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Publication of AR108210A1publicationCriticalpatent/AR108210A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Peptides Or Proteins
(AREA)
Abstract
La descripción proporciona proteínas de unión triespecíficas y/o trivalentes que comprenden cuatro cadenas de polipéptidos que forman tres sitios de unión con antígenos que específicamente unen una o varias proteínas blanco, en donde un primer par de polipéptidos que forman la proteína de unión posee dominios variables duales que tienen una orientación cruzada y en donde un segundo par de polipéptidos que forman la proteína de unión posee un dominio variable simple. La descripción también proporciona métodos para preparar proteínas de unión triespecíficas y/o trivalentes y usos de tales proteínas de unión.The description provides trispecific and / or trivalent binding proteins comprising four polypeptide chains that form three binding sites with antigens that specifically bind one or more white proteins, wherein a first pair of polypeptides that form the binding protein has variable domains. Duals that have a cross-orientation and where a second pair of polypeptides that form the binding protein has a simple variable domain. The description also provides methods for preparing triespecific and / or trivalent binding proteins and uses of such binding proteins.
ARP170100972A2016-04-132017-04-17
THREE-SPECIFIC AND / OR TRIVAL UNION PROTEINS
AR108210A1
(en)