TR200402164T4 - Triptaz inhibitörler - Google Patents

Triptaz inhibitörler

Info

Publication number
TR200402164T4
TR200402164T4 TR2004/02164T TR200402164T TR200402164T4 TR 200402164 T4 TR200402164 T4 TR 200402164T4 TR 2004/02164 T TR2004/02164 T TR 2004/02164T TR 200402164 T TR200402164 T TR 200402164T TR 200402164 T4 TR200402164 T4 TR 200402164T4
Authority
TR
Turkey
Prior art keywords
same
methylene
tryptase inhibitors
phenylene
identically
Prior art date
Application number
TR2004/02164T
Other languages
English (en)
Inventor
Stadlwieser Josef
Bar Thomas
Rudiger Ulrich Wolf
Dominik Andreas
Bundschuh Daniela
Zech Karl
Sommerhoff Christian
Martin Thomas
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of TR200402164T4 publication Critical patent/TR200402164T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formül I'e ait bilesikler ve bu bilesiklerin tuzlari olup M, asagidaki formüle sahip merkez yapi bloku n,1 yada 2, U1 ve U2, birbirlerinin ayni olarak metilen[-CH2-], A1,-O-B1-A3-yada-O-C(O)-NH-, A2, -O-B2-A4-yada-OC(O)-NH-, A3,-O-C(O)-NH-ve A4,-O-C(O)-NH-, B1 ve B2, birbirlerinin ayni olarak etilen, K1,-B3-Z1-B5-X1, K2,-B4-Z2-B6-X2, B3 ve B4, birbirlerinin ayni olarak metilen, B5 ve B6, birbirlerinin ayni olarak da metilen, X1 ve X2, birbirilerinin ayni olarak amino, Z1 veZ2, birbirlerinin ayni yada farkli olarak 1,3-fenilen yada 1,4-fenilen'dir.
TR2004/02164T 1999-12-20 2000-12-16 Triptaz inhibitörler TR200402164T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99125382 1999-12-20

Publications (1)

Publication Number Publication Date
TR200402164T4 true TR200402164T4 (tr) 2004-10-21

Family

ID=8239660

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02164T TR200402164T4 (tr) 1999-12-20 2000-12-16 Triptaz inhibitörler

Country Status (13)

Country Link
US (1) US6815557B2 (tr)
EP (1) EP1244614B1 (tr)
JP (1) JP2003518087A (tr)
AT (1) ATE268322T1 (tr)
AU (1) AU783371B2 (tr)
CA (1) CA2392127A1 (tr)
DE (1) DE60011300T2 (tr)
DK (1) DK1244614T3 (tr)
ES (1) ES2222270T3 (tr)
PT (1) PT1244614E (tr)
SI (1) SI1244614T1 (tr)
TR (1) TR200402164T4 (tr)
WO (1) WO2001046128A2 (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60200935T2 (de) 2001-01-31 2005-09-01 Altana Pharma Ag Diazocinderivate und deren verwendung als tryptase inhibitoren
WO2002066420A2 (en) 2001-02-21 2002-08-29 Altana Pharma Ag Tryptase inhibitors
CA2438685A1 (en) 2001-02-21 2002-08-29 Altana Pharma Ag Tryptase inhibitors
WO2002074732A2 (en) * 2001-03-15 2002-09-26 Altana Pharma Ag Tryptase-inhibitors
WO2002074733A2 (en) * 2001-03-15 2002-09-26 Altana Pharma Ag Tryptase-inhibitors
US6962941B2 (en) 2001-06-19 2005-11-08 Altana Pharma Ag Tryptase inhibitors
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3999946A (en) * 1976-02-23 1976-12-28 Allied Chemical Corporation Time-temperature history indicators
US4228126A (en) * 1977-11-25 1980-10-14 Allied Chemical Corporation Diacetylene time-temperature indicators
EP0763016B1 (en) * 1994-06-01 2000-01-26 Axys Pharmaceuticals, Inc. Compositions and methods for treating mast-cell mediated conditions
CA2200561A1 (en) * 1994-09-23 1996-03-28 Ken D. Rice Compositions and methods for treating mast-cell inflammatory conditions
EP0934293A1 (en) 1996-07-30 1999-08-11 Arris Pharmaceutical Corporation Novel compounds and compositions for treating diseases associated with tryptase activity
AU8997498A (en) 1997-09-05 1999-03-29 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitor
US6221914B1 (en) 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
AU1208999A (en) 1997-11-10 1999-05-31 Array Biopharma, Inc. Compounds which inhibit tryptase activity
ES2233025T3 (es) 1998-02-06 2005-06-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Agente inhibidores de la triptasa.
JP2002502845A (ja) 1998-02-06 2002-01-29 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ トリプターゼ阻害物質
EP1115731A2 (de) 1998-09-04 2001-07-18 Byk Gulden Lomberg Chemische Fabrik GmbH Neue pyranosen
CA2381919A1 (en) 1999-08-10 2001-02-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tryptase inhibitors
US6960588B1 (en) 1999-09-14 2005-11-01 Altana Pharma Ag Tryptase inhibitors

Also Published As

Publication number Publication date
AU783371B2 (en) 2005-10-20
WO2001046128A3 (en) 2001-11-22
JP2003518087A (ja) 2003-06-03
ATE268322T1 (de) 2004-06-15
US20030073720A1 (en) 2003-04-17
AU3013101A (en) 2001-07-03
WO2001046128A2 (en) 2001-06-28
DE60011300D1 (de) 2004-07-08
DK1244614T3 (da) 2004-09-27
EP1244614A2 (en) 2002-10-02
EP1244614B1 (en) 2004-06-02
CA2392127A1 (en) 2001-06-28
US6815557B2 (en) 2004-11-09
SI1244614T1 (en) 2004-10-31
PT1244614E (pt) 2004-10-29
DE60011300T2 (de) 2005-08-04
ES2222270T3 (es) 2005-02-01

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