PT691988E - INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS - Google Patents

INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS

Info

Publication number
PT691988E
PT691988E PT94912327T PT94912327T PT691988E PT 691988 E PT691988 E PT 691988E PT 94912327 T PT94912327 T PT 94912327T PT 94912327 T PT94912327 T PT 94912327T PT 691988 E PT691988 E PT 691988E
Authority
PT
Portugal
Prior art keywords
proliferation
stellic
utilizations
inhibitor
cells
Prior art date
Application number
PT94912327T
Other languages
Portuguese (pt)
Inventor
Vladimir Kozlov
Irena Tsyrlova
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of PT691988E publication Critical patent/PT691988E/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
PT94912327T 1993-03-31 1994-03-29 INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS PT691988E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4094293A 1993-03-31 1993-03-31

Publications (1)

Publication Number Publication Date
PT691988E true PT691988E (en) 2003-02-28

Family

ID=21913839

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94912327T PT691988E (en) 1993-03-31 1994-03-29 INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS

Country Status (17)

Country Link
US (3) US6022848A (en)
EP (1) EP0691988B1 (en)
JP (1) JPH08510997A (en)
CN (1) CN1089344C (en)
AT (1) ATE225370T1 (en)
AU (1) AU694111B2 (en)
CA (1) CA2159506A1 (en)
DE (1) DE69431473T2 (en)
DK (1) DK0691988T3 (en)
ES (1) ES2185649T3 (en)
IL (1) IL109177A (en)
NZ (1) NZ263736A (en)
PT (1) PT691988E (en)
RU (1) RU2155066C2 (en)
TW (1) TW403761B (en)
UA (1) UA40613C2 (en)
WO (1) WO1994022915A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
PT691988E (en) * 1993-03-31 2003-02-28 Wellstat Therapeutics Corp INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS
AU712204C (en) * 1993-03-31 2004-02-26 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
ATE258444T1 (en) * 1998-03-13 2004-02-15 Univ British Columbia THERAPEUTIC CHEMOKINE RECEPTOR ANTAGONISTS
CA2245224A1 (en) * 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
CA2305787A1 (en) * 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
US7378098B2 (en) * 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
CA2335109A1 (en) * 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
US20050059584A1 (en) * 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7368425B2 (en) * 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
ES2522890T3 (en) 2000-12-06 2014-11-19 Anthrogenesis Corporation Method to collect placental stem cells
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
NZ527849A (en) 2001-02-14 2006-09-29 Anthrogenesis Corp Post-partum mammalian placenta, its use and placental stem cells therefrom
US6515001B2 (en) 2001-03-05 2003-02-04 Chemokine Therapeutic Corporation IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2003102151A2 (en) * 2002-05-30 2003-12-11 Celgene Corporation Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors
AU2002325432A1 (en) * 2002-08-02 2004-02-23 Alexandr Mikhailovich Dygay Medicinal agent and method for curing pathological syndrome associated to hemodiscrasia
CA2505534A1 (en) * 2002-11-26 2004-06-10 Anthrogenesis Corporation Cytotherapeutics, cytotherapeutic units and methods for treatments using them
EP1601248A4 (en) * 2003-02-13 2010-01-27 Anthrogenesis Corp Use of umbilical cord blood to treat individuals having a disease, disorder or condition
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
US20050143420A1 (en) * 2003-12-02 2005-06-30 Moutouh-De Parseval Laure Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US7741287B2 (en) * 2004-08-18 2010-06-22 Ipf Pharmaceuticals Gmbh Peptides for the treatment of herpes virus infections
RU2283654C1 (en) * 2005-03-30 2006-09-20 Борис Владимирович Афанасьев Growth factor of protein nature and method for producing growth factors of protein nature and fibroblast proliferation inhibitor
DK1957633T3 (en) 2005-10-13 2014-03-17 Anthrogenesis Corp Immunomodulation USING PLACE SPEECH STEM CELLS
JP2009521930A (en) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション Co-culture of placental stem cells and stem cells derived from a second source
KR20190104428A (en) 2005-12-29 2019-09-09 안트로제네시스 코포레이션 Placental stem cell populations
US20100249209A1 (en) * 2006-06-09 2010-09-30 Kabushiki Kaisha Yakult Honsha Gene involved in immortalization of human cancer cell and use thereof
SI2120977T1 (en) * 2007-02-12 2014-01-31 Anthrogenesis Coroporation Treatment of inflammatory diseases using placental stem cells
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
RU2010116271A (en) * 2007-09-26 2011-11-10 Селджин Селльюлар Терапьютикс (Us) ANGIOGENIC CELLS FROM HUMAN PLACENTAL PERFUSAT
WO2009045360A2 (en) * 2007-09-28 2009-04-09 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
AU2008325142A1 (en) * 2007-11-07 2009-05-14 Anthrogenesis Corporation Use of umbilical cord blood in the treatment of premature birth complications
KR101829310B1 (en) * 2008-06-30 2018-02-14 얀센 바이오테크 인코포레이티드 Differentiation of pluripotent stem cells
US8828376B2 (en) * 2008-08-20 2014-09-09 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
KR20240052847A (en) * 2008-08-20 2024-04-23 셀룰래리티 인코포레이티드 Improved cell composition and methods of making the same
US8728805B2 (en) * 2008-08-22 2014-05-20 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
RU2562154C2 (en) * 2008-11-19 2015-09-10 Антродженезис Корпорейшн Amniotic adhesive cells
BRPI0921999B8 (en) * 2008-11-21 2021-05-25 Anthrogenesis Corp use of a therapeutically effective amount of placental stem cells
EP3190179A1 (en) 2009-07-02 2017-07-12 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
EP3284818B1 (en) * 2010-01-26 2022-03-09 Celularity Inc. Treatment of bone-related cancers using placental stem cells
TW201902496A (en) 2010-04-07 2019-01-16 美商安瑟吉納西斯公司 Using angiogenesis of placental stem cells
AU2011237743A1 (en) 2010-04-08 2012-11-01 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
KR20190108599A (en) 2010-07-13 2019-09-24 안트로제네시스 코포레이션 Methods of generating natural killer cells
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN113559126A (en) 2011-06-01 2021-10-29 人类起源公司 Treatment of pain using placental stem cells
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
CN115137753A (en) 2013-02-05 2022-10-04 细胞结构公司 Natural killer cells from placenta

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1142466A (en) * 1979-01-09 1983-03-08 Cesar Milstein Cell lines
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
SG47987A1 (en) * 1989-05-10 1998-04-17 Somatogen Inc Production in bacteria and yeast of haemoglobin and analogues thereof
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
ATE124421T1 (en) * 1989-09-25 1995-07-15 Genetics Inst METHOD FOR INHIBITING THE GROWTH OF STEM CELLS.
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
JPH06504056A (en) * 1990-12-20 1994-05-12 ザ・ユニバーシティ・オブ・アラバマ・リサーチ・ファウンデーション Transgenic cross-linked hemoglobin
WO1992020369A1 (en) 1991-05-14 1992-11-26 Dana Farber Cancer Institute Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents
US5334706A (en) 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5786334A (en) 1992-08-14 1998-07-28 Technology Resources International, Inc. Hexapeptide having immunostimulatory activity
US5939391A (en) 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
PT691988E (en) * 1993-03-31 2003-02-28 Wellstat Therapeutics Corp INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS
US5631219A (en) 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof

Also Published As

Publication number Publication date
AU6493794A (en) 1994-10-24
NZ263736A (en) 2000-12-22
DK0691988T3 (en) 2003-04-14
EP0691988A1 (en) 1996-01-17
DE69431473D1 (en) 2002-11-07
WO1994022915A1 (en) 1994-10-13
UA40613C2 (en) 2001-08-15
EP0691988B1 (en) 2002-10-02
US6432917B1 (en) 2002-08-13
DE69431473T2 (en) 2003-08-07
CN1124491A (en) 1996-06-12
ATE225370T1 (en) 2002-10-15
IL109177A0 (en) 1994-06-24
US6022848A (en) 2000-02-08
RU2155066C2 (en) 2000-08-27
AU694111B2 (en) 1998-07-16
CN1089344C (en) 2002-08-21
ES2185649T3 (en) 2003-05-01
US20020098583A1 (en) 2002-07-25
JPH08510997A (en) 1996-11-19
IL109177A (en) 2000-12-06
CA2159506A1 (en) 1994-10-13
EP0691988A4 (en) 1997-07-30
TW403761B (en) 2000-09-01

Similar Documents

Publication Publication Date Title
PT691988E (en) INHIBITOR OF PROLIFERATION OF STELLIC CELLS AND THEIR UTILIZATIONS
PT784677E (en) INHIBITOR OF PROLIFERACAOD STEM CELLS AND THEIR UTILIZATIONS
NO984628L (en) Inhibitor and stimulator of stem cell proliferation and applications thereof
IL128221A0 (en) Cell adhesion inhibitors
NO20001583D0 (en) Stimulation of hematopoietic cells in vitro
NO932620L (en) Amindiol protease inhibitors
GR3023233T3 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
NZ324921A (en) Cathepsin K crystal structure and methods of identifying inhibitors of this protease
GB9916810D0 (en) Killing cells
GEP20012440B (en) Biphenylsulfonamide Matrix Metalloproteinase Inhibitors