TR200000478T2 - Arylpyridazinones as inhibitors of prostaglandin endoperoxide H synthase biosynthesis. - Google Patents

Arylpyridazinones as inhibitors of prostaglandin endoperoxide H synthase biosynthesis.

Info

Publication number
TR200000478T2
TR200000478T2 TR2000/00478T TR200000478T TR200000478T2 TR 200000478 T2 TR200000478 T2 TR 200000478T2 TR 2000/00478 T TR2000/00478 T TR 2000/00478T TR 200000478 T TR200000478 T TR 200000478T TR 200000478 T2 TR200000478 T2 TR 200000478T2
Authority
TR
Turkey
Prior art keywords
inhibitors
cox
arylpyridazinones
cyclooxygenase
prostaglandin endoperoxide
Prior art date
Application number
TR2000/00478T
Other languages
Turkish (tr)
Inventor
A. Black Lawrence
Basha Anwer
Kolasa Teodozyj
E. Kort Michael
Liu Huaqing
M. Mccarty Catherine
V. Patel Meena
J. Rohde Jeffrey
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of TR200000478T2 publication Critical patent/TR200000478T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Bu bulus, siklooksijenaz (COX) inhibitörleri olan ve özelde siklooksijenaz-2' nin (COX/2) seçici inhibitörleri olan piridazinon bilesiklerini anlatmaktadir, COX-2, aralarinda gastrointestinal (GI) yolu ve böbrekler bulunan bir çok dokuda önemli bir "bakici" enzim olan kurucu izoform olan siklooksijenaz-1' in (COX-1) tersine, iltihaplanma ile ortaya çikan uyarilabilir izoformdur. Bu bilesiklerin COX-2 için seçiciligi, su anda piyasadaki steroidal-olmayan iltihaplanmaya-karsi ilaçlar (NSAIDler) ile görülen istenmeyen GI ve renal (böbrek) yan etkilerini en aza düsürmektedir.This invention describes pyridazinone compounds, which are inhibitors of cyclooxygenase (COX) and specifically selective inhibitors of cyclooxygenase-2 (COX / 2). Contrary to the founding isoform, cyclooxygenase-1 (COX-1), it is an excitable isoform that occurs with inflammation. The selectivity of these compounds for COX-2 minimizes the undesirable GI and renal (kidney) side effects currently seen with non-steroidal anti-inflammatory drugs (NSAIDs) on the market.

TR2000/00478T 1997-08-22 1998-08-10 Arylpyridazinones as inhibitors of prostaglandin endoperoxide H synthase biosynthesis. TR200000478T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91702397A 1997-08-22 1997-08-22
US12957098A 1998-08-05 1998-08-05

Publications (1)

Publication Number Publication Date
TR200000478T2 true TR200000478T2 (en) 2002-04-22

Family

ID=26827711

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00478T TR200000478T2 (en) 1997-08-22 1998-08-10 Arylpyridazinones as inhibitors of prostaglandin endoperoxide H synthase biosynthesis.

Country Status (14)

Country Link
JP (1) JP2003516925A (en)
KR (1) KR100675028B1 (en)
CN (1) CN1167687C (en)
AR (1) AR015422A1 (en)
AU (1) AU741317B2 (en)
BG (1) BG64675B1 (en)
CZ (1) CZ300847B6 (en)
HU (1) HUP0400909A3 (en)
IL (1) IL133552A (en)
NO (1) NO315423B1 (en)
NZ (1) NZ501808A (en)
PL (1) PL194175B1 (en)
SK (1) SK286972B6 (en)
TR (1) TR200000478T2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300570B6 (en) * 1998-10-27 2009-06-17 Abbott Laboratories Inhibitors of biosynthesis prostaglandin endoperoxide H synthase
FR2969606B1 (en) * 2010-12-22 2013-01-11 Pf Medicament DERIVATIVES OF DIARYLPYRIDAZINONES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS
CN107334767B (en) * 2017-06-08 2019-03-05 中国医学科学院医药生物技术研究所 A kind of application of pyridazinone compound in oncotherapy
JP7147444B2 (en) * 2018-10-03 2022-10-05 株式会社島津製作所 Sample injection device and sample injection system
CN114560814B (en) * 2022-03-02 2023-10-20 天津理工大学 Synthesis method of substituted 2, 3-naphthyridine ketone compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238490A (en) * 1979-02-12 1980-12-09 Diamond Shamrock Corporation Antihypertensive pyridazin(2H)-3-ones
BR8108745A (en) * 1980-08-07 1982-07-06 Diamond Shamrock Corp DIFENYLPYRIDAZINONE HERBICIDES AND PLANT GROWTH REGULATORS
US4404203A (en) * 1981-05-14 1983-09-13 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
WO1988009675A1 (en) * 1987-06-05 1988-12-15 Medicis Corporation Inhibition of arachidonic acid metabolism
AU691673B2 (en) * 1994-11-14 1998-05-21 Dow Agrosciences Llc Pyridazinones and their use as fungicides
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
EP0833664A1 (en) * 1995-06-12 1998-04-08 G.D. SEARLE & CO. Combination of a cyclooxygenase-2 inhibitor and a leukotriene b 4? receptor antagonist for the treatment of inflammations
ES2224366T3 (en) * 1997-03-14 2005-03-01 MERCK FROSST CANADA & CO. PIRIDAZINONAS AS INHIBITORS OF CICLOOXIGENASA-2.

Also Published As

Publication number Publication date
HUP0400909A3 (en) 2004-10-28
IL133552A0 (en) 2001-04-30
NZ501808A (en) 2002-12-20
IL133552A (en) 2005-12-18
BG104241A (en) 2000-10-31
CZ2000446A3 (en) 2000-05-17
BG64675B1 (en) 2005-11-30
AR015422A1 (en) 2001-05-02
AU8697698A (en) 1999-03-16
PL355418A1 (en) 2004-04-19
NO20000863L (en) 2000-02-22
CN1277605A (en) 2000-12-20
CZ300847B6 (en) 2009-08-26
KR100675028B1 (en) 2007-01-29
PL194175B1 (en) 2007-05-31
HUP0400909A2 (en) 2004-07-28
AU741317B2 (en) 2001-11-29
SK2312000A3 (en) 2001-02-12
NO315423B1 (en) 2003-09-01
NO20000863D0 (en) 2000-02-22
SK286972B6 (en) 2009-08-06
KR20010023196A (en) 2001-03-26
CN1167687C (en) 2004-09-22
JP2003516925A (en) 2003-05-20

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