NO20004220D0 - Inhibitors of phospholipase enzymes - Google Patents
Inhibitors of phospholipase enzymesInfo
- Publication number
- NO20004220D0 NO20004220D0 NO20004220A NO20004220A NO20004220D0 NO 20004220 D0 NO20004220 D0 NO 20004220D0 NO 20004220 A NO20004220 A NO 20004220A NO 20004220 A NO20004220 A NO 20004220A NO 20004220 D0 NO20004220 D0 NO 20004220D0
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- phospholipase enzymes
- phospholipase
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3006298A | 1998-02-25 | 1998-02-25 | |
| PCT/US1999/003899 WO1999043651A2 (en) | 1998-02-25 | 1999-02-24 | Inhibitors of phospholipase enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004220D0 true NO20004220D0 (en) | 2000-08-23 |
| NO20004220L NO20004220L (en) | 2000-10-05 |
Family
ID=21852314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004220A NO20004220L (en) | 1998-02-25 | 2000-08-23 | Inhibitors of phospholipase enzymes |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1056719A2 (en) |
| JP (1) | JP2002504539A (en) |
| KR (1) | KR20010041343A (en) |
| CN (1) | CN1299347A (en) |
| AU (1) | AU2782699A (en) |
| BG (1) | BG104780A (en) |
| BR (1) | BR9908280A (en) |
| CA (1) | CA2322161A1 (en) |
| EA (1) | EA200000868A1 (en) |
| EE (1) | EE200000486A (en) |
| HR (1) | HRP20000552A2 (en) |
| HU (1) | HUP0100757A3 (en) |
| ID (1) | ID27280A (en) |
| IL (1) | IL137718A0 (en) |
| NO (1) | NO20004220L (en) |
| PL (1) | PL342995A1 (en) |
| SK (1) | SK12742000A3 (en) |
| TR (1) | TR200002446T2 (en) |
| WO (1) | WO1999043651A2 (en) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4591800A (en) * | 1999-05-05 | 2000-11-21 | Aventis Pharma Limited | Ureas as cell adhesion modulators |
| EP1305285B1 (en) | 2000-07-25 | 2007-05-16 | Merck & Co., Inc. | N-substituted indoles useful in the treatment of diabetes |
| AU2002243692B2 (en) | 2001-01-29 | 2006-06-08 | 3-Dimensional Pharmaceuticals, Inc. | Substituted indoles and their use as integrin antagonists |
| US20030013656A1 (en) | 2001-05-03 | 2003-01-16 | Bing Wang | Pyruvate derivatives |
| US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| JP4399253B2 (en) | 2001-06-20 | 2010-01-13 | ワイス | Substituted indoleic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| JPWO2003000668A1 (en) * | 2001-06-25 | 2004-10-07 | 日本曹達株式会社 | Oxa (thia) zolidine compound, production method and anti-inflammatory drug |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| PL370445A1 (en) * | 2001-12-03 | 2005-05-30 | Wyeth | Inhibitors of cytosolic phospholipase a2 |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| SI1451154T1 (en) * | 2001-12-03 | 2008-06-30 | Wyeth Corp | Inhibitors of cytosolic phospholipase a2 |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| CN100457730C (en) | 2002-08-29 | 2009-02-04 | 默克公司 | Indoles having anti-diabetic activity |
| JP4340232B2 (en) | 2002-08-29 | 2009-10-07 | メルク エンド カムパニー インコーポレーテッド | Indoles having anti-diabetic activity |
| MXPA05004929A (en) | 2002-11-07 | 2005-08-18 | Akzo Nobel Nv | Indoles useful in the treatment of androgen-receptor related diseases. |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| WO2004052854A2 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| AU2003297727A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| BR0316584A (en) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Substituted oxo-acetyl amino indole acetic acid derivatives as plasminogen activator inhibitor-1 inhibitors (parent-1) |
| CA2509238A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| TW200510305A (en) * | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| MXPA06014535A (en) | 2004-06-18 | 2007-06-05 | Biolipox Ab | Indoles useful in the treatment of inflammation. |
| EP1781645A1 (en) | 2004-08-23 | 2007-05-09 | Wyeth | Oxazolo-naphthyl acids as plasminogen activator inhibitor type-1(pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
| DE602005007765D1 (en) * | 2004-10-27 | 2008-08-07 | Hoffmann La Roche | NEW INDOL OR BENZIMIDAZOLE DERIVATIVES |
| US8097623B2 (en) | 2005-01-19 | 2012-01-17 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| BRPI0614340A2 (en) | 2005-08-17 | 2011-04-12 | Wyeth Corp | replaced indoles and methods of use |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US8168673B2 (en) | 2008-01-22 | 2012-05-01 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| AR072297A1 (en) | 2008-06-27 | 2010-08-18 | Novartis Ag | DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE. |
| DK2448938T5 (en) | 2009-06-29 | 2015-10-05 | Incyte Corp | Pyrimidinones AS PI3K inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| CA2796311A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | Fused derivatives as pi3k.delta. inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| WO2012087881A1 (en) | 2010-12-20 | 2012-06-28 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| EP3888657A1 (en) | 2011-09-02 | 2021-10-06 | Incyte Holdings Corporation | Heterocyclylamines as pi3k inhibitors |
| AR090548A1 (en) | 2012-04-02 | 2014-11-19 | Incyte Corp | BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS |
| EP2875013B1 (en) | 2012-07-17 | 2017-11-29 | Glaxosmithkline Intellectual Property (No. 2) Limited | Indolecarbonitriles as selective androgen receptor modulators |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| LT3831833T (en) | 2015-02-27 | 2023-02-27 | Incyte Holdings Corporation | Processes for the preparation of a pi3k inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| EA202190952A1 (en) | 2018-10-05 | 2021-12-22 | Аннапурна Байо, Инк. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE314373B (en) * | 1966-04-12 | 1969-09-08 | Sumitomo Chemical Co | |
| FR1492929A (en) * | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Novel substituted 1- (omega-carboxyalkyl) indoles and method of preparation |
| US3505354A (en) * | 1967-05-18 | 1970-04-07 | Geigy Chem Corp | 2-methyl-3-p-halobenzoylindole-n-aliphatic acids |
| DE1816335A1 (en) * | 1968-12-21 | 1970-07-09 | Thiemann Gmbh Chem Pharm Fabri | 2-methyl-5-alkoxy-3-acyl-indole-1-acetic - acid and esters thereof |
| US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
| DE68904342T2 (en) * | 1988-04-13 | 1993-05-06 | Ici America Inc | CYCLIC AMIDES. |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| ES2110086T3 (en) * | 1992-05-13 | 1998-02-01 | Syntex Inc | SUBSTITUTED INDOLES AS ANGIOTENSIN II ANTAGONISTS. |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| DE4338770A1 (en) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶ |
| EP0923546B1 (en) * | 1996-08-01 | 2003-11-26 | Merckle GmbH | Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a2 |
| AU717430B2 (en) * | 1996-08-26 | 2000-03-23 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
-
1999
- 1999-02-24 JP JP2000533409A patent/JP2002504539A/en not_active Withdrawn
- 1999-02-24 EP EP99908379A patent/EP1056719A2/en not_active Withdrawn
- 1999-02-24 HU HU0100757A patent/HUP0100757A3/en unknown
- 1999-02-24 TR TR2000/02446T patent/TR200002446T2/en unknown
- 1999-02-24 CN CN99805385A patent/CN1299347A/en active Pending
- 1999-02-24 AU AU27826/99A patent/AU2782699A/en not_active Abandoned
- 1999-02-24 ID IDW20001594A patent/ID27280A/en unknown
- 1999-02-24 WO PCT/US1999/003899 patent/WO1999043651A2/en not_active Application Discontinuation
- 1999-02-24 CA CA002322161A patent/CA2322161A1/en not_active Abandoned
- 1999-02-24 PL PL99342995A patent/PL342995A1/en unknown
- 1999-02-24 EE EEP200000486A patent/EE200000486A/en unknown
- 1999-02-24 BR BR9908280-2A patent/BR9908280A/en not_active IP Right Cessation
- 1999-02-24 SK SK1274-2000A patent/SK12742000A3/en unknown
- 1999-02-24 EA EA200000868A patent/EA200000868A1/en unknown
- 1999-02-24 IL IL13771899A patent/IL137718A0/en unknown
- 1999-02-24 KR KR1020007009456A patent/KR20010041343A/en not_active Application Discontinuation
-
2000
- 2000-08-23 NO NO20004220A patent/NO20004220L/en unknown
- 2000-08-24 HR HR20000552A patent/HRP20000552A2/en not_active Application Discontinuation
- 2000-09-19 BG BG104780A patent/BG104780A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002504539A (en) | 2002-02-12 |
| CN1299347A (en) | 2001-06-13 |
| HUP0100757A3 (en) | 2001-11-28 |
| HRP20000552A2 (en) | 2001-04-30 |
| KR20010041343A (en) | 2001-05-15 |
| HUP0100757A1 (en) | 2001-08-28 |
| CA2322161A1 (en) | 1999-09-02 |
| TR200002446T2 (en) | 2000-12-21 |
| WO1999043651A2 (en) | 1999-09-02 |
| WO1999043651A3 (en) | 1999-12-16 |
| NO20004220L (en) | 2000-10-05 |
| EA200000868A1 (en) | 2001-04-23 |
| AU2782699A (en) | 1999-09-15 |
| SK12742000A3 (en) | 2001-05-10 |
| IL137718A0 (en) | 2001-10-31 |
| EP1056719A2 (en) | 2000-12-06 |
| EE200000486A (en) | 2002-02-15 |
| BG104780A (en) | 2001-10-31 |
| BR9908280A (en) | 2000-10-31 |
| ID27280A (en) | 2001-03-22 |
| PL342995A1 (en) | 2001-07-16 |
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