preferably about 0.5. To about 2% by weight). 乂 Desquamation promoters can be present. Examples, α m wei acid and ^ acid based ° The word "acid" means not only the free acid, but also its salts and alkyl groups or Aryl groups, and lactones produced by removing water to form a ring-shaped linear fluorene structure c. Representative acids are glycolic acid, lactic acid, and malic acid. Salicylic acid is representative of / 5-hydroxycarboxylic acid. When present, the amount of these materials may be from about 0.01 to about 15% by weight of the composition. : It is required that a variety of herbal extracts can be included in the composition of the present invention. Examples are green tea, chamomile,: y: grass extract and its extract combinations. The extract can be water-soluble or water-insoluble in a solvent, which is hydrophilic or hydrophobic, respectively. Water and ethanol are preferred extractive solvents. It may also include materials such as fatty acids, retinyltrisylsilane (available from Cladant under the trademark Silcare 1M-5), dehydroepiandrosterone (DHEA), and combinations thereof. Neuraminamines (including

Ceramide 1, Ceramide 3, Ceramide 3B, and Ceramide 6) and pseudoneuraminides can also be eliminated for many of the compositions of the present invention. ΒΙ 85632 -15-2UU4U45 / 3. The amount of these materials may be from about 0.1 to about 1% by weight. ^ Coffee to about 10%, colorant, perfume, opaque composition. Each of these: :: friction agents may also be included in the present invention (M to 3% by weight ratio. It is about ° .. 5 to about 5% by weight, the word, including, means that it is not limited to any subsequent mention And components, but containing most or less functional importance of unspecified pieces. In other words, the steps, files or options need not be exclusive. Whenever the word " include " or " When used, these terms denote equivalents to "included" as defined above. Except in the operating and comparative examples or where it is explicitly stated otherwise, I should understand that Amended by the word "numbers and planes". The following examples will more fully illustrate the specific embodiments of the present invention. All parts, percentages and ratios cited herein and in the scope of the appended patent applications are weight ratios, unless otherwise stated Mode description Example 1 Table I summarizes a typical cosmetic cream according to the present invention.

Table I Ingredients ---- Weight% ^ ---- Phase · ------------ A ^ -------- ~ -------- monohydrate __----- -Difference ___ 0.05 Ammonium paraoxonate ___- 0.15 ~ Magnesium aluminum silicate _____ 0.60 ~ Triethanolamine _____- 1.20 85632 -16- 200404573 Phase B Retinoid 0.20 Natrosol® 250HHR (ethyl fiber Prime) 0.50 Butanediol 3.00 Emu Oil 2.00 Phase C Sodium Stearate Sodium Lactate 0.10 Ester Mono Stearate 1.50 Stearate Alcohol 1.50 Isostearate Palmitate 3.00 Silicone Fluid 1.00 Cholesterol 0.25 Ephraim Stearin Ester 1.00 Butylated hydroxydibenzobenzene 0.05 Vitamin E acetate 0.01 PEG-100 Stearate 2.00 Stearate 3.00 Propyl paraoxoate 0.10 Parsol MCX® 2.00 Caprylic acid / caprylic acid triacid Purpose 0.50 Hydroxyoctanoic acid 0.01 c12-15 Alkyl caprylate 3.00 Phase D Malonate 3.00 Phase E Vitamin A standard acid acid formula 0.10 Bisabolol 0.01 Vitamin A acetic acid formula 0.01 Fragrance 0.03 Retinol 50C 0.02 85632 -17- 200404573 Example 2 A water-in-oil topical liquid makeup foundation using the malonate of the present invention is described in Table II below. .

Table II Ingredients by weight% Phase A Cyclomethylsilicone 9.25 Cetyl octanoate 2.00 Dimethicone Polyol 20.00 Phase B Talc 3.38 Pigment (Iron Oxide) 10.51 Spheron L-1500 (Ishite) 0.50 Phase C Synthesis Can Durachem 0602 0.10 Picocosanoic acid 0.30 Phase D Cyclopentyl silicone 1.00 Tristearic acid oleyl ester 0.30 Phase E Polyacrylic acid acrylate (Laureth-7) 0.50 Propyl paraoxobenzoate 0.25 phase F fragrance 0.05 phase G water balance malonate 1 ampere 3.00 fluorenyl paraoxobenzoate 0.12 -18-1, (44 85632 200404573 propylene glycol 8.00 test acid amine 4.00 taste oil 3.00 sodium chloride 2.00 dehydroacetic acid Sodium 0.30 Example 3 A skin cream incorporating the malonate salt of the present invention is shown here. Table III Ingredients% by weight Emu Oil 6.93 In acetic acid 5.00 Dimethylethanolammonium malonate 5.00 Permethyl 101A1 3.00 Sepigel 3052 2.50 Q2-14033 2.00 Isopropyl stearate 1.33 Arlatone 21214 1.00 Cetyl alcohol CO-1695 0.72 SEFA cotton seed 5 0.67 Tocopheryl acetate 0.50 Panthenol 0.50 Stearyl alcohol 0.48 Titanium dioxide 0.40 EDTA disodium 0. 10 Glydant Plus6 0.10 PEG-100 stearic acid 0.10 stearic acid 0.10 purified water balance 85632 -19- 200404573

Iso-hexapod, Presperse Inc., South PlainHeld, NJ

2 Polyacrylamide (and) (: 13-14 isoparaffin (and) polymethacrylate, Seppic Corporation, Fairfield, NJ

3 Dimethicol with (and) dimethiconol, Dow Corning Corp. Midland, MI

4 Sulfuryl early stearate and Sucrococoate, ICI Americas Inc., Wilmington, DE 5 Sucrose esters of fatty acids

6 DMDM Allantoin (and) Iodopropynyl Butyl Carbamate, Lonza Inc., Fairlawn, NJ Example 4 Table IV is an example of a powder cosmetic composition according to the present invention.

Table IV Ingredient Weight% Polysilicone-11 27.5 Cyclomethylsilicone 54 Petroleum 11 Tris (hydroxymethyl) methanemalonate 7 Dimethicone copolyol 0.5 Example 5 Table V presents a comparison according to the present invention. Examples of anhydrous compositions. 85632 -20-200404573 Table v Ingredients by weight% Cyclomethylsilicone 80.65 Dimethyone 9.60 Squalane 6.00 Isostearic acid 1.90 Borage Borage seed oil 0.90 Lithium malonate (50% aqueous solution) 0.50 Palmitic acid Flavonol 0.25 Neuraminamine 6 0.10 Tocopherol 0.10 Example 6 Table VI summarizes an aerosol packaging foaming cleaner suitable for the present invention.

Table VI Ingredients% by weight Sunflower oil 20.00 Maleic acid soybean oil 5.00 Silicone aminoester 1.00 Polyglycero-4 oleate 1.00 C 1 4 -1 6 Sodium dibasic acid sodium 15.00 Sodium lauryl ether sulfate (25% Active) 15.00 Cocoaamine Aminopropyl Betaine 15.00 DC 1784® (50% Silicone Emulsion) 5.00 Polyquaternium-11 1.00 Bis (diamidoethanolammonium) malonate 1.00 Water difference-21-ς07 85632 200404573 used 9 2 / 〇 weight i ratio of Table VI? Chen shrinkage and 8% propellant make aerosol. The propellant is a combination of dimethyl ether, isobutane and propane. Example 7 An adhesive cosmetic patch can also be prepared according to the present invention. A viscous water was prepared by mixing 30 g of 2-acrylamido-2-methylpropanesulfonic acid monomer / 20 g of distilled water and 5 g of a 1% aqueous solution of methylene-bis-acrylamidoamine. The solution was then activated with a 0.4% magnesium superphosphate catalyst. After the catalyst was briefly mixed with the water reducing solution, 0.1 g of ammonium malonate / 5 ml of water was added. The resulting solution was applied to a 50/50 blend of polypropylene and a hydrophilic polyester and allowed to cure. The resulting deposited hydrogel was heated in a hot air oven at 40 ° C for 24 hours. The final water content of the hydrogel is 50%. A polystyrene backing was placed on the adhesive hydrogel. Example 8 A disposable single use personal wipe product according to the present invention is described. A 70/30 polyester / spiral non-woven wipe was prepared at a weight of 1.8 grams and a size of 15 cm x 20 cm. To this wipe was impregnated a composition as outlined in Table VII below.道 _ -22- 200404573 Table νιιη ingredients octyl amphoteric diacetic acid PEG-40 hydrogenated castor oil microbiotin E acetate

Magnesium glycoside oil hexanediol gluconolactone silicone microemulsion witch hazel flavor water Example 9 Compare a variety of carboxylates to measure Ludiz 1 疋 it is the opposite in the pig skin test- Response of a piece of pig y with a diameter of 1 cm TMS-i Perkin_Elme ^ Mechanical load of eight grams to record the deflection of the skin. The mouth of the sword was immediately measured in meters. I earn two skins. Water was used as the second child: each block was used as an internal control. It was measured for drying before and 24 hours after the first treatment. Each treatment includes applying the test or material solution to the skin for 5 minutes, and then removing but not missing. . Dry conditions are 2rc and humidity below 10%. Results are recorded in the table ... S89 85632 -23- 200404573

Table VIII ----- ^ Flexibility value of the comparison material ^ 'Water (reference standard) 1.00 ^^-Succinate * 0.85' ~ ^ Glycolate * 0.85 ^^^ Malonate * *-~- -^ __ 1.36 Ammonium salt dimethyl ethanol salt From the results it is clear that malonate gives the skin an important flexibility. Conversely, succinate and glycolate make the skin significantly harder. The effects of glycolate and succinate are statistically similar. These results indicate that allyl salts and compositions containing these salts can improve softness, tenderness and flexibility. Table IX records the Roveblade values (using different Phase D activators) measured for the cosmetic cream formulations detailed in Table I. The malonate-based cream has a higher flexibility value than the base cream or glycolate-based cream. The results show that the use of malonate achieves a softer, softer and more flexible skin.

Table IX Evaluation materials * Flexibility value water (reference standard) 1.00 Base paste (no salt) 0.89 Base paste (glycolate) 0.84 Base paste (malonate) 1.12 The salts in brackets indicate phase D of Example 1. Actives (Table I) -24- 51Θ 85632 200404573 The above description and examples illustrate specific embodiments of the invention selected. According to this specific embodiment, changes and adjustments of the artist will be suggested, all of which are within the spirit and scope of the present invention. 85632 25-

Claims (1)

200404573 Patent application scope: 1 chemical composition, including: (0 about 0.0001 to about 300/3 weight ratio of malonic acid salts; (11) about 1 to about 99.9% by weight cosmetics can be Accepted carrier; wherein the composition exhibits a flexibility value greater than 1 in a pig skin test. 2 · The composition according to item 1 of the patent application scope, wherein the malonic acid is about 1000: 1 to about 1 respectively : Half-neutralized and fully-neutralized acid present in a molar ratio of 1000. 3 · A composition according to item 2 of the scope of patent application, wherein the molar ratio is from about 2: 1 to about 1: 20.00. 4 The composition according to item 1 of the scope of patent application, wherein the salt has a cationic counter atom of malonate, which is selected from the group consisting of lithium, sodium, potassium, town, word, ammonium, and combinations thereof. Inorganic cations. 5. The composition according to item 丨 of the scope of the patent application, wherein the cationic counterion of the malonate is an organic cation having 2 to 1,000 carbon atoms, which is selected from the group consisting of Ethanolamine, diethanolamine, propanolamine, monoethanolamine, amidine , Ethylamine, propylamine, isopropylamine, butylamine, isobutylamine, tertiary butylamine, pentylamine, isopentylamine, hexylamine, cyclohexylamine, cyclopentylamine, norbornelamine, octylamine, ethylhexylamine , Nonylamine, decylamine, pyrrolidone, amino acids (lysine, glutamic acid, alanine, glutamine, histidine, aglycol), 2-amino-2-fluorenyl- A group consisting of 1-propanol, -field f-t-ethanolamine, tris (hydroxymethyl) amine, and combinations thereof. 6 · A method for controlling signs of aging, including: 5Π 85632 200404573 Provides makeup including the following Compositions: (i) from about 0.0001 to about 30% by weight of malonic acid salts; (ii) from about 1 to about 99.9% by weight of cosmetically acceptable carriers; wherein the composition exhibits greater than A value of flexibility of 1; and applying the cosmetic composition to the skin. 7. The method according to item 6 of the scope of patent application, wherein the controlled signs of aging are softness, tenderness and flexibility. 85632 2- 200404573 柒, Designated Representative Map: (1) The designated representative map in this case is: () Figure (2) The yuan of the representative map Symbol representing briefly described: Ba, when the case if the formula, please show most features disclosed in the invention of the formula: [H02CCH2C02] '[X] + + [X] 2 [02CCH2C02] -2 I II 85632