MX9707379A - IMIDAZO[1,2-a]PYRIDINE DERIVATIVES. - Google Patents
IMIDAZO[1,2-a]PYRIDINE DERIVATIVES.Info
- Publication number
- MX9707379A MX9707379A MX9707379A MX9707379A MX9707379A MX 9707379 A MX9707379 A MX 9707379A MX 9707379 A MX9707379 A MX 9707379A MX 9707379 A MX9707379 A MX 9707379A MX 9707379 A MX9707379 A MX 9707379A
- Authority
- MX
- Mexico
- Prior art keywords
- 4alkyl
- imidazo
- pyridine derivatives
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 represents halogen; R1 and R2 are independently selected from H, halogen, C1-4alkyl, C1-4alkyl substituted by one or more fluorine atoms, C1-4alkoxy, C1-4hydroxyalkyl, SC1-4alkyl, C(O)H or C(O)C1-4alkyl; and R3 represents C1-4alkyl. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9506965.4A GB9506965D0 (en) | 1995-04-04 | 1995-04-04 | Chemical compounds |
| GB9506965.4 | 1995-04-04 | ||
| GB9512099.4 | 1995-06-14 | ||
| GBGB9512099.4A GB9512099D0 (en) | 1995-06-14 | 1995-06-14 | Chemical compounds |
| GBGB9516117.0A GB9516117D0 (en) | 1995-08-05 | 1995-08-05 | Chemical compounds |
| GB9516117.0 | 1995-08-05 | ||
| PCT/EP1996/001438 WO1996031509A1 (en) | 1995-04-04 | 1996-04-02 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707379A true MX9707379A (en) | 1997-11-29 |
| MXPA97007379A MXPA97007379A (en) | 1998-07-03 |
Family
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Also Published As
| Publication number | Publication date |
|---|---|
| PL322623A1 (en) | 1998-02-02 |
| SK133297A3 (en) | 1998-07-08 |
| NZ304886A (en) | 1998-11-25 |
| IS4570A (en) | 1997-09-25 |
| NO974595L (en) | 1997-12-03 |
| AU5276696A (en) | 1996-10-23 |
| HUP9801602A3 (en) | 1999-01-28 |
| CA2216809A1 (en) | 1996-10-10 |
| EP0819127A1 (en) | 1998-01-21 |
| WO1996031509A1 (en) | 1996-10-10 |
| KR19980703559A (en) | 1998-11-05 |
| EA199700209A1 (en) | 1998-04-30 |
| CN1186492A (en) | 1998-07-01 |
| NO974595D0 (en) | 1997-10-03 |
| CZ313397A3 (en) | 1998-03-18 |
| BG101934A (en) | 1999-04-30 |
| JPH11501049A (en) | 1999-01-26 |
| HUP9801602A2 (en) | 1998-11-30 |
| TR199701105T1 (en) | 1998-02-21 |
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