TR200003071T2 - New heterocyclic substituted amides with cysteine-protease effect - Google Patents

New heterocyclic substituted amides with cysteine-protease effect

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Publication number
TR200003071T2
TR200003071T2 TR2000/03071T TR200003071T TR200003071T2 TR 200003071 T2 TR200003071 T2 TR 200003071T2 TR 2000/03071 T TR2000/03071 T TR 2000/03071T TR 200003071 T TR200003071 T TR 200003071T TR 200003071 T2 TR200003071 T2 TR 200003071T2
Authority
TR
Turkey
Prior art keywords
cysteine
substituted amides
heterocyclic substituted
new heterocyclic
protease effect
Prior art date
Application number
TR2000/03071T
Other languages
Turkish (tr)
Inventor
Wilfried Lubisch Dr.
Achim M�Ller Dr.
Hans-J�Rg Treiber Dr.
Knopp Dr.Monika
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200003071T2 publication Critical patent/TR200003071T2/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Eldeki bulus, enzim önleyicilerini, özellikle sistein proteazlarini meydana getiren genel formül I'in amidlerini konu almaktadir. FORMÜL (1)The present invention is concerned with amides of the general formula I, which forms enzyme inhibitors, in particular cysteine proteases. FORMULA (1)

TR2000/03071T 1998-04-20 1999-04-19 New heterocyclic substituted amides with cysteine-protease effect TR200003071T2 (en)

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DE19817460 1998-04-20

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JP (1) JP2002512240A (en)
KR (1) KR20010042839A (en)
CN (1) CN1306526A (en)
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BG (1) BG104885A (en)
BR (1) BR9909819A (en)
CA (1) CA2328720A1 (en)
HR (1) HRP20000788A2 (en)
HU (1) HUP0101839A3 (en)
ID (1) ID26728A (en)
IL (1) IL138999A0 (en)
NO (1) NO20005261L (en)
PL (1) PL343551A1 (en)
SK (1) SK15062000A3 (en)
TR (1) TR200003071T2 (en)
WO (1) WO1999054320A1 (en)
ZA (1) ZA200006714B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10114762A1 (en) * 2001-03-26 2002-10-02 Knoll Gmbh Treatment of lung diseases, especially adult respiratory distress syndrome, by administration of cysteine protease inhibitor, especially calpain inhibitor
EP1935885A3 (en) * 2001-05-22 2008-10-15 Neurogen Corporation Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues.
KR20040012851A (en) 2001-05-22 2004-02-11 뉴로젠 코포레이션 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
US7618959B2 (en) 2002-11-05 2009-11-17 Smithklinebeecham Corp Antibacterial agents
WO2004043916A1 (en) 2002-11-12 2004-05-27 Merck & Co., Inc. Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
US7084154B2 (en) 2003-02-11 2006-08-01 Pharmacopeia Drug Disclovery, Inc. 2-(aminomethyl) arylamide analgesics
RU2485114C2 (en) 2006-12-29 2013-06-20 Эбботт Гмбх Унд Ко.Кг Carboxamide compounds and use thereof as calpain inhibitors
CA2677803A1 (en) 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
TWI453019B (en) 2007-12-28 2014-09-21 Abbvie Deutschland Carboxamide compounds
TWI519530B (en) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 Carboxamide compounds and their use as calpain inhibitors
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
US8598211B2 (en) 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
JP2013544866A (en) 2010-12-09 2013-12-19 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー Carboxamide compounds and their use as calpain inhibitors V
US9150545B2 (en) 2012-04-03 2015-10-06 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
US10071584B2 (en) 2012-07-09 2018-09-11 Apple Inc. Process for creating sub-surface marking on plastic parts
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
US11292801B2 (en) 2016-07-05 2022-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
SG10201912574WA (en) 2016-09-28 2020-02-27 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2023165334A1 (en) * 2022-03-01 2023-09-07 成都威斯克生物医药有限公司 Keto amide derivatives and pharmaceutical use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06504547A (en) * 1990-12-28 1994-05-26 ジョージア・テック・リサーチ・コーポレーション Peptide ketoamides, keto acids and ketoesters
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
JP2848232B2 (en) * 1993-02-19 1999-01-20 武田薬品工業株式会社 Aldehyde derivatives
EP0831920A4 (en) * 1995-06-06 2003-03-19 Athena Neurosciences Inc Novel cathepsin and methods and compositions for inhibition thereof
DE19642591A1 (en) * 1996-10-15 1998-04-16 Basf Ag New piperidine-ketocarboxylic acid derivatives, their production and use
DE19648793A1 (en) * 1996-11-26 1998-05-28 Basf Ag New benzamides and their application
DE19650975A1 (en) * 1996-12-09 1998-06-10 Basf Ag New heterocyclically substituted benzamides and their application
SK282680B6 (en) * 1996-12-11 2002-11-06 Basf Aktiengesellschaft Ketobenzamides, pharmaceutical preparations containing them and t heir us for disease suppression

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