TNSN06223A1 - Direct compression formulation and process - Google Patents
Direct compression formulation and processInfo
- Publication number
- TNSN06223A1 TNSN06223A1 TNP2006000223A TNSN06223A TNSN06223A1 TN SN06223 A1 TNSN06223 A1 TN SN06223A1 TN P2006000223 A TNP2006000223 A TN P2006000223A TN SN06223 A TNSN06223 A TN SN06223A TN SN06223 A1 TNSN06223 A1 TN SN06223A1
- Authority
- TN
- Tunisia
- Prior art keywords
- dpp
- direct compression
- acceptable
- formulation
- tablets
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of being directly compressed with specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53770604P | 2004-01-20 | 2004-01-20 | |
PCT/EP2005/000400 WO2005067976A2 (en) | 2004-01-20 | 2005-01-17 | Direct compression formulation and process |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN06223A1 true TNSN06223A1 (en) | 2007-12-03 |
Family
ID=39962907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2006000223A TNSN06223A1 (en) | 2004-01-20 | 2006-07-19 | Direct compression formulation and process |
Country Status (4)
Country | Link |
---|---|
CN (2) | CN101618216B (en) |
AR (1) | AR099137A2 (en) |
TN (1) | TNSN06223A1 (en) |
ZA (1) | ZA200605513B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104856970B (en) * | 2015-06-23 | 2017-08-25 | 张磊 | A kind of vildagliptin tablet for treating type II diabetes |
CN105233300B (en) * | 2015-11-05 | 2019-10-25 | 北京泰德制药股份有限公司 | A kind of stable vildagliptin composition and preparation method thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3131402A1 (en) * | 1981-08-07 | 1983-02-24 | Kilian & Co GmbH, 5000 Köln | METHOD AND TABLET PRESS FOR THE SUCCESSFUL PRODUCTION OF A VARIETY OF TABLETS OF THE SAME WEIGHT |
DE19823831A1 (en) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | New pharmaceutical use of isoleucyl thiazolidide and its salts |
FR2822826B1 (en) * | 2001-03-28 | 2003-05-09 | Servier Lab | NOVEL ALPHA-AMINO ACID SULPHONYL DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
FR2824825B1 (en) * | 2001-05-15 | 2005-05-06 | Servier Lab | NOVEL ALPHA-AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP2005519052A (en) * | 2002-01-11 | 2005-06-30 | アスファルマ リミテッド | Pravastatin pharmaceutical preparation and method of use thereof |
JP2003327532A (en) * | 2002-05-10 | 2003-11-19 | Takeda Chem Ind Ltd | Peptidase inhibitor |
-
2005
- 2005-01-17 CN CN200910164779XA patent/CN101618216B/en active Active
- 2005-01-17 CN CNA2005800056665A patent/CN101262851A/en active Pending
-
2006
- 2006-07-04 ZA ZA200605513A patent/ZA200605513B/en unknown
- 2006-07-19 TN TNP2006000223A patent/TNSN06223A1/en unknown
-
2015
- 2015-01-20 AR ARP150100149A patent/AR099137A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101262851A (en) | 2008-09-10 |
CN101618216A (en) | 2010-01-06 |
CN101618216B (en) | 2012-01-04 |
AR099137A2 (en) | 2016-06-29 |
ZA200605513B (en) | 2007-11-28 |
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