TR199701105T1 - � midazo (1,2-a) pyridin t � revleri. - Google Patents

� midazo (1,2-a) pyridin t � revleri.

Info

Publication number
TR199701105T1
TR199701105T1 TR97/01105T TR9701105T TR199701105T1 TR 199701105 T1 TR199701105 T1 TR 199701105T1 TR 97/01105 T TR97/01105 T TR 97/01105T TR 9701105 T TR9701105 T TR 9701105T TR 199701105 T1 TR199701105 T1 TR 199701105T1
Authority
TR
Turkey
Prior art keywords
alkyl
formula
revleri
midazo
pyridin
Prior art date
Application number
TR97/01105T
Other languages
Turkish (tr)
Inventor
John Beswick Paul
Baxter Campbell Ian
Naylor Alan
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of TR199701105T1 publication Critical patent/TR199701105T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu bulus formul (I) e sahip bilesikler ve bunlarin farmasötik açidan kabuledilebilir türevlerini saglar; bu formülde: R0 halojeni temsil eder; R1 ve R2 bagimsiz olarak H, halojen, C1-4 alkil, bir veya daha fazla flor atomu ile sübstitüde edilmis C1-4 alkil, C1-4 alkoksi, C1-4 hidroksialkil, SC1-4 alkil, C(O)H veya C(O)C1-4 alkilden seçilir; ve R3 C1-4 alkili temsil eder.Formül (I) e sahip bilesikler, COX-2 için güçlü ve seçimli inhibitörlerdir ve çesitli saglik durumu ve hastalik ile baglantili agri, ates ve enflamasyonun tedavisinde kullanim için yararlidirlar.This invention provides compounds of formula (I) and their pharmaceutically acceptable derivatives; in this formula: R0 represents halogen; R1 and R2 are independently substituted with H, halogen, C1-4 alkyl, C1-4 alkyl substituted with one or more fluorine atoms, C1-4 alkoxy, C1-4 hydroxyalkyl, SC1-4 alkyl, C (O) H or C (O) selected from C1-4 alkyl; and R3 represents C1-4 alkyl. Compounds of formula (I) are potent and selective inhibitors for COX-2 and are useful for use in the treatment of various health conditions and disease-related pain, fever and inflammation.

TR97/01105T 1995-04-04 1996-04-02 � midazo (1,2-a) pyridin t � revleri. TR199701105T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds

Publications (1)

Publication Number Publication Date
TR199701105T1 true TR199701105T1 (en) 1998-02-21

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/01105T TR199701105T1 (en) 1995-04-04 1996-04-02 � midazo (1,2-a) pyridin t � revleri.

Country Status (17)

Country Link
EP (1) EP0819127A1 (en)
JP (1) JPH11501049A (en)
KR (1) KR19980703559A (en)
CN (1) CN1186492A (en)
AU (1) AU5276696A (en)
BG (1) BG101934A (en)
CA (1) CA2216809A1 (en)
CZ (1) CZ313397A3 (en)
EA (1) EA199700209A1 (en)
HU (1) HUP9801602A3 (en)
IS (1) IS4570A (en)
NO (1) NO974595L (en)
NZ (1) NZ304886A (en)
PL (1) PL322623A1 (en)
SK (1) SK133297A3 (en)
TR (1) TR199701105T1 (en)
WO (1) WO1996031509A1 (en)

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PE20011333A1 (en) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2
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CN1518550A (en) 2001-06-21 2004-08-04 ʷ��˿�������ȳ�ķ���޹�˾ Imidazo [1,2-A] pyridine derivatives for prophylaxis and treatment of herpes viral infections
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EP1432712B1 (en) 2001-10-05 2006-05-17 SmithKline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
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GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
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GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
AU2002357740A1 (en) 2001-12-11 2003-06-23 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
DK1474395T3 (en) 2002-02-12 2008-02-11 Smithkline Beecham Corp Nicotinamide derivatives useful as p38 inhibitors
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Also Published As

Publication number Publication date
NO974595D0 (en) 1997-10-03
WO1996031509A1 (en) 1996-10-10
IS4570A (en) 1997-09-25
CA2216809A1 (en) 1996-10-10
KR19980703559A (en) 1998-11-05
BG101934A (en) 1999-04-30
NO974595L (en) 1997-12-03
CN1186492A (en) 1998-07-01
NZ304886A (en) 1998-11-25
EP0819127A1 (en) 1998-01-21
CZ313397A3 (en) 1998-03-18
SK133297A3 (en) 1998-07-08
JPH11501049A (en) 1999-01-26
PL322623A1 (en) 1998-02-02
EA199700209A1 (en) 1998-04-30
MX9707379A (en) 1997-11-29
AU5276696A (en) 1996-10-23
HUP9801602A2 (en) 1998-11-30
HUP9801602A3 (en) 1999-01-28

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