EA202191078A3 - TRISSPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR PREVENTION OR TREATMENT OF HIV INFECTION - Google Patents
TRISSPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR PREVENTION OR TREATMENT OF HIV INFECTIONInfo
- Publication number
- EA202191078A3 EA202191078A3 EA202191078A EA202191078A EA202191078A3 EA 202191078 A3 EA202191078 A3 EA 202191078A3 EA 202191078 A EA202191078 A EA 202191078A EA 202191078 A EA202191078 A EA 202191078A EA 202191078 A3 EA202191078 A3 EA 202191078A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- binding proteins
- prevention
- treatment
- trisspecific
- trivalent binding
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 6
- 108091008324 binding proteins Proteins 0.000 title abstract 6
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В данном документе предусмотрены композиции, содержащие триспецифические и/или тривалентные связывающие белки, содержащие четыре полипептидные цепи, которые образуют три антигенсвязывающих участка, которые специфически связывают один или несколько целевых белков HIV или один или несколько Т-клеточных рецепторов, где первая пара полипептидов, образующих связывающий белок, содержит два вариабельных домена, характеризующихся перекрестной ориентацией, и где вторая пара полипептидов, образующих связывающий белок, содержит один вариабельный домен. В данном документе также предусмотрены способы получения триспецифических и/или тривалентных связывающих белков и варианты применения таких связывающих белков для лечения и/или предупреждения инфекции, вызываемой HIV/СПИД.Provided herein are compositions containing trispecific and / or trivalent binding proteins containing four polypeptide chains that form three antigen binding sites that specifically bind one or more target HIV proteins or one or more T cell receptors, where the first pair of polypeptides forming binding protein contains two variable domains characterized by cross-orientation, and where the second pair of polypeptides forming the binding protein contains one variable domain. This document also provides methods for making trispecific and / or trivalent binding proteins and options for using such binding proteins for the treatment and / or prevention of HIV / AIDS infection.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331169P | 2016-05-03 | 2016-05-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA202191078A2 EA202191078A2 (en) | 2021-07-30 |
| EA202191078A3 true EA202191078A3 (en) | 2021-11-30 |
Family
ID=77443265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202191078A EA202191078A3 (en) | 2016-05-03 | 2016-10-24 | TRISSPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR PREVENTION OR TREATMENT OF HIV INFECTION |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA202191078A3 (en) |
-
2016
- 2016-10-24 EA EA202191078A patent/EA202191078A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA202191078A2 (en) | 2021-07-30 |
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