TN2018000345A1 - Trispecific and/or trivalent binding proteins - Google Patents

Trispecific and/or trivalent binding proteins

Info

Publication number
TN2018000345A1
TN2018000345A1 TNP/2018/000345A TN2018000345A TN2018000345A1 TN 2018000345 A1 TN2018000345 A1 TN 2018000345A1 TN 2018000345 A TN2018000345 A TN 2018000345A TN 2018000345 A1 TN2018000345 A1 TN 2018000345A1
Authority
TN
Tunisia
Prior art keywords
trispecific
binding proteins
proteins
binding
trivalent
Prior art date
Application number
TNP/2018/000345A
Inventor
Christian Beil
Jochen Beninga
Carsten Corvey
Christian Lange
Wulf Dirk Leuschner
Gary Nabel
Ercole Rao
Edward Seung
Ronnie Wei
Lan Wu
Zhi-Yong Yang
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Priority claimed from PCT/US2017/027488 external-priority patent/WO2017180913A2/en
Publication of TN2018000345A1 publication Critical patent/TN2018000345A1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein posscss a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
TNP/2018/000345A 2016-04-13 2017-04-13 Trispecific and/or trivalent binding proteins TN2018000345A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662322036P 2016-04-13 2016-04-13
US201662331191P 2016-05-03 2016-05-03
US201662412187P 2016-10-24 2016-10-24
EP17305298 2017-03-17
PCT/US2017/027488 WO2017180913A2 (en) 2016-04-13 2017-04-13 Trispecific and/or trivalent binding proteins

Publications (1)

Publication Number Publication Date
TN2018000345A1 true TN2018000345A1 (en) 2020-06-15

Family

ID=69629979

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP/2018/000345A TN2018000345A1 (en) 2016-04-13 2017-04-13 Trispecific and/or trivalent binding proteins

Country Status (3)

Country Link
EC (1) ECSP18084491A (en)
TN (1) TN2018000345A1 (en)
ZA (1) ZA201806629B (en)

Also Published As

Publication number Publication date
ZA201806629B (en) 2021-06-30
ECSP18084491A (en) 2019-01-31

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