TR202022177A1 - FORMULATION CONTAINING ESSENTIAL OIL AND PROPOLIS - Google Patents

FORMULATION CONTAINING ESSENTIAL OIL AND PROPOLIS

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Publication number
TR202022177A1
TR202022177A1 TR2020/22177A TR202022177A TR202022177A1 TR 202022177 A1 TR202022177 A1 TR 202022177A1 TR 2020/22177 A TR2020/22177 A TR 2020/22177A TR 202022177 A TR202022177 A TR 202022177A TR 202022177 A1 TR202022177 A1 TR 202022177A1
Authority
TR
Turkey
Prior art keywords
essential oil
propolis
eucalyptus
composition
oil
Prior art date
Application number
TR2020/22177A
Other languages
Turkish (tr)
Inventor
Erdoğan Orhan İlkay
Original Assignee
Gazi Ueniversitesi Rektoerluegue
Gazi̇ Üni̇versi̇tesi̇
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gazi Ueniversitesi Rektoerluegue, Gazi̇ Üni̇versi̇tesi̇ filed Critical Gazi Ueniversitesi Rektoerluegue
Priority to TR2020/22177A priority Critical patent/TR202022177A1/en
Priority to PCT/TR2021/051300 priority patent/WO2022146329A1/en
Publication of TR202022177A1 publication Critical patent/TR202022177A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Mevcut buluş, oral sprey solüsyon formunda, Salvia fruticosa Mill. (Anadolu adaçayı) Uçucu Yağı, Eucalyptus camaldulensis Dehn. (Ökaliptus) Uçucu Yağı, Origanum majorana L. (Mercanköşk) Uçucu Yağı, Matricaria chamomilla L. (Alman papatyası) Uçucu Yağı, Citrus limon (L.) Osbeck (Limon) Uçucu Yağı, Propolis Ekstresi ve taşıyıcı olarak Pruni Amygdali var. Dulci Oleum (Tatlı Badem Yağı) içeren kompozisyonlar, bu kompozisyonların hazırlanması ve kullanımı ile ilgilidir.The present invention is in the form of an oral spray solution, Salvia fruticosa Mill. (Anatolian sage) Essential Oil, Eucalyptus camaldulensis Dehn. (Eucalyptus) Essential Oil, Origanum majorana L. (Marjoram) Essential Oil, Matricaria chamomilla L. (German chamomile) Essential Oil, Citrus lemon (L.) Osbeck (Lemon) Essential Oil, Propolis Extract and Pruni Amygdali as carrier. Compositions containing Dulci Oleum (Sweet Almond Oil) relate to the preparation and use of these compositions.

Description

TARIFNAME UÇUCU YAG VE PROPOLIS IÇEREN FORMÜLASYON Teknik Alan Mevcut bulus, oral Sprey solüsyon formunda, Salvia fruticosa Mill. (Anadolu adaçayi) Uçucu Yagi, Eucalyptus camaldulensis Dehn. (Ökaliptus) Uçucu Yagi, Origanuin majorana L. (Mercankösk) Uçucu Yagi, Matricaria chainoinilla L. (Alinan papatyasi) Uçucu Yagi, Citrus limon (L.) Osbeck (Limon) Uçucu Yagi, Propolis Ekstresi ve tasiyici olarak Pruni Amygdali var. Dulci Oleum (Tatli Badem Yagi) içeren kompozisyonlar, bu kompozisyonlarin hazirlanmasi ve kullanimi ile ilgilidir. Teknigin Bilinen Durumu Agiz ve dis sagligi alaninda en yaygin saglik problemlerinden birisi agizda olusan yara ve aftlardir. Agiz içi yaralar bazen birkaç gün içerisinde kendiliginden iyilesirken bazen iltihaplanarak aft olarak bilinen agrili yaralara dönüsebilir. Kötü kokulu nefese yol açan agiz kokusu da (halitozis) toplumda sik karsilasilan saglik sorunlarindan bir digeridir. Dis çürükleri gibi agiz içi sebeplerin yani sira baska faktörlerin de yol açtigi agiz kokusuna özellikle anaerob bakteriler sebep olinaktadir. Dünyada ve Türkiye'de genel olarak bir projeksiyon yapildiginda; antimikrobiyal etkili agiz bakiin ürünleri formunda; mentol Ve ökaliptol ile aromasi düzeltilmis çok sayida kimyasal kökenli kompozisyon bulunmaktadir. Bitkisel kökenli olanlarin ise genellikle içinde nane uçucu yagi bulunmaktadir. Ancak bulus kapsamindaki kompozisyonda kullanilan uçucu yaglarin çoguna, antimikrobiyal etkili agiz bakim spreylerinde su ana kadar rastlanmamistir. TR 2015/ 17556 bogaz iltihabi veya yarasinda kullanim için adaçayi ve içeren karisim ile TR 2019/20249 Okaliptus yagi içeren dis agrisi kesici sprey formülasyon ile ilgilidir. Çesitli bitkisel kompozisyonlar teknigin bilinen durumunda açiklanmis olsa da, bulus konusu uçucu yag kombinasyonunu ve propolis içeren, farkli alanlarda kullanilabilen güçlü antimikrobiyal etkili bir kompozisyon bulunmamaktadir. Teknigin bilinen durumunda agiz yaralari ve aft benzeri oral enfeksiyonlarin tedavisinde, agiz kokusunun önlenmesinde, giderilmesinde ve dis çürümesinden koruyucu olarak kullanilabilen güçlü antimikrobiyal etkili bitkisel kompozisyonlara ihtiyaç bulunmaktadir. Bulusun Kisa Açiklamasi Mevcut bulusun amaci, agiz kokusunun önlenmesinde, giderilmesinde ve ait, yara benzeri oral enfeksiyonlarin tedavisinde kullanilabilecek güçlü antimikrobiyal etkili bitkisel kompozisyonlarin gelistirilmesine yöneliktir. Bulus konusu oral sprey solüsyon formundaki kompozisyon; Salvia fruticosa Mill. (Anadolu adaçayi) ekstresi uçucu yagi, Eucalyptus camaldulensis Dehn. (Ökaliptus) ekstresi uçucu yagi, Origanum majorana L. (Mercankösk) ekstresi uçucu yagi, Matricaria chamomilla L. (Alman papatyasi) ekstresi uçucu yagi, Citrus limon (L.} Osbeck (Limon) ekstresi uçucu yagi, Propolis Ekstresi ve tasiyici olarak Pruni Amygdali Var. Dulci Oleum (Tatli Badem Yagi) içermektedir. Söz konusu kompozisyon agizda olusan yara ve aft benzeri oral enfeksiyonlarin tedavisi, agiz kokusunun önlenmesi ve giderilmesi gibi farkli alanlarda kullanilabilir. Bulusun Detayli Açiklamasi Bulus konusu oral sprey solüsyon formundaki kompozisyon; Salvia fruticosa Mill. (Anadolu adaçayi) uçucu yagi, Eucalyptus camaldulensis Dehn. (Ökaliptus) uçucu yagi, Origanum majorana L. (Mercankösk) uçucu yagi, Matricaria chamomilla L. (Alman papatyasi) uçucu yagi, Citrus limon (L.) Osbeck (Limon) uçucu yagi, Propolis Ekstresi, ve tasiyici olarak Pruni Amygdali var. Dulci Oleum (Tatli Badem Yagi) içermektedir. Bulus konusu kompozisyon güçlü antimikrobiyal etkiye sahiptir. Agizda olusan yara ve aft benzeri oral enfeksiyonlarin tedavisinde, agiz kokusunun önlenmesi ve giderilmesinde kullanilabilir. Kompozisyondaki Salvia fruticosa Mill. (Anadolu adaçayi) uçucu yag orani tercihen %2 (h/hl"dir. (uçucu yag hacmi/toplam kompozisyon hacmi) Kompozisyondaki Eucalyptus camaldulensis Dehn. (Ökaliptus) uçucu yag orani tercihen %2 Kompozisyondaki Origanum Majorana L. (Mercankösk) uçucu yag orani tercihen %2 (h / h ) °dir. Kompozisyondaki Matricaria chamomilla L. (Alman papatyasi) uçucu yag orani tercihen %2 Kompozisyondaki Citrus Limon (L) Osbeck (Limon) uçucu yag orani tercihen %2 (h/h]"dir. Kompozisyondaki Propolis ekstresinin orani tercihen %20 (h/hi°dir. Propolis ektresi tercihen etanol Ile SEyreltilmis olabilir. Kompozisyondaki Pruni Amygdali var. Dulci Oleum (Tatli Badem Yagi) orani tercihen %25 Kompozisyondaki ek olarak Gliserin içerebilir. Etanol orani tercihen %20 (h/h)9dir. Kompozisyondaki ek olarak Etanol içerebilir. Etanol orani tercihen %5 (_h/h)°dir. Kompozisyondaki ek olarak Deiyonize SU içerebilir. Deiyonize su orani tercihen %20 (h/h),dir. Bulus konusu kompozisyonun hacmi tercihen 100 m|"dir. Birim fcrmülasyon örnek Olarak asagida belirtilmistir. Ekstre mI/100 ml (h/h) Salvia fruticosa Mill. (Anadolu adaçayi) uçucu yagi %2 Eucalyptus camaldulensis Dehn. (Ökaiiptus) uçucu yagi % 2 Origanum majorana L. (Mercankösk) uçucu yagi % 2 Matricaria chamomilla L. (Alman papatyasi) uçucu yagi % 2 Citrus limon (L.) Osbeck (Limon) uçucu yagi %2 Propolis ekstresi (tercihen etanol ile seyretilmis) % 20 Pruni Amygdali var. Duici Oleum (Tatli Badem Yagi) % 25 Gl i serin % 20 Etanol % 5 Deiyonize su %20 100 ml"lik birim formülasyon tercihen 2 ml Salvia fruticosa Mill., 2 ml Eucalyptus camaldulensis Dehn., 2 ml Origanum majorana L., 2 ml Matricaria chamomilla L., 2 ml Citrus limon (L.) Osbeck, 20 ml Propolis ekstresi (tercihen etanol ile seyreltilmis), 25 ml Pruni Amygdali var. Dulci Oleum, 20 ml Gliserin, 5 ml Etanol ve 20 ml Deiyonize su içerir. Bulus konusu kompozisyonlar asagidaki proses ile hazirlanabilirler. . Salvia fruticosa Mill. Eucalyptus camaldulensis Dehn., Origanum majorana L., Matricaria chamomilla L.Ve Citrus limon (L.) Osbeck uçucu yaglari, Pmni Amygdali var. Dulci Oleum içerisinde karistirilir ve bitkisel karisim elde edilir, 0 Ham propolis etanol ile reaktörde çözülür, o Çözülen ürün saf su ile karistirilip tekrar islenir, o lsitildiktan sonra alkol istenilen oranda ayristirilir, o Elde edilen ürüne alkol eklenir ve propolis sivi ekstresi elde edilir, 0 Elde edilen propolis ekstresi ilk asamada elde edilen bitkisel karisima eklenir, o Karisima gliserin ve deiyonize su eklenir, 0 Final karisim karistirilir ve homojen bir solüsyon elde edilir. Bulus konusu birim kompozisyon (100 ml) tercihen asagidaki proses ile hazirlanabilirî 100 ml"lik birim formülasyonda yer alacak uçucu yaglardan [Salvia fruticosa Mill. (Anadolu adaçayi) uçucu yagi, Eucalyptus camaldulensis Dehn. (Ökaliptus) uçucu yagi, Origanum majorana L. (Mercankösk) uçucu yagi, Matricaria chamomilla L. (Alman papatyasi) uçucu yagi, Citrus limon (L.) Osbeck (Limon) uçucu yagi] 2"ser ml alinarak 25 m1 Pruni Amygdali var. Dulci OleUm (Tatli Badem Yagi) içinde karistirilir. Diger yandan 1 kg ham propolis 5 kg etanol ile reaktörde çözülür. Çözülen ürün belirli oranlarda saf` su ile karistirilip tekrar islenir. Belirli bir sicaklikta belirli bir süre isitildiktan sonra alkol istenilen oranda ayristirilir. Elde edilen üründe esansiyel yaglarin çözülebilmesi için %5 oraninda alkol , tercihen etanol eklenir. Bu propolis sivi ekstresinden 20 ml birim formülasyona ilave edilir. En son son gliserin ve deiyonize sudan da 207ser ml ilave edilerek, hepsi karistirilir ve homojen bir solüsyon hazirlanir. TR TR TR DESCRIPTION FORMULATION CONTAINING ESSENTIAL OIL AND PROPOLIS Technical Field The present invention is in the form of oral spray solution, Salvia fruticosa Mill. (Anatolian sage) Essential Oil, Eucalyptus camaldulensis Dehn. (Eucalyptus) Essential Oil, Origanuin majorana L. (Marjoram) Essential Oil, Matricaria chainoinilla L. (Albanian daisy) Essential Oil, Citrus limon (L.) Osbeck (Lemon) Essential Oil, Propolis Extract and Pruni Amygdali as a carrier. Compositions containing Dulci Oleum (Sweet Almond Oil) are related to the preparation and use of these compositions. Known State of the Technique One of the most common health problems in the field of oral and dental health is wounds and canker sores in the mouth. While oral wounds sometimes heal on their own within a few days, they can sometimes become inflamed and turn into painful sores known as canker sores. Bad breath (halitosis), which causes foul-smelling breath, is another common health problem in society. Bad breath, which is caused by intra-oral causes such as dental caries as well as other factors, is especially caused by anaerobic bacteria. When a general projection is made in the world and in Turkey; in the form of oral care products with antimicrobial effects; There are many chemical compositions whose aroma has been corrected with menthol and eucalyptol. Those of plant origin usually contain peppermint essential oil. However, most of the essential oils used in the composition within the scope of the invention have not yet been found in oral care sprays with antimicrobial effects. TR 2015/17556 relates to a mixture containing sage for use in sore throat or inflammation, and TR 2019/20249 relates to an toothache relieving spray formulation containing eucalyptus oil. Although various herbal compositions have been described in the state of the art, there is no composition with a strong antimicrobial effect that contains the essential oil combination and propolis of the invention and can be used in different areas. In the state of the art, there is a need for herbal compositions with strong antimicrobial effects that can be used in the treatment of mouth sores and canker sores-like oral infections, in the prevention and elimination of bad breath, and as a protection against tooth decay. Brief Description of the Invention The aim of the present invention is to develop herbal compositions with strong antimicrobial effects that can be used in the prevention and elimination of bad breath and in the treatment of bacterial, wound-like oral infections. The composition of the invention in oral spray solution form; Salvia fruticosa Mill. (Anatolian sage) extract essential oil, Eucalyptus camaldulensis Dehn. (Eucalyptus) extract essential oil, Origanum majorana L. (Marjoram) extract essential oil, Matricaria chamomilla L. (German chamomile) extract essential oil, Citrus limon (L.} Osbeck (Lemon) extract essential oil, Propolis Extract and Pruni as a carrier. It contains Amygdali Var. Dulci Oleum (Sweet Almond Oil). The composition in question can be used in different areas such as the treatment of wounds and aphthous-like oral infections in the mouth, prevention and elimination of bad breath. Detailed Description of the Invention The composition in oral spray solution form, which is the subject of the invention, is Salvia fruticosa Mill. (Anatolian sage) essential oil, Eucalyptus camaldulensis Dehn. (Eucalyptus) essential oil, Origanum majorana L. (Marjoram) essential oil, Matricaria chamomilla L. (German chamomile) essential oil, Citrus limon (L.) Osbeck (Lemon) essential oil. , Propolis Extract, and Pruni Amygdali as a carrier. It contains Dulci Oleum (Sweet Almond Oil). The composition of the invention has a strong antimicrobial effect. It can be used in the treatment of oral infections such as wounds and canker sores in the mouth, and to prevent and eliminate bad breath. Salvia fruticosa Mill in the composition. (Anatolian sage) essential oil rate is preferably 2% (v/hl). (essential oil volume/total composition volume) Eucalyptus camaldulensis Dehn. (Eucalyptus) essential oil rate in the composition is preferably 2% Origanum Majorana L. (Marjoram) essential oil in the composition. The ratio is preferably 2% (v/v). The essential oil ratio of Matricaria chamomilla L. (German chamomile) in the composition is preferably 2%. The essential oil ratio of Citrus Lemon (L) Osbeck (Lemon) in the composition is preferably 2% (v/v). The ratio of Propolis extract in the composition is preferably 20% (v/hi). Propolis extract may preferably be diluted with ethanol. The ratio of Pruni Amygdali var. Dulci Oleum (Sweet Almond Oil) in the composition is preferably 25%. Additionally, it may contain Glycerin. The ratio of ethanol is preferably 20%. (v/v)9. It may additionally contain Ethanol in the composition. The ethanol ratio is preferably 5% (_v/v). It may additionally contain Deionized WATER in the composition. The deionized water ratio is preferably 20% (v/v). The composition of the invention is Its volume is preferably 100 m². The unit formulation is given below as an example. Extract mI/100 ml (v/v) Salvia fruticosa Mill. (Anatolian sage) essential oil 2% Eucalyptus camaldulensis Dehn. (Eucalyptus) essential oil 2% Origanum majorana L. (Marjoram) essential oil 2% Matricaria chamomilla L. (German chamomile) essential oil 2% Citrus lemon (L.) Osbeck essential oil 2% Propolis extract (preferably with ethanol) diluted) 20% Pruni Amygdali var. Duici Oleum (Sweet Almond Oil) 25% Gl i serine 20% Ethanol 5% Deionized water 20% 100 ml unit formulation preferably 2 ml Salvia fruticosa Mill., 2 ml Eucalyptus camaldulensis Dehn., 2 ml Origanum majorana L., 2 Contains ml Matricaria chamomilla L., 2 ml Citrus limon (L.) Osbeck, 20 ml Propolis extract (preferably diluted with ethanol), 25 ml Pruni Amygdali var. Dulci Oleum, 20 ml Glycerin, 5 ml Ethanol and 20 ml Deionized water. The compositions of the invention can be prepared by the following process: Salvia fruticosa Mill. Eucalyptus camaldulensis Dehn., Origanum majorana L., Matricaria chamomilla L. and Citrus limon (L.) Osbeck essential oils are mixed in Pmni Amygdali var. Dulci Oleum and the herbal mixture is obtained. 0 Crude propolis is dissolved in the reactor with ethanol, o The dissolved product is mixed with pure water and processed again, o After heating, the alcohol is separated at the desired rate, o Alcohol is added to the resulting product and propolis liquid extract is obtained, 0 The obtained propolis extract is the product obtained in the first stage. is added to the herbal mixture, o Glycerin and deionized water are added to the mixture, 0 The final mixture is mixed and a homogeneous solution is obtained. The unit composition of the invention (100 ml) can preferably be prepared by the following process. It consists of the essential oils to be included in the 100 ml unit formulation [Salvia fruticosa Mill. (Anatolian sage) essential oil, Eucalyptus camaldulensis Dehn. (Eucalyptus) essential oil, Origanum majorana L. ( Marjoram essential oil, Matricaria chamomilla L. (German chamomile) essential oil, Citrus limon (L.) Osbeck (Lemon) essential oil] 25 m1 of Pruni Amygdali var. It is mixed in Dulci OleUm (Sweet Almond Oil). On the other hand, 1 kg of raw propolis is dissolved in the reactor with 5 kg of ethanol. The dissolved product is mixed with pure water in certain proportions and processed again. After heating at a certain temperature for a certain period of time, the alcohol is separated at the desired rate. In order to dissolve the essential oils in the resulting product, 5% alcohol, preferably ethanol, is added. 20 ml of this propolis liquid extract is added to the formulation. Finally, 207 ml of glycerin and deionized water are added, all are mixed and a homogeneous solution is prepared. TR TR TR

TR2020/22177A 2020-12-29 2020-12-29 FORMULATION CONTAINING ESSENTIAL OIL AND PROPOLIS TR202022177A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TR2020/22177A TR202022177A1 (en) 2020-12-29 2020-12-29 FORMULATION CONTAINING ESSENTIAL OIL AND PROPOLIS
PCT/TR2021/051300 WO2022146329A1 (en) 2020-12-29 2021-11-26 A formulation comprising an essential oil and propolis

Applications Claiming Priority (1)

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US6027716A (en) * 1997-04-02 2000-02-22 Farmo-Nat Ltd. Synergistic herbal extracts
US8980334B2 (en) * 2001-02-28 2015-03-17 Axiomedic Ltd. Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
BR112012013345A2 (en) * 2009-12-04 2016-03-01 Colgate Palmolive Co oral compositions containing a combination of natural extracts and related methods

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