TR200606490A2 - WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu. - Google Patents
WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu.Info
- Publication number
- TR200606490A2 TR200606490A2 TR2006/06490A TR200606490A TR200606490A2 TR 200606490 A2 TR200606490 A2 TR 200606490A2 TR 2006/06490 A TR2006/06490 A TR 2006/06490A TR 200606490 A TR200606490 A TR 200606490A TR 200606490 A2 TR200606490 A2 TR 200606490A2
- Authority
- TR
- Turkey
- Prior art keywords
- wrn
- induced cell
- cell signals
- mediated modulation
- telomere
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
Abstract
WRN modülatörlerinin kullanımı tarif edilmektedir. WRN aktivatörleri, büyümenin durdurulması, apoptozi veya proliferatif yaşlanmayı indüklemek için kullanılabilirken WRN inhibitörleri, büyüme durmasını, apoptoziyi veya proliferatif yaşlanmayı azaltmak için kullanılabilir. WRN modülatörlerinin tanımlanmasına yönelik yöntemler de tarif edilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57262504P | 2004-05-19 | 2004-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200606490A2 true TR200606490A2 (tr) | 2008-05-21 |
Family
ID=34982215
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2006/06490A TR200606490A2 (tr) | 2004-05-19 | 2005-05-19 | WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu. |
TR2006/06490T TR200606490T1 (tr) | 2004-05-19 | 2005-05-19 | WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2006/06490T TR200606490T1 (tr) | 2004-05-19 | 2005-05-19 | WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080221052A1 (tr) |
EP (2) | EP2434009A1 (tr) |
JP (1) | JP2007537758A (tr) |
KR (1) | KR20070030219A (tr) |
CN (2) | CN101869575A (tr) |
AU (1) | AU2005245932A1 (tr) |
BR (1) | BRPI0511142A (tr) |
CA (1) | CA2566859C (tr) |
HK (1) | HK1104062A1 (tr) |
IL (1) | IL179199A (tr) |
MX (1) | MXPA06013263A (tr) |
NO (1) | NO20065782L (tr) |
NZ (1) | NZ551323A (tr) |
RU (1) | RU2006144817A (tr) |
TR (2) | TR200606490A2 (tr) |
WO (1) | WO2005113764A2 (tr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100086941A1 (en) * | 2008-10-01 | 2010-04-08 | Adami Guy R | Methods for determining aged based accumulation of senescent cells using senescence specific DNA damage markers |
US20110052676A1 (en) * | 2009-09-01 | 2011-03-03 | James Vincent Gruber | Composition For Delaying Cellular Senescence |
RU2550267C2 (ru) * | 2012-12-12 | 2015-05-10 | Елена Андреевна Чирясова | Способ воздействия на пролиферативный статус клеток с помощью специфических нуклеотидных последовательностей g-цепи теломерной днк человека |
US11530413B2 (en) | 2017-07-21 | 2022-12-20 | Novartis Ag | Compositions and methods to treat cancer |
US20210371855A1 (en) * | 2018-06-15 | 2021-12-02 | Ideaya Biosciences, Inc. | Methods of inhibiting proliferative cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2521565B1 (fr) | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
FR2534487B1 (fr) * | 1982-10-15 | 1988-06-10 | Dior Christian Parfums | Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede |
US5077211A (en) * | 1988-07-06 | 1991-12-31 | Applied Genetics, Inc. | Purification and administration of dna repair enzymes |
WO2001074342A2 (en) * | 2000-03-31 | 2001-10-11 | Trustees Of Boston University | Use of locally applied dna fragments |
US6090620A (en) * | 1995-12-29 | 2000-07-18 | University Of Washington | Genes and gene products related to Werner's syndrome |
US6228583B1 (en) * | 1997-08-04 | 2001-05-08 | Massachusetts Institute Of Technology | Assays for compounds which extend life span |
SE0200929D0 (sv) | 2002-03-26 | 2002-03-26 | Alstom Switzerland Ltd | An apparatus and method for suspending a stator core of an electric generator |
AU2004233188A1 (en) | 2003-04-11 | 2004-11-04 | Trustees Of Boston University | Modulation of telomere-initiated cell signaling |
-
2005
- 2005-05-19 JP JP2007527438A patent/JP2007537758A/ja active Pending
- 2005-05-19 CA CA2566859A patent/CA2566859C/en not_active Expired - Fee Related
- 2005-05-19 KR KR1020067026455A patent/KR20070030219A/ko not_active Application Discontinuation
- 2005-05-19 MX MXPA06013263A patent/MXPA06013263A/es not_active Application Discontinuation
- 2005-05-19 BR BRPI0511142-0A patent/BRPI0511142A/pt not_active IP Right Cessation
- 2005-05-19 WO PCT/US2005/017553 patent/WO2005113764A2/en active Application Filing
- 2005-05-19 TR TR2006/06490A patent/TR200606490A2/tr unknown
- 2005-05-19 AU AU2005245932A patent/AU2005245932A1/en not_active Abandoned
- 2005-05-19 EP EP10184985A patent/EP2434009A1/en not_active Withdrawn
- 2005-05-19 CN CN201010166072A patent/CN101869575A/zh active Pending
- 2005-05-19 TR TR2006/06490T patent/TR200606490T1/tr unknown
- 2005-05-19 EP EP05750059A patent/EP1761629A2/en not_active Withdrawn
- 2005-05-19 CN CN200580015751XA patent/CN1965076B/zh not_active Expired - Fee Related
- 2005-05-19 US US11/569,243 patent/US20080221052A1/en not_active Abandoned
- 2005-05-19 NZ NZ551323A patent/NZ551323A/en unknown
- 2005-05-19 RU RU2006144817/13A patent/RU2006144817A/ru not_active Application Discontinuation
-
2006
- 2006-11-12 IL IL179199A patent/IL179199A/en not_active IP Right Cessation
- 2006-12-13 NO NO20065782A patent/NO20065782L/no unknown
-
2007
- 2007-11-15 HK HK07112486.9A patent/HK1104062A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2005113764A3 (en) | 2006-03-30 |
CN1965076A (zh) | 2007-05-16 |
KR20070030219A (ko) | 2007-03-15 |
EP2434009A1 (en) | 2012-03-28 |
US20080221052A1 (en) | 2008-09-11 |
AU2005245932A1 (en) | 2005-12-01 |
BRPI0511142A (pt) | 2007-12-04 |
RU2006144817A (ru) | 2008-06-27 |
CA2566859A1 (en) | 2005-12-01 |
NZ551323A (en) | 2010-03-26 |
CN1965076B (zh) | 2011-01-26 |
EP1761629A2 (en) | 2007-03-14 |
MXPA06013263A (es) | 2007-08-14 |
JP2007537758A (ja) | 2007-12-27 |
NO20065782L (no) | 2006-12-18 |
WO2005113764A2 (en) | 2005-12-01 |
IL179199A0 (en) | 2007-03-08 |
HK1104062A1 (en) | 2008-01-04 |
CA2566859C (en) | 2011-07-19 |
TR200606490T1 (tr) | 2007-01-22 |
IL179199A (en) | 2010-12-30 |
CN101869575A (zh) | 2010-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE513833T1 (de) | Thienopyridinverbindungen und verfahren zu ihrer verwendung | |
MX2009012623A (es) | Moduladores de cinasa heterociclicos. | |
MY158447A (en) | Compounds modulating c-fms and/or c-kit activity and uses thereof | |
TNSN07027A1 (en) | Pyrrolo-pyridine kinase modulators | |
ATE443775T1 (de) | Hif-prolylhydroxylase-aktivitätstest | |
TR200606490T1 (tr) | WRN aracılığında telomerin başlattığı hücre sinyallerinin modülasyonu. | |
TNSN07028A1 (en) | Fused ring heterocycle kinase modulators | |
ATE402709T1 (de) | Neue tellurium-verbindungen und ihre verwendung als immunmodulatoren | |
ATE480615T1 (de) | Verfahren zur proliferation von stammzellen | |
TW200745109A (en) | Pyrrolo-pyridine kinase modulators | |
TW200640936A (en) | Proteasome inhibitors and methods of using the same | |
JO3450B1 (ar) | أشكال جرعات تحرير جديدة معدلة لمثبطات زانثين اوكسيدوريدوكتيز أو مثبطات زانثين اوكسيديز | |
EA201000094A1 (ru) | Производные пиримидинил-пиридазинона | |
TW200722099A (en) | Monitoring and modulating HGF/HGFR activity | |
IL193495A0 (en) | Culture medium containing kinase inhibitors and uses thereof | |
WO2012037155A3 (en) | Tyrosine kinase inhibitors | |
BRPI0515518A (pt) | análogos de loxapina e métodos de usos dos mesmos | |
CL2012002904A1 (es) | Combinación o composición farmacéutica que comprende un inhibidor de la señalización de células y/o de la angiogénesis y un inhibidor de la quinasa aurora (aki); kit faramcéutico que la comprende; su uso en el tratamiento de enfermedades oncológicas y fibróticas; y compuestos derivados de indol y pirimidina sustituidos. | |
MX2021003731A (es) | Inhibidores de vap-1. | |
WO2008090417A3 (en) | Inhibition of nf-kb | |
MX2022004270A (es) | Inhibidores de aldosa reductasa para el tratamiento de la deficiencia de fosfomannomutasa 2. | |
MX2019012169A (es) | Ensayos para evaluar la actividad de moduladores de miembros de la familia de hidroxiesteroide (17-beta) deshidrogenasa (hsd17b). | |
WO2006104751A3 (en) | Methods and compositions for modulating rho-mediated gene transcription | |
MX2022005065A (es) | Compuestos heterocíclicos de carboxilato como inhibidores de glicolato oxidasa. | |
WO2007084949A3 (en) | Modulators of cardiac cell hypertrophy and hyperplasia |