TR201001630T1 - Stafilokinaz varyantı. - Google Patents

Stafilokinaz varyantı.

Info

Publication number
TR201001630T1
TR201001630T1 TR2010/01630T TR201001630T TR201001630T1 TR 201001630 T1 TR201001630 T1 TR 201001630T1 TR 2010/01630 T TR2010/01630 T TR 2010/01630T TR 201001630 T TR201001630 T TR 201001630T TR 201001630 T1 TR201001630 T1 TR 201001630T1
Authority
TR
Turkey
Prior art keywords
staphylokinase
staphylokinase variant
variant
reduced
thrombolytically
Prior art date
Application number
TR2010/01630T
Other languages
English (en)
Inventor
Collen Desire
Original Assignee
Thrombogenics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thrombogenics N.V. filed Critical Thrombogenics N.V.
Publication of TR201001630T1 publication Critical patent/TR201001630T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Buluş, düşük T-hücresi immünojenesitesi ve yüksek seviyelerde eksprese olabilen antikorların dolaşımı ile azaltılmış klirens sergileyen, optimize edilen trombolitik olarak veya fibrinolitik olarak aktif bir stafilokinaz varyantına ilişkindir.
TR2010/01630T 2007-10-09 2007-10-09 Stafilokinaz varyantı. TR201001630T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/008871 WO2009046742A1 (en) 2007-10-09 2007-10-09 Staphylokinase variant

Publications (1)

Publication Number Publication Date
TR201001630T1 true TR201001630T1 (tr) 2010-05-21

Family

ID=39004749

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2010/01630T TR201001630T1 (tr) 2007-10-09 2007-10-09 Stafilokinaz varyantı.

Country Status (4)

Country Link
CN (1) CN101848928B (tr)
IL (1) IL204171A (tr)
TR (1) TR201001630T1 (tr)
WO (1) WO2009046742A1 (tr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102108351B (zh) * 2009-08-19 2013-04-03 河北师范大学 一种低免疫原性葡激酶突变体及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1053330B1 (en) * 1998-02-04 2005-05-04 Thromb-X N.V. Identification, production and use of staphylokinase derivatives with reduced immunogenicity and/or reduced clearance
CN100335498C (zh) * 1999-12-02 2007-09-05 思罗姆-X股份有限公司 通过消除t－细胞表位来降低异源蛋白的免疫原性的方法

Also Published As

Publication number Publication date
WO2009046742A1 (en) 2009-04-16
CN101848928A (zh) 2010-09-29
IL204171A (en) 2015-05-31
CN101848928B (zh) 2013-07-17

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