TR200002446T2 - Inhibitors of phospholipase enzymes - Google Patents

Inhibitors of phospholipase enzymes

Info

Publication number
TR200002446T2
TR200002446T2 TR2000/02446T TR200002446T TR200002446T2 TR 200002446 T2 TR200002446 T2 TR 200002446T2 TR 2000/02446 T TR2000/02446 T TR 2000/02446T TR 200002446 T TR200002446 T TR 200002446T TR 200002446 T2 TR200002446 T2 TR 200002446T2
Authority
TR
Turkey
Prior art keywords
inhibitors
phospholipase enzymes
compounds
phospholipase
enzymes
Prior art date
Application number
TR2000/02446T
Other languages
Turkish (tr)
Inventor
S. Seehra Jasbir
Kaila Neelu
Mckew John
Lovering Frank
E. Bemis Jean
Xiang Yibin
Original Assignee
Genetics Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute, Inc. filed Critical Genetics Institute, Inc.
Publication of TR200002446T2 publication Critical patent/TR200002446T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Yeni bilesikler açiklanmais olup bu bilesikler özellikle sitosolik fosfolifaz A2 olmak üzere fosfolifaz enzimlerine iliskin aktiveteyi inhibite eder. Bu bilesiklerden olusan farmakolojik kompozisyonlar ve bu kompozisyonlari kullanarak tedavi yöntemleri de açiklanmistir.New compounds have been disclosed, and these compounds inhibit activity related to phospholipase enzymes, particularly cytosolic phospholipase A2. Pharmacological compositions consisting of these compounds and treatment methods using these compositions are also described.

TR2000/02446T 1998-02-25 1999-02-24 Inhibitors of phospholipase enzymes TR200002446T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3006298A 1998-02-25 1998-02-25

Publications (1)

Publication Number Publication Date
TR200002446T2 true TR200002446T2 (en) 2000-12-21

Family

ID=21852314

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02446T TR200002446T2 (en) 1998-02-25 1999-02-24 Inhibitors of phospholipase enzymes

Country Status (19)

Country Link
EP (1) EP1056719A2 (en)
JP (1) JP2002504539A (en)
KR (1) KR20010041343A (en)
CN (1) CN1299347A (en)
AU (1) AU2782699A (en)
BG (1) BG104780A (en)
BR (1) BR9908280A (en)
CA (1) CA2322161A1 (en)
EA (1) EA200000868A1 (en)
EE (1) EE200000486A (en)
HR (1) HRP20000552A2 (en)
HU (1) HUP0100757A3 (en)
ID (1) ID27280A (en)
IL (1) IL137718A0 (en)
NO (1) NO20004220L (en)
PL (1) PL342995A1 (en)
SK (1) SK12742000A3 (en)
TR (1) TR200002446T2 (en)
WO (1) WO1999043651A2 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE263162T1 (en) * 1999-05-05 2004-04-15 Aventis Pharma Ltd UREA DERIVATIVES AND THEIR USE AS CELL ADHESION MODULATORS
DE60128475T2 (en) 2000-07-25 2008-02-07 Merck & Co., Inc. N-SUBSTITUTED INDOLE USED IN THE TREATMENT OF DIABETES
CA2436130A1 (en) 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
ES2314100T3 (en) 2001-05-03 2009-03-16 Monsanto Technology Llc PIRUVATO DERIVATIVES
DK1397130T3 (en) 2001-06-20 2007-11-12 Wyeth Corp Substituted Indole Acid Derivatives as Inhibitors of Plasminogen Activator Inhibitor-1 (PAI-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7291639B2 (en) 2001-06-20 2007-11-06 Wyeth Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
JPWO2003000668A1 (en) * 2001-06-25 2004-10-07 日本曹達株式会社 Oxa (thia) zolidine compound, production method and anti-inflammatory drug
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
SI1451154T1 (en) * 2001-12-03 2008-06-30 Wyeth Corp Inhibitors of cytosolic phospholipase a2
DK1892239T3 (en) * 2001-12-03 2013-03-25 Wyeth Llc Inhibitors of cytosol phospholipase A2
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
AU2003260085B2 (en) 2002-08-29 2008-09-11 Merck & Co., Inc. Indoles having anti-diabetic activity
CA2495943C (en) 2002-08-29 2009-07-21 Merck & Co., Inc. Indoles having anti-diabetic activity
KR20050072812A (en) 2002-11-07 2005-07-12 악조 노벨 엔.브이. Indoless useful in the treatment of androgen-receptor related diseases
AU2003296323A1 (en) 2002-12-10 2004-06-30 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CN1723197A (en) 2002-12-10 2006-01-18 惠氏公司 Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
AU2003296324A1 (en) 2002-12-10 2004-06-30 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DE60306548T2 (en) 2002-12-10 2007-06-21 Wyeth SUBSTITUTED 3-CARBONYL-1-YL-ACETIC DERIVATIVES AS PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) INHIBITORS
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
ATE405549T1 (en) 2004-06-18 2008-09-15 Biolipox Ab INDOLES SUITABLE FOR THE TREATMENT OF INFLAMMATION
MX2007002178A (en) 2004-08-23 2007-04-02 Wyeth Corp Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases.
KR100912146B1 (en) * 2004-10-27 2009-08-14 에프. 호프만-라 로슈 아게 New indole or benzimidazole derivatives
CN101142185A (en) * 2005-01-19 2008-03-12 比奥里波克斯公司 Indoles useful in the treatment of inflammation
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
AU2006279496A1 (en) 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
AR072297A1 (en) 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
KR101763656B1 (en) 2009-06-29 2017-08-01 인사이트 홀딩스 코포레이션 Pyrimidinones as pi3k inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
JP5816678B2 (en) 2010-04-14 2015-11-18 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Condensed derivatives as PI3Kδ inhibitors
WO2011163195A1 (en) 2010-06-21 2011-12-29 Incyte Corporation Fused pyrrole derivatives as pi3k inhibitors
JP5961187B2 (en) 2010-12-20 2016-08-02 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ N- (1- (substituted phenyl) ethyl) -9H-purin-6-amine as a PI3K inhibitor
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
WO2013033569A1 (en) 2011-09-02 2013-03-07 Incyte Corporation Heterocyclylamines as pi3k inhibitors
AR090548A1 (en) 2012-04-02 2014-11-19 Incyte Corp BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
MY198512A (en) 2012-07-17 2023-09-01 Glaxosmithkline Ip No 2 Ltd Indolecarbonitriles as selective androgen receptor modulators
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
NZ734993A (en) 2015-02-27 2024-03-22 Incyte Holdings Corp Salts of pi3k inhibitor and processes for their preparation
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CN113490668A (en) 2018-10-05 2021-10-08 安娜普尔纳生物股份有限公司 Compounds and compositions for treating diseases associated with APJ receptor activity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE314373B (en) * 1966-04-12 1969-09-08 Sumitomo Chemical Co
FR1492929A (en) * 1966-05-11 1967-08-25 Roussel Uclaf Novel substituted 1- (omega-carboxyalkyl) indoles and method of preparation
US3505354A (en) * 1967-05-18 1970-04-07 Geigy Chem Corp 2-methyl-3-p-halobenzoylindole-n-aliphatic acids
DE1816335A1 (en) * 1968-12-21 1970-07-09 Thiemann Gmbh Chem Pharm Fabri 2-methyl-5-alkoxy-3-acyl-indole-1-acetic - acid and esters thereof
US4894386A (en) * 1987-04-15 1990-01-16 Ici Americas Inc. Aliphatic carboxamides
DE68904342T2 (en) * 1988-04-13 1993-05-06 Ici America Inc CYCLIC AMIDES.
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
DE69314786T2 (en) * 1992-05-13 1998-02-19 Syntex Inc SUBSTITUTED INDOLE AS ANGIOTENSIN II ANTAGONISTS
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
DE4338770A1 (en) * 1993-11-12 1995-05-18 Matthias Dr Lehr Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶
WO1998005637A1 (en) * 1996-08-01 1998-02-12 Merckle Gmbh Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a¿2?
AU717430B2 (en) * 1996-08-26 2000-03-23 Genetics Institute, Llc Inhibitors of phospholipase enzymes

Also Published As

Publication number Publication date
JP2002504539A (en) 2002-02-12
AU2782699A (en) 1999-09-15
CN1299347A (en) 2001-06-13
EA200000868A1 (en) 2001-04-23
ID27280A (en) 2001-03-22
HUP0100757A3 (en) 2001-11-28
CA2322161A1 (en) 1999-09-02
HRP20000552A2 (en) 2001-04-30
NO20004220D0 (en) 2000-08-23
SK12742000A3 (en) 2001-05-10
HUP0100757A1 (en) 2001-08-28
WO1999043651A3 (en) 1999-12-16
BG104780A (en) 2001-10-31
KR20010041343A (en) 2001-05-15
PL342995A1 (en) 2001-07-16
IL137718A0 (en) 2001-10-31
EE200000486A (en) 2002-02-15
BR9908280A (en) 2000-10-31
NO20004220L (en) 2000-10-05
EP1056719A2 (en) 2000-12-06
WO1999043651A2 (en) 1999-09-02

Similar Documents

Publication Publication Date Title
TR200002446T2 (en) Inhibitors of phospholipase enzymes
DK0966465T3 (en) Inhibitors of IMPDH enzymes
EA200100992A1 (en) IMPDH ENZYME INHIBITORS
ATE265426T1 (en) POTASSIUM CHANNEL BLOCKERS
DE60143520D1 (en) INHIBITORS OF HISTON DEACETYLASE
ATE413386T1 (en) PPAR-GAMMA MODULATORS
MY138140A (en) N-aroylphenylalanine derivatives
ATE339196T1 (en) CELL ADHESION INHIBITORS
TR200000481T2 (en) Derivatives of N-Alkoxyphenylalanine.
ATE290382T1 (en) HETEROCYCLIC POTASSIUM CHANNEL INHIBITORS
ATE226193T1 (en) SUBSTITUTED CYCLIC AMINE AS METALLOPROTEASE INHIBITORS
ATE250571T1 (en) POTASSIUM CHANNEL BLOCKERS
TW200621253A (en) 2-amido-thiazole-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
BR9708735A (en) Urea derivatives as inhibitors of the impdh enzyme
PT691988E (en) INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
WO2000071703A3 (en) Inhibition of histone deacetylase
PT1001930E (en) N-HYDROXIFORMAMIDE DERIVATIVES AS MATRIX METALOPROTEINES INHIBITORS
PT784677E (en) INHIBITOR OF PROLIFERACAOD STEM CELLS AND THEIR UTILIZATIONS
DE60042209D1 (en) ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES
TR199802638T2 (en) Use of naaladase inhibitors in cancer treatment.
ATE516027T1 (en) ORAZAMID OROTAT TO PREVENT LIVER DAMAGE
ATE290857T1 (en) BRETYLIUM-CONTAINING COMPOSITIONS AND KITS AND THE USE THEREOF FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES
TR200000624T2 (en) A method for increasing the effectiveness of an enzyme.
BRPI0415207A (en) hair growth inhibition