Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Us HealthfiledCriticalSanofi Sa
Publication of AR118602A1publicationCriticalpatent/AR118602A1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
En el presente documento se proporcionan composiciones que comprenden proteínas de unión triespecíficas y/o trivalentes que comprenden cuatro cadenas polipeptídicas que forman tres sitios de unión a antígeno que se unen específicamente a una o más proteínas diana del VIH, en las que un primer par de polipéptidos que forman la proteína de unión poseen dominios variables dobles que tienen una orientación cruzada, y en la que el segundo par de polipéptidos posee un dominio variable único. También se proporcionan en el presente documento métodos para preparar proteínas de unión triespecíficas y/o trivalentes y usos de dichas proteínas de unión para el tratamiento y/o la prevención del VIH / SIDA.Provided herein are compositions comprising trivalent and / or trivalent binding proteins comprising four polypeptide chains that form three antigen-binding sites that specifically bind to one or more HIV target proteins, wherein a first pair of polypeptides that make up the binding protein possess dual variable domains that are cross-oriented, and wherein the second pair of polypeptides possesses a single variable domain. Also provided herein are methods for preparing trivalent and / or trivalent binding proteins and uses of such binding proteins for the treatment and / or prevention of HIV / AIDS.
ARP200100963A2019-04-092020-04-06
TRIESPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR THE TREATMENT OF HIV INFECTION
AR118602A1
(en)