TR201807677A2 - Oti̇zmde etki̇li̇ kombi̇ne surami̇n ve feksofenadi̇n i̇çeren farmasöti̇k formülasyon - Google Patents
Oti̇zmde etki̇li̇ kombi̇ne surami̇n ve feksofenadi̇n i̇çeren farmasöti̇k formülasyon Download PDFInfo
- Publication number
- TR201807677A2 TR201807677A2 TR2018/07677A TR201807677A TR201807677A2 TR 201807677 A2 TR201807677 A2 TR 201807677A2 TR 2018/07677 A TR2018/07677 A TR 2018/07677A TR 201807677 A TR201807677 A TR 201807677A TR 201807677 A2 TR201807677 A2 TR 201807677A2
- Authority
- TR
- Turkey
- Prior art keywords
- suramin
- brain
- suramine
- combination
- fexsofenadine
- Prior art date
Links
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 title claims abstract 8
- 229960005314 suramin Drugs 0.000 title claims abstract 8
- AXDLCFOOGCNDST-UHFFFAOYSA-N N-methyl-DL-tyrosine Natural products CNC(C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010003805 Autism Diseases 0.000 claims abstract 5
- 208000020706 Autistic disease Diseases 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 5
- 229940079593 drug Drugs 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 239000003182 parenteral nutrition solution Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000004556 brain Anatomy 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 2
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 2
- 229960003592 fexofenadine Drugs 0.000 abstract 2
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 239000013583 drug formulation Substances 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bu buluşta Otistik spektrum bozukluğunda kısmen etkili olduğu bildirilen Suramin isimli etkin maddenin vücuda alındığında etkisini güçlendirecek bir ilaç formülasyonu geliştirilmiştir. İlaçlar beyine yüksek oranda geçememektedirler. Bu kan beyin engeli nedeni ile olmaktadır. Otizmede etkili olduğu bulunan Suramin de beyine yüksek oranda geçemediğinden tedavi etkisi düşük olmaktadır. Bu buluşta Feksofenadin isimli etkin maddenin kan beyin engelini kolayca geçebildiği, uygun kombinasyonda ve dozlarında, Suraminin ile birleşerek bu engeli aşmasına yardımcı olduğu ortaya konmuştur. Suramin ve Feksofenadin kombinasyonu Suraminin beyine daha yüksek oranda geçmesine neden olarak daha iyi bir tedavi sağlamaktadır.
Claims (1)
- ISTEMLER . Otizm tedavisinde kullanilan kombine bir ilaç olup özelligi; Suramin, F eksofenadin, veya bunlarin tuzlari ile bir ya da birden fazla farmasötik olarak kabul edilebilir yardimci madde içermesidir. . Istem l,e göre Otizm tedavisinde kullanilan kombine bir ilaç olup özelligi; Suraminin . Istem 1 ve 2,ye göre Otizm tedavisinde kullanilan kombine bir ilaç olup özelligi parenteral çözelti hazirlanabilecek steril liyofilize toz olmasidir. . Otizm tedavisinde kullanilan kombine bir ilaç üretmek için bir yöntem olup özelligi; bu yöntem liyofilizasyondur.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2018/07677A TR201807677A2 (tr) | 2018-05-30 | 2018-05-30 | Oti̇zmde etki̇li̇ kombi̇ne surami̇n ve feksofenadi̇n i̇çeren farmasöti̇k formülasyon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2018/07677A TR201807677A2 (tr) | 2018-05-30 | 2018-05-30 | Oti̇zmde etki̇li̇ kombi̇ne surami̇n ve feksofenadi̇n i̇çeren farmasöti̇k formülasyon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201807677A2 true TR201807677A2 (tr) | 2018-07-23 |
Family
ID=64606407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/07677A TR201807677A2 (tr) | 2018-05-30 | 2018-05-30 | Oti̇zmde etki̇li̇ kombi̇ne surami̇n ve feksofenadi̇n i̇çeren farmasöti̇k formülasyon |
Country Status (1)
| Country | Link |
|---|---|
| TR (1) | TR201807677A2 (tr) |
-
2018
- 2018-05-30 TR TR2018/07677A patent/TR201807677A2/tr unknown
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